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ANTIOXIDANT EFFICIENCY OF VARIOUS EXTRACTS OF SEED COAT AND COTYLEDON OF CAJANUS CAJAN (L.) MILLSP.
Cajanus cajan L. (Pigeonpea) is an important pulse crop of India. The aim of this study was to determine and compare the antioxidant activity and bioactive compounds of seed coat and cotyledon of C. cajan. The antioxidant properties of pet ether, chloroform, ethanol and aqueous extracts of the seed coat and cotyledon of C. cajan were examined by a ferric thiocynate (FTC) assay, DPPH radical scaven...
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PURIFICATION AND CHARACTERIZATION OF ANTI-HYPERGLYCEMIC BIOACTIVE MOLECULE FROM COSTUS PICTUS D. DON
Costus pictus D. Don., commonly known as the ‘Insulin plant’ is being used as a natural remedy to treat diabetes mellitus. The present study is focused to identify the chemical constituent responsible for the anti-diabetic activity of Costus pictus. The methanol extract was prepared from the fresh leaves of Costus pictus and washed with water to remove excess oxalic acid content present to get...
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INDOLE 1,2,3,4-TETRAHYDROPYRIMIDINONE: SYNTHESIS, CHARACTERIZATION AND IT’S BIOLOGICAL APPLICATIONS
The present research work involves the use of exclusively and commercially available indole-3-carbaldehyde as a starting material to synthesize novel pyrimidine analogues. The synthesis of series of indole and pyrimidine containing N-substituted-4-(1H-indol-3-yl)-6-methyl-2-oxo-1, 2, 3, 4-tetrahydro-pyrimidine-5-carbohydrazide U(1-10) has been done by using principle of Biginelli condensation reac...
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A STUDY ON IDENTIFICATION OF RISK FACTORS OF POLYCYSTIC OVARIAN SYNDROME BY CONDUCTING SURVEY AND MINIMIZING THEM THROUGH PATIENT COUNSELING AND ITS IMPACT ON QUALITY OF LIFE
Background: Polycystic ovarian syndrome (PCOS) is a very common Endocrine Disorder encountered in women in which there is an imbalance of female sex hormones. It is associated with problems such as menstrual irregularities, Hirsutism, Obesity, Insulin resistance, acne, and in later life infertility with Diabetes mellitus and uterine cancer. Objectives: 1. Identify the subjects who are at risk for ...
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IN-SILICO SCREENING OF FLAVONOLS AGAINST BRUGIA MALAYI ASPARAGINYL tRNA SYNTHETASE
Lymphatic Filariasis is one of the most abandoned tropical diseases caused by the parasite, Brugia malayi. The existing conventional drugs act generally on the larval stages of the parasite. The enzyme asparaginyl tRNA synthetase is an excellent molecular target as it plays a crucial role in protein synthesis. Evidences based on the literature presented clues to discover the flavonoids as potentia...
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DESIGN, DEVELOPMENT AND EVALUATION OF POLYHERBAL TABLET OF TWO ANTI-ULCER LEAVES
Aim: The present study was to develop and evaluate antiulcer polyherbal tablet as designing of oral herbal formulation. The methanolic extracts of Abrus precatorius (MEAP) and Cordia wallichi (MECW) leaves were used in different concentrations in the formulations. Materials and Method: The current exploration was to design a gastro-retentive drug delivery system of MEAP and MECW using swelling pol...
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AN UPDATED REVIEW ON THE THERAPEUTIC POTENTIAL OF PRUNUS ARMENIACA
Excessive drug therapy, environmental pollutants, hepatic cancer and alcoholic intoxicants are the main causes of liver disorders. The hepatic disorders/toxicity can occur by several mechanisms like cytochrome P450 activation, lipid peroxidation, induction of nitric acid synthase, mitochondrial dysfunction, activation of pro-inflammatory mediators and bile acid-indu...
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A REVIEW ON CARBON DOTS PRODUCED FROM BIOMASS WASTE-ITS DEVELOPMENT AND BIO-APPLICATIONS
Carbon nanomaterials belong to the carbonaceous family of less than 10 nm in size called Carbon dots (C-dots); the latest class of engineered nanoparticles has recently gained popularity for their unique characteristic features, such due to their low toxicity and miniature size, it can penetrate cells easily, thus becoming highly biocompatible. The advancement of science and its collaboration with...
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RELATIONSHIP BETWEEN SMOKING AND HISTOLOGY OF LUNG CANCER IN MALAPPURAM DISTRICT OF KERALA, SOUTH INDIA
Background: Lung Cancer is the commonly diagnosed neoplasm in males in India. The main histological types of lung cancer are squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. However, histological types may vary with the changes in geographical region, smoking status and other social factors. This study aimed to find out the relationship of smoking and histolo...
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ACUTE, SUB-ACUTE AND ANTIOXIDANT ACTIVITIES OF ARTHROPHYTUM SCOPARIUM AERIAL PARTS
This study aims to evaluate the in-vitro and in-vivo antioxidant activity of different extracts prepared from the aerial parts of Arthrophytum scoparium. Polyphenols flavonoids and tannins contents were determined. The acute toxicity of ASE was carried out based on OECD during two weeks to ascertain the LD50. In sub-acute toxicity, a 100, 200 and 400 mg/kg/day extract was orally administrated for ...
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