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COMPARISON OF PCR AND CELL CULTURE FOR HUMAN ADENOVIRUS DETECTION IN GASTROENTERITIS AND RESPIRATORY TRACT INFECTED NORTH INDIAN CHILDREN
Acute gastroenteritis (AGE) and acute respiratory tract infection (ARTI) are the most common causes of morbidity and mortality in young children worldwide. This study aimed to analyze the sensitivity and specificity of laboratory diagnostic methods. We compared to cell culture and polymerase chain reaction (PCR) technique for the detection of Human adenovirus (HAdV) in AGE and ARTI children below ...
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ANTIOXIDANT POTENTIAL, TOTAL PHENOLIC AND FLAVONOID CONTENT OF ROOTS OF SEVEN ASPARAGUS SPECIES FROM NORTH-WEST INDIA
The aim of current study was to compare the total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of roots of seven Asparagus species from North-West India. Total phenolic content measured by Folin-Ciocalteu method ranged from 3.85 ± 0.25 (A. racemosus) to 7.74 ± 0.03 (A. falcatus), 3.42 ± 0.14 (A. racemosus) to 7.22 ± 0.12 (A. falcatus) and 1.12 ± 0.13 (A. offi...
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FATTY ACID PROFILING IN DIPLOID (n = 12) AND TETRAPLOID CYTOTYPES (n = 24) OF PHYSALIS ANGULATA LINN. FROM RAJASTHAN BY GAS CHROMATOGRAPHY
Present paper reports the chemical constituents in the fatty acids obtained from the whole plant of diploid and tetraploid Physalis angulata Linn. collected from hot desert areas of Rajasthan. The fatty acid analysis was carried out by gas chromatography-flame ionization detector (GC-FID). Meiotic studies confirm the ploidy level of the plant. Diploid (n = 12) cytotype is reported from Udaipur dis...
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DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHY-ELECTRO-SPRAY IONIZATION-MASS SPECTROMETRY METHOD FOR THE QUANTITATION OF ERGOCALCIFEROL IN HUMAN PLASMA
A LC-MS method was developed and validated for determination of ergocalciferol in human plasma. n-hexane was used as extraction solvent while kinetex C18 50*2.1 mm, 1.7µm was used as analytical column for chromatographic separation. Mobile phase was acetonitrile: 0.1% formic acid in methanol (90:10). Turbo ion spray with positive polarity was used as an interface with API QTRAP 5500 LC/MS/MS syst...
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ANTI-INFLAMMATORY ACTIVITY, HPTLC ANALYSIS OF β-SITOSTEROL FROM METHANOLIC LEAF EXTRACTS OF THUNBERGIA GRANDIFLORA ROXB., TRADITIONAL HERBAL PLANT FROM MIZORAM, INDIA
Thunbergia grandiflora Roxb. (Mizo local name- Vakohrui or Zawngafian), commonly known as Bengal clockvine, is a long-lived, dicotyledonous plant traditionally used in the state of Mizoram, India for the treatment of cancer, diabetes, eye diseases, cuts and wounds etc. This study aimed to conduct in-vitro, in-vivo anti-inflammatory studies and HPTLC fingerprinting and quantifying the bioactive com...
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TINOSPORA CORDIFOLIA: A REVIEW ON SINGLE HERB WITH MULTIPLE PHARMACOLOGICAL EFFECTS
Given their well-known lack of side effects in comparison to pharmaceuticals, natural materials with medical potential are rising in prominence in clinical research. Since the dawn of civilization, humans have relied on plants as a vital resource for healing. Medicines, health aids, pharmaceuticals, dietary supplements, cosmetics and other similar items derived from plants are becoming more popula...
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ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) IN HAIL REGION, SAUDI ARABIA
Background: Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill patients characterized by extensive inflammation in the lungs and associated with several complications. Therefore, the present study aimed to identify the common risk factors associated with ARDS in Hail Region, Northern Saudi Arabia. Methodology: This study investigated retrospectively 68 pa...
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QbD BASED RP-HPLC METHOD DEVELOPMENT FOR FIVE FLUOROQUINOLONE ANTI-BACTERIALS – THROUGH CREATION OF DESIGN SPACE FOR CRITICAL ATTRIBUTES
Quality by Design (QbD) has become an important concept for the pharmaceutical industry, and ICH recommends this concept through the Guideline Q8 (R2) wherein if the method is proved to be rugged and robust within the limits of a Design Space then approval may be requested for such a Design Space, and the method does not need redevelopment, revalidation, and reapproval during transfers, thereby sa...
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CELL VIABILITY AND CYTOTOXIC EFFECT OF ACANTHOPHORA SPICIFERA (RED SEAWEED) ON HT29 COLON CANCER CELL LINE
Acanthophora Spicifera is a species of marine red seaweed and in the family Rhodomelaceae. They were freshly collected from Mandapam Coastal Area, Rameswaram Tamil Nadu, India and rinsed in seawater and packed in aseptic bags for further proceedings to the laboratory. Seaweeds are potential renewable resources in the marine environment. It has been used as antioxidant and antimutagen. The results ...
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FORMULATION AND EVALUATION OF QUERCETIN LOADED CHITOSAN-HYDROXY-APATITE BIO COMPOSITE MICROSPHERES FOR PERIODONTITIS
Periodontitis is a group of inflammatory pathological conditions involving periodontal ligaments and supporting alveolar bone which may result in the degeneration of supporting structures of teeth ultimately leading to tooth loss. Present research work is focused on the formulation, optimization and evaluation of chitosan microspheres and chitosan- hydroxyapatite biocomposite microspheres to have ...
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