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IMPACTS OF HUMAN PHARMACEUTICALS ON FISH HEALTH
Human pharmaceuticals and their metabolites affect the endocrine system and physiology of aquatic wildlife, which is an important global ecological concern. The published data from open-source toxicology and worldwide web resources reveal about 175 pharmaceuticals that can affect estrogen pathways to disrupt the endocrine system and metabolism. Such studies demand additional investigations on fish...
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EVIDENCE BASED STUDY OF EFFECT OF SWARNA YOGA (GOLD FORMULATIONS) IN CHILDREN: A SYSTEMATIC REVIEW
Background: In the field of pediatrics, a number of herbo-metallic preparations are available which tend to enhance immunity in children. Various Ayurveda texts have mentioned these preparations, especially gold formulations like Swarna Prashan, Suvarnabindu, Suvarna Vacha, Kumarabharana Rasa etc. in children, and many clinical studies have also been published to establish their safety and efficac...
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ANTIOXIDANT PECTIN FROM CACTUS OPUNTIA DILLENII GROWING IN NINH THUAN COAST, VIETNAM: EXTRACTION, PHYSIC-CHEMISTRY CHARACTERIZATION AND ANTIOXIDANT ACTIVITY
The extraction condition, physic-chemistry characterization, and antioxidant activity of pectin from cactus Opuntia dillenii found commonly growing in the Ninh Thuan coast, Vietnam, were studied. The extraction conditions of antioxidant pectin content, such as temperature, time, cactus-to-solvent ratio, solvent pH, and extraction numbers, were surveyed. A correlation between pectin content and ant...
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DESIGN EXPERT SOFTWARE ASSISTED DEVELOPMENT AND EVALUATION OF CEFPODOXIME PROXETIL MATRIX TABLET
Cefpodoxime Proxetil is third generation, broad-spectrum Cephalosporin Antibiotic & it has an oral bioavailability of only 50% and biological half life 2 h so to improve it’s bioavailability sustain release matrix formulation was designed. Sustained release matrix tablets of Cefpodoxime Proxetil prepared by direct compression method based on combination of natural Acacia gum & Karaya gum...
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HPTLC METHOD DEVELOPMENT AND VALIDATION FOR IDENTIFICATION AND QUANTIFICATION OF LUPEOL IN THE LEAVES OF ALSTONIA SCHOLARIS
In ancient literature plant Alstonia scholaris (Apocynaceae) has been considered medicinally important in the treatment of various ailments. Extracts of this plant have shown wide spectra of pharmacological activities like anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, etc. These activities can be attributed to the depositories of various phytoconstituents like alkaloids, flavono...
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ISOTINE, AN HERBAL EYEDROPS, IMPROVES CATARACT-INDUCED BLINDNESS: A RETROSPECTIVE OBSERVATIONAL STUDY
Gradual vision loss is linked to degenerative changes and cataract. The Isotine-herbal eyedrop has been clinically used for 36 years with a claim to reverse the cataract-induced visual impairment. This retrospective observational study on 308 cataract patients, registered between 2017 to 2019 at Basu Eye hospital, Bareli, UP, India, having 3 months of treatment, shows the significant therapeutic r...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
An analytical method consists of a detailed, stepwise list of instructions to be followed in the qualitative, quantitative, or structural analysis of a sample for one or more analytes and using a specified technique. A novel, simple, precise, sensitive, and reproducible RP-HPLC method for the simultaneous estimation of Dapagliflozin and Saxagliptin in bulk and pharmaceutical formulation was develo...
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AILANTHUS EXCELSA ROXB (MAHA NEEM)- AN HOLISTIC INSIGHT OF THE MULTIPURPOSE TREE
In recent years, Plants and herbal drugs obtaining from natural resources are again gaining importance throughout the world in maintaining the healthcare conditions of individuals. The regular use of natural sources and plant-derived products throughout the world has increased serious concerns over their quality, safety, and efficacy. Adding to the natural scientific resources and knowledge, the t...
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NANOTECHNOLOGY BASED ORAL FORMULATIONS OF TOLBUTAMIDE BY USING BIODEGRADABLE POLYMER
The present study concerns the development, characterization, and optimization of nanoparticulate oral formulations of Tolbutamide using poly (ԑ-caprolactone) which is a biodegradable polymer. Emulsion Solvent Evaporation technique was used for preparation of drug-loaded polymeric nanoparticles. This research was carried out to improve the therapeutic efficacy of tolbutamide by increasing its bio...
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FACTORIAL DESIGN BASED OPTIMIZATION AND IN-VITRO – EX-VIVO EVALUATION OF CLOBETASOL LOADED NANO STRUCTURED LIPID CARRIERS
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers (NLCs) loaded with Clobetasol-17-propionate (CP) as a new approach for the topical treatment of psoriasis. CP-loaded NLCs were prepared by melt emulsification and ultra-sonication method and optimized using 33 full factorial designs (Design-Expert software 11.0), by using solid lipid (compritol A...
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