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FORMULATION AND EVALUATION OF TOPICAL ITRACONAZOLE NANOGEL
Itraconazole is a triazole antifungal category drug used for the treatment of local &Systemic fungal infections. Itraconazole is not recommended to neutropenic and other immune-compromised patients who have difficulty swallowing the oral capsule formulation, and it has many side effects. Commercially, Itraconazole topical gel preparation is not available in the market; thus, this formulation i...
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GC-MS ANALYSIS AND IN VITRO ANTILEISHMANIAL ACTIVITY OF ETHYLACETATE FRACTION OF ALLIUM CEPA (EAFAC)
In this study, GC-MS analysis shown that ethyl acetate fraction of Allium cepa (EAFAC) (band one) consists of 55 compounds which shown antileishmanial activity. (IC50 73.1 ± 2.1 ug/ml) is the inhibitory concentration which is observed for ethyl acetate fraction of Allium cepa (EAFAC) (band one). Leishmania major is the specie used for this leishmanicidal assay. In this bioassay, Amphotericin B (I...
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A PHARMACIST BASED INTERVENTION TO IMPROVE THE CARE OF PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS IN A PRIVATE INSTITUTION
The study was intended to evaluate the effectiveness of patient counselling in improving the quality of life (QOL) and knowledge, attitude and practices (KAP) of hypertensive and diabetic patients in a private educational institution. The study was conducted for a period of six months with the help of validated KAP and QOL questionnaire. Impact of patient counselling was studied by comparing the K...
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COMPARATIVE ANALYSIS OF SOCIO-ECONOMIC STATUS IN RHD PATIENTS: A TERTIARY CARE INTERPRETATION AND EXPLORING REASONS TO IMPROVE ADHERENCE
Rheumatic heart disease (RHD) is a major burden in developing countries and leads to heart valve damage resulting from acute rheumatic fever (ARF). RHD and its complications cause more than 1.4 million deaths per year, globally. The mortality in RHD depends on the factors related to socio-economic status and tertiary care, especially in developing countries like India. In this study, a comparative...
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PRESCRIPTION KNOWLEDGE AMONG PATIENTS WITH CARDIOVASCULAR DISEASES AT THE MOI TEACHING AND REFERRAL HOSPITAL, KENYA
Cardiovascular diseases (CVDs) cause 30% of deaths globally and are reported to be on the increase in sub-Saharan Africa. Medications prescribed for a CVD require a lifetime commitment. As a result patient must adhere to prescribed medication. However, prescription adherence is influenced to a large part by prescription knowledge. Although disease outcome is influenced by prescription knowledge, e...
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STABILITY INDICATING ASSAY FOR DILTIAZEM AND ITS METABOLITES IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY FOR PHARMACOKINETIC APPLICATION
A simple and sensitive Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry method was developed to perform a stability study of diltiazem and its metabolites in human plasma using various buffer reagents at a different strength. The method was applied for the quantification of diltiazem and its two major metabolites N-desmethyl diltiazem and desacetyl diltiazem in human plasma. The an...
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EFFECT OF TRICHOSANTHES DIOICA AQUEOUS FRUIT EXTRACT IN DIABETES AND DIABETIC COMPLICATIONS
Anti-diabetic and protective activity of T. dioica aqueous extract in diabetic complications in streptozotocin (STZ)-induced diabetic rats was evaluated. Albino rats (n = 24) were divided into four groups, of six animals each. Group 1 (normal control) and Group 2 (diabetic control) received normal saline (10 ml/kg/day p.o.) whereas Group 3 (Standard, insulin 6 U/kg/day s.c) and Group 4 received 10...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR THE SIMULTANEOUS ESTIMATION OF ELBASVIR AND GRAZOPREVIRIN PHARMA-CEUTICAL DOSAGE FORMS BY RP-HPLC
The present study aimed to develop and validate stability indicating method for the simultaneous determination of Elbasvir and Grazoprevir in its pharmaceutical dosage form using RP-HPLC. Chromatographic separation was done with Discovery C18 (250 mm × 4.6 mm, 5 µ) column using 0.1% ortho-phosphoric acid (OPA) and acetonitrile in the ratio 50:50% v/v as mobile phase on isocratic mode. The column...
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ADSORPTION OF CIPROFLOXACIN FROM AQUEOUS SOLUTION ONTO FE3O4/GRAPHENE OXIDE NANOCOMPOSITE
In this research, ciprofloxacin adsorption (CIP) onto graphene oxide synthesized with Fe3O4 (Fe3O4-GO) was applied via various adsorbent dose, contact time, temperature and initial CIP concentration. The results showed that the percentage removal of CIP decreases from 98.1 to %77.4, as the CIP concentration increases from 25 to 200 mg/L. Also, the amount of CIP adsorbed per unit mass of adsorbent...
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ANTIMICROBIAL AND ANTIPLASMODIAL ACTIVITY DISPLAYED BY ACTINOMYCETES ISOLATED FROM SOILS FROM KAVANGO AND HARDAP REGIONS IN NAMIBIA
Plasmodium falciparum and multidrug resistant bacteria such as Mycobacterium avium, Staphylococcus aureus and Escherichia coli are among the top causes of morbidity and mortality especially in developing countries. These pathogens are responsible for the reported antibiotic resistance incidents globally. Due to the increase in antibiotic resistance worldwide, there is an urgent need for new bioact...
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