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EFFECT OF ACYRANTHUS ASPERA ON HIGH-FAT DIET AND STREPTOZOTOCIN INDUCE DIABETIC RATS: ROLE OF OXIDATIVE STRESS, PPAR-Α, GLUT-2 AND INSULIN SIGNALLING
Diabetes mellitus is a complex disorder where oxidative stress plays a crucial role in the development and progression of the disease. In the present work, the rat model evaluated pancreas and liver tissue damage caused by a high-fat diet and diabetic complications. Male Wistar rats were administered with HFD- corn oil orally for 28 days followed by streptozotocin (STZ) injection to induce diabete...
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PARKINSON’S DISEASE: ADVANCES IN PRECLINICAL SCREENING MODELS
About 1.5% of the world's population is suffering from Parkinson's disease, mostly above 55 years of age. It is identified by dopaminergic neuron loss in the striatum's Substantia nigra & dopamine loss (DA). The disease of Parkinson is the second most widespread neurodegenerative disorder. It adversely affects the motor system as the disease increases the destruction of the motor system. It is...
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PROTECTIVE ROLE OF HONEY AND ROYAL JELLY ON CISPLATIN INDUCED OXIDATIVE STRESS IN LIVER OF RAT
Background: Cisplatin is active cytotoxic agents in the treatment of cancer and has many adverse side effects, including hepatotoxicity. Honey and royal jelly are natural products and having antioxidants properties. Aim of the study: To investigate the protective role of combined administration of honey and royal jelly against cisplatin-induced changes in biomarkers of oxidative stress in rat live...
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MICROSCOPIC CHARACTERISATION OF ROOT, STEM AND LEAVES OF AN UNRESOLVED SPECIES: RUBUS INDICUS (ROSACEAE)
The genus, Rubus is considered as highly potent plant crop and possesses economical, medicinal and ecological importance. Rubus plant species have been utilized inbreeding programme and has identified various pharmaceutical compounds. However, the taxonomy of the genus Rubus has been in a state of flux, because of the absence of comprehensive work and associated taxonomic disputes. Among the genus...
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ANTIOXIDANT ACTIVITY OF A NEW FLAVONE GLYCOSIDE FROM THE STEMS OF GMELINA ARBOREA ROXB.
Gmelina arborea Roxb. belongs to the Verbenaceae family, commonly known as Gambhar. It is distributed throughout India, Ceylon, Malayan and Philippine Islands. Its roots have anthelmintic properties. Its flowers are useful in the treatment of leprosy and blood diseases. Its fruit has diuretic properties and aphrodisiac. It is also used in anemia leprosy and vaginal discharges. Leaves have shown an...
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DESIGN, OPTIMIZATION AND EVALUATION OF BUCCAL DRUG DELIVERY SYSTEM OF PROPRANOLOL FOR HYPERTENSION TREATMENT
The main objectives of the present study were to design, optimization and evaluation of buccal drug delivery system of propranolol for hypertension treatment. Propranolol is non-selective β-adrenergic blockers. It shows first-pass metabolism so its bioavailability is decreased and its absolute bioavailability is only about 26%. The buccal tablets of propranolol formulated, by using different muco...
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APHRODISIAC AND SPERMATOGENIC POTENTIAL OF UNSAPONIFIABLE FRACTION FROM SEEDS OF HYGROPHILA SPINOSA T. ANDER IN RATS
Seeds of Hygrophila spinosa T. Ander (Acanthaceae) are traditionally used as an aphrodisiac and spermatogenic in the Indian System of Medicine. Studies were planned to evaluate the effect of unsaponifiable (sterol-enriched) fraction from chloroform extract, of the seeds of Hygrophila spinosa as spermatogenic and as aphrodisiac in-vivo, using rats as experimental animals. An unsaponifiable fraction...
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INAPPROPRIATE NUTRITIONAL INTAKES DURING RAMADAN IN OBESE WOMEN PATIENTS WITH FATTY LIVER PRECLUDE ITS BENEFICIAL EFFECT
Introduction: Ramadan is a lunar month in the Islamic calendar. During this month, individuals who desire to keep a strict fast from dawn to sunset prevent stop eating and drinking. We evaluated the dietary intakes of patients with fatty liver during this month. Material and Methods: Sixty eligible overweight and obese women with fatty liver diagnosed via ultrasonography who had referred to the ma...
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FORMULATION AND EVALUATION OF PROBIOTIC CHOCOLATE
Human gut serves as a home to over 100-1000 microbial species, which primarily modulate the host internal environment and thereby, play a major role in host health. Humans are a unique reservoir of heterogeneous and vivacious group of microbes, which together forms the human-microbiome superorganism. Probiotic bacteria are beneficial to human health by improving the gutmicro biota balance and the ...
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PHYTOPHARMACOGNOSTICAL STUDY OF TUBERS OF EULOPHIA NUDA LINDL.
Plants and plants-based medicines have been used to treat many ailments since the ancient times. Family Orchidaceae to which orchids belongs is the largest family among monocotyledons. The genus Eulophia comprises perennial terrestrial orchids with fleshy tubers, rarely pseudobulbs. One such perennial herb having underground tubers, Eulophia nuda, belonging to family Orchidaceae, has been tradit...
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