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OPTIMIZING THE FORMULATION VARIABLES FOR ERLOTINIB LOADED CHITOSAN NANOPARTICLES
Objective: There is rapidly growing interest in the development of nanoparticles drug delivery mainly for anticancer drugs as it promises to solve problems to several related to anticancer drugs. The aim of present work was to formulate erlotinib loaded chitosan nanoparticles using probe sonication technique. The objective of the study was to investigate the effect of surface stabilizers and sonic...
2081
900
DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxaci...
2081
918
SYNTHESIS AND ANTIBACTERIAL SCREENING OF SCHIFF BASES DERIVED FROM 3-(5-BROMOTHIOPHEN-2-YL)-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
A series of new Schiff bases were synthesized by condensation of 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde with different aromatic aldehydes. The 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde was prepared from 1-(1-(5-bromothiophen-2-yl)ethylidene)-2-(4-chlorophenyl)hydrazine by the Vilsmeier Haack reaction. The 1-(1-(5-bromothiophen-2-yl)ethyl...
2079
841
EVALUATION OF THE AMELIORATIVE EFFECT OF ALPINIA OFFICINARUM METHANOL EXTRACT IN AN EXPERIMENTAL MODEL OF DEPRESSION
The active ingredient flavonoids especially Flavones, e.g., Quercetin was identified from the methanol extract of Alpinia officinarum. This study evaluates the antidepressant activity of Alpinia officinarum (L.) wild Hance (Zingiberaceae) in Swiss Albino mice models. The antidepressant activity was evaluated by using different animal models viz. tail suspension test, despair swim test, potentiatio...
2078
897
APPLICATION OF STABILITY INDICATING UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CAFFEINE IN GEL FORMULATION, PLASMA AND URINE
A simple, sensitive and stability indicating UV spectrophotometric method was developed and validated for the estimation of caffeine in a gel formulation, plasma and urine samples using acidified alcohol as solvent. At absorbance maxima of 265 nm, the linearity was found to be in range of 4-20 µg/ml with correlation coefficient 0.9988. The method was applied for estimation of caffeine in a gel fo...
2078
1001
AN ANALYSIS OF PHARMACOLOGICAL ACTIVITIES OF PORTULACA OLERACEA
Portulaca oleracea belonging to the family Portulacaceae has a wide occurrence throughout the World. It has numerous nutritional and medicinal benefits to humans because it is a good source of many minerals, vitamins, fatty acids, alkaloids, flavonoids, aspartic acid, coumarins, glutathione, etc. It is used in the traditional system of medicine in many countries like India, Nigeria, Palestine, Chi...
2077
889
IN-VIVO CHARACTERIZATION OF TRANSDERMAL PATCHES OF ALISKIREN HEMIFUMARATE FOR TREATMENT OF HYPERTENSION
The low bioavailability of drugs in the oral drug delivery system is the main concern and the development of a delivery system with a controlled release profile. This research aims in the dose reduction of aliskiren hemifumarate, evaluate the release efficacy of the drug from the patches by using various permeation enhancers. FTIR studies established the drug and polymer compatibility. The transde...
2076
895
IN-VIVO ANTIOXIDANT AND ANTIHYPERLIPIDEMIC ACTIVITY OF SYZYGIUM CERASOIDEUM EXTRACTS IN RATS
Antioxidant and antihyperlipidemic activities of the extracts of Syzygium cerasoideum were investigated by studying their in-vivo effects on triton and cholesterol induced hyperlipidemia. Highest antioxidant activity was exhibited by methanolic extract followed by chloroform extract of S. cerasoideum. In triton induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum an...
2076
870
HEPATOPROTECTIVE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF BOERHAAVIA DIFFUSA LINN. AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN MICE
Boerhaavia diffusa is a natural herb possesses potent diuretic, anticancer and antioxidation properties. This work was designed to investigate the effect of hydro alcoholic extract of Boerhaavia diffusa Linn. on hepatoprotective efficacy in D-galactosamine-intoxication in mice. Albino Mice divided into 5 groups each consisting of 6 animals. Group 1 served as vehicle control, Group 2 served as hepa...
2075
820
THE PROTECTIVE ROLE OF RAPHANUS SATIVUS ROOTS IN REVERSING THE RENAL ALTERATIONS AND OXIDATIVE DAMAGE AGAINST STREPTOZOTOCIN INDUCED DIABETES IN RATS
Oxidative stress and hyperglycemia are two major factors implicated in the development of renal damage. Roots of Raphanus sativus have been reported to possess both ant diabetic and antioxidant activities. So, the present study was aimed to investigate whether aqueous root extract of Raphanus sativus (ARRS) is effective in reversing the renal alterations and oxidative damage against streptozotocin...
2075
842