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DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR THE ESTIMATION OF LYMECYCLINE IN CAPSULE DOSAGE FORM
Lymecycline is a tetracycline broad-spectrum antibiotic. Present work describes a simple, accurate, precise, economical and reproducible spectrophotometric method in ultraviolet region has been developed and validated for the assay of Lymecycline in bulk and in Pharmaceutical formulations in diluent. Lymecycline is a tetracycline broad-spectrum antibiotic. Lymecycline like other tetracyclines is u...
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TO EVALUATE THE USE AND SAFETY OF BLOOD THINNING AGENTS IN TERTIARY CARE HOSPITAL
Objective: To ensure the basic principles of drug utilization and the use and safety of blood thinning agents in tertiary care hospital. Experimental design: The study included 224 patients’ and was conducted in a tertiary care hospital and we were focused on to find out the drug-drug interactions of anticoagulants, antiplatelet, and thrombolytic agents, to study the major area involvement for b...
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735
GENDER WISE PREVALENCE OF COMORBIDITIES AND MEDICATION ADHERENCE AMONG TYPE 2 DIABETICS IN MALAPPURAM
Background: Type 2 diabetes is a major lifestyle disease often seen with comorbidities or complications. This study is conducted to find out the gender-wise prevalence of comorbidities and medication adherence among the diabetics in Malappuram. Methods: A cross-sectional study was conducted among the 179 diabetics selected for the study. A pre-tested interview schedule was used to collect informat...
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MICROWAVE INDUCED SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG SIMVASTATIN USING POLOXAMER 188 BY MICROWAVE IRRADIATION METHOD
To increase the solubility of poorly water-soluble drug simvastatin using hydrophilic carrier poloxamer 188 using solid dispersion techniques by microwave irradiation method. The microwave irradiation technique was used to prepare solid dispersions in minimum time interval in different drug carrier ratios, i.e. 1:2, 1:5, 1:8 and was subjected to microwave for different times, i.e. 3 min, 5 min, an...
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ANTIOXIDANT, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF DIFFERENT FRACTIONS FROM METHANOLIC EXTRACT OF PSIDIUM GUAJAVA L. LEAVES
Psidium guajava Linn. the most popular and widely cultivated fruiting plant all over Bangladesh. The present study was aimed to investigate the antioxidant, analgesic and antimicrobial activities of n-hexane (HPG), chloroform (CLPG) and ethyl acetate fractions (ET APG) obtained from methanol extract of Psidium guajava (MPG) leaves. The in-vitro antioxidant activity of fractions HPG, CLPG and ET AP...
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602
IN-VITRO ANTIOXIDANT PROPERTIES OF DELONIX ELATA WHOLE PLANT EXTRACTS
Delonix elata (D. elata) whole plant was chosen to evaluate in-vitro anti-oxidant activities. The total polyphenols and flavonoids were determined after the extraction. DPPH (2, 2'-diphenyl-1-picrylhydrazy), H2O2 (Hydrogen peroxide), NO (Nitric oxide) and TBARS (Thiobarbituric acid) methods were used to evaluate antioxidant activities of D. elata whole plant. The results showed that the highest le...
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ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...
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ANTI-OSTEOPOROTIC ACTIVITY OF CUCURBITA PEPO AND LOW LEVEL LASER BEAM ON GLUCOCORTICOID INDUCED OSTEOPOROSIS IN RATS
Objective: The main aim of the present study is to investigate the activity of the anti-osteoporotic activity of Cucurbita pepo seed powder (CPSP) and low level laser beam (LLLT) on glucocorticoid induced osteoporosis in rat model. Materials and Methods: Animals were randomly divided into six groups containing six rats each (n=6). Group I normal control, Group II dexamethasone induced osteoporotic...
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822
IN-SILICO MOLECULAR DOCKING ANALYSIS OF ISOLATED HOMOISOFLAVANONES FROM BULBS OF LEDABOURIA REVOLUTA AS GABAA RECEPTOR INHIBITORS
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate central nervous system (CNS); it activates the GABAA receptors that play a role in epilepsy. Targeting GABAA receptors through specific enhancement of neuronal inhibition involving GABA can be a better mechanism for identification of novel antiepileptic drugs. In this report, screening of novel isolated homoisof...
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750
CANAGLIFLOZIN SILICA LIPID HYBRID PARTICLES FOR IMPROVED SOLUBILITY AND DISSOLUTION
Silica lipid-hybrid formulations have gained an increased interest in recent times as a means to enhance the solubility as well as dissolution of poorly water-soluble lipophilic drugs. The objective of the present investigation was to design and optimize silica lipid hybrid particles of Canagliflozin to improve its solubility. Canagliflozin is an antidiabetic drug used to improve glycaemic control...
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