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ANTIMICROBIAL SCREENING AND ANTI-ULCEROGENIC EFFECTS OF LEPIDIUM SATIVUM EXTRACT ON H. PYLORI INDUCED GASTRIC ULCER IN A RAT MODEL
Purpose: Helicobacter pylori (H-pylori) infection has been commonly associated with gastric ulcers. Lepidium sativum (L. Sativum) is an herbaceous edible plant, botanically related to mustard and watercress with remarkable pharmacological features. In this study, we investigate the anti-microbial and anti-oxidant effect of L. sativum seed methanolic extract in-vitro and correlate this with the gas...
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AN OVERVIEW OF HERBAL FORMULATIONS: FROM PROCESSING TO PHARMACOVIGILANCE
Herbs have been a surviving unit since we were born on this planet. Currently, they are the most probed topic in the food industry or pharmacotherapy due to their multidimensional approach where one herb targets various diseases and proffers a wide range of health benefits. Moreover, some herbal supplements are merchandised globally, and people are devouring these products blithely to extract addi...
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ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PATHOGENIC BACTERIA CAUSING URINARY TRACT INFECTION IN TERTIARY CARE HOSPITAL IN KATHMANDU, NEPAL
Urinary tract infection (UTI) is one of the common clinical conditions in patients presenting to the tertiary care hospital. In general, most of the case of UTI was being treated by empirical antimicrobial therapy before the laboratory results of urine culture; since the antimicrobial susceptibility test of uropathogenic bacteria and antibiotic resistance for enhanced management of UTI with a comm...
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REVIEW: AVAILABLE ANALYTICAL METHODS FOR THE ESTIMATION OF FIRST LINE, SECOND LINE ORAL AND NEWER ANTI-TB DRUGS
Tuberculosis (TB) is one of the top ten causes of death worldwide. Presently, one-quarter of the world's population is thought to be infected with TB. New infections occur in about 1% of the population each year. Tuberculosis is a major global health threat. There is a progressive increase in multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR). Multi drug resistance (MDR)-T...
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IN-VITRO NEUROPROTECTIVE ACTIVITY OF SILIBININ AGAINST MPTP (1-METHYL-4-PHENYL-1, 2, 3, 6-TETRAHYDROPYRIDINE) INDUCED NEUROTOXICITY MODEL
In the present study, we examined the effect of Silibinin on the accumulation of oxidative stress induced by MPTP by in-vitro. After decapitation, healthy rat brain was removed rapidly from the skull and rinsed with cold artificial cerebrospinal fluid (ACSF) which has been equilibrated with 95% O2 / 5% CO2 gas mixture. Group I brain was incubated in CSF serve as normal, Group II lenses brain was i...
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BIOCHEMICAL ANALYSIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES OF THEAFLAVINS AND FLAVONOIDS RICH EXTRACT (TFE) AND ITS SILVER NANOCONJUGATES: A COMPARATIVE STUDY
Black tea, the most widely consumed aromatic non-alcoholic beverage second to water, is prepared by boiling cured leaves of Camellia sinensis. It is reported that black tea contains plenty of bioactive constituents, including complex polyphenols like theaflavins (TF2A, TF2B, TF3) and thearubigins that exhibit a wide range of pharmacological properties and also contribute to its quality and bioacti...
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TRIGONELLA FOENUM-GRAECUM L. SEED MUCILAGE-BASE MUCOADHESIVE MICROSPHERES OF DICLOFENAC SODIUM
The study was aimed to discover the properties of Trigonella foenum-graecum L. seed mucilage (TFGSM) in the formulation of mucoadhesive microspheres of diclofenac sodium to prolong the residence time at the site of absorption. Diclofenac sodium microspheres were formulated by ion gelation technique. Different polymer ratios of TFGSM and sodium alginate were used to formulate eight formulations (F1...
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STUDY OF MANGIFERIN ISOLATED FROM LEAVES OF MANGIFERA INDICA ON MYELOID LEUKEMIA ALONG WITH DIFFERENT HUMAN CANCER CELL LINES
In different myeloid leukemia cases resistance to diverse treatment regimen owes to multiple molecular mechanisms of cellular network. Epigenetic dysregulation, gene mutations, overexpression of multidrug resistance genes, abnormal immune function, the presence of chemotherapy-resistant leukemia-initiating cells, and aberrant signaling pathways could be the lead cause of this kind of aberration. S...
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AN OVERVIEW ON QUALITY BY DESIGN IN PHARMACEUTICAL PRODUCT DEVELOPMENT
The concept of Quality by Design reflects current global regulatory thinking related to pharmaceutical products. The pharmaceutical industry needs to improve its performance. Newer technologies need to be implemented that can effectively reduce the cost and, at the same time, improves product quality. Quality by design (QbD) is the best solution to build quality in all pharmaceutical products. The...
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ANTI-CANCER EFFECT OF PANCHAGAVYA ON HUMAN COLON ADENOCARCINOMA (HCT-116) CELL LINE
The objective of the study was to investigate the in-vitro anti-cancer effect of Panchagavya on the Human Colon Adencarcinoma (HCT-116) cell line. Panchayavya was formulated using five products from Cows, namely; Cow dung, Cow urine, Cow milk, Cow curd and Cow ghee. The whole mixture was further freeze-dried and stored until further assay conduction. The growth inhibitory activity of the raw Panch...
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