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LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLION
The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent...
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INFLAMMATION: A POTENTIAL SCENARIO ON NOVEL TARGETS AND TARGETED DRUG THERAPY
Inflammation is the vascular event shown by the body against the external material by activating different cells and releasing various chemical mediators to prevent noxious effects. Many drugs like steroidal and non-steroidal drugs are available till the date to treat inflammation but have a number of side effects and centralized on to counteract the COX and LOX pathways. This perspective will use...
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EVALUATION OF SAFETY PROFILE OF ANTI HYPERTENSIVE DRUGS WITH THE EFFECT OF PATIENT COUNSELING
Objective: To establish does response relationship to the hypertensive patients and ensure safety profile of drugs through counseling of patients. Method: Patients who have suffered by secondary hypertension with blood pressure range of above 145-170/100-110 mmHg are selected and divided in two groups. First group of patients to administer for Nifedipine 5mg and furosemide 40mg administered for...
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DESIGN OF CONTROLLED RELEASE NON-ERODIBLE POLYMERIC ATENOLOL MATRIX TABLET USING MICROWAVE OVEN-ASSISTED SINTERING TECHNIQUE
The objective of the present study was to evaluate the effect of microwave sintering condition on matrix formation and subsequent drug release from polymer matrix tablet for controlled release. The Atenolol floating SR matrix tablets were prepared by using tragacanth, sodium bicarbonate, Eudragit S-100 and citric acid was incorporated as a gas generating agents. Atenolol controlled release tablets...
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EVALUATION OF THE ROLE OF ZINC AS ADD-ON THERAPY ON GLYCAEMIC CONTROL AND SYMPTOMS AND SIGNS OF NEUROPATHY IN THE PATIENTS WITH DIABETES MELLITUS
Introduction: Diabetic neuropathy occurs in about half of the individuals with long-standing diabetes manifested as polyneuropathy, mononeuropathy and autonomic neuropathy. There is evidence indicating the involvement of zinc in diabetes. Aim: To evaluate the effect of Zinc as add-on therapy in Diabetic Neuropathy on the basis of clinical signs and symptoms and glycaemic control. Materials and Met...
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SEROLOGICAL TESTING IN ASTHMA PATIENTS VISITING MAHAVIR HOSPITAL AND RESEARCH CENTRE
Background: The hypothalamic pituitary adrenal (HPA) axis in asthmatic patients is influenced by many factors. Stress, cytokines and exogenous corticosteroids play an important role in regulating the HPA axis and thus affecting the adreno corticotrophic hormone (ACTH) and cortisol levels among these patients. It is well accepted that the HPA axis represents a major immune-regulatory system that pl...
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ISOLATION AND STRUCTURAL ELUCIDATION OF DEGRADATION PRODUCTS OF RANOLAZINE
Degradation studies are important to know the potentials degradation products and to develop a stability indicating method. Ranolazine active pharmaceutical ingredients subjected to in detailed forced degradation study using several stressing agents (HCl, NaOH, H2O2). Degradation products of Ranolazine under hydrolytic and oxidative stress conditions were identified, and their stabilities were ass...
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IN-VITRO SENSITIVITY OF AMPHOTERICIN B, ITRACONAZOLE AND FLUCONAZOLE – RESISTANT AGAINST CANDIDA ALBICANS
Aim: To study In-Vitro sensitivity of Amphotericin B, Itraconazole and Fluconazole -Resistant against Candida albicans. Methods and Results: A panel of 14 clinical isolates of Candida albicans was tested. Strains were labeled and given a unique identification number. Candida albicans ITCC 4718 were included as quality control organisms in each set of experiments. Interactions in vitro between...
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EFFECT OF TWO LEVELS FROM GINSENG AND GREEN COFFEE ON OBESE RATS
The present study aimed to investigate the effect of two levels from (green coffee, ginseng and their combination) on nutritional and biochemical status of obese rats. Forty eight male albino rats (Sprague Dawley Strain) used in this study, the rats divided into two main groups. The first main group (6 rats) fed on basal diet (as a control negative group). The second main group (42 rats) was fed e...
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DESIGN, SYNTHESIS, AND EVALUATION OF 1,4-NAPHTHOQUINONE DERIVATIVES AS POTENTIAL EPITHELIAL GROWTH FACTOR RECEPTOR INHIBITORS
In this manuscript, we designed and synthesized 1,4-naphthoquinone derivatives. These derivatives were characterized using the different analytical techniques such as 1H NMR, 13C NMR, FTIR, Mass spectroscopy, melting point, and elemental analysis. The synthesized compounds (MB (1-10)) further subjected to assess the anticancer activity using different cancer cell lines such as MCF-7, HeLa, and Hep...
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