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SCREENING THE EFFECT OF VASICINE IN MULTIPLE SCLEROSIS USING HUMAN TISSUE CHIP MODEL
From time immemorial pharmacologists and researchers have always been in search for novel drug screening methods. One such unique technique that is gripping the world by its leash is “human tissue chip technology”. This study explores the creation of Multiple Sclerosis (MS) using human tissue chip and assessing the ability of Vasicine a quinazoline alkaloid derived from Adhatoda Justiciae plan...
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A REVIEW ON EVIDENCE-BASED CLINICAL RESEARCH IN TRADITIONAL MEDICINE FOR COMBAT COVID-19
Covid-19, caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a life-threatening disease that has been declared a global pandemic. Even with the intervention of numerous medical systems to combat Covid-19, an effective remedy is not yet in sight rather than supportive therapies accompanied with anti-viral drugs and vaccines. The usage of these medicines has caused for unexpe...
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MICROSPONGES DRUG DELIVERY SYSTEM
Microsponges are novel drug delivery systems made up of cross-linked spongy, polymeric, porous, spherical microspheres particles which vary in size from 5-300 μm. This delivery system as the advantage of producing controlled release formulations of poorly soluble drugs. It increases drug stability, reduces side effects and modifies drug release profiles making it a versatile drug delivery vehicle...
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A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AS ANTIDOTES IN THE TREATMENT OF SNAKE BITES IN INDIA
Envenoming and deaths resulting from snakebites are particularly important public health problems in the rural tropics. Snake envenomation is included since 2009 in the World Health Organization (WHO) list of Neglected Tropical Diseases, as this condition remains largely neglected by national and international health authorities. The only available specific treatment is antivenom therapy, which co...
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DEVELOPMENT AND VALIDATION OF CHROMATOGRAPHIC DETERMINATION OF CARVEDILOL PHOSPHATE IN BULK AND PHARMACEUTICAL DOSAGE FORM USING FLUORESCENCE DETECTOR
An accurate, sensitive and precise RP-HPLC –Fluorescence method has been developed and validated for the estimation of Carvedilol Phosphate (CP) from bulk drug and Pharmaceutical Dosage form. The separation was achieved by a Brownlee analytical C18 column (250mm X 4.6mm, 5μm) in isocratic mode, with mobile phase comprises of Acetonitrile : Methanol : Buffer in proportion of 70:20:10v/v/v, buffe...
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AFFINITY CHROMATOGRAPHY PURIFICATION AND PARTIAL CHARACTERISATION OF D-GALACTOSE BINDING LECTIN FROM SEEDS OF JATROPHA CURCAS L.
A lectin curcin was isolated from mature seeds of Jatropha curcas L. Seeds were collected locally and purified by affinity chromatography on guar gum column. The lectin content was found to be 1.3 mg/ml. Curcin agglutinated B+ve human RBC type showing galactose and N-galactosylamine specificity. Galactose sugar was found to be the most potent inhibitor of curcin hemagglutinating activity (minimum ...
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COMPARATIVE STUDY OF POTENTIAL LEVELS OF VERMICOMPOST USING DIFFERENT WASTES FROM ERODE DISTRICT
Waste disposal has become one of the major problems we are facing today. The rapid increase in the generation of huge extent of waste is one feature of the environmental crisis. This is accompanying with recent global development with respect to rapid urbanization and population growth which has resulted into development of large quantity of organic solid waste. Vermi composting has become progres...
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STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXY-METHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS
Rheological properties of carboxymethyl locust bean gum (CMLBG) solutions having different concentrations and solution pH were evaluated through steady shear and oscillatory measurements and were used to describe the erosion propensity of CMLBG coat of compression coated placebo tablets. CMLBG solutions, irrespective of concentration and solution pH, exhibited predominant viscous character as the ...
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TLC BIOAUTOGRAPHY AND LCMS-MS ANALYSIS FOR IDENTIFICATION OF COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS IN ABIES WEBBIANA LEAVES EXTRACT
This study was performed to identify the antimicrobial compounds in Abies webbiana leaves. The antimicrobial compounds were identified by LCMS-MS. The microbial inhibitory activity was evaluated on Staphylococcus aureus ATCC 6538 using REMA technique and Agar-overlay TLC bioautography. The chloroform extract of Abies webbiana leaves was used for the study. The MIC against Staphylococcus aureus was...
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ATTITUDE PERCEPTION AND RECOMMENDATIONS BY ”Pharm. D” STUDENTS UNDER-GOING THEIR COURSEWORK IN A GOVERNMENT UNIVERSITY – A MAILED QUESTIONNAIRE SURVEY
Background: The quality of education offered by Pharmacy institutions in the country varies widely. There are only a few institutions which maintain internationally recognized standard. Aim: To assess the pharmacy student’s (Pharm. D) perception today, their course, curriculum, and facilities provided. Methods: A postal survey was conducted on the Pharm. D students in Tamil Nadu, India, affiliat...
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