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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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25.

SYNTHESIS, EVALUATION AND POLYMORPHISM STUDIES OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENT ANTIBACTERIAL AGENTS

Ten, 2-substituted benzimidazole derivatives were prepared and assessed against two Gram-positive bacteria (Streptococcus mutans, Staphylococcus aureus) and two Gram-negative bacteria (Psuedomonas aeruginosa, Escherichia coli). The derivatives were obtained by the condensation of 2-((1H-benzo[d] imidazol-2-yl) thio) acetohydrazide(4) with different substituted aromatic aldehydes and their structur...

K. L. S. Konyak, M. M. Maste, A. Saxena * and P. Inamdar

Department of Pharmaceutical Chemistry, KLE University College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(5).1929-34

1929-1934

3168

1312

36.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR DETERMINATION OF LOXAPINE SUCCINATE IN CAPSULE DOSAGE FORM

To develop and validate simple, selective, specific, sensitive and accurate stability indicating assay method by RP-HPLC for determination of Loxapine succinate in the capsule dosage form. Several trials are taken by changing mobile phase composition, and ratio and finally the drug was eluted on a C18 Purospher star (250 mm × 4.6 mm, 5 µm) column using mobile phase consisting of water: Methanol:...

K. A. Thakor * and T. Y. Pasha

Department of Chemistry, Parul Institute of Pharmacy and Research, Parul University, Limda, Waghodia, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2362-68

2362-2368

3167

1470

21.

DEVELOPMENT OF BIOSIMILARS: AN OVERVIEW OF THE REGULATORY FRAMEWORK IN INDIA, USA, EU; MAJOR CHALLENGES AND RELATED CASE STUDIES

A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countrie...

V. L. D. Sai Swetha Penugonda *, Vishnu Priya Cherukuri, Naga Sowjanya Vaka and Ravi Kumar Reddy Juturi

Department of Pharmaceutical Regulatory Affairs, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, affiliated to Andhra University, Visakhapatnam, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6341-52

6341-6352

3167

2232

11.

DIFFERENT ROLES OF PHARMACISTS AS A HEALTH CARE PROFESSIONAL: A BRIEF REVIEW

In terms of providing professional services, the pharmacy profession has expanded significantly and is now recognized as essential to the multidisciplinary delivery of health care. Because pharmacists are vital healthcare professionals who improve patient care and encourage wellness, their position in society's healthcare is crucial. Pharmacists are sometimes referred to as chemists and druggists ...

Debgopal Ganguly, Sourav Jana, Mahafuz Sahana, Vivek Jana, Kingshuk Nandi, Hira Das * and Rajesh Ghosh

School of Pharmacy, Seacom Skills University, Bolpur, Birbhum, Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(8).3715-27

3715-3727

3167

1163

39.

ADRENAL MYELOLIPOMA ASSOCIATED WITH CHOLELITHIASIS- A CASE REPORT

Adrenal myelolipomas are rare benign endocrinologically inactive tumor composed of mature adipose tissue and hematopoietic cells in varying proportions. Most lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. Its characteristic appearance on sonography and computed tomography enables preoperative diagnosis with a hi...

R. Kalra, N. Dahiya*, G. Singh, S. Modi and P Goel**

Department of Pathology* and Surgery**, Pt. BDS PGIMS, Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(4).1031-33

1031-1033

3166

1396

22.

CHARACTERISATION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES FROM SHINGLES PATIENTS

Even after treating Shingles patients with antiviral drugs, they are found to suffer from secondary bacterial infections. With this background as a guide, we undertook an investigation to isolate the bacterial pathogens from the pus of Shingles patients. Among the isolates obtained during the one year study period, Staphylococcus aureus sp. was found to be multi drug resistant and hence it was cho...

Venkadesan B, Raja Priya P, Muthulakshmi K and Jasmine R*

P.G. Department of Biotechnology, Bishop Heber College, Tiruchirappalli 620 017, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(11).2880-83

2880-2883

3166

1265

45.

PERCENTAGE OF PATIENT AFFORDABILITY AND ELIGIBILITY FOR ANTIVIRAL THERAPY ACCORDING TO CHILD PUGH SCORE IN HEPATITS “C” VIRUS (HCV) POSITIVE PATIENTS

Hepatitis C is a liver disease caused by the hepatitis C virus. Acute HCV infection is usually asymptomatic and is only very rarely associated with life threatening disease. About 15-45% of infected persons spontaneously clear the virus within 6 months of infection without any treatment, whereas remaining 55-85 % were develop chronic HCV infection and risk of cirrhosis occur. A prospective, observ...

S. Sareen*, S. Kosey and A. Goyal

Department of Pharmacy Practice, Indo Soviet Friendship College of Pharmacy, Moga, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(11).4863-68

4863-4868

3166

1359

37.

FOLATE ANCHORED CONJUGATES OF POLY (AMIDOAMINE) (PAMAM) DENDRIMER FOR CONTROLLED SITE SPECIFIC DELIVERY OF PIROXICAM IN ARTHRITIC RATS

The purpose of the present study was to synthesize and evaluate the potential of folate-G.4.0-PAMAM dendrimer conjugates as acceptable vehicle for site specific delivery of piroxicam (PXM) to inflammatory regions and to determine its targeting efficiency in carreganan induced arthritic rats. PXM was selected as a model acidic anti inflammatory drug.  Folic acid was linked to the surface amino gro...

R. N. Prajapati *, S. K. Prajapati, S. Alok and R. Gupta

Institute of Pharmacy, Shri Venkateshwara University, Gajraula, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3889-96

3889-3896

3166

1703

62.

COMPARE THE EFFICACY AND SAFETY OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS WITH OTHER ORAL HYPOGLYCEMIC AGENTS IN TYPE 2 DIABETES MELLITUS PATIENTS

Background: The incidence of Diabetes Mellitus has increased dramatically in recent decades. Di Peptidyl Peptidase 4 inhibitors (DPP-4) have their role in glycemic control. An impaired ‘incretin effect’, occurs in patients with type 2 Diabetes Mellitus in response to glucose intake. Objectives: The main objective of the study is to compare therapeutic outcomes and adverse drug reactions among ...

V. Konuru * and T. R. M. Reddy

Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(11).4963-67

4963-4967

3166

1332

16.

QMS VERSUS HPLC-UV FOR LAMOTRIGINE PLASMA MONITORING

Lamotrigine (LTG), a synthetic anticonvulsant, may lead to therapy failure or toxicity risks due to the wide inter and intra individual pharmacokinetic variations. Those wide variations in LTG require its therapeutic drug monitoring (TDM). Our study aims to compare the QMS method with the HPLC-UV which is considered as a reference method for TDM of LTG. The study was conducted in the Clinical Phar...

E. Gaïes, M. Bouhlel *, R. Charfi, N. Jebabli, N. Baazaoui, I. Salouage, H. El-Jebari, A. Klouz and S. Trabelsi

Department of Clinical Pharmacology, National Centre of Pharmacovigilance, Tunis, Tunisia.

DOI: 10.13040/IJPSR.0975-8232.9(12).5186-90

5186-5190

3165

1259