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FORMULATION AND EVALUATION OF ORAL ANTI-DIABETIC IN-SITU GEL SYSTEM OF PIOGLITAZONE
Pioglitazone is an oral anti-diabetic agent used in treating class – II diabetes mellitus. T1/2of pioglitazone was 3-6 hrs and is eliminated rapidly. Hence sustained release is needed to prolong its duration of action and to increase its oral bioavailability. The main aim of the study was formulation and evaluation of an in-situ gel system of Pioglitazone to increase its bioavailability as a con...
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1223
TINOSPORA CORDIFOLIA: A REVIEW ON SINGLE HERB WITH MULTIPLE PHARMACOLOGICAL EFFECTS
Given their well-known lack of side effects in comparison to pharmaceuticals, natural materials with medical potential are rising in prominence in clinical research. Since the dawn of civilization, humans have relied on plants as a vital resource for healing. Medicines, health aids, pharmaceuticals, dietary supplements, cosmetics and other similar items derived from plants are becoming more popula...
3110
1920
A SUCCESSFUL ATTEMPT TO ENHANCE SOLUBILITY OF BCS CLASS II DRUG USING LIQUISOLID COMPACT TECHNIQUE
The main purpose of the current research work is to enhance solubility and dissolution of BCS Class II drug, Flurbiprofen using liquid-solid compact technology. Flurbiprofen is a non-steroidal anti-inflammatory drug indicated for acute and chronic treatment of rheumatoid arthritis, osteoarthritis, and spondylytis. The rationale to select Flurbiprofen as the model drug is that it belongs to BCS Cla...
3110
1920
SYNTHESIS OF NOVEL 2-PHENYL-1-BENZOFURAN-3(2H)-ONE DERIVATIVES AS NEW LEADS FOR ANTI-CANCER ACTIVITY
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl acetonitrile by bromination at an alpha position which yielded bromophenyl acetonitrile which was a lachrymator compound. Benzofuranone was synthesized by reacting benzene diols and trio...
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1569
BIOFILM AND METTALO BETA-LACTAMASE PRODUCTION IN ASSOCIATION WITH SERUM RESISTANT ACTIVITY AMONG CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA
Biofilms are communities of bacteria that are append to a surface and play significant role in the persistence diligence of bacterial infections. Bacteria with a biofilm are more defiant to antibiotics compared with planktonic bacteria. Biofilm producing bacteria are able to take possession on medical devices such as catheters and implants. The incidence of Biofilm producing microorganism runs aro...
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1298
PHYTOCHEMICAL INVESTIGATION, ANTIOXIDANT AND CYTOTOXIC ACTIVITY STUDIES OF ROOT BARK EXTRACTS OF ARTOCARPUS HETEROPHYLLUS LAM.
Plant drugs enjoy much acclaim and worldwide acceptability even in the midst of amazing advancements in modern medicine. Current research in drug discovery from medicinal plants involves an approach combining botanical, phytochemical, and pharmacological techniques. In the present study, we selected the root bark of the plant Artocarpus heterophyllus Lam. belonging to the family Moraceae, to estab...
3105
1966
BIOMOLECULAR PROTECTIVE EFFECT OF THE METHANOLIC EXTRACT OF THE FLOWERS OF CAESALPINIA PULCHERRIMA, SWARTZ. AGAINST OXIDATIVE DAMAGE
Free radicals and reactive oxygen species (ROS) production above basal levels cause irreversible damage to the cell membrane, DNA and other cellular structures by oxidizing lipids, proteins and nucleic acids resulting in dysfunction of biomolecules within cells and, finally, cell death. These free radical-induced reactions are ascertained to play multiple roles in degenerative or pathological even...
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1347
ANALYSIS OF CUTANEOUS ADVERSE DRUG REACTIONS PRESENTING TO THE DERMATOLOGY DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL: A PROSPECTIVE, OBSERVATIONAL STUDY
Background: Cutaneous adverse drug reactions (CADRs), having a wide range in terms of its spectrum, are an important cause of morbidity and mortality. They comprise 2-3% of all ADRs. This study was conducted to analyze various parameters of CADRs at our setup. Methodology: This prospective, observational study was carried out for 1 year at our setup after ethical approval. Those diagnosed as CADRs...
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1307
FATTY ACID PROFILING IN DIPLOID (n = 12) AND TETRAPLOID CYTOTYPES (n = 24) OF PHYSALIS ANGULATA LINN. FROM RAJASTHAN BY GAS CHROMATOGRAPHY
Present paper reports the chemical constituents in the fatty acids obtained from the whole plant of diploid and tetraploid Physalis angulata Linn. collected from hot desert areas of Rajasthan. The fatty acid analysis was carried out by gas chromatography-flame ionization detector (GC-FID). Meiotic studies confirm the ploidy level of the plant. Diploid (n = 12) cytotype is reported from Udaipur dis...
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1418
STANDARDIZATION AND QUALITY ASSESSMENT OF TRADITIONAL POLYHERBAL FORMULATION FOR THE TREATMENT OF HEMORRHOIDS (PILES)
Polyherbal formulations are a collection of therapeutic entities that are formulated and prepared on the basis of the healing properties of individual ingredients with respect to the condition of sickness. The main objectives of the present study were to evaluate the pharmacognostic parameters of a traditional polyherbal formulation for the treatment of hemorrhoids (piles). The pharmacognostic par...
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