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EFFECT OF ETHANOLIC EXTRACTS OF INDIAN MEDICINAL PLANTS ON THE NON-ENZYMATIC ANTIOXIDANT SYSTEM IN STREPTOZOTOCIN INDUCED DIABETIC RATS IN COMPARISON WITH GLIBENCLAMIDE
Objective: To investigate the effects of ethanolic extracts of leaf and fruit of Trichosanthes dioica and leaf of Clitoria ternatea were studied on the altered non-enzymatic antioxidant system such as reduced glutathione (GSH), Vitamin E, C and A in streptozotocin-induced diabetic Wistar rats. Methods: Male adult Wistar albino rats divided into eleven groups of six rats each were assigned to non-d...
2074
869
HEPATOPROTECTIVE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF BOERHAAVIA DIFFUSA LINN. AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN MICE
Boerhaavia diffusa is a natural herb possesses potent diuretic, anticancer and antioxidation properties. This work was designed to investigate the effect of hydro alcoholic extract of Boerhaavia diffusa Linn. on hepatoprotective efficacy in D-galactosamine-intoxication in mice. Albino Mice divided into 5 groups each consisting of 6 animals. Group 1 served as vehicle control, Group 2 served as hepa...
2073
820
FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF VERAPAMIL HYDROCHLORIDE
Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump. As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the proced...
2073
851
QUANTITATIVE SIMULTANEOUS ESTIMATION OF ASPIRIN AND OMEPRAZOLE BY RP-HPLC METHOD IMPLEMENTING AQbD APPROACH IN PHARMACEUTICAL DOSAGE FORM
A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Aspirin (ASP) and Omeprazole (OMP). By using box benchen design method have been developed and optimized. Effective chromatographic separation achieved using C18 column (250 × 4.6 mm, 5 µm) as a stationary phase and mobile phase consisted of ...
2072
799
EFFECT OF TRICHOSANTHES DIOICA AQUEOUS FRUIT EXTRACT IN DIABETES AND DIABETIC COMPLICATIONS
Anti-diabetic and protective activity of T. dioica aqueous extract in diabetic complications in streptozotocin (STZ)-induced diabetic rats was evaluated. Albino rats (n = 24) were divided into four groups, of six animals each. Group 1 (normal control) and Group 2 (diabetic control) received normal saline (10 ml/kg/day p.o.) whereas Group 3 (Standard, insulin 6 U/kg/day s.c) and Group 4 received 10...
2071
832
NEWER VACCINE INTRODUCTION (PNEUMOCOCCAL CONJUGATE VACCINE) FROM THE STATE’S OWN RESOURCES IN HARYANA, INDIA: AN EXAMPLE OF ADVOCACY TO POLICY AND ACCELERATED PUBLIC HEALTH ACTION
Introduction: Global pneumonia mortality (50%) caused by pneumococcus is responsible for invasive pneumococcal disease. Pneumococcal Conjugate Vaccine (PCV) has been introduced by the Government of India in a phased manner in selected states, but Haryana was not included. Objective: To draw key lessons learned from the process of newer vaccine introduction (PCV) in Haryana from the state’s resou...
2071
559
THE PATTERN OF ANTIBIOTICS PRESCRIPTION AT AL-RASS HOSPITAL
Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational prescription of antibiotics. This study evaluated the prescribing pattern of antibiotics at Al-Rass hospital in Qassim region. Methodology: A retrospective cross-sectional study was ...
2070
733
IN-VITRO BIOLOGICAL ACTIVITIES OF FRACTIONS OF ETHYL ACETATE FRACTION OF THE WATER EXTRACT OF ARTOCARPUS HETEROPHYLLUS SENESCENT LEAVES
Artocarpus heterophyllus belongs to the family Moraceae. In Sri Lankan traditional medicine the water extract of A. heterophyllus senescent leaves is used to control diabetes mellitus. The hypoglycemic activity of ethyl acetate fraction of water extract of senescent leaves has been reported. Ethyl acetate fraction (EA/W) was fractionated using sephadex LH-20 column chromatography using the solvent...
2068
1042
COMPARATIVE DISSOLUTION BEHAVIOUR OF TEN MARKETED CHLORAMPHENICOL CAPSULES IN INDONESIA
Background: Chloramphenicol capsules are found in several brands with different prices in the market. This study aimed to obtain in-vitro biopharmaceutics quality data from the generic and branded name products. Methods: Ten products were selected, consisted of 3 generics (A, B and C) and 7 branded names (D, E, F, G, H, I and J); F was chosen as an innovator. The dissolution test was performed by ...
2068
862
TRENDS IN ANTIEPILEPTIC DRUGS PRESCRIPTION PATTERN AMONG PATIENTS VISITING A TERTIARY CARE CENTER
The objectives were to observe the drug pattern of epileptic patients with their seizure type, to analyze the type of therapy received by the patients, to observe if epileptic patients are receiving an appropriate dose, to identify the side effects in epileptic patients associated with drug treatment and to observe the cost of conventional and newer antiepileptic drugs (AED’s). This was a cross-...
2068
690