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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL COUMARIN ANALOGUES
The desired target Compounds (4a-e), (5a-e) and (6a-e) were prepared in two steps. Reaction of 3-acetyl-6-bromo-2H-chromen-2-one (1) with 3-(Aryl)-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-e) in presence of aqueous KOH solution and the reaction mixture stirred for 2 hours and then filtered, furnished the desired 6-bromo-3-((E)-3-(3-(Aryl)-1-phenyl- 1H-pyrazole-4-yl) acryloyl)- 2H-chromen-2- ones ...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ERLOTINIB HYDROCHLORIDE BY SOLID DISPERSION TECHNIQUE WITH POLOXAMER 188: PREPARATION AND IN-VITRO EVALUATION
Solid dispersions (SDs) of Erlotinib hydrochloride (ETN) were prepared to enhance the solubility by solvent evaporation (SE) and Melting (MM) method using poloxamer 188 (PL 188) in the ratio of 1:1, 1:3 and 1:5 (w:w). The solubility of the drug was increased in a concentration-dependent manner of polymer and follow linearity order. The solid dispersion was characterized by Fourier transform infrar...
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FORMULATION, DEVELOPMENT AND EVALUATION OF SUBLINGUAL ANTI-EMETIC TABLET BY MELT GRANULATION TECHNIQUE
Prochlorperazine maleate is used for the treatment of motion sickness and classified under BCS class II for treatment of emesis, the per-oral route is preferred route of administration but first-pass effect and poor bioavailability limits its application. To overcome these limitations, efforts were made to enhance the bioavailability of drugs via the development of a sublingual tablet by melt gran...
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1998
SYNTHESIS, CHARACTERISATION AND PHARMACOLOGICAL EVALUATION OF NOVEL COUMARIN DERIVATIVES
In the present study a new series of coumarin derivatives have been synthesized by condensation of ethyl acetoacetate and resorcinol. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR and Mass spectral analysis. These compounds were screened for their Analgesic and Anti-inflammatory activities. Among the synthesized compounds II (a-1 to c-3)....
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW4-(SUBSTITUTED\ARYL)-((1, 3–DIPHENYL-1H-PYRAZOLE-4-YL) METHYLENEAMINO)-1, 5-DIMETHYL-2-PHENYLPYRAZOLILDIN-3-ONE DERIVATIVES
Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated....
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STUDIES ON SOME BIOCHEMICAL CHANGES DURING CITRIC ACID PRODUCTION IN A SYNTHETIC MEDIUM BY A MUTANT ASPERGILLUS NIGER AB1801
An experimental study was carried out to examine the biochemical changes in the fermentation broth during citric acid production by a mutant Aspergillus niger AB1801. The production of citric acid was increased upto 8th day of fermentation, and then declined. pH decreased continuously, dry cell weight followed continuous increment pattern. Amino nitrogen and urea nitrogen decreased gradually, but ...
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EVALUATION OF IN-VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF MONOCHORIA VAGINALIS LEAVES ON Hep2 AND HeLa CELL LINES
The entire plant (Monochoria vaginalis (Burm. f.) C. Presl.) except root is being used as a vegetable and has been used in traditional Indian system of medication for treating various diseases. But there are not many scientific data on the antioxidant and anticancer activity of M. vaginalis. Therefore, we aimed to determine the in-vitro antioxidant and anticancer activity of methanolic extract of ...
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FORMULATION DEVELOPMENT AND EVALUATION OF ATORVASTATIN CALCIUM LIQUISOLID TABLETS
The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was us...
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IN-SILICO MOLECULAR SCREENING OF NATURAL PLANT PRODUCTS FOR THE IDENTIFICATION OF NOVEL POTENTIAL CHEMOTHERAPEUTIC AGENTS AGAINST BREAST CANCER
In-silico computational approaches help in ascertaining drug targets via bioinformatics tools. HER2 is the most valuable therapeutic target for breast cancer therapy. The overexpression of HER2 protein plays a very critical role in the progression of breast cancer. Plant-derived natural products have received increasing attention over the past 20-30 years for their potential as novel therapeutic a...
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LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLION
The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent...
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