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ANTIBACTERIAL EFFICACY OF BIOGENIC COPPER NANOPARTICLES SYNTHESIZED FROM OCIMUM SANCTUM LEAF EXTRACT
A major challenge in treating bacterial infections is the increasing incidence of microbial resistance to antibiotics. This poses a serious threat prompting the search for alternative strategies to treat bacterial infections. Metal nanoparticles as novel antibiotic agents hold promise because they show strong antibacterial activity against various bacterial species, including Gram-positive and Gra...
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PHARMACOGNOSTIC AND PHYTOCHEMICAL STUDIES ON A RELIGIOUS HERB OCIMUM TENUIFLORUM L.
"The Queen of Herbs" – Tulsi (Ocimum tenuiflorum), is the most sacred herb of India, also known as the holy Basil, is ubiquitous in Hindu tradition. Tulsi has been revered in India for over five thousand years as a healing balm for body, mind, and spirit. It is known to bestow an amazing number of health benefits. Modern scientific research offers impressive evidence that Tulsi reduces stress, e...
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WOUND HEALING ACTIVITY OF ETHANOLIC EXTRACT OF LUFFA ACUTANGULA (FRUIT)
The present study investigates the wound healing activity of ethanolic extract of the fruit of Luffa acutangula. The medicinal values of the Luffa acutangula have been mentioned ancient literature as useful in disorders of wound. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using soxhlation method. Ethanolic extract of Luffa acutangula was evaluated for its wound heali...
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EFFECT OF PHYSICAL MODIFICATION ON DISSOLUTION OF NABUMETONE: A BCS CLASS II DRUG
Objective: Physically modified forms of BCS class II drug Nabumetone (NBT) was studied for dissolution in water and pharmacopoeial dissolution media (2%w/v sodium lauryl sulfate in water). Characterization was to identify the suitability of physical processing like heating, cooling, grinding, and milling operations anticipated during commercial manufacturing of dosage forms. Materials and Methods:...
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RASAGILINE MESYLATE, A BCS CLASS III DRUG; EX-VIVO PERMEATION ENHANCEMENT STUDY THROUGH EXCISED RAT ABDOMINAL SKIN
Rasagiline Mesylate (RM), an antiparkinson drug, belongs to BCS class III drug having high solubility with low permeability. It undergoes extensive first-pass metabolism with oral bioavailability of only 35%. In the present research work, efforts were made to improve its permeation as requisite for the transdermal drug delivery system. RM was authenticated by determination of melting point. Furthe...
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IN-VITRO BIOLOGICAL ACTIVITIES OF FRACTIONS OF ETHYL ACETATE FRACTION OF THE WATER EXTRACT OF ARTOCARPUS HETEROPHYLLUS SENESCENT LEAVES
Artocarpus heterophyllus belongs to the family Moraceae. In Sri Lankan traditional medicine the water extract of A. heterophyllus senescent leaves is used to control diabetes mellitus. The hypoglycemic activity of ethyl acetate fraction of water extract of senescent leaves has been reported. Ethyl acetate fraction (EA/W) was fractionated using sephadex LH-20 column chromatography using the solvent...
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IN-VIVO ANTIHYPERLIPIDEMIC ACTIVITY AND PRELIMINARY PHYTOCHEMICAL SCREENING OF BAUHINIA ACUMINATA
The global burden of CVD is rising due to its increasing prevalence in lower- and middle-income countries where 80% of all global CVD-related deaths occur. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The present study was aimed to investigate the potential antihyperlipidemic activity of ethanolic leaf extract of Bauhinia acuminata in atherogenic di...
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DESIGN AND OPTIMIZATION OF CAPECITABINE NIOSOMES DERIVED FROM PRONIOSOMES
The aim of this investigation was to design and optimize the Capecitabine niosomes derived from proniosomes using central composite design. Two independent variables viz., the molar ratio of drug to cholesterol (X1), surfactant loading (X2) and two dependent variables viz., the percentage drug entrapment (PDE) and mean volume diameter (MVD) were selected for the study. Proniosomes were prepared by...
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FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLE GEL FOR TOPICAL DELIVERY OF CLOBETASOL PROPIONATE TO ENHANCE ITS PERMEATION USING SILK SERICINAS PERMEATION ENHANCER
The objective of this present work was to develop Solid Lipid Nanoparticle (SLN) gel for topical delivery of clobetasol propionate to enhance its permeation using silk sericin as a permeation enhancer. The proposed Clobetasol propionate gel loaded with solid lipid nanoparticle was prepared by solvent injection method. The effects of different strengths of lipid on the particle size, zeta potential...
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EVALUATION OF COLOUR FASTNESS PROPERTIES OF MICROBIAL PIGMENT EXTRACT FROM NOVEL SOURCES FOR TEXTILE ECOFRIENDLY DYEING & STUDY OF CIE LAB COLOUR VALUE
The pigment has acquired the greatest importance because of its excellent color value. The potential use of various carbon sources as microbial pigments for textile coloration. Flowers, leaves, fruits, vegetables, and tubers are the rich source of the secondary metabolites. In the current study, the use of microbial extract isolated from a fermentation process from 14 varieties by using Penicilliu...
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