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FORMULATION AND OPTIMIZATION OF CHLORTHALIDONE LOADED NANO-PARTICLES BY ANTISOLVENT PRECIPITATION USING BOX-BEHNKEN DESIGN
Chlorthalidone is a long-acting diuretic recommended for treatment of oedema associated with congestive heart failure. It is oral active diuretic mainly acting on distal convoluted tubule of nephron. Chlorthalidone is poorly soluble in water at room temperature. Nanoparticles have great potential as a carrier and can improve the solubility of poorly water-soluble drugs like chlorthalidone. The aim...
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IN-VITRO ANTICHOLINESTERASE ACTIVITY OF PHYLLANTHUS EMBLICA AND TAMARINDUS INDICA
Alzheimer’s disease (AD) is a major type of dementia. AD is associated with memory impairment and cognitive deficit. It is characterized by low levels of acetylcholine in the brain of AD patients. The inhibition of acetylcholinesterase (AChE) has been one of the most used strategies for the management of mild to moderate AD. In the present study, n-hexane, ethyl acetate, and hydroalcoholic leaf ...
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ANTIOXIDATIVE AND HYPOLIPIDEMIC EFFECT OF PUERARIA TUBEROSA WATER EXTRACT (PTWE) IN RATS WITH HIGH FAT DIET INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is chronic liver diseases ensuing from excessive fat accumulation in liver attributed to high dietary fat and carbohydrate and lower hepatic activity. It is associated with obesity and high BMI (body mass index). The excess carbohydrate-rich diet activates its conversion to TG (triglycerides), which gets accumulated in adipose and non-adipose tissues in th...
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SYNTHESIS AND ANTIBACTERIAL SCREENING OF FIVE NEW AZOMETHINE DERIVATIVES OF 2-AMINO-2-METHYL-1-PROPANOL
In this present investigation author reporting the anti-bacterial activity of five new azo methines, namely 2-((1-hydroxy-2- methyl propan-2-ylimino) methyl)-6-methoxyphenol (AZM1), 4-((1-hydroxy-2- methyl propan-2-ylimino) methyl)-6-methoxyphenol(AZM2), 4-((1-hydroxy-2-methyl propan-2-ylimino) methyl)-2,6,dimethxy phenol (AZM3), 2- (3, 4- dimethoxybenzylideneamino)- 2- methylpropan-1-ol (AZM4) an...
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IMPACT OF PHARMACISTS’ HEALTH EDUCATIONAL INTERVENTION ON ANEMIA IN PREGNANCY IN RURAL SETTINGS IN KANO, NIGERIA
The worsening trend of anemia in pregnancy continues to be a cause for concern in many developing countries. There is a need for synergy involving all health care professionals in order to reverse this alarming trend. The objective of this study was to assess the impact of pharmacists initiated health education intervention on anemia in pregnancy in the rural setting, in Kano, Nigeria. A total of...
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GC-MS ANALYSIS, PHYTOCHEMICALS AND IN-VITRO ANTIOXIDANT PROPERTIES OF ROOT EXTRACTS OF PHLOGACANTHUS THYRSIFLORUS NEES., WESTERN ASSAM, INDIA
The Phlogacanthus thyrsiflorus roots have been used by the tribal population of western Assam to treat the hepatic disorder. The present study focuses on phytochemical screening, GC-MS analysis and in-vitro antioxidant activities using different extracts. Plant total phenolics, flavonoids, reducing power assay and antioxidant activity was evaluated. DPPH, FRAP, ABTS, Metal chelating activity,...
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ETHNOGYNAECOLOGICAL DISORDERS OF MEDICINAL PLANTS USED BY TRIBAL PEOPLE IN GEDAMALAI, NAMAKKAL DISTRICT, SOUTHERN EASTERN GHATS, TAMIL NADU
The present exploration is an attempt to an ethnobotanical study was conducted in Eastern Ghats of Tamil Nadu, for the investigation of a medicinal plant used to treat several diseases by the local health healers by Gedamalai Tribes, Namakkal District. Data were collected during March 2015-January 2016. Quantitative analysis, including the informant consensus factor and use-value was performed to ...
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MONITORING AND ANALYSIS OF ADR IN PATIENTS COMING TO PSYCHIATRY OPD WITH DEPRESSION AT A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
AIM: To monitor the adverse drug reactions due to various antidepressants prescribed in patients coming to psychiatry OPD with depression at a tertiary care hospital in northern India. Methods: This was a prospective observational longitudinal study conducted for a period of 12 months in a tertiary care outpatient facility. Patients who fulfilled the inclusion and exclusion criteria and those who ...
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PHYTOPHARMACOGNOSTICAL STUDY OF TUBERS OF EULOPHIA NUDA LINDL.
Plants and plants-based medicines have been used to treat many ailments since the ancient times. Family Orchidaceae to which orchids belongs is the largest family among monocotyledons. The genus Eulophia comprises perennial terrestrial orchids with fleshy tubers, rarely pseudobulbs. One such perennial herb having underground tubers, Eulophia nuda, belonging to family Orchidaceae, has been tradit...
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ANTI-CANCER EFFECT OF PANCHAGAVYA ON HUMAN COLON ADENOCARCINOMA (HCT-116) CELL LINE
The objective of the study was to investigate the in-vitro anti-cancer effect of Panchagavya on the Human Colon Adencarcinoma (HCT-116) cell line. Panchayavya was formulated using five products from Cows, namely; Cow dung, Cow urine, Cow milk, Cow curd and Cow ghee. The whole mixture was further freeze-dried and stored until further assay conduction. The growth inhibitory activity of the raw Panch...
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