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RELATIONSHIP BETWEEN SMOKING AND HISTOLOGY OF LUNG CANCER IN MALAPPURAM DISTRICT OF KERALA, SOUTH INDIA
Background: Lung Cancer is the commonly diagnosed neoplasm in males in India. The main histological types of lung cancer are squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. However, histological types may vary with the changes in geographical region, smoking status and other social factors. This study aimed to find out the relationship of smoking and histolo...
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ESTIMATION, RECOVERY STUDY & ASSAY OF MARKETED DOSAGE FORM OF BUPROPION HYDROCHLORIDE THROUGH DERIVATIVE SPECTROSCOPIC METHOD
Depression is the most common and spreadable disorder in recent age as people are going through a lot of pressure in their daily work caliber and so many unconditional events. A new approach called derivatization spectroscopy was developed for the anti-depressant agent, marketed formulation of Bupropion hydrochloride, to confirm the interfering substances from the excipients of solid dosage form, ...
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A COMPREHENSIVE REVIEW ON BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR PHARMACEUTICALS
Bioanalysis is most widely used for drug discovery and development. Bioanalytical methods have been working for the quantitative estimation of drugs, or its metabolites and biomarkers in its biological samples. The steps involved in bioanalysis comprise of many steps that are from sample collection to sample analysis and then data reporting. The first step involves sample collection from clinical ...
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CURRENT AND FUTURE ADVANCEMENT OF FAST DISSOLVING ORAL THIN FILM
The development of fast-dissolving oral thin films has recently followed the progression of dosage forms from straightforward ordinary tablets and capsules to modified release tablets and capsules, oral disintegrating tablets, and wafers. A hydrophilic polymer used in fast- dissolving oral thin films quickly hydrates or adheres when applied on the tongue or in buccal cavity. These films melt or di...
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ACUTE A SUB-CHRONIC TOXICITY AND IMMUNOMODULATORY ACTIVITY OF AN AQUEOUS EXTRACT OF EUPHORBIA RESINIFERA IN RODENTS
Euphorbia resinifera Berg. (ER) an endemic Moroccan plant has been used to treat different diseases. In spite of its toxicological potential, no scientific report until now was made to evaluate in-vivo neither the toxic effect nor its immunomodulatory activity. The objective was to evaluate the safety of an aqueous extract (AE) of ER in-vivo and its effect on the biochemical, immunological and his...
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SYNTHESIS AND CHARACTERIZATION OF 2-(PYRIDIN-2-YL)GUANIDINE DERIVATIVES AND THEIR METAL COMPLEXES AS POTENTIAL ANTIBACTERIAL AGENTS USING PHOSPHORYL CHLORIDE
Guanidines were prepared by the condensation reaction of primary amine (-NH2) with urea derivatives (R2NCONR2) in the presence of POCl3. In this research guanidine-pyridine, hybrid derivatives were synthesized by substituted urea derivatives namely 1,1,3,3-tetramethylurea and N, N′-dimethylurea with 2-aminopyridine. The metal complexes were obtained by reaction of metal(II) chloride with guani...
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PHENOLIC ACID DERIVATIVES AS PRESERVATIVES: SYNTHESIS, ANTIOXIDANT, ANTIMICROBIAL POTENTIAL AND THEIR PRESERVATIVE EFFECTIVENESS
Natural phenolic acids alkyl esters viz methyl, ethyl, propyl was synthesized and characterized by spectral means FTIR, 1HNMR, and 13CNMR. All the synthesized esters were examined for their antimicrobial potential, preservative efficacy and antioxidant potential. Among the synthesized ester derivative caffeic acid and gallic acid, derivatives were displayed excellent antioxidant and antimicrobial ...
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COMPUTATIONAL APPROACH FOR DESIGNING AND DEVELOPMENT OF POTENT DRUG INHIBITOR FOR APP GENE IN ALZHEIMER’S DISEASE
Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, reasoning, planning, language, and perception, and eventually even the ability to carry out the simplest tasks. Many scientists believe that Alzheimer's disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain ...
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QUANTIFICATION AND VALIDATION OF AMLODIPINE BESYLATE, OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE BY RP-HPLC IN MARKETED DOSAGE FORM
The endeavor of the present work is to develop a simple, economical, efficient, novel green analytical method for the estimation of Amlodipine besylate, Olmesartan medoxomil and Hydrochlorothiazide in pharmaceutical formulation. Quantification was carried out using an Inertsil CN-3.5 μm (4.6 ×250 mm) column, where the mobile phase consisting of 10 mm Phosphate buffer (pH 3.0) and Acetonitrile (4...
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A CRITICAL REVIEW ON THE MEDICINAL HERB AEGLE MARMELOS (LINN.) CORREA
Plants are essential to the survival of every species on Earth. Animal and plant life have a history of mutual consumption since antiquity. Earth's sole producers are plant is a fact. As researchers learn more about plants, this assumption is being challenged. The Rutaceae family's citrus species Aegle marmelos (Bael), a well-known medicinal herb, has a lengthy study history. In addition to its us...
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