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SYNTHESIS, CHARACTERIZATION, AND DNA- BINDING INTERACTION STUDIES OF A NEW MANNICH BASE AND IT’S METAL COMPLEXES
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important ...
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VARIOUS MEDICINAL PLANTS: A PROMISING TREATMENT FOR MULTIDRUG-RESISTANT BACTERIA ISOLATED FROM WOUND INFECTION
Bacteria have proved remarkably developing resistant to a known antibiotic; however, Medicinal plants have manifested notably useful for the control of bacterial infections. This study aimed to isolate and identify the multidrug-resistant bacteria from wound infection, then examine the antibacterial activity of different concentration of the ethanolic extracts of Cymbopogon proximus, Azadirachta i...
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CANNABIS SATIVA L.: A REVIEW OF THE MEDICINAL PROPERTIES OF THIS ‘WONDER PLANT’ AND AN UPDATE ON THE NIGERIA SITUATION
Cannabis sativa L. is an annual herbal plant of the family Cannabinaceae and abundant in nature. It is known locally as igbo, taba, blaze, joint, pot, dope, ganja, sensi, kpoli, weed, and morocco on the streets of Nigeria, and used as a medicinal plant for many centuries in many different parts of the world. Although native to Central Asia, Cannabis is now grown globally. Cannabis is the most abus...
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FORMULATION CHARACTERIZATION AND OPTIMIZATION OF CEFIXIME TRI-HYDRATE HYDROGEL TABLET BY USING DESIGN EXPERT
The purpose of current research work has been made to formulate a gastro-retentive drug delivery system (GRDDS) of those drugs having a narrow absorption window or having good absorption at the proximal part of the gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailability of a drug. Gastro-retentive hydrogel tablet of Cefixime trihydrate was prepared by the direct ...
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GASTROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF TRICHOSANTHES DIOICA FRUIT ON EXPERIMENTAL GASTRIC ULCER IN RATS
Peptic ulcer is a condition associated with a number of factors involving excessive acid secretion in the stomach. This condition is difficult to control with single drug therapy and complete cure cannot be achieved. Even after discontinuation of the drug the relapse rate is high, and the long-term use of synthetic drugs produces adverse effects on the human body. The present study is expected to ...
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GREENING THE INDIAN PHARMACEUTICAL SUPPLY CHAIN: A STEP TOWARDS SUSTAINABILITY
Environmental management is becoming the need of the hour due to rising pollution and environmental hazards. Incorporating green thinking into an organization will not serve the purpose in entirety. Therefore, we need to move towards greening the entire supply chain, here termed as Green supply chain management (GSCM). Adopting green supply chain management practices has been argued to enhance the...
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A STUDY OF POSSIBLE PROTECTION BY NEFIRACETAM ON ESLICARBAZEPINE INDUCED MEMORY IMPAIRMENT IN TEMPORAL LOBE EPILEPSY
Memory impairment (MI) is commonly seen in epilepsy and is at times aggravated by antiepileptic therapy. Recent studies reported that co-administration of nootropic agent with an antiepileptic drug (AED) might decrease the MI. This study was designed to evaluate MI activity of Eslicarbazepine (ESL) in temporal lobe epilepsy (TLE) and to assess the protective effect of Nefiracetam (NEF) which is a ...
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RP-UPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF ELVITEGRAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE IN SOLID DOSAGE FORM
A stability indicating method was developed and validated for simultaneous estimation of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate (Tenofovir D F) in solid dosage form using RP-UPLC method. Waters Acquity UPLC system with Column Endoversilo C18 (50 × 2.1 nm, 1.8 μm) having PDA detector at 252 nm wavelength was used. Mobile phase having a mixture of 700 ml of Acet...
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DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF NANOCRYSTALS OF NITROFURANTOIN
Nitrofurantoin is a broad-spectrum bactericidal antibiotic that affects both gram-negative and gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidal effects by inhibiting the synthesis of DNA, RNA, protein, and cell wall synthesis. Nanocrystals of NFT were prepared by a cold high-pressure homogenization technique. To improve the dissolution rate, the drug was formulated in...
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CHEMICAL COMPOSITION OF FAGOPYRUM ESCEULENTUM MOENCH SEED THROUGH GC-MS
Medicinal herbs are a precious heritage for us and since long is a part of traditional as well modern system of medicine. These herbs provide less toxic and more effective drug molecules which are helpful in various ailments. In the present work, we have focused on an edible herb which bears a large number of medicinal properties. Fagopyrum esceulentum Moench (Buckwheat) has a long tradition of be...
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