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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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11.

LIQUISOLID TABLET: AN EFFECTIVE APPROACH TOWARDS IMPROVEMENT OF DISSOLUTION RATE OF FAMOTIDINE AS POORLY SOLUBLE DRUGS

This paper examined the liquisolid compact method as one of the tools for greater dissolution of the practically water-insoluble drug famotidine (FM). Therefore, the model drug, FM, has been formulated as directly compacted tablets and liquisolid compacts and then investigated for in-vitro release properties at diverse dissolution circumstances. According to the method, it is possible to convert t...

M. Saeedi, J. Akbari *, R. Enayatifard, K. Morteza-Semnani, S. M. H. Hashemi, A. Babaei, S. A. Mashhadi and M. Eghbali

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

DOI: 10.13040/IJPSR.0975-8232.12(2).803-12

803-812

1747

855

3

11.

IN-VITRO MUTAGENIC, GENOTOXIC AND ANEUGENIC POTENTIAL OF OMEPRAZOLE

The aim of this investigation was to re-evaluate the in-vitro mutagenic, genotoxic, and aneugenic potential of omeprazole through the Ames test, comet (SCGE), and cytokinesis-block micronucleus assays (CBMN), as previous reports on the mutagenic and genotoxic effects of omeprazole are scarce and inconclusive. The results of this study indicated a negative mutagenic effect through the Ames test. Co...

V. Kutsar, S. LaFolette, J. Ringenberg, R. Dudley and A. Vaglenov *

Department of Pharmaceutical Science, University of Findlay, 1000 North Main Street, Findlay, Ohio, USA.

DOI: 10.13040/IJPSR.0975-8232.12(4).2065-75

2065-2075

1747

745

0

18.

EFFECT OF QUERCETIN AND NERVE GROWTH FACTOR ON BIOCHEMICAL PARA-METERS OF THE BRAIN TISSUE IN RATS WITH EXPERIMENTAL NEURO-DEGENERATIVE DISORDER

The work was initiated to induce a toxic model of a neurodegenerative disorder with Alzheimer’s disease symptoms in rats and to study the effect of quercetin, an anti-oxidant, and nerve growth factor on some biochemical parameters and parameters of behavioral performance of the animals. It was established that upon induction of the neurodegenerative disorder by an intranasal administration of al...

T. M. Ishankhodjaev *, B. R. Zainutdinov, M. A. Mustafakulov, E. A. Ibragimova, Z. Z. Ibragimov, S. U. Irgasheva, N. I. Mamadalieva and T. S. Saatov

Institute of Biophysics and Biochemistry Under Mirzo Ulugbek National University of Uzbekistan, 174 University Town, Olmazor District, Tashkent, Republic of Uzbekistan.

DOI: 10.13040/IJPSR.0975-8232.11(10).4918-23

4918-4923

1746

504

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15.

THE POTENTIAL PROTECTIVE EFFECT OF STRAWBERRY EXTRACT AGAINST INDOMETHACIN-INDUCED LIVER TOXICITY AND GASTRIC ULCERATION IN RATS: BIOCHEMICAL, HISTOPATHOLOGICAL AND GENETIC STUDIES

The objective of this study was to determine the hepatoprotective effect of strawberry extract (150 mg/kg.b.w) in rats against Indomethacin sodium-induced gastric ulceration. Oral indomethacin administration (5 mg/kg.b.w.) resulted in a substantial rise in total plasma cholesterol, triglycerides (HDL), factor-alfa (TNF-α), nitric oxide (NO), liver and stomach necrosis, tumor necrosis factor-alfa ...

S. A. Hassan, S. M. A. Elwafa H. A. El-Baz, M. A. Hussein * and N. A. Gobba

Biochemistry Department, Faculty of Applied Medical Sciences, October 6 University, Sixth of October City, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(6).3120-33

3120-3133

1745

617

0

53.

HAEMOTOXICITY OF LEAD (Pb) ON THE BLOOD PARAMETERS OF FRESH WATER TELEOST HETEROPNEUSTES FOSSILIS (BLOCH)

Blood parameters are important indicators for assessing the health status of living organisms subject to changing environment. Blood parameters (Hb%, TEC, TLC, ESR, PCV, MCH, and MCV) of Heteropneustes fossilis exposed to lead were investigated at different time intervals. Acclimatized specimens were divided into four groups: Group-A (Control), Group-B (2.25 ppm), Group-C (2.65 ppm), Group-D (2.85...

V. K. Verma, N. Gupta * and D. K. Gupta

Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).1444-51

1444-1451

1743

669

4

59.

DETECTION OF B. ABORTUS S19 ON UTERINE RAT (RATTUS NORVEGICUS) WITH IMMUNOHISTOCHEMICAL METHOD

Objective: Brucellosis in humans is the most common zoonotic infection in the world. Brucellosis can be prevented by vaccination but no effective vaccines are known for prevention of human brucellosis and minimal impact of animal brucellosis. Outer membrane proteins (OMPs) of Brucella sp. have been the focus of vaccine development and the diagnosis of brucellosis. Methods: The pathogenesis study o...

F. Purnamawati *, S. Santoso and Aulanni’am

Biomedical Science Master Program, Medical Faculty, Universitas of Brawijaya Malang, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(9).4021-28

4021-4028

1742

932

0

50.

DEVELOPMENT AND VALIDATION OF NOVEL UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF MEBENDAZOLE IN PHARMACEUTICAL FORMULATION

Mebendazole is a broad-spectrum anthelmintic drug that is widely used in the treatment of helminthic infections. A simple, accurate, and precise UV-visible spectrophotometric method has been developed and validated for the determination of Mebendazole in tablet formulation. The solvent used for the development of the proposed method was Phosphate buffer 6.8 at 278.6 nm. The Beers' law was obeyed i...

S. Shrivastava * and C. D. Kaur

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2317-22

2317-2322

1738

875

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20.

MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS

Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, in...

R. S. El-Houssieny, M. M. Aboulwafa *, W. F. Elkhatib and N. A. Hassouna

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(9).4279-92

4279-4292

1737

627

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29.

DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR THE ESTIMATION OF LYMECYCLINE IN CAPSULE DOSAGE FORM

Lymecycline is a tetracycline broad-spectrum antibiotic. Present work describes a simple, accurate, precise, economical and reproducible spectrophotometric method in ultraviolet region has been developed and validated for the assay of Lymecycline in bulk and in Pharmaceutical formulations in diluent. Lymecycline is a tetracycline broad-spectrum antibiotic. Lymecycline like other tetracyclines is u...

U. Narasimhulu *, M. Madhu, C. Sireesha, V. Vyshnavi and S. Rafi

Department of Pharmaceutical Analysis and Quality Assurance, Annamacharya College of Pharmacy, New Boyanapalli, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1749-56

1749-1756

1736

1103

0

10.

A SYSTEMIC REVIEW ON BIOMEDICAL APPLICATIONS AND SYNTHESIS OF METALLIC NANOPARTICLES

 ...

Santosh S. Bhujbal * and Rakesh M. Pawara

Department of Pharmacognosy, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4666-75

4666-4675

1736

340

0