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IDENTIFICATION OF HUMAN cAMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT INHIBITORS
Cyclic adenosine monophosphate (cAMP) dependent protein kinase plays a major role in cell signaling pathway. Over expression of extracellular cAMP dependent protein kinase catalytic subunit caused tumorgenesis in prostate. This protein may provide a base for the design of clinically applicable therapeutic strategies. In order to develop potential inhibitor of cAMP dependent protein kinase catalyti...
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A NOVEL STABILITY INDICATING UPLC METHOD FOR THE ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN TABLET DOSAGE FORM
UPLC is a modern technique which refers to Ultra Performance Liquid Chromatography and enhances in three main areas: Speed, resolution, and sensitivity. In this present study, an accurate and precise UPLC method was developed and validated for the stability indicating assay method to estimate Tezacaftor and Ivacaftor simultaneously in both bulk and tablet dosage form. This method was developed usi...
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IN-VIVO ANTIOXIDANT AND ANTIHYPERLIPIDEMIC ACTIVITY OF SYZYGIUM CERASOIDEUM EXTRACTS IN RATS
Antioxidant and antihyperlipidemic activities of the extracts of Syzygium cerasoideum were investigated by studying their in-vivo effects on triton and cholesterol induced hyperlipidemia. Highest antioxidant activity was exhibited by methanolic extract followed by chloroform extract of S. cerasoideum. In triton induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum an...
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TEMPLATE SYNTHESIS AND SPECTRAL STUDIES OF BIOLOGICALLY ACTIVE NI(II), AND CU(II) TRANSITION METAL COMPLEXES OF TETRADENTATE AZA-OXO (N2O2) MACROCYCLIC LIGAND
A novel series of transition metal complexes of [M(C19H18N2O2S)X2], where M = Ni(II), Cu(II), X = Cl-, NO3-, ½ SO42- and (C19H18N2O2S) moiety corresponds to the tetradentate aza-oxo macrocyclic species, were synthesized by template condensation reaction of 1,4-bis(2-formylphenoxy)butane and thiourea in the presence of divalent metal salts in 1:1:1 ratio. The metal complexes were characterized and...
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FORMULATION DEVELOPMENT AND EVALUATION OF METOPROLOL SUCCINATE SUSTAINED RELEASE AND HYDROCHLOROTHIAZIDE IMMEDIATE RELEASE BILAYER TABLET
Bilayer tablet concept has been investigated to develop a combination of sustained and immediate release formulations. The present study aims to develop and evaluate to provide a combined therapy through a single tablet in which combinations of Metoprolol succinate and Hydrochlorothiazide were used. The pharmacokinetics advantage of this formulation was, drug release from the fast releasing layer ...
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FORMULATION AND EVALUATION OF POLY-HERBAL ANTI-ACNE FACEWASH
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects the major oil gland-containing areas, such as the face, back, and trunk. It involves increased sebum production and hair follicles abnormally desquamate as a result of rising androgen levels that coincide with puberty. It is generally characterized by, the formation of seborrhea, comedones, inflammatory papules...
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EFFECT OF NOVEL BENZISOXAZOLE DERIVATIVES AGAINST EHRLICH ASCITES CARCINOMA CELLS IN SWISS ALBINO MICE: CYTOTOXIC AND HAEMATALOGICAL STUDIES
The present study is to investigate the cytotoxicity properties and haematological indices of synthesized molecules (S1-S4) in comparison to the standard drug 5 fluorouracil which reflects the anticancer potentials of the above molecules. Cytotoxicity studies were performed by in vitro MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyl teterazolium bromide) assay. Haematological studies were done b...
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INHIBITION KINETICS OF E. COLI BY METHANOLIC ROOT EXTRACT OF ALSTONIA SCHOLARIS
The potential of methanol extract as a potent antimicrobial agent has been observed to be an effective means to combat disease causing pathogenic organisms. Growth pattern of Escherichia coli cells showed that the growth of cells decreased with an increase in concentration of extract. The specific relationship between the specific growth rate and the substrate concentration was thus be obtained by...
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EXTRACTIVE SPECTROPHOTOMETRY METHOD FOR ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL FORMULATIONS USING BROMOTHYMOL BLUE
An accurate and precise method was developed for Rosiglitazone Maleate in the visible range of electromagnetic spectrum sing Bromothymol Blue (BTB) in alkaline medium resulting in a blue chromogen showing its absorption maxima at 615 nm. Sandell’s sensitivity to the proposed method was found to be 1.5 × 10-4 µg/ml. The extracted complexes obey Beer–Lambert’s law in the concentration range ...
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SYNTHESIS, CHARACTERISATION AND PHARMACOLOGICAL EVALUATION OF NOVEL COUMARIN DERIVATIVES
In the present study a new series of coumarin derivatives have been synthesized by condensation of ethyl acetoacetate and resorcinol. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR and Mass spectral analysis. These compounds were screened for their Analgesic and Anti-inflammatory activities. Among the synthesized compounds II (a-1 to c-3)....
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