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RENAL FUNCTION OUTCOMES IN PATIENTS RECEIVING TDF – CONTAINING ANTIRETROVIRAL THERAPY: A RETROSPECTIVE PILOT STUDY IN NAMIBIA
Introduction and Aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implica...
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IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS -1
The development of a highly effective AIDS vaccine will depend on the success of designing immunogens that will elicit immune response against broadly neutralizing antibodies to naturally circulating strains of HIV- can be done by reverse vaccinology. Reverse vaccinology is a good approach for provoking the broadly neutralizing antibody response by identifying the specific epitopes i.e. surface pr...
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IS EMERGENCY CONTRACEPTIVE ACCESSIBILITY A BARRIER IN DEVELOPING COUNTRIES? A REVIEW
Significant portion of maternal death in developing countries was attributed to induced abortions secondary to unwanted pregnancies. Using emergency contraception as a backup method can contribute to reduce unwanted pregnancy secondary to method failure, contraception non-use and also rape. The need for emergency contraception is clearly demonstrated by the occurrence of unwanted pregnancy and i...
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EVALUATION OF ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF DILLENIA INDICA L. USING IN-VIVO APPROACHES
Dillenia indica (DI) is a traditionally used medicinal plant which is reported to exhibit wide range of pharmacological activities. However, no vast scientific study has been conducted in this regard. The present study was designed to investigate the antihyperglycemic, antihyperlipidemic and antioxidative activities of the Dillenia indica fruits. Aqueous and methanolic extracts of the fruits were ...
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INFLUENCE OF RIPENING ON ANTIOXIDANT ACTIVITY OF CELL WALL POLYSACCHARIDES IN PRUNUS ARMANIACA LINN.
Cell wall polysaccharides have been of great importance to society and mankind over the years. In the present study Cell wall polysaccharides were extracted from different stages viz- Immature green, mature green and ripe stages of Prunus armaniaca Linn. A decrease in the yield of pectin was observed during ripening.The pectin Extracted from various stages of fruit ripening was further analysed fo...
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MORPHOLOGICAL CHANGES IN HUMAN RBCs DUE TO EXPOSURE TO SELECTED MEDICINAL PLANT LEAF EXTRACTS IN-VITRO
The aim of this experiment was to find out the in-vitro effects of the extracts of certain plants, considered to have medicinal value, on the erythrocyte model. The plants, selected for the study, were Tulsi (Ocimum tenuiflorum), Neem (Azadirachta indica) and Amla (Phyllanthus emblica).Three different concentrations of leaf extracts were prepared using tris-HCl, namely 0.3 mg/ml, 0.15 mg/ml and 0....
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TECHNOLOGICAL DEVELOPMENT IN COMPARISON WITH IDEAL FORMULATION OF BCS CLASS IV DRUG – RIFAXIMIN
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of do...
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IN VITRO ANTIBACTERIAL ACTIVITY STUDIES OF TUBER AND SEED EXTRACTS OF GLORIOSA SUPERBA LINN. AGAINST SOME SELECTED HUMAN PATHOGEN
The present study deals with the antibacterial activity of Acetone, Dichloromethane, methanol extracts of the tuber and seed of Gloriosa superba L. (Liliaceae) using disc diffusion method against human pathogens, such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeurognisoa, Staphylocuccus aureus. In the present investigation all the extracts were found to be effectiv...
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SYNTHESIS, CHARACTERIZATION AND NUCLEASE ACTIVITY OF AU (III) – COMPLEXES OF BIACETYL MONOXIME THIOSEMICARBAZONE (BAMOT) AND SUBSTITUTED THIOSEMICARBAZONES
Metal complexes of Au(III) with Thiosemicarbazone and Substituted Thiosemicarbazones different thiosemicarbazones have been synthesized. The present communication reports the structural study of the Au(III) complexes with Biacetyl Monoxime Thiosemicarbazones and these complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physicochemical and spe...
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RP-HPLC METHOD QUANTITATIVE ESTIMATION OF TAPENTADOL HYDROCHLORIDE AND ITS TABLETS
The objective was to develop and validate an easy, economical, fast, reliable, reproducible, precise and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of tapentadol hydrochloride (TAP, a mu opioid-receptor agonist, and noradrenaline reuptake inhibitor) in the bulk and pharmaceutical dosage form. The chromatographic separation was achieved by u...
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