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ISOLATION AND SCREENING OF CYANOBACTERIAL CULTURES FROM BILASPUR DISTRICT OF CHHATTISGARH: EXTRACTION AND PURIFICATION OF BIO-ACTIVE METABOLITES
Metabolites from natural sources (microbes, plants, animals) have helped to double the human life span during the 20th century, combated pain and suffering, and revolutionized the practice of medicine. Microbes have provided compounds that have cured or reduced the effect of human diseases for 70 years. Microbial products include antibiotics against bacteria and fungi, antitumor drugs, immunosuppr...
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MICROENCAPSULATION: A STRATEGY TO SURPASS PHOTO INSTABILITY AND LOW PENETRABILITY OF SKIN LIGHTENING AGENTS
Objective: Kojic acid and arbutin are potent agents for effective treatment of hyperpigmentation. However, low photostability, low permeability and high irritancy exhibited by them make topical delivery a challenge. The aim of this study was to develop novel photostable and highly penetrable formulation of kojic acid and arbutin to combat hyper-pigmentation effectively at lower concentrations in c...
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CHEMICAL COMPOSITION AND ANTIMICROBIAL PROPERTIES OF DIFFERENT BASIL OILS
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; taneth...
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2D QSAR STUDY OF INDOLE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS
The NSAIDs are popular in reducing acute and chronic inflammation as they have no abuse liability. QSAR (Quantitative structure-activity relationship) approach is a very useful and widespread technique for drug design. 2D QSAR models are based on descriptors derived from a two-dimensional graph representation of a molecule. The 2D QSAR study was performed on selected twenty-four compounds from syn...
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A REVIEW ON CHROMEN DERIVATIVES AS ANTIEPILEPTICS
Chromens are oxygen-containing heterocycles, abundantly found in nature in the form of flavone, is flavones, flavanones, catechins, anthocyanins and collectively known as flavonoids and isoflavonoids. Being a polar and ionizable aromatic compound, it improves the pharmacokinetic characteristics of lead molecules. Imidazole derivatives have occupied a unique place in the field of medicinal chemistr...
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AN ATTEMPT TO UNDERSTAND AND VALIDATE THE FACTORS CONTROLLING IN-SITU RAFT FORMATION PROCESS
In this study, in-situ raft forming Levofloxacin Suspension formulation was developed. In-vitro conditions like temperature, pH, and RPM simulating the in-vivo conditions like gastric pH, body temperature, and gastric motility respectively were identified as critical process parameters in system scale-up studies. Challenging and characterization were performed in-vitro. The working limits were ide...
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ASSESSMENT OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF WHEY PROTEIN AND QUANTIFICATION BY REVERSE PHASE HPLC
Dairy and milk consumption are habitually included as important essentials in a healthy and balanced diet. It is the principal food for mammals and provides all the essential energy and nutrients to guarantee proper growth and development. Whey protein present in the milk is quickly digested and therefore amino acids are delivered quickly to muscles to help start the muscle-building process. The m...
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TOPICAL TREATMENT USING ANTIHISTAMINIC, STEROID AND A COMBINATION OF BOTH IN ALLERGIC RHINITIS-A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL
This study evaluates the effectiveness of corticosteroid fluticasone propionate, antihistaminic azelastine, and a combination of both as well as to find out the prognostic significance of absolute eosinophil count (AEC) in the topical treatment of allergic rhinitis. All cases presenting with symptoms of nasal allergy were included maintaining double-blind status. A total of 225 participants of gro...
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SYNTHESIS OF TUNGSTEN NANOPARTICLES FOR THEIR BIOMEDICAL APPLICATION
The application of nanobiotechnology is an emerging area of nanoscience and nanotechnology. In the present studies, tungsten nanoparticles were synthesized and reduced chemically, and character-rization was done by UV, SEM, TEM, FT-IR, and XRD. The size of nanoparticles was found to be 20 nm. Further, these nanoparticles were teste for various biological applications. In antimicrobial activity, it...
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FORMULATION AND EVALUATION OF NOVEL SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF SUMATRIPTAN SUCCINATE
In migraine disease which is an autoimmune disorder, 5-HT1 receptor agonist like Sumatriptan succinate (STS) is widely used. Its bioavailability is 15-17% due to extensive presystemic metabolism. The objective of this work was to prepare Sumatriptan succinate (STS) in a self nanoemulsifying drug delivery system (SNEDDS) and then convert it into solid-SNEDDS (S-SNEDDS) via extrusion/spheronization ...
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