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ANTIBACTERIAL AND PHYTOCHEMICAL STUDIES ON THE LEAVES OF ADENOCALYMMA ALLIACEUM MIERS.
Adenocalymma alliaceum is an important medicinal plant belongs to the family Bignoniaceae. The antibacterial and phytochemical studies on the leaves of this plant were carried out by using the disc diffusion method and Thin Layer Chromatography. The methanolic leaf extract showed a brown colored band on TLC plate with an Rf value 0.25 represents the presence of sulfide compound. The extract was te...
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ADSORPTION OF CIPROFLOXACIN FROM AQUEOUS SOLUTION ONTO FE3O4/GRAPHENE OXIDE NANOCOMPOSITE
In this research, ciprofloxacin adsorption (CIP) onto graphene oxide synthesized with Fe3O4 (Fe3O4-GO) was applied via various adsorbent dose, contact time, temperature and initial CIP concentration. The results showed that the percentage removal of CIP decreases from 98.1 to %77.4, as the CIP concentration increases from 25 to 200 mg/L. Also, the amount of CIP adsorbed per unit mass of adsorbent...
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MEDICAL DEVICE REGULATIONS AND CURRENT CHALLENGES IN THE GROWTH OF MEDICAL DEVICES IN INDIA: AN OVERVIEW
Medical device, a device or instrument or apparatus or that is used to treat or prevent or diagnose or mitigate or cure the disease or to replace the structure of the body parts mimicking the natural function. The medical device sector started to grow rapidly in the last 8 years. Developed countries like the USA, European Union, and Japan concentrated on this sector to increase their production ca...
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METHOD DEVELOPMENT AND VALIDATION OF LC-ESI-MS/MS TECHNIQUE FOR THE ESTIMATION OF MODAFINIL IN HUMAN PLASMA; APPLICATION TO PHARMACOKINETICS IN HEALTHY RABBITS
A new simple and sensitive liquid chromatography-electrospray ionization-tandem-mass spectrometric (LC-ESI-MS/MS) technique was developed and validated for the estimation of modafinil in human plasma and the method was applied to study pharmacokinetics in healthy rabbits. Chromatography was attained on Phenomenex- C18 (50mm × 4mm) 5µ column and acetonitrile, methanol and 0.1% formic acid (25:60:...
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IDENTIFICATION AND BIOACTIVE POTENTIAL OF ENDOPHYTIC FUNGI FROM MARINE WEEDS AVAILABLE IN THE COASTAL AREA OF BANGLADESH
Endophyte is a rich source of bioactive metabolites for medicinal exploitation as an increasing number of novel compounds with bioactive potential are now being isolated from this source. This study was conducted to characterize and explore endophytic fungi from marine weeds available in Bangladesh. The whole weed was used for isolation of endophytic fungi in the water agar media and the isolated ...
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N-[MORPHOLINO (4-NITROPHENYL) METHYL] NICOTINAMIDE AND ITS METAL COMPLEXES: SYNTHESIS AND EXPLORATION OF THEIR BIOACTIVITY
Synthetic organic compounds, containing relatively higher number of nitrogen attracting interest in the current medical research due to their utility in chemotherapy. The development of new medicines with more number of nitrogen atoms in their structural framework is an important challenging task for medicinal chemists. The lipophilicity of Mannich bases and their metal complexes enables them to b...
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SYNTHESIS, EVALUATION AND POLYMORPHISM STUDIES OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENT ANTIBACTERIAL AGENTS
Ten, 2-substituted benzimidazole derivatives were prepared and assessed against two Gram-positive bacteria (Streptococcus mutans, Staphylococcus aureus) and two Gram-negative bacteria (Psuedomonas aeruginosa, Escherichia coli). The derivatives were obtained by the condensation of 2-((1H-benzo[d] imidazol-2-yl) thio) acetohydrazide(4) with different substituted aromatic aldehydes and their structur...
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QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES OF SULFADIAZINE- SALICYLALDEHYDE SCHIFF BASE AS AN ANTI-MYCOBACTERIAL AGENTS
Quantitative structure activity relationship is among the most widely used computational technology for analogue-based drug design. A molecular modelling approach using sulfadiazine- salicylaldehyde Schiff base analogue as anti-mycobacterial activity from recently reported literature were taken and was designed using MOE 2009.10. Sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate...
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ASSOCIATION BETWEEN VITAMIN D RECEPTOR FOKI POLYMORPHISM AND CHRONIC PERIODONTITIS IN SYRIAN POPULATION
Background: Chronic periodontitis (ChP) is the most common form of periodontal diseases. The progression rate may be influenced by local, systemic conditions and environmental factors that can alter the normal host response to bacterial plaque and affect the susceptibility to disease. Several studies have reported a role for vitamin D receptor (VDR) gene polymorphisms in numerous immunological act...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LEDIPASVIR AND SOFOSBUVIR IN FIXED DOSAGE FORM
Ledipasvir and Sofosbuvir Combination have been approved for the treatment of Chronic Hepatitis C Viral Infection. Here an accurate, valid, elementary, and error-free reverse-phase liquid chromatography strategy was developed for the quantitation of Ledipasvir and Sofosbuvir in its bulk form as well as in fixed dosage form. Effective chromatographic separation of Ledipasvir and Sofosbuvir was achi...
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