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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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61.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL COUMARIN ANALOGUES

The desired target Compounds (4a-e), (5a-e) and (6a-e) were prepared in two steps. Reaction of 3-acetyl-6-bromo-2H-chromen-2-one (1) with 3-(Aryl)-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-e) in presence of aqueous KOH solution and the reaction mixture stirred  for 2 hours and then filtered, furnished the desired 6-bromo-3-((E)-3-(3-(Aryl)-1-phenyl- 1H-pyrazole-4-yl) acryloyl)- 2H-chromen-2- ones ...

S. B. Patil * and N. M. Goudgaon

Department of Chemistry, Ramaiah Institute of Technology, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).960-65

960-965

3355

1367

46.

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ERLOTINIB HYDROCHLORIDE BY SOLID DISPERSION TECHNIQUE WITH POLOXAMER 188: PREPARATION AND IN-VITRO EVALUATION

Solid dispersions (SDs) of Erlotinib hydrochloride (ETN) were prepared to enhance the solubility by solvent evaporation (SE) and Melting (MM) method using poloxamer 188 (PL 188) in the ratio of 1:1, 1:3 and 1:5 (w:w). The solubility of the drug was increased in a concentration-dependent manner of polymer and follow linearity order. The solid dispersion was characterized by Fourier transform infrar...

M. K. Meena, D. Choudhary, M. Chouhan, P. Shukla and S. K. Sinha *

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(1).387-93

387-393

3355

1677

54.

FORMULATION, DEVELOPMENT AND EVALUATION OF SUBLINGUAL ANTI-EMETIC TABLET BY MELT GRANULATION TECHNIQUE

Prochlorperazine maleate is used for the treatment of motion sickness and classified under BCS class II for treatment of emesis, the per-oral route is preferred route of administration but first-pass effect and poor bioavailability limits its application. To overcome these limitations, efforts were made to enhance the bioavailability of drugs via the development of a sublingual tablet by melt gran...

R. P. Chitlange * and V. A. Kilor

Department of Pharmaceutics, Gurunanak College of Pharmacy, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4039-52

4039-4052

3355

1998

28.

SYNTHESIS, CHARACTERISATION AND PHARMACOLOGICAL EVALUATION OF NOVEL COUMARIN DERIVATIVES

In the present study a new series of coumarin derivatives have been synthesized by condensation of ethyl acetoacetate and resorcinol. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR and Mass spectral analysis. These compounds were screened for their Analgesic and Anti-inflammatory activities. Among the synthesized compounds II (a-1 to c-3)....

P. Selvam*, N. Ramlakshmi and S. Arunkumar

Research Scholar, Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(2).413-17

413-417

3354

1437

23.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW4-(SUBSTITUTED\ARYL)-((1, 3–DIPHENYL-1H-PYRAZOLE-4-YL) METHYLENEAMINO)-1, 5-DIMETHYL-2-PHENYLPYRAZOLILDIN-3-ONE DERIVATIVES

Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated....

Jabali J. Vora , Akash R. Patel *, Dinesh R. Patel and Sandip dholakia

Ph. D. Scholar, Department of Chemistry, Hemchandracharya North Gujarat University, Patan, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(1).162-67

162-167

3352

1619

60.

STUDIES ON SOME BIOCHEMICAL CHANGES DURING CITRIC ACID PRODUCTION IN A SYNTHETIC MEDIUM BY A MUTANT ASPERGILLUS NIGER AB1801

An experimental study was carried out to examine the biochemical changes in the fermentation broth during citric acid production by a mutant Aspergillus niger AB1801. The production of citric acid was increased upto 8th day of fermentation, and then declined. pH decreased continuously, dry cell weight followed continuous increment pattern. Amino nitrogen and urea nitrogen decreased gradually, but ...

P. Ghosh, S. Ganguly* and A. K. Banik

Department of Chemical Engineering (Biochemical Engineering Division), University of Calcutta, 92, A. P. C. Road, Kolkata- 700 009, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).2287-90

2287-2290

3352

1565

26.

EVALUATION OF IN-VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF MONOCHORIA VAGINALIS LEAVES ON Hep2 AND HeLa CELL LINES

The entire plant (Monochoria vaginalis (Burm. f.) C. Presl.) except root is being used as a vegetable and has been used in traditional Indian system of medication for treating various diseases. But there are not many scientific data on the antioxidant and anticancer activity of M. vaginalis. Therefore, we aimed to determine the in-vitro antioxidant and anticancer activity of methanolic extract of ...

M. R. Prabha * and G. K. Nivethitha

Post Graduate and Research Department of Botany, Thiagarajar College (Autonomous), Affiliated to Madurai Kamaraj University, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(7).3340-48

3340-3348

3352

1497

60.

FORMULATION DEVELOPMENT AND EVALUATION OF ATORVASTATIN CALCIUM LIQUISOLID TABLETS

The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was us...

P. R. Patil *, P. R. Mahaparale and K. U. Shaikh

Department of Pharmacy, Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1849-59

1849-1859

3351

2156

17.

IN-SILICO MOLECULAR SCREENING OF NATURAL PLANT PRODUCTS FOR THE IDENTIFICATION OF NOVEL POTENTIAL CHEMOTHERAPEUTIC AGENTS AGAINST BREAST CANCER

In-silico computational approaches help in ascertaining drug targets via bioinformatics tools. HER2 is the most valuable therapeutic target for breast cancer therapy. The overexpression of HER2 protein plays a very critical role in the progression of breast cancer. Plant-derived natural products have received increasing attention over the past 20-30 years for their potential as novel therapeutic a...

K. S. N. M. Megana and Y. Suneetha *

Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4546-51

4546-4551

3350

1533

32.

LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLION

The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent...

P. K. Sankaran *, R. Gunapriya, M. Kumaresan and G. Karthikeyan

Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3876-80

3876-3880

3349

1378