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HIGH-THROUGHPUT STRUCTURE BASED VIRTUAL SCREENING TARGETING CNS FOR INHIBITED ACETYLCHOLINESTERASE REACTIVATION
Organophosphorus (OP) nerve agents blocks acetylcholinesterase and do not allow the degradation of acetylcholine. Post-treatment of organophosphate poisoning involves the treatment with oxime reactivators as an antidote, which will dephosphorylate the phosphate bond between enzyme and nerve agent. Due to CNS permeability failure of these oximes, the introduction of low molecular non-oximes has bec...
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BREAKTHROUGHS IN TRANSDERMAL NANOSTRUCTURED LIPID CARRIER DRUG DELIVERY SYSTEMS
The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of d...
1830
806
SYNTHESIS OF SILVER NANOPARTICLES USING SWERTIPUNICOSIDE AND ITS ACTIVITY ON HUMAN BREAST CANCER CELL LINE (MCF-7)
In the current study, synthesis of silver nanoparticles (AgNPs) using swertipunicoside was tested against human breast cancer cell line (MCF-7). The swertipunicoside was tested against the normal cell line such as vero cells to find out the toxicity of the compound. The synthesized AgNPs were characterized using UV-visible spectroscopy, x - ray powder diffraction (XRD), fourier-transform infrared ...
1829
752
ENHANCED MECHANISM OF METAL NANOPARTICLES USING SYZYGIUM CUMINI AS A POTENTIAL SYNTHESIZER AND ITS INHIBITORY EFFECT
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resis...
1829
798
ALLELOPATHIC POTENTIAL OF LEAF LEACHATES OF CHROMOLAENA AND LANTANA ON MUNG BEAN (VIGNA RADIATA L. CV. K-851) SEEDS
Chromolaena and Lantana plants were analyzed to evaluate the existence of allelopathic effect using fully viable seeds of mung bean as the bioassay material. The study shows that pretreatment of mung bean seeds with various concentrations [1:1 and 1:2 (w/v)] of Chromolaena and Lantana leaf leachate for 24 h interval reduced the percentage germination. DNA and RNA contents were significantly reduce...
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741
1, 3, 4-OXADIAZOLE AND ITS POTENCY: A REVIEW
Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. Oxadiazole or furadiazole is a five-membered heterocyclic nucleus and is considered to be derived from furan by replacement of two methane (-CH=) groups by pyridine type nitrogen. Oxadiazole ...
1829
825
MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS
Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, in ...
1828
756
MEASUREMENT OF NATURAL RADIOACTIVITY IN BUILDING MATERIALS SAMPLES BY USING (HPGe) SYSTEM
In the present work, we have measured natural radioactivity in twelve building materials samples for four kinds (Brick, cement, gypsum and sand) obtained from some Iraqi governorates by using High Purity Germanium (HPGe) radiation detectors system. The results of measurements have shown that the average values specific activity concentrations for 238U, 232Th and 40K which were equal to (24.236 ± ...
1827
841
EXPLORATION OF AMORPHOPHALLUS PAEONIIFOLIUS STARCH AS NATURAL BINDER
The aim of the present work was to characterize the starchy components of Amorphophallus paeoniifolius tuber and evaluate its potential as a binder. The tuber starch was extracted and characterized in terms of Phyto-chemical and physicochemical properties. Cyproheptadine was selected as model drug, and drug excipient compatibility studies were carried. Granules containing 5%, 7.5%, 10%, and 12.5% ...
1827
1117
LIPID BASED PARENTERAL DRUG DELIVERY SYSTEM
Lipid-based drug delivery systems in the form of triglyceride emulsions, micellar systems and liposomes have been used for parenteral administration for the last few decades. Large number of new chemical entities (NCE) presents formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. In addition, high drug concentrations can lead to irrita...
1826
673