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EFFECT OF SOLANUM CHRYSOTRICHUM SCHLDL. ON CELL PROLIFERATION IN VITRO
The effect of four extracts of Solanum chrysotrichum on the proliferation of bacteria, yeasts, mouse spleen cells and human transformed cells was determined. Dry leaves grounded were consecutively macerated 24 h with hexane, chloroform, methanol and water. Dilutions of 1, 10 and 100 µg/mL / DMSO were used for the assays with normal mouse spleen cells, DU-145 and MCF-7 cells. The cellular prolifer...
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IN-VITRO ANTIBACTERIAL AND CYTOTOXICITY EVALUATION OF SOME NOVEL TETRAZOLE DERIVATIVES
A series of tetrazol derivatives 1(a-c) and 2(a-c) were synthesized by Mannich base reaction. Synthesized compounds 1(a-c) and 2(a-c) were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectral, and elemental analysis. Synthesized compounds 1(a-c) and 2(a-c) were screened for dental plaque bacteria and cytotoxicity activity. The compound 1b was highly active against Enterococcus feacalis in antibacter...
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ROLE OF CD4+T CELL SUBSETS IN THE DETERMINATION OF THE CLINICAL OUTCOME OF JAPANESE ENCEPHALITIS INFECTION
Japanese encephalitis is the most common arthropod-borne human encephalitis in the world. JEV clinical outcomes vary from complete recovery to recovery with neuropsychiatric sequelae to death. Contribution of T cells to the control and immunopathology of JEV infection has been reported in various studies. CD4+ T cells were found to be major T cells that has role in protection as well as affecting ...
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MODELING ANTIBACTERIAL ACTIVITY OF 4-THIOZOLIDONE DERIVATIVES
In the present work, efforts have been made to model the antibacterial activity of 4-thiazolidone derivatives against pathogenic bacteria P. aeruginosa by using QSAR (quantitative structure-activity relationship) methodology. Multivariate analysis gave excellent model which was tested using cross validation using leave one out method. The cross- validation method was applied to the data set in ord...
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DESIGN AND EVLUATION OF COLLOIDAL CARRIER SYSTEM FOR ORAL DELIVERY OF ENZYME
The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...
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HISTOPATHOLOGICAL ALTERATIONS IN KIDNEY DUE TO THE EFFECT OF VARIOUS STAGES OF NAGABHASMA (LEAD) PREPARATION
Background: Nagabhasma is a lead-based Ayurvedic medicine. Numerous reports indicate the toxic effects of lead used in this preparations on various systems of our body. But Ayurveda claims that the toxic effect of lead gets nullified thereby acquiring the medicinal property by following stringent and traditional method of preparation. Objectives: Therefore, the present study is designed to evaluat...
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QUANTIFICATION OF VITAMIN B – 12 CONTENT IN MULTIVITAMINS AND ELEMENTS IN MINERAL SUPPLEMENTS IN CHILE, BY TOTAL REFLECTION X-RAY FLUORESCENCE
This manuscript presents the application of a detailed set of analytical technologies to the content of assorted micronutrient supplement and mineral supplement products on the market in the city of Concepcion, Chile. We applied TXRF as a screening technique for the evaluation of 1) The vitamin B-12 content in multivitamins and 2) the elemental composition (P, K, Ca, Mn, Cr, Fe, Cu and Zn) in mine...
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DEVELOPMENT AND IN VITRO EVALUATION OF SELF EMULSIFYING FORMULATION FOR EMBELIN
The purpose of present work was to improve the oral bioavailability of embelin by formulating this hydrophobic phytoconstituent as self emulsifying drug delivery system (SEDDS). SEDDS improves the oral bioavailability by overcoming the dissolution step, enzymatic degradation and hepatic first pass metabolism of phytoconstituent. On the basis of solubility study of embelin, ethyl oleate, tween 80 a...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CEFPODOXIME PROXETIL
A new simple and rapid reverse-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous estimation of cefpodoxime proxetil in bulk drugs and pharmaceutical dosage form. The separation was accomplished on a sunfire C-18 (250 × 4.6 mm, 5 μm) column with a mobile phase consisting of Methanol; Water (70:30 v/v) at a flow rate of 0.8 mL/min. The...
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A NOVEL STABILITY INDICATING UPLC METHOD FOR THE ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN TABLET DOSAGE FORM
UPLC is a modern technique which refers to Ultra Performance Liquid Chromatography and enhances in three main areas: Speed, resolution, and sensitivity. In this present study, an accurate and precise UPLC method was developed and validated for the stability indicating assay method to estimate Tezacaftor and Ivacaftor simultaneously in both bulk and tablet dosage form. This method was developed usi...
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