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PROBIOTIC POTENTIAL AND STRESS TOLERANCE IN LACTOBACILLUS MU1008 ISOLATED FROM CHILLED YOGURT SAMPLES OF MAJMAAH
In recent years, scientific research has confirmed the presence of large amounts of probiotic Lactobacillus sp. in fermented dairy products, which shows a positive impact on human health. This study was designed to isolate Lactobacillus with probiotic potential from local and commercial samples. 40 Lactobacilli strained were isolated from commercial and local yogurt samples by tenfold dilution p...
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CARBON NANOTUBES AN ADVANCED DRUG DELIVERY SYSTEM – A REVIEW
In today’s 21st century, Carbon nanotubes (CNTs) are the most researched material by world investigation of the growing industry due to their various reasons properties for use in many applications either in medical or other potential applications. Carbon nanotubes become increasingly popular in various fields simply because of their small size and amazing optical, electric, and magnetic propert...
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FORMULATION, DEVELOPMENT AND EVALUATION OF SUBLINGUAL ANTI-EMETIC TABLET BY MELT GRANULATION TECHNIQUE
Prochlorperazine maleate is used for the treatment of motion sickness and classified under BCS class II for treatment of emesis, the per-oral route is preferred route of administration but first-pass effect and poor bioavailability limits its application. To overcome these limitations, efforts were made to enhance the bioavailability of drugs via the development of a sublingual tablet by melt gran...
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DEVELOPMENT AND INVESTIGATION OF EUDRAGIT S-100 ENCAPSULATED CHITOSAN COATED LIPOSOMES OF PREDNISOLONE FOR COLON TARGETING
The objective of the study was to formulate coated liposomes containing Prednisolone for colon targeting and localization of the therapy to the inflamed colon mucosa. Liposomes were prepared using thin film hydration method. Liposomal formulations were optimized using 32 factorial design using varying concentrations of SPC and cholesterol as independent variables and % EE as the dependent variable...
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ACUTE A SUB-CHRONIC TOXICITY AND IMMUNOMODULATORY ACTIVITY OF AN AQUEOUS EXTRACT OF EUPHORBIA RESINIFERA IN RODENTS
Euphorbia resinifera Berg. (ER) an endemic Moroccan plant has been used to treat different diseases. In spite of its toxicological potential, no scientific report until now was made to evaluate in-vivo neither the toxic effect nor its immunomodulatory activity. The objective was to evaluate the safety of an aqueous extract (AE) of ER in-vivo and its effect on the biochemical, immunological and his...
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AYURVEDA A PROMISING TOOL FOR THE ERADICATION OF COVID-19
The COVID-19 pandemic has created a global health crisis posing an unprecedented public health emergency. The number of deaths and people being infected is increasing daily throughout the globe. This situation is much more severe due to possible devastating situations because of several social and economic factors. Effective management to address this infection is still evolving, and attempts are ...
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EFFECT OF PHYSICAL MODIFICATION ON DISSOLUTION OF NABUMETONE: A BCS CLASS II DRUG
Objective: Physically modified forms of BCS class II drug Nabumetone (NBT) was studied for dissolution in water and pharmacopoeial dissolution media (2%w/v sodium lauryl sulfate in water). Characterization was to identify the suitability of physical processing like heating, cooling, grinding, and milling operations anticipated during commercial manufacturing of dosage forms. Materials and Methods:...
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LIPID-BASED NANOCARRIER DRUG DELIVERY SYSTEM FOR BRAIN TARGETING THROUGH NASAL ROUTE: A REVIEW
The majority of the drugs that are available in the market which are intended for activity in the central nervous system, are not capable of being transported across the Blood-brain barrier. The nasal route of drug administration is one of the most promising routes of drug administration that can permeate the drug through BBB. The permeability of drugs across the BBB is depending on the physicoche...
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ANTIEPILEPTIC ACTIVITY OF RUBIADIN ISOLATED FROM THE ROOTS OF RUBIA CORDIFOLIA IN MICE
Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with bett...
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DEVELOPMENT AND EVALUATION OF CANDESARTAN CILEXETIL TABLETS USING CRYSTAL AGGREGATES PREPARED BY POLYMER ENRICHED BRIDGING LIQUID
The main objective of the study was to formulate tablets of Candesartan cilexetil using the crystal agglomerates for the enhancement in flow properties and solubility. The crystal agglomerates were prepared by polymer enriched bridging liquid (PEBL) technique. The process requires three solvent systems, the good solvent for the drug, the bad solvent and the bridging liquid. The hydrophilic polymer...
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