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ANTIMICROBIAL ACTIVITY IN METHANOLIC SEED EXTRACT OF ANNONA SQUAMOSA
Annona squamosa (sugar apple) is commonly cultivated in tropical South America occasionally in southern Florida as well as in Jamaica, Puerto Rico, Barbados, and dry regions of Australia. It was growing in Indonesia early in the 17th century and has been widely adopted in southern China, tropical Africa, Egypt, and the lowlands of Palestine. This plant is a small well-branched tree or shrub that b...
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HISTOLOGICAL ALTERATIONS IN THE TESTES OF GAMMA-IRRADIATED MICE INDUCED BY ADHATODA VASICA LEAF EXTRACT
Extract of Adhatoda vasica leaves has been used to treat various diseases and disorders in Ayurvedic and Unani medicine. Effect of ethanolic extract of Adhatoda vasica against gamma radiation-induced changes in terms of histological alterations in testes of Swiss albino mice were studied at post-irradiation intervals between 1-30 days. Mice exposed to 6 Gy gamma radiation showed radiation-induced ...
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CANCER CHEMOTHERAPY-INDUCED CACHEXIA: THE ORPHAN DISEASE
Cancer remains a major cause of mortality worldwide, with chemotherapy serving as a cornerstone of cancer treatment. While effective in targeting malignant cells, chemotherapy is associated with debilitating side effects, including cachexia a complex, multifactorial syndrome characterized by unintentional weight loss, muscle wasting, fatigue, and reduced physical function. This condition arises fr...
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SYNTHESIS, MOLECULAR SIMULATION, AND ANTIOXIDANT CAPABILITY OF A NEW CLASS OF 2-PHENYL-1-BENZOPYRAN-4-ONE ON HUMAN MYELOPEROXIDASE ENZYME
The aim of the study was synthesis and characterization of 2-phenyl-1-benzopyran-4-one as a potential myeloperoxidase inhibitor. The oxidative stress was related to the generation of Reactive oxygen species (ROS), which is responsible for the enhancement of several degenerative diseases, such as osteoarthritis, cancer, diabetes, cardiovascular diseases, etc. Due to this fact, the study was targete...
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DEVELOPMENT OF FLOATING DRUG DELIVERY SYSTEM FOR LORATADINE: IN-VITRO AND IN-VIVO EVALUATION
The reason for this exploration was to develop gastro-retentive drug delivery systems (GRDDS) of loratadine (LTD) to lengthen the gastric residence time (GRT) by using different polymers like hydroxypropyl methyl celluloses (i.e., HPMC K4 M, HPMC K15 M, HPMCK 100 M), xanthan gum and other excipients such as microcrystalline cellulose (MCC), sodium bicarbonate (NaHCO3), magnesium stearate. All LTD ...
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PERFORMANCE IMPLICATIONS OF CLINICAL PHARMACIST INFORMATION ON GESTATIONAL DIABETES MELLITUS AT A TEACHING HOSPITAL IN SOUTHERN INDIA
Context: Gestational diabetes mellitus (GDM) early diagnosis of disease can reduce the morbidity and mortality by prevention of maternal and fetal complications. Aims: To assess the impact of clinical pharmacist knowledge on GDM mothers. Setting Tertiary care teaching hospital of North Karnataka, India. Methods and Materials: A randomized controlled cross-sectional study was carried out for a peri...
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EVALUATION OF COLOUR FASTNESS PROPERTIES OF MICROBIAL PIGMENT EXTRACT FROM NOVEL SOURCES FOR TEXTILE ECOFRIENDLY DYEING & STUDY OF CIE LAB COLOUR VALUE
The pigment has acquired the greatest importance because of its excellent color value. The potential use of various carbon sources as microbial pigments for textile coloration. Flowers, leaves, fruits, vegetables, and tubers are the rich source of the secondary metabolites. In the current study, the use of microbial extract isolated from a fermentation process from 14 varieties by using Penicilliu...
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PROTECTIVE ROLE OF HONEY AND ROYAL JELLY ON CISPLATIN INDUCED OXIDATIVE STRESS IN LIVER OF RAT
Background: Cisplatin is active cytotoxic agents in the treatment of cancer and has many adverse side effects, including hepatotoxicity. Honey and royal jelly are natural products and having antioxidants properties. Aim of the study: To investigate the protective role of combined administration of honey and royal jelly against cisplatin-induced changes in biomarkers of oxidative stress in rat live...
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INAPPROPRIATE NUTRITIONAL INTAKES DURING RAMADAN IN OBESE WOMEN PATIENTS WITH FATTY LIVER PRECLUDE ITS BENEFICIAL EFFECT
Introduction: Ramadan is a lunar month in the Islamic calendar. During this month, individuals who desire to keep a strict fast from dawn to sunset prevent stop eating and drinking. We evaluated the dietary intakes of patients with fatty liver during this month. Material and Methods: Sixty eligible overweight and obese women with fatty liver diagnosed via ultrasonography who had referred to the ma...
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FLAVONOIDS AS COMPLEMENTARY AND ALTERNATIVE TREATMENT OPTIONS FOR DIABETES MELLITUS
Diabetes is a metabolic disorder, which is characterized by insulin deficiency, insulin resistance, and aberrant metabolism in glucose, protein, and lipid. The primary causes of diabetes are Genetic and environmental factors. Diabetes is a chronic progressive disease that leads to both microvascular and macrovascular complications. This disease affects around 5% of the world population now. But, r...
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