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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF DOLUTEGRAVIR AND RILPIVIRINE BY FORCED DEGRADATION STUDIES
Background: Dolutegravir and Rilpivirine are two antiretroviral drugs that have been approved for the treatment of HIV Infection. An error-free, accurate, precise and valid reverse-phase liquid chromatography method was developed for the quantitation of Dolutegravir and Rilpivirine in its bulk form as well as in combined dosage form by forced degradation studies. Methods: Chromatographic separatio...
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IN-VIVO PLATELET ANTI-AGGREGATION ACTIVITY OF CRUDE FUCOIDAN OF SARGASSUM POLYCYSTUM
Platelet or thrombosis is one of the most important factors in blood clots formation. However, activation of platelet aggregation plays a significant role in homeostasis process, but in excess, it causes different cardiovascular diseases such as myocardial infarction, atherothrombosis disease, and coronary artery disease. To reduce the occurrence of these diseases, anti-platelet agents can be used...
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HYDROXYCHLOROQUINE (HCQ) AS AN EMERGING AND PROMISING DRUG CANDIDATE IN COVID-19 PANDEMIC – A SYSTEMATIC REVIEW
Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of...
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ANTIMICROBIAL ACTIVITY OF EUGENOL AGAINST HUMAN PATHOGENIC BACTERIA BY MINIMAL INHIBITORY CONCENTRATION, MINIMAL BACTERICIDAL CONCENTRATION AND DISC-DIFFUSION METHODS
Essential oils from plants have been reported to have antibacterial activity. Essential oil is a mixture of many chemicals, and one or more chemicals in essential oil may have antibacterial activity. In our laboratory, essential oil from the leaves of Ocimum sanctum L. was found to have antibacterial activity against 18 human bacteria. GC-MS analysis of the Ocimum sanctum essential oil revealed th...
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THE POTENTIAL OF INDONESIAN TRADITIONAL HERBAL MEDICINE AS IMMUNOMODULATORY AGENTS: A REVIEW
The prevalence of infectious diseases in the world, including in Indonesia, has increased significantly. One of the factors of death due to infectious disease is decreasing the human body's immune system. Therefore, studies on immunomodulatory agents need further investigation. Many studies have shown that secondary metabolite compounds contained in plants have immunomodulatory properties. These c...
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COMPARISON OF CONVENTIONAL AND REAL-TIME PCR FOR MONITORING OF RESPIRATORY SYNCYTIAL VIRUS AMONG PEDIATRIC PATIENTS IN NORTHERN INDIA 2011-2014
Background: In India, the respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections (17 to 32%) in the pediatric age group. Viral detection during the acute phase of infection is a critical step for care and prevention. Objectives: We sought to investigate the detection of RSV by rt-RT-PCR, conventional PCR and cell culture among pediatric patients. Methods: Throat/n...
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COMPARATIVE EVALUATION OF ANTIDEPRESSANT ACTIVITY OF VARIOUS EXTRACTS OF NYCTANTHES ARBOR-TRISTIS
The present study evaluates the antidepressant activity of Nyctanthes arbor-tristis (NT). In the present study antidepressant effects of hydroalcoholic leaf extract (250 & 500 mg/kg) (NTL), flower extract (250 & 500 mg/kg) (NTF) and combination extract (leaf+flower extract in equal ratio) (250 & 500 mg/kg) (NTC) of Nyctanthes arbor-tristis were evaluated by the use of forced swim test....
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FORMULATION AND EVALUATION OF A pH DEPENDENT MULTI-PARTICULATE COLON TARGETED DRUG DELIVERY SYSTEM USING POWDER LAYERING TECHNOLOGY OF KETOPROFEN
Multiparticulates consist of discrete, small, multiple unit systems of active pharmaceutical ingredients exhibiting the desired drug release pattern. The present work is concerned with the formulation and evaluation of a pH-dependent multiparticulate colon targeted drug delivery system of ketoprofen, a well established anti-inflammatory drug used in the management of inflammatory bowel disease. Th...
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DETERMINATION OF LETHAL CONCENTRATION FIFTY (LC50) OF WHOLE PLANT ETHANOLIC EXTRACT OF AMARANTHUS VIRIDIS, CYNODON DACTYLON & AERVA SANGUINOLENTA ON ZEBRAFISH (DANIO RERIO) EMBRYOS
Introduction: Most potent toxic elements are derived from nature only. So safety and toxicological evaluation of plant extracts which are otherwise thought to be very safe, are mandatory. The zebrafish embryo has become an important model organism for toxicological research due to its small size, genetic similarity to humans, etc. The Objective: The objective of the present study is to determine a...
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ISOLATION AND CHARACTERIZATION OF BIOFILM FORMING MULTIPLE DRUG-RESISTANT BACTERIA FROM PATIENTS INFECTED WITH UTI
Biofilms are protective organic extracellular polymeric substances secreted by a microbial population which prevents the penetration of antimicrobial substances such as antibiotics. The existence of biofilms has become a significant problem in the case of infections as well as industrial processes. Although, biofilms may act as an advantage to the microbial community, they are found to cause food ...
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