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EFFECT OF SOLANUM CHRYSOTRICHUM SCHLDL. ON CELL PROLIFERATION IN VITRO
The effect of four extracts of Solanum chrysotrichum on the proliferation of bacteria, yeasts, mouse spleen cells and human transformed cells was determined. Dry leaves grounded were consecutively macerated 24 h with hexane, chloroform, methanol and water. Dilutions of 1, 10 and 100 µg/mL / DMSO were used for the assays with normal mouse spleen cells, DU-145 and MCF-7 cells. The cellular prolifer...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ERLOTINIB HYDROCHLORIDE BY SOLID DISPERSION TECHNIQUE WITH POLOXAMER 188: PREPARATION AND IN-VITRO EVALUATION
Solid dispersions (SDs) of Erlotinib hydrochloride (ETN) were prepared to enhance the solubility by solvent evaporation (SE) and Melting (MM) method using poloxamer 188 (PL 188) in the ratio of 1:1, 1:3 and 1:5 (w:w). The solubility of the drug was increased in a concentration-dependent manner of polymer and follow linearity order. The solid dispersion was characterized by Fourier transform infrar...
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FORMULATION DEVELOPMENT AND EVALUATION OF ATORVASTATIN CALCIUM LIQUISOLID TABLETS
The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was us...
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ANTI-ULCER ACTIVITY OF PSIDIUM GUAJAVA ON PYLORUS LIGATION INDUCED GASTRIC ULCER IN ALBINO RATS
The present study deals with the phytochemical analysis and evaluation of antibacterial activity of hydroalcohol, acetone, and hexane extracts of the leaves of Psidium guajava. The antimicrobial activity was measured by the agar well diffusion method. Gastric volume, pH, total and free acidity and the ulcerative index was also measured in hydroalcoholic extract of Psidium guajava on gastric ulcer ...
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DESIGN AND EVLUATION OF COLLOIDAL CARRIER SYSTEM FOR ORAL DELIVERY OF ENZYME
The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...
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INFLUENCE OF FORMULATION VARIABLES ON THE IN VITRO DISSOLUTION OF GUM DAMAR BASED MATRIX TABLETS
The objective of the study was to examine the influence of two variables, concentration of the matrixing agent and diluent on the release of diclofenac sodium from hydrophobic matrix tablets. A 32 full factorial design was employed to optimize drug release profile. Concentration of the hydrophobic matrixing agent (X1) and type of diluent (X2) were taken as independent variables. The dependent vari...
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QUANTIFICATION OF VITAMIN B – 12 CONTENT IN MULTIVITAMINS AND ELEMENTS IN MINERAL SUPPLEMENTS IN CHILE, BY TOTAL REFLECTION X-RAY FLUORESCENCE
This manuscript presents the application of a detailed set of analytical technologies to the content of assorted micronutrient supplement and mineral supplement products on the market in the city of Concepcion, Chile. We applied TXRF as a screening technique for the evaluation of 1) The vitamin B-12 content in multivitamins and 2) the elemental composition (P, K, Ca, Mn, Cr, Fe, Cu and Zn) in mine...
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FORMULATION, DEVELOPMENT AND EVALUATION OF SUBLINGUAL ANTI-EMETIC TABLET BY MELT GRANULATION TECHNIQUE
Prochlorperazine maleate is used for the treatment of motion sickness and classified under BCS class II for treatment of emesis, the per-oral route is preferred route of administration but first-pass effect and poor bioavailability limits its application. To overcome these limitations, efforts were made to enhance the bioavailability of drugs via the development of a sublingual tablet by melt gran...
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A NOVEL STABILITY INDICATING UPLC METHOD FOR THE ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN TABLET DOSAGE FORM
UPLC is a modern technique which refers to Ultra Performance Liquid Chromatography and enhances in three main areas: Speed, resolution, and sensitivity. In this present study, an accurate and precise UPLC method was developed and validated for the stability indicating assay method to estimate Tezacaftor and Ivacaftor simultaneously in both bulk and tablet dosage form. This method was developed usi...
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ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF HYPTIS SUAVEOLENS
Plants have served as a source of new pharmaceutical products and inexpensive starting materials for the synthesis of some known drugs. Components with medicinal properties from plants play an important role in conventional Western medicine. In the ethnopharmacological approach, local knowledge about the potential uses of the plants is very useful as compared to the random approach where indigenou...
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