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PHYTOCHEMICAL INVESTIGATION, ANTIOXIDANT AND CYTOTOXIC ACTIVITY STUDIES OF ROOT BARK EXTRACTS OF ARTOCARPUS HETEROPHYLLUS LAM.
Plant drugs enjoy much acclaim and worldwide acceptability even in the midst of amazing advancements in modern medicine. Current research in drug discovery from medicinal plants involves an approach combining botanical, phytochemical, and pharmacological techniques. In the present study, we selected the root bark of the plant Artocarpus heterophyllus Lam. belonging to the family Moraceae, to estab...
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NICKEL OXIDE NANOPARTICLES SYNTHESIS BY CHEMICAL REDUCTION TECHNIQUE AND IT’S APPLICATION AS ANTIMICROBIAL AND DYE DEGRADING AGENT
Nanoparticles are fascinating materials that find many applications in basic and applied research. The chemical reduction technique is one of the easiest methods for synthesizing Nickel Oxide Nanoparticles (NiO NPs) in low-temperature ranges. Nickel Nitrate Hexahydrate (Ni(NO3)2.6H2O), Ascorbic acid, NaOH, and NaBH4 were applied as starting reagents to synthesize NiO NPs. Noble metal oxide nanopar...
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ANTI-ATHEROSCLEROTIC BIOACTIVE COMPOUND FROM A MARINE MOLLUSC, CHICOREUS SP.
This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expres...
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MICROSPONGES DRUG DELIVERY SYSTEM
Microsponges are novel drug delivery systems made up of cross-linked spongy, polymeric, porous, spherical microspheres particles which vary in size from 5-300 μm. This delivery system as the advantage of producing controlled release formulations of poorly soluble drugs. It increases drug stability, reduces side effects and modifies drug release profiles making it a versatile drug delivery vehicle...
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FORMULATION AND EVALUATION OF METOPROLOL LOADED SOLID LIPID NANOPARTICLES
The main aim of the present study is to formulate and evaluate solid lipid nanoparticles of Metoprolol. Metoprolol is an anti-hypertension drug used in the treatment of hypertension, angina pectoris, and heart failure. Metoprolol belongs to BCS class-I, which has high solubility and high permeability. The drug needs to be administered frequently (2-3 times a day), and it has side effects and poor ...
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EFFECT OF ASPARAGUS CURILLUS ON LEVELS OF MATRIX METALLO PROTEINASES IN GCF AND SALIVA OF PERIODONTAL PATIENTS
This study was planned to evaluate the anti-inflammatory effect of roots of Asparagus curillus in periodontal inflammation via assessing gingival crevicular fluid (GCF) and salivary inflammatory markers namely MMP-8, -9, 13, TIMP-1 and IL-6. Samples of GCF and saliva were obtained from patients with chronic periodontitis (n = 98) and healthy controls (n = 27). Study population (n = 98) was divided...
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CORONAVIRUS TO COVID-19 PANDEMIC: AN OVERVIEW
Coronaviruses wrapped with the layers of positive-sense RNA viruses specified by the club-like projections from their surface responsible for a variety of diseases in the animal kingdom. After the two historical episodes of coronaviruses i.e., severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this time world strike...
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SYNTHESIS OF NOVEL 2-PHENYL-1-BENZOFURAN-3(2H)-ONE DERIVATIVES AS NEW LEADS FOR ANTI-CANCER ACTIVITY
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl acetonitrile by bromination at an alpha position which yielded bromophenyl acetonitrile which was a lachrymator compound. Benzofuranone was synthesized by reacting benzene diols and trio...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROFILE OF EPLERENONE BY LIQUISOLID COMPACTS USING NOVEL EXCIPIENTS
Eplerenone is a poorly soluble drug that belongs to class II biopharmaceutical classification system. It is a selective aldosterone receptor antagonist, which binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreases the sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure and used in congestive heart failure...
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COMPARISON OF PCR AND CELL CULTURE FOR HUMAN ADENOVIRUS DETECTION IN GASTROENTERITIS AND RESPIRATORY TRACT INFECTED NORTH INDIAN CHILDREN
Acute gastroenteritis (AGE) and acute respiratory tract infection (ARTI) are the most common causes of morbidity and mortality in young children worldwide. This study aimed to analyze the sensitivity and specificity of laboratory diagnostic methods. We compared to cell culture and polymerase chain reaction (PCR) technique for the detection of Human adenovirus (HAdV) in AGE and ARTI children below ...
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