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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CLASS-2 RESIDUAL SOLVENTS IN LULICONAZOLE BY HS-GC
A simple headspace gas chromatographic (HS-GC) method has been developed and validated for the simultaneous determination of residual solvents like methanol, methyl isobutyl ketone, cyclohexane and toluene in luliconazole by Flame ionization detector (FID). The separation was achieved on 30 m long DB-624 column, 0.53 mm in inner diameter, and 3.0 µm in film thickness. The headspace and chromatogr...
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SELF-EMULSIFYING SYSTEMS: A REVIEW
Effective delivery of drugs can be made through various routes of administration, and the oral route is considered to be the most convenient for the administration of drugs to patients. Poor aqueous solubility was acknowledged as the main reason for the poor oral absorption of chemical entities. Apart from the conventional solubilization approaches like co-solvency, salt formation, solid dispersio...
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IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS -1
The development of a highly effective AIDS vaccine will depend on the success of designing immunogens that will elicit immune response against broadly neutralizing antibodies to naturally circulating strains of HIV- can be done by reverse vaccinology. Reverse vaccinology is a good approach for provoking the broadly neutralizing antibody response by identifying the specific epitopes i.e. surface pr...
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IS EMERGENCY CONTRACEPTIVE ACCESSIBILITY A BARRIER IN DEVELOPING COUNTRIES? A REVIEW
Significant portion of maternal death in developing countries was attributed to induced abortions secondary to unwanted pregnancies. Using emergency contraception as a backup method can contribute to reduce unwanted pregnancy secondary to method failure, contraception non-use and also rape. The need for emergency contraception is clearly demonstrated by the occurrence of unwanted pregnancy and i...
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IN VITRO ANTIBACTERIAL ACTIVITY STUDIES OF TUBER AND SEED EXTRACTS OF GLORIOSA SUPERBA LINN. AGAINST SOME SELECTED HUMAN PATHOGEN
The present study deals with the antibacterial activity of Acetone, Dichloromethane, methanol extracts of the tuber and seed of Gloriosa superba L. (Liliaceae) using disc diffusion method against human pathogens, such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeurognisoa, Staphylocuccus aureus. In the present investigation all the extracts were found to be effectiv...
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SYNTHESIS, CHARACTERIZATION AND NUCLEASE ACTIVITY OF AU (III) – COMPLEXES OF BIACETYL MONOXIME THIOSEMICARBAZONE (BAMOT) AND SUBSTITUTED THIOSEMICARBAZONES
Metal complexes of Au(III) with Thiosemicarbazone and Substituted Thiosemicarbazones different thiosemicarbazones have been synthesized. The present communication reports the structural study of the Au(III) complexes with Biacetyl Monoxime Thiosemicarbazones and these complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physicochemical and spe...
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MORPHOLOGICAL CHANGES IN HUMAN RBCs DUE TO EXPOSURE TO SELECTED MEDICINAL PLANT LEAF EXTRACTS IN-VITRO
The aim of this experiment was to find out the in-vitro effects of the extracts of certain plants, considered to have medicinal value, on the erythrocyte model. The plants, selected for the study, were Tulsi (Ocimum tenuiflorum), Neem (Azadirachta indica) and Amla (Phyllanthus emblica).Three different concentrations of leaf extracts were prepared using tris-HCl, namely 0.3 mg/ml, 0.15 mg/ml and 0....
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INFLUENCE OF RIPENING ON ANTIOXIDANT ACTIVITY OF CELL WALL POLYSACCHARIDES IN PRUNUS ARMANIACA LINN.
Cell wall polysaccharides have been of great importance to society and mankind over the years. In the present study Cell wall polysaccharides were extracted from different stages viz- Immature green, mature green and ripe stages of Prunus armaniaca Linn. A decrease in the yield of pectin was observed during ripening.The pectin Extracted from various stages of fruit ripening was further analysed fo...
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TECHNOLOGICAL DEVELOPMENT IN COMPARISON WITH IDEAL FORMULATION OF BCS CLASS IV DRUG – RIFAXIMIN
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of do...
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AN OBSERVATIONAL STUDY ON ENDEMIC DISEASES IN MULTISPECIALITY HEALTH CARE SYSTEM
Background: A cross sectional study, to determine the endemicity, by systematic investigations in institutional settings to assess the prevalence of diseases. Methods: The study was conducted by observational method over a period of seven months regarding the prevalence of particular disease and disease with co-morbidities. Among the several diseases of distinct clinical spectrum, various risk f...
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