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SYNTHESIS, EVALUATION AND POLYMORPHISM STUDIES OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENT ANTIBACTERIAL AGENTS
Ten, 2-substituted benzimidazole derivatives were prepared and assessed against two Gram-positive bacteria (Streptococcus mutans, Staphylococcus aureus) and two Gram-negative bacteria (Psuedomonas aeruginosa, Escherichia coli). The derivatives were obtained by the condensation of 2-((1H-benzo[d] imidazol-2-yl) thio) acetohydrazide(4) with different substituted aromatic aldehydes and their structur...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR DETERMINATION OF LOXAPINE SUCCINATE IN CAPSULE DOSAGE FORM
To develop and validate simple, selective, specific, sensitive and accurate stability indicating assay method by RP-HPLC for determination of Loxapine succinate in the capsule dosage form. Several trials are taken by changing mobile phase composition, and ratio and finally the drug was eluted on a C18 Purospher star (250 mm × 4.6 mm, 5 µm) column using mobile phase consisting of water: Methanol:...
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DEVELOPMENT OF BIOSIMILARS: AN OVERVIEW OF THE REGULATORY FRAMEWORK IN INDIA, USA, EU; MAJOR CHALLENGES AND RELATED CASE STUDIES
A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countrie...
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DIFFERENT ROLES OF PHARMACISTS AS A HEALTH CARE PROFESSIONAL: A BRIEF REVIEW
In terms of providing professional services, the pharmacy profession has expanded significantly and is now recognized as essential to the multidisciplinary delivery of health care. Because pharmacists are vital healthcare professionals who improve patient care and encourage wellness, their position in society's healthcare is crucial. Pharmacists are sometimes referred to as chemists and druggists ...
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ADRENAL MYELOLIPOMA ASSOCIATED WITH CHOLELITHIASIS- A CASE REPORT
Adrenal myelolipomas are rare benign endocrinologically inactive tumor composed of mature adipose tissue and hematopoietic cells in varying proportions. Most lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. Its characteristic appearance on sonography and computed tomography enables preoperative diagnosis with a hi...
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CHARACTERISATION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES FROM SHINGLES PATIENTS
Even after treating Shingles patients with antiviral drugs, they are found to suffer from secondary bacterial infections. With this background as a guide, we undertook an investigation to isolate the bacterial pathogens from the pus of Shingles patients. Among the isolates obtained during the one year study period, Staphylococcus aureus sp. was found to be multi drug resistant and hence it was cho...
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PERCENTAGE OF PATIENT AFFORDABILITY AND ELIGIBILITY FOR ANTIVIRAL THERAPY ACCORDING TO CHILD PUGH SCORE IN HEPATITS “C” VIRUS (HCV) POSITIVE PATIENTS
Hepatitis C is a liver disease caused by the hepatitis C virus. Acute HCV infection is usually asymptomatic and is only very rarely associated with life threatening disease. About 15-45% of infected persons spontaneously clear the virus within 6 months of infection without any treatment, whereas remaining 55-85 % were develop chronic HCV infection and risk of cirrhosis occur. A prospective, observ...
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FOLATE ANCHORED CONJUGATES OF POLY (AMIDOAMINE) (PAMAM) DENDRIMER FOR CONTROLLED SITE SPECIFIC DELIVERY OF PIROXICAM IN ARTHRITIC RATS
The purpose of the present study was to synthesize and evaluate the potential of folate-G.4.0-PAMAM dendrimer conjugates as acceptable vehicle for site specific delivery of piroxicam (PXM) to inflammatory regions and to determine its targeting efficiency in carreganan induced arthritic rats. PXM was selected as a model acidic anti inflammatory drug. Folic acid was linked to the surface amino gro...
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COMPARE THE EFFICACY AND SAFETY OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS WITH OTHER ORAL HYPOGLYCEMIC AGENTS IN TYPE 2 DIABETES MELLITUS PATIENTS
Background: The incidence of Diabetes Mellitus has increased dramatically in recent decades. Di Peptidyl Peptidase 4 inhibitors (DPP-4) have their role in glycemic control. An impaired ‘incretin effect’, occurs in patients with type 2 Diabetes Mellitus in response to glucose intake. Objectives: The main objective of the study is to compare therapeutic outcomes and adverse drug reactions among ...
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QMS VERSUS HPLC-UV FOR LAMOTRIGINE PLASMA MONITORING
Lamotrigine (LTG), a synthetic anticonvulsant, may lead to therapy failure or toxicity risks due to the wide inter and intra individual pharmacokinetic variations. Those wide variations in LTG require its therapeutic drug monitoring (TDM). Our study aims to compare the QMS method with the HPLC-UV which is considered as a reference method for TDM of LTG. The study was conducted in the Clinical Phar...
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