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THE IMPACT OF CARCINOGENIC CHEMICAL USE AMONG CARDAMOM FARMERS AND THE PREVALENCE OF CANCER IN IDUKKI DISTRICT, KERALA
The prevalence of cancer is drastically increasing among cardamom farmers using chemical pesticides in Idukki district. The chemicals, mainly Organochlorine and organophosphates, result in various disease conditions. The main aim of the study was to explore the prevalence of cancer and other disease conditions among farmers and other people who were exposed to chemical pesticides. A community-base...
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EFFECT OF BISPHENOL-A ON THE CARDIOVASCULAR SYSTEM IN PREGNANT RATS
Bisphenol-A (BPA) is a chemical produced in large volumes worldwide and has large market diffusion in many consumer products. BPA is used mainly as a monomer in the production of polycarbonate plastics and as a precursor of epoxy resins. So the present study was undertaken to examine the toxic effect of BPA on heart function in pregnant rat models. BPA (50 mg/kg.b.wt/day and 500 mg/kg.b.wt/day) wa...
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EFFECT OF ETHANOLIC EXTRACTS OF INDIAN MEDICINAL PLANTS ON THE NON-ENZYMATIC ANTIOXIDANT SYSTEM IN STREPTOZOTOCIN INDUCED DIABETIC RATS IN COMPARISON WITH GLIBENCLAMIDE
Objective: To investigate the effects of ethanolic extracts of leaf and fruit of Trichosanthes dioica and leaf of Clitoria ternatea were studied on the altered non-enzymatic antioxidant system such as reduced glutathione (GSH), Vitamin E, C and A in streptozotocin-induced diabetic Wistar rats. Methods: Male adult Wistar albino rats divided into eleven groups of six rats each were assigned to non-d...
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A COMPREHENSIVE REVIEW OF THE TRADITIONAL AND PHYTOPHARMACOLOGICAL USES OF ROSA DAMASCENA MILL.
Mother nature has gifted with many herbs that have been found to have various pharmacological and therapeutic activities. One among them is the Rose plant which is available everywhere easily and has been used for ages. There are at least 200 species of rose flowers, amongst them Rosa damascena Mill. species is widely utilized in many industries for different purposes. Rosa damascena well-known as...
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EFFICACY OF SANKHAHOLI (EVOLVULUS ALSINOIDES LINN.) IN THE MANAGEMENT OF ESSENTIAL HYPERTENSION: A RANDOMIZED STANDARD CONTROL CLINICAL STUDY
Background: Hypertension is one of the major risk factors for stroke, heart attack, heart failure, and kidney failure, thereby cause of deaths and disability worldwide. The most predominant type of HTN is essential hypertension (HTN). Unani scholars mentioned clinical manifestations and management of hypertension and have documented it under the context of ‘Imtila.’ The drug Sankhaholi (Evolvu...
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FORMULATION AND EVALUATION OF COLON TARGETED MICROSPHERES OF GLIPIZIDE
The objective of the present study was to formulate and evaluate microspheres of Glipizide using guar gum and HPMC K4M as polymers for colon-specific delivery for better treatment of Type 2 diabetes. The glipizide microspheres were prepared by ionotropic gelation method by the use of various cross-linking agents. The microspheres were then studied for physical appearance, particle size, surface mo...
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ANTIVIRAL ACTIVITY OF SPARTIUM JUNCEUM AGAINST HERPES SIMPLEX VIRUS TYPE 1: AN IN-VITRO STUDY
This study was carried out to evaluate the antiviral activities of methanol and aqueous extracts prepared from the flowers and stems of Spartium junceum L., used as herbal medicine in the treatment of gastric ulcer in Turkish folk medicine, against herpes simplex virus type 1 (HSV-1). The maximum non-toxic concentration of the extracts (MNTC) was determined against Vero cells by using the serial t...
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AN EFFICIENT SYNTHESIS OF SOME NOVEL BIOACTIVE AZETIDINONE DERIVATIVES INCLUDING 5-(BENZOFURAN-2-YL) AND 1-PHENYL-1H-PYRAZOLE-3-CARBOXAMIDE MOIETY
In continuation of our efforts in the development of novel drugs, in the present article we have described synthesis of a series of novel azetidinones derivatives (4a-i) containing 5-(benzofuran-2-yl) and 1-phenyl-1H-pyrazole-3-carboxamide moiety, with excellent yields and without formation of undesirable side products from cyclo condensation reaction of N'- (benzylidene) -5- (benzofuran- 2- yl) -...
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CANNABIS SATIVA L.: A REVIEW OF THE MEDICINAL PROPERTIES OF THIS ‘WONDER PLANT’ AND AN UPDATE ON THE NIGERIA SITUATION
Cannabis sativa L. is an annual herbal plant of the family Cannabinaceae and abundant in nature. It is known locally as igbo, taba, blaze, joint, pot, dope, ganja, sensi, kpoli, weed, and morocco on the streets of Nigeria, and used as a medicinal plant for many centuries in many different parts of the world. Although native to Central Asia, Cannabis is now grown globally. Cannabis is the most abus...
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EVALUATION OF ANTIMICROBIAL, ANTHELMINTIC AND ANTIOXIDANT ACTIVITIES OF HOPEA PONGA (DENNST.) BARK
The present work involves the extraction of phytochemicals from the bark of the medicinal plant Hopea ponga, with various solvents and evaluation of their antimicrobial, anthelmintic and antioxidant activities by following standard methods. The antioxidant capacity of the plant extracts was measured by their ability to scavenge free radicals such as (a) DPPH (2,2-diphenyl-1-picrylhydrazyl), (b) AB...
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