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DESIGN EXPERT SOFTWARE ASSISTED DEVELOPMENT AND EVALUATION OF CEFPODOXIME PROXETIL MATRIX TABLET
Cefpodoxime Proxetil is third generation, broad-spectrum Cephalosporin Antibiotic & it has an oral bioavailability of only 50% and biological half life 2 h so to improve it’s bioavailability sustain release matrix formulation was designed. Sustained release matrix tablets of Cefpodoxime Proxetil prepared by direct compression method based on combination of natural Acacia gum & Karaya gum...
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CITRAL ATTENUATES N-NITROSODIETHYLAMINE INDUCED LIVER CARCINOGENESIS IN EXPERIMENTAL WISTAR RATS
Antioxidants are one of the key troupes in tumorigenesis, several natural and artificial antioxidants were shown to have anticancer effects. The aim of the current study is to reveal the chemopreventive nature of citral during diethylnitrosamine (DEN) -induced liver cancer in male Wistar albino rats. Administration of DEN to rats caused in amplified relative liver weight and serum marker enzymes a...
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EVALUATION OF MULTITARGETED ANTIPSYCHOTIC ACTIVITY OF UNMADGAJAKESARI – A HERBOMINERAL FORMULATION – AN ANIMAL EXPERIMENTAL STUDY
Schizophrenia is a chronic and complex mental disorder characterized by hallucinations and delusions that significantly affect emotions, behavior, and mental processes. Currently used antipsychotics are characterized by the multireceptor mode of action (antagonism of dopamine D2 and serotonin receptors), there is no consensus regarding an "ideal" target engagement. Moreover, they are associated wi...
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ANTIMICROBIAL ACTIVITY OF LEAVES OF FICUS BENGHALENSIS AGAINST ISOLATED DENTAL PATHOGENS
Dental caries is considered one of the major oral health issues throughout the world. Synthetic drugs and antibiotics have major side effects and can develop resistance. Ficus benghalensis F. benghalensis is a plant with enormous established pharmaceutical properties. The present study was designed to evaluate the antimicrobial activity of water, and ethanolic extracts of F. Benghalensis leaves ag...
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THE EFFECT OF MEDIA AND FERMENTATION CONDITION TOWARD ANTIBACTERIAL ACTIVITIES OF BACILLUS SP. DA11 ASSOCIATED WITH SARCOPHYTON SP.
The emergence of antibiotic-multidrug resistant microorganisms is an essential issue in the health sector. Consequently, the exploration of new antimicrobial compounds from many promising resources is urgently required. Soft coral-associated bacteria are potential as antimicrobial compound producers. This study aims to get the best medium and fermentation conditions in the production of secondary ...
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PHARMACOLOGICAL EVALUATION OF SOME NOVEL THIENO 1, 2, 3-TRIAZINES-4-ONES FOR ITS ANALGESIC ACTIVITY
The analgesic activity was assessed using hot plate method, formalin induced paw licking test, acetic acid induced writhing test. Preliminary investigations were carried out with water, DMSO and chloroform for solubility. For analgesic activity 1, 2, 3- triazine-4-ones series of compounds CP1, CP2, CP3 showed significant increase in jumping time of mice in hot plate method at only higher dose leve...
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SOLID DISPERSIONS OF FENOFIBRATE BY DROPPING METHOD
The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. T...
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FORMULATION, EVALUATION AND RADIOGRAPHIC STUDY OF STOMACH SPECIFIC FLOATING TABLETS CONTAINING VENLAFAXINE HYDROCHLORIDE FOR TREATMENT OF DEPRESSION
Depression is a chronic, recurring, and potentially life-threatening illness. The present work is to formulate floating tablets of Venlafaxine hydrochloride as this drug is used to treat depression. GIT absorption of Venlafaxine hydrochloride is poor due to low aqueous solubility. Thus, an attempt was made to enhance it gastric residence time that will improve its dissolution profile. The floating...
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FORMULATION AND EVALUATION OF TOPICAL ITRACONAZOLE NANOGEL
Itraconazole is a triazole antifungal category drug used for the treatment of local &Systemic fungal infections. Itraconazole is not recommended to neutropenic and other immune-compromised patients who have difficulty swallowing the oral capsule formulation, and it has many side effects. Commercially, Itraconazole topical gel preparation is not available in the market; thus, this formulation i...
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DESIGN, FORMULATION AND OPTIMIZATION OF RUTIN TRIHYDRATE EMULGEL BY RESPONSE SURFACE METHODOLOGY
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is a BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated ...
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