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SOLID DISPERSIONS OF FENOFIBRATE BY DROPPING METHOD
The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. T...
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DEVELOPMENT OF BIOSIMILARS: AN OVERVIEW OF THE REGULATORY FRAMEWORK IN INDIA, USA, EU; MAJOR CHALLENGES AND RELATED CASE STUDIES
A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countrie...
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A PHYTO PHARMACOLOGICAL REVIEW ON TRADITIONAL MEDICINAL PLANT ZIZIPHUS RUGOSA LAM
Ziziphus rugosea member of Rhamnaceae family, is found in the deciduous and semi-evergreen forests of Western Ghats, India. It is commonly known as suran in Hindi. chunukoli in Urdu, badara in Sanskrit, and toran in Marathi. Z. rugosa is traditionally used in the treatment of skin diseases, mouth ulcers, dropsy, boils, diarrhea, tachycardia, syphilis, miscarriage, misconception, flatulence, hyster...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-{4-[(6-CHLORO-4-OXO-4H-CHROMEN-3-YLMETHYLENE) IMINO] PHENYL}-2-(SUBSTITUTED PHENOXY ACETAMIDE) DERIVATIVES
Some N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-(substituted phenoxy) acetamide derivatives (3) were synthesized by reacting N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-chloroacetamide (2) with some substituted phenol in dry acetone in the presence of K2CO3 and catalytic amount of KI. The chemical structures of the compounds were elucidated by IR, 1H-NMR ...
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IDENTIFICATION OF NEW HIV-1 PROTEASE INHIBITORS BY MULTIPLE LINEAR REGRESSION (MLR) AND PHYSICO-CHEMICAL DESCRIPTORS
In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some 5,6-dihydro-2-pyrones derivativesusing statistical work.Using only 4 topological and physico-chemical molecular descriptors, we have achieved 84.81% correct classification of the compounds with and without its activity.A heurisimatedtic algorithm selects the best multipl...
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EVALUATION OF MULTITARGETED ANTIPSYCHOTIC ACTIVITY OF UNMADGAJAKESARI – A HERBOMINERAL FORMULATION – AN ANIMAL EXPERIMENTAL STUDY
Schizophrenia is a chronic and complex mental disorder characterized by hallucinations and delusions that significantly affect emotions, behavior, and mental processes. Currently used antipsychotics are characterized by the multireceptor mode of action (antagonism of dopamine D2 and serotonin receptors), there is no consensus regarding an "ideal" target engagement. Moreover, they are associated wi...
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COMPARATIVE ACUTE AND SUB-ACUTE TOXICITY STUDY OF HYDRO-ALCOHOLIC EXTRACTS OF CENTELLA ASIATICA AND EVOLVULUS ALSINOIDES IN SWISS ALBINO MICE
In this study, the in-vivo toxicity of Centella asiatica & Evolvulus alsinoides were evaluated by acute and sub-acute toxicity assays according to the guidelines of OECD 423 & 407 respectively. For LD50 evaluation, a single dose of hydro-alcoholic extracts of both plants was orally administered to Swiss albino mice at doses of 200, 400, 800, 1600 and 2000 mg/kg. Then the animals were obse...
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NEUROPROTECTION OF ETHANOLIC EXTRACT OF WITHANIA SOMNIFERA AND WITHANOLIDE A IN MOTOR CO-ORDINATION ON EXPERIMENTAL HUNTINGTON’S RAT MODEL
Neurodegeneration is a powerful initiator for a number of nervous system related diseases that come under the term “neurodegenerative diseases”. Neurodegenerative diseases are incurable, results in the progressive degeneration of nerve cells and causes problems with movement and mental functioning that became a challenge in present day’s health care. For this study we made a model of Hunting...
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EVALUATION OF PHYTOCHEMICAL PROPERTIES AND ANTIOXIDANT ACTIVITIES OF DIFFERENT SOLVENT EXTRACTS OF PASPALUM CONJUGATUM LEAVES GROWING IN BANGLADESH
Secondary metabolites found in various plants play an important role in curing various diseases and are used as important raw materials for the production of traditional and modern medicine. One of these plants, Paspalum conjugatum, a member of the Poaceae family, has been used for different purposes since prehistoric times. In this research work, we extracted the powdered leaves of P. conjugatum...
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PHARMACOLOGICAL EVALUATION OF SOME NOVEL THIENO 1, 2, 3-TRIAZINES-4-ONES FOR ITS ANALGESIC ACTIVITY
The analgesic activity was assessed using hot plate method, formalin induced paw licking test, acetic acid induced writhing test. Preliminary investigations were carried out with water, DMSO and chloroform for solubility. For analgesic activity 1, 2, 3- triazine-4-ones series of compounds CP1, CP2, CP3 showed significant increase in jumping time of mice in hot plate method at only higher dose leve...
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