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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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23.

ANTIOXIDANT, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF DIFFERENT FRACTIONS FROM METHANOLIC EXTRACT OF PSIDIUM GUAJAVA L. LEAVES

Psidium guajava Linn. the most popular and widely cultivated fruiting plant all over Bangladesh. The present study was aimed to investigate the antioxidant, analgesic and antimicrobial activities of n-hexane (HPG), chloroform (CLPG) and ethyl acetate fractions (ET APG) obtained from methanol extract of Psidium guajava (MPG) leaves. The in-vitro antioxidant activity of fractions HPG, CLPG and ET AP...

C. Sultana, N. K. Kundo, S. Islam, R. Ahmed, S. Afrin, N. Saqueeb and M. I. I. Wahed *

Department of Pharmacy, University of Rajshahi, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.11(6).2733-38

2733-2738

2977

1158

16.

A STUDY OF POSSIBLE PROTECTION BY NEFIRACETAM ON ESLICARBAZEPINE INDUCED MEMORY IMPAIRMENT IN TEMPORAL LOBE EPILEPSY

Memory impairment (MI) is commonly seen in epilepsy and is at times aggravated by antiepileptic therapy. Recent studies reported that co-administration of nootropic agent with an antiepileptic drug (AED) might decrease the MI. This study was designed to evaluate MI activity of Eslicarbazepine (ESL) in temporal lobe epilepsy (TLE) and to assess the protective effect of Nefiracetam (NEF) which is a ...

B. Ray, K. L. Krishna *, T. Madesh, V. Francis and J. M. Asher

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagar, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2236-39

2236-2239

2976

1204

35.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF APIXABAN IN PHARMACEUTICAL FORMULATIONS

A simple, accurate, precise, and rapid high-performance thin-layer chromatographic (HPTLC) method for determination of Apixaban (API) in bulk drug and the pharmaceutical formulation was developed and validated. The separation was performed on aluminum plates, pre-coated with silica gel 60F254 as the stationary phase using toluene: methanol (7:3 v/v), as mobile phase. Densitometric measurement of t...

S. V. Warghade * and K. G. Bothara

Department of Pharmaceutical Chemistry, STES’s Smt. Kashibai Navale College of Pharmacy, Kondhwa, Savitribai Phule Pune University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(7).3399-04

3399-3404

2976

1778

32.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS

An analytical method consists of a detailed, stepwise list of instructions to be followed in the qualitative, quantitative, or structural analysis of a sample for one or more analytes and using a specified technique. A novel, simple, precise, sensitive, and reproducible RP-HPLC method for the simultaneous estimation of Dapagliflozin and Saxagliptin in bulk and pharmaceutical formulation was develo...

N. Boggula * and P. S. Pandiyan

Faculty of Pharmaceutical Sciences, Mewar University, Mewar Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).314-20

314-320

2976

1745

9.

PHARMACOLOGICAL POTENTIAL OF POLYHERBAL COMBINATION FOR THE TREATMENT OF GLOMERULONEPHRITIS IN ALBINO RATS

The polyherbal combination was prepared by using aqueous and methanol root extracts of A. officinalis, B. diffusa, C. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea and V. negundo in equal proportion for the dose of 25 mg/kg and 50 mg/kg body weight. Albino Wistar rats were selected for the study; the serum uric acid, urea, creatinine, BUN, and albumin level were m...

H. Maurya and T. Kumar *

Department of Pharmaceutical Sciences, Kumaun University, Bhimtal Campus, Bhimtal, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4889-98

4889-4898

2975

1548

14.

ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF ANACARDIUM OCCIDENTALE, AEGLE MARMELOS AND ACHYRANTHES ASPERA IN ALLOXAN-INDUCED DIABETIC RATS

Diabetes mellitus is a major endocrine metabolic disorder of multiple etiologies characterized by chronic hyperglycemia; with disturbances of carbohydrate, protein, and fat metabolism. It is caused by the deficiency or ineffective production of insulin by pancreas, which results in increase or decrease in concentrations of glucose in the blood. There is number of chemical agents available to contr...

Brijyog *, L. P. Singh, S. Kumar and S. Verma

Institute of Pharmacy, Harish Chandra P.G. College, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4932-36

4932-4936

2975

1433

30.

FORMULATION AND EVALUATION OF SUSTAINED RELEASE IN-SITU GEL OF AMIKACIN BY USING 32 FULL FACTORIAL DESIGN

Objectives: This work aimed to formulate and evaluate amikacin, fourth-generation fluoroquinolone antibiotic agent containing an in-situ gelling system based on sol-to-gel transition for ophthalmic delivery to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations based a sol-to-gel transition in the cul-de-sac upon instillation. Methods: In t...

S. Sahoo *, K. Malviya, N. Oza, A. Solanki and Prasanta K. Mohapatra

C. U. Shah College of Pharmacy and Research, Wadhwan, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3333-46

3333-3346

2975

1711

37.

PROTECTIVE EFFECTS OF ALOE VERA AGAINST RADIATION INDUCED BIOCHEMICAL DISORDERS IN LIVER OF SWISS ALBINO MICE

In this study, radioprotection against radiation-induced hepatic damage in Swiss albino mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation...

P. Dadupanthi

Department of Zoology, University of Rajasthan, Jaipur, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1275-80

1275-1280

2974

1274

28.

VALIDATED KINETIC SPECTROPHOTOMETRIC DETERMINATION OF DRUGS USING ALKALINE POTASSIUM PERMANGANATE OXIDATION

A simple and sensitive kinetic method is described for the determination of drugs viz., Bendamustine hydrochloride (BEN), Ciprofloxacin hydrochloride (CIP), Dorzolamide hydrochloride (DOR), Pantoprazole sodium (PAN), Warfarin sodium (WAR). This method is based upon a kinetic investigation of drug oxidation with alkaline potassium permanganate. Kinetics of the oxidation reaction is followed spectro...

M. Prashanthi and G. Venkateshwarlu *

Department of Chemistry, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(6).2861-69

2861-2869

2974

1620

8.

MEROPENEM INDUCED THROMBOCYTOSIS – A RARE ADVERSE DRUG REACTION

Thrombocytosis is defined as platelet count greater than 400, 000/mm3. Thrombocytosis can be either primary or secondary. Meropenem is a parenteral carbapenem antibiotic that has great bactericidal activity against almost all significant aerobes and anaerobes. Common adverse effects such as pain at the injection site, skin rash, transitory metabolic disorders such as increased liver enzyme ...

Tajinder Kaur, Anshu Mujalda, Kaveripatti Kannan Aishwarya * and Raghu Naina

Department of Obstetrics and Gynaecology, MMCMSR, Sadopur, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2973-76

2973-2976

2974

900