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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
An analytical method consists of a detailed, stepwise list of instructions to be followed in the qualitative, quantitative, or structural analysis of a sample for one or more analytes and using a specified technique. A novel, simple, precise, sensitive, and reproducible RP-HPLC method for the simultaneous estimation of Dapagliflozin and Saxagliptin in bulk and pharmaceutical formulation was develo...
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GASTROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF TRICHOSANTHES DIOICA FRUIT ON EXPERIMENTAL GASTRIC ULCER IN RATS
Peptic ulcer is a condition associated with a number of factors involving excessive acid secretion in the stomach. This condition is difficult to control with single drug therapy and complete cure cannot be achieved. Even after discontinuation of the drug the relapse rate is high, and the long-term use of synthetic drugs produces adverse effects on the human body. The present study is expected to ...
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CHEMICAL COMPOSITION OF FAGOPYRUM ESCEULENTUM MOENCH SEED THROUGH GC-MS
Medicinal herbs are a precious heritage for us and since long is a part of traditional as well modern system of medicine. These herbs provide less toxic and more effective drug molecules which are helpful in various ailments. In the present work, we have focused on an edible herb which bears a large number of medicinal properties. Fagopyrum esceulentum Moench (Buckwheat) has a long tradition of be...
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1867
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF APIXABAN IN PHARMACEUTICAL FORMULATIONS
A simple, accurate, precise, and rapid high-performance thin-layer chromatographic (HPTLC) method for determination of Apixaban (API) in bulk drug and the pharmaceutical formulation was developed and validated. The separation was performed on aluminum plates, pre-coated with silica gel 60F254 as the stationary phase using toluene: methanol (7:3 v/v), as mobile phase. Densitometric measurement of t...
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ANTIOXIDANT, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF DIFFERENT FRACTIONS FROM METHANOLIC EXTRACT OF PSIDIUM GUAJAVA L. LEAVES
Psidium guajava Linn. the most popular and widely cultivated fruiting plant all over Bangladesh. The present study was aimed to investigate the antioxidant, analgesic and antimicrobial activities of n-hexane (HPG), chloroform (CLPG) and ethyl acetate fractions (ET APG) obtained from methanol extract of Psidium guajava (MPG) leaves. The in-vitro antioxidant activity of fractions HPG, CLPG and ET AP...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE IN-SITU GEL OF AMIKACIN BY USING 32 FULL FACTORIAL DESIGN
Objectives: This work aimed to formulate and evaluate amikacin, fourth-generation fluoroquinolone antibiotic agent containing an in-situ gelling system based on sol-to-gel transition for ophthalmic delivery to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations based a sol-to-gel transition in the cul-de-sac upon instillation. Methods: In t...
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ANTI-MITOTIC ACTIVITY OF GANODERMA APPLANATUM
Traditionally, mushrooms have importance in the diet. Since they possess both nutritional and medicinal value, research on mushrooms is the new area for developing lead molecules to treat cancer and other ailments. Ganoderma is a famous genus in the medicinally important mushrooms. Cancer is a fatal disease in which uncontrolled proliferation is the major crunch point to be considered. The current...
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VALIDATED KINETIC SPECTROPHOTOMETRIC DETERMINATION OF DRUGS USING ALKALINE POTASSIUM PERMANGANATE OXIDATION
A simple and sensitive kinetic method is described for the determination of drugs viz., Bendamustine hydrochloride (BEN), Ciprofloxacin hydrochloride (CIP), Dorzolamide hydrochloride (DOR), Pantoprazole sodium (PAN), Warfarin sodium (WAR). This method is based upon a kinetic investigation of drug oxidation with alkaline potassium permanganate. Kinetics of the oxidation reaction is followed spectro...
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FORMULATION AND IN-VITRO CHARACTERIZATION OF 5-FLUOROURACIL AND FLAVONOID DUAL LIPID DRUG CONJUGATES LOADED SELF NANOMULSIFYING DRUG DELIVERY SYSTEM FOR CANCER TARGETING
Objective: The Failure in chemotherapy is mainly because of the resistance of the chemotherapeutic drugs towards the neoplastic cells. The main reason behind this study was to develop a novel combination of 5-Fluorouracil (5-FU) lipid curcumin conjugates for the treatment of cancer. Methods: In this study, the lipid group stearic acid and oleic acid was conjugated with the parent drug moiety 5-Flu...
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A STUDY ON THE ANTIMICROBIAL EFFECTS OF CRUDE PRINCIPLES EXTRACTED FROM PIPER BETLE LINN. LEAF STALKS AND OCIMUM SANCTUM LINN. LEAVES
The nature harbours a huge source of active principles possessing antimicrobial property. This phenomenon provokes microbiologists, ethnopharmacologist and natural product chemists to perform extensive research on phytoprinciples. The extensive use of these principles in phytotherapy is becoming an excellent alternative strategy against the occurrence of microbial resistance due to some convention...
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