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NOVEL RP-HPLC AND UV METHOD DEVELOPMENT AND VALIDATION FOR INOTUZUMAB OZOGAMICIN IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
A simple, Precise, Accurate method was developed for the estimation of Inotuzumab Ozogamicin by RP-HPLC and UV technique. Chromatographic conditions used were stationary phase Discovery c18 150 × 4.6 mm, 5 m. Mobile phase O- phosphoric acid buffer: Acetonitrile in the ratio of 50v:50v and the flow rate were maintained at 1 ml/min, detection wavelength at 240nm, column temperature was set to 30 º...
1721
778
SCREENING SELECTED SPECIES OF GOMPHOSTEMMA WALL. EX BENTH. FROM WESTERN GHATS FOR ANTI-INFLAMMATORY ACTIVITY
Gomphostemma Wall. ex Benth. belongs to the family Lamiaceae. The present study evaluated selected species of Gomphostemma endemic to the Western Ghats for their anti-inflammatory property. Traditionally, many species of Gomphostemma are used to treat malarial fever and inflammations caused by insect stings. Methanol extracts of Gomphostemma heyneanum var. heyneanum, G. heyneanum var. rottleri and...
1720
699
ANTIDIABETIC EFFECT OF ETHANOLIC LEAVES EXTRACTS OF AZIMA TETRACANTHA LAM. IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Objective: The goal of the present examination was to investigate anti-diabetic activity of Azima tetracantha Lam. leaves in streptozotocin-induced diabetic rats. Materials and Method: At a regular interval of an experimental protocol, blood glucose, insulin, glycogen, HDL, LDL, VLDL, FFA, PL, and TC and organs to bodyweight proportion were assessed in streptozotocin-induced diabetic rats. Histolo...
1719
932
PHARMACOGNOSTICAL INVESTIGATION OF PURITY OF ASPARAGUS RACEMOSUS ROOTS
The pharmaceutical market of the Russian Federation receives medicines produced both in compliance with the international standards of good manufacturing practice and those coming from developing countries where manufacturers operate according to their national regulations. Asparagus racemosus is a medicinal plant that is widely used in oriental medicine and is included in the Ayurvedic pharmacope...
1718
871
FORMULATION CHARACTERIZATION AND OPTIMIZATION OF CEFIXIME TRI-HYDRATE HYDROGEL TABLET BY USING DESIGN EXPERT
The purpose of current research work has been made to formulate a gastro-retentive drug delivery system (GRDDS) of those drugs having a narrow absorption window or having good absorption at the proximal part of the gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailability of a drug. Gastro-retentive hydrogel tablet of Cefixime trihydrate was prepared by the direct ...
1718
878
DESIGN, DEVELOPMENT AND EVALUATION OF POLYHERBAL TABLET OF TWO ANTI-ULCER LEAVES
Aim: The present study was to develop and evaluate antiulcer polyherbal tablet as designing of oral herbal formulation. The methanolic extracts of Abrus precatorius (MEAP) and Cordia wallichi (MECW) leaves were used in different concentrations in the formulations. Materials and Method: The current exploration was to design a gastro-retentive drug delivery system of MEAP and MECW using swelling pol...
1716
723
ENCAPSULATION OPTIMIZATION OF TAMARIND SEED ANTIOXIDANTS IN ALGINATE HYDROGELS USING RESPONSE SURFACE METHODOLOGY: STUDY OF CONTROLLED RELEASE BEHAVIOR IN SIMULATED GASTROINTESTINAL CONDITIONS
Tamarindus indica seeds - a byproduct of the food industry, are generated in huge amounts during tamarind pulp processing. These seeds are a source of a wide range of polyphenols with natural antioxidant content. In this study, we have encapsulated the polyphenolic components extracted from the seeds in an optimized condition. Statistical optimization of the encapsulation parameters was done using...
1715
713
REVITALIZING RATIONALITY THROUGH PDAA CYCLE-A UNION THERAPY CONCEPT
Medicine has been a noble profession since time immemorial. Many cultures have the view that it is linked with the supernatural deity. The persons were priests in many civilizations. They had high status in Society. They were considered as a medium of communication between the supernatural and were assumed to have powers. In those times, those priests used rituals and follow some religious code of...
1715
820
DESIGN EXPERT SOFTWARE ASSISTED DEVELOPMENT AND EVALUATION OF CEFPODOXIME PROXETIL MATRIX TABLET
Cefpodoxime Proxetil is third generation, broad-spectrum Cephalosporin Antibiotic & it has an oral bioavailability of only 50% and biological half life 2 h so to improve it’s bioavailability sustain release matrix formulation was designed. Sustained release matrix tablets of Cefpodoxime Proxetil prepared by direct compression method based on combination of natural Acacia gum & Karaya gum...
1712
962
SCREENING AND EVALUATION OF ANTIDIABETIC POTENCY OF VERNONIA ARBOREA USING ZEBRAFISH MODEL
Introduction: Vernonia arborea, belonging to the Asteraceae family, found in the Western Ghats of India and Sri Lanka, was traditionally used in wound healing. It is proven that some of the plants of this genus have anti-diabetic properties. e.g., V. amygdalina. So this study was done to screen and to evaluate the anti-diabetic potency of the leaf extract of Vernonia arborea in diabetic Zebrafish ...
1712
856