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GC-MS ANALYSIS, PHYTOCHEMICALS AND IN-VITRO ANTIOXIDANT PROPERTIES OF ROOT EXTRACTS OF PHLOGACANTHUS THYRSIFLORUS NEES., WESTERN ASSAM, INDIA
The Phlogacanthus thyrsiflorus roots have been used by the tribal population of western Assam to treat the hepatic disorder. The present study focuses on phytochemical screening, GC-MS analysis and in-vitro antioxidant activities using different extracts. Plant total phenolics, flavonoids, reducing power assay and antioxidant activity was evaluated. DPPH, FRAP, ABTS, Metal chelating activity,...
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PHYTOPHARMACOGNOSTICAL STUDY OF TUBERS OF EULOPHIA NUDA LINDL.
Plants and plants-based medicines have been used to treat many ailments since the ancient times. Family Orchidaceae to which orchids belongs is the largest family among monocotyledons. The genus Eulophia comprises perennial terrestrial orchids with fleshy tubers, rarely pseudobulbs. One such perennial herb having underground tubers, Eulophia nuda, belonging to family Orchidaceae, has been tradit...
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POTENTIAL ACTIVITY OF SPICES ON ACE2 EXPRESSION – A MINI REVIEW
Spices, nature's gift to mankind are the reservoir of secondary metabolites – alkaloids, flavonoids, saponins, tannins, glycerides, sulfides, and other oxygen/nitrogen compounds that can effectively treat viral infections, bacterial infections, and respiratory problems. Since ancient days they have been used for its anti-inflammatory, carminative, antioxidant, anti-clotting, anti-microbial, anti...
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ESTIMATION OF IPRATROPIUM BROMIDE BY EXTRACTION FREE SPECTRO-PHOTOMETRIC METHOD USING SULPHONAPTHALEIN DYE
The present paper portrays a simple, rapid, nonextractive spectrophotometric method for the estimation of an anticholinergic drug, Ipratropium Bromide. The method is based on the formation of an instantaneous stable yellow colored ion pair complex of drug with a chloroformic solution of reagent Bromophenol Blue (BPB) which shows absorption maxima at 416 nm. Job’s plot of continuous variation aff...
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CURRENT SCENARIOS ON REGULATORY LANDSCAPE OF INDIAN PHARMACEUTICAL INDUSTRIES
India is the fourth largest generic pharmaceutical market in the world. Indian pharmaceutical industries are very well established in today’s world and continuously producing a variety of products, which are useful in the treatment of various diseases and grabbing the market segments. India has a large number of resources to contribute vitality in the research and manufacturing process, and due ...
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EFFECTS OF BETA-ADRENOCEPTOR BLOCKERS ON THE PLATELET AND CARDIOMETABOLIC INDICES IN UNCONTROLLED HYPERTENSION
Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study wa...
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ENHANCED MECHANISM OF METAL NANOPARTICLES USING SYZYGIUM CUMINI AS A POTENTIAL SYNTHESIZER AND ITS INHIBITORY EFFECT
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resis...
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FORMULATION CHARACTERIZATION AND OPTIMIZATION OF CEFIXIME TRI-HYDRATE HYDROGEL TABLET BY USING DESIGN EXPERT
The purpose of current research work has been made to formulate a gastro-retentive drug delivery system (GRDDS) of those drugs having a narrow absorption window or having good absorption at the proximal part of the gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailability of a drug. Gastro-retentive hydrogel tablet of Cefixime trihydrate was prepared by the direct ...
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DESIGN AND DEVELOPMENT OF DANTROLENE SPHERICAL AGGLOMERATES FOR IMPROVEMENT IN BIOAVAILABILITY
The purpose of this research was to obtain directly compressible agglomerates of Dantrolene using spherical agglomerates. Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Sodium hydroxide acted as a good solvent, aqueous solution of PEG 6000 in hydrochloric acid served as bad solvent and isopropyl acetate was used as bridging liquid. The optimization of for...
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ANTIOXIDANT MEDIATED ULCER HEALING POTENTIAL OF HYPERIN ISOLATED FROM FLOWERS OF RHODODENDRON ARBOREUM IN EXPERIMENTAL RAT
Hyperin, a flavonoid is an active phytochemical constituent gift in numerous plants as well as, Hypericum perforatum, Drosera rotundifolia, Stachys byzantina, Prunella vulgaris, Rumex acetosella, Abelmoschus manihot and Rhododendron arboreum. It’s protecting result on cultured PC12 cells against toxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Hyperin, isoquercitrin and querce...
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