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ISOLATION AND QUANTIFICATION OF GALLIC ACID FROM EULOPHIA OCHREATA LINDL. BY HPTLC
In the healthcare system, the development and modernization of phytomedicine in phytochemistry play a central and important role in drug development. Isolation and purification of bioactive compounds from naturally occurring substance are of prime importance. A sensitive and reliable high-performance thin-layer chromatography method has been developed for the estimation of gallic acid in the alcoh...
1815
869
DEVELOPMENT AND CHARACTERIZATION OF MICROPARTICLES OF SUMATRIPTAN SUCCINATE CARRIER SYSTEM VIA NASAL ROUTE
Sumatriptan succinate is the 5H1 receptor agonist and used in the treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. An attempt was made to formulate the nasal mucoadhesive microparticle of Sumatriptan succinate with excipients like mucoadhesive polymers i.e., HPMC, ethyl cellul...
1814
893
SOLID DISPERSIONS OF FENOFIBRATE BY DROPPING METHOD
The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. T...
1812
740
ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF HYPTIS SUAVEOLENS
Plants have served as a source of new pharmaceutical products and inexpensive starting materials for the synthesis of some known drugs. Components with medicinal properties from plants play an important role in conventional Western medicine. In the ethnopharmacological approach, local knowledge about the potential uses of the plants is very useful as compared to the random approach where indigenou...
1812
830
TO INVESTIGATE THE EFFECT OF SPAN 60 AND SPAN 80 POLYMER ON RELEASE RATE OF SIMVASTATIN NOISOME IN COMPARISON WITH PURE SIMVASTATIN
The main objective of the present study was to develop and evaluate the simvastatin noisome using different grades of nonionic surfactants. It was hypothesized that niosomes would increase in vitro release of simvastatin in comparison to the API Mumbai. Niosome were prepared by thin-film hydration method and evaluated for particle size, entrapment efficiency, PDI, and in vitro release. The differe...
1810
675
IN-VITRO ANTI-CANCER ACTIVITY OF TWO BRITTLE STAR SPECIES: OPHIOCOMA ERINACEUS AND OPHIOMASTRIX ANNULOSA
Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. The brittle starfish was shown to contain the bioactive components which exhibit various biological activities including cytotoxicity effects. Hence, the present study was carried out to determine the cytotoxicity of the extracts of two different starfish species like Ophiocoma erinaceu...
1807
708
ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF ANACARDIUM OCCIDENTALE, AEGLE MARMELOS AND ACHYRANTHES ASPERA IN ALLOXAN-INDUCED DIABETIC RATS
Diabetes mellitus is a major endocrine metabolic disorder of multiple etiologies characterized by chronic hyperglycemia; with disturbances of carbohydrate, protein, and fat metabolism. It is caused by the deficiency or ineffective production of insulin by pancreas, which results in increase or decrease in concentrations of glucose in the blood. There is number of chemical agents available to contr...
1807
802
A MODIFIED EFFICIENT METHOD FOR ISOLATION OF RHEIN FROM CASSIA ANGUSTIFOLIA (SENNA)
Chemically, rhein is 9, 10-Dihydro-4, 5-dihydroxy-9, 10-dioxo-2-anthracenecarboxylic acid, and use as an intermediate to synthesize diacerein which widely used in the treatment of degenerative diseases like, osteoarthritis, osteoporosis, and rheumatoid arthritis and hence has commercial importance. Rhein occurs in free state in nature in different plant families like Cassia, Rhamnus, and Rheum but...
1807
1432
TROXERUTIN IMPROVES INSULIN SIGNALING IN TNFα TREATED 3T3-L1 ADIPOCYTES
Chronic low-grade inflammation of adipose tissue is associated with obesity and insulin resistance (IR). The aim of this study is to determine the effect of troxerutin (TX) on insulin signaling in tumor necrosis factor α (TNFα) treated 3T3-L1 adipocytes. Differentiated 3T3-L1 adipocytes were pre-treated with TX, elastatinal (ELAS) or sodium salicylate (SAL) before exposure to recombinant human T...
1807
350
ISOLATION AND PURIFICATION OF NIMBIDIN FROM AZADIRACHTA INDICA OF WESTERN GHATS AND EVALUATE ITS ANTIOXIDANT, ANTI-BACTERIAL AND ANTI-DIABETIC PROPERTIES
Azadirachta Indica has always been known to be the bestowed with good health for many centuries in India. It has been found that the Neem is native to Asian countries. There are three major active components in A. indica, namely nimbin, nimbidin, and nimbiene. The compound nimbidin was isolated by chromatographic techniques. A. indica leaves extract was prepared, and the phytochemical analysis was...
1806
1026