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FORMULATION AND EVALUATION OF HEPARIN MICRONEEDLE TRANSDERMAL PATCH
There is an urgent need to replace the injection currently used for low molecular weight heparin (LMWH) multi-dose therapy with a non-invasive delivery device. In this study, unsaturated polyester resin and peroxide were used to fabricate microneedle mould by using 3M microneedle. Dissolving microneedle arrays transdermal patch was prepared by using 20 % w/v polymers of PVA and PVP (polyvinyl alco...
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EVALUATION OF ANTIOXIDANT ACTIVITY AND QUANTIFICATION OF α–ASARONE IN RHIZOMES OF ACORUS CALAMUS L. USING HPTLC FINGERPRINTING
This study aimed to analyze antioxidant activity and quantify alpha-asarone by using High-performance thin-layer chromatography (HPTLC). Alpha-asarone is a secondary metabolite in hydroalcoholic (1:1) rhizome extracts of Acorus calamus L. (AC), a medicinal plant being used around the globe traditionally. Sweet flag, AC is a member of the Acoraceae family, and is commonly used unaided as well as in...
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GAINING INSIGHT INTO PATIENTS MEDICATIONS AND THEIR SELF-REPORTED EXPERIENCE OF ADVERSE DRUG REACTIONS: A CROSS SECTIONAL STUDY IN THE EMERGENCY DEPARTMENT
Aim: To gain an insight into patients medications and their experience of self-reported adverse drug reactions. Methods: A cross sectional study was conducted in the Emergency Department of a teaching hospital in the Midlands, United Kingdom from February to March, 2012.The study included patients aged 16 or over and currently on treatment with one or more medications. All patients were questioned...
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DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF SEROTONIN HYDROCHLORIDE
The aim of the present work is to develop the formulation the orodispersible tablets of Serotonin hydrochloride. The tablets were prepared by direct compression technique using microcrystalline cellulose (MCC) as directly compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG) and Crospovidone were used. Method: Using different concentrations o...
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SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND ANTIOXIDANT STUDIES OF MIXED LIGAND SCHIFF BASE COMPLEXES DERIVED FROM P- NITROANILINE AND 2, 4-DINITROANILINE
Four isatin mixed ligand complexes of the type ML1L2, where M =Co(II), Ni(II), Cu(II) and Zn(II) (LI = Schiff base formed by the condensation of isatin and p-nitroaniline and L2= Schiff base formed by the condensation of isatin and 2,4-dinitroaniline) are synthesized. Mixed ligand complexes are different from routine metal complexes that they have a minimum of two special kinds of ligands linked...
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GREEN NANOTECHNOLOGY AND NANOPARTICLES: AN ECO-FRIENDLY APPROACH
The field of nanotechnology is one of the notable active analysis areas in modern material science. Recent advances in Nanoscience and nanotechnology have led to the development of nanoparticles, which ultimately decrease potential health and environment hazards. Interest in developing environmentally friendly procedures for the synthesis of metallic nanoparticles has been increased. The purpose...
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RENAL FUNCTION OUTCOMES IN PATIENTS RECEIVING TDF – CONTAINING ANTIRETROVIRAL THERAPY: A RETROSPECTIVE PILOT STUDY IN NAMIBIA
Introduction and Aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implica...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CEFPODOXIME PROXETIL
A new simple and rapid reverse-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous estimation of cefpodoxime proxetil in bulk drugs and pharmaceutical dosage form. The separation was accomplished on a sunfire C-18 (250 × 4.6 mm, 5 μm) column with a mobile phase consisting of Methanol; Water (70:30 v/v) at a flow rate of 0.8 mL/min. The...
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TOXICITY STUDIES OF BOUGAINVILLEA GLABRA AND MUCUNA PRURIENS
The present study was aimed to evaluate the acute toxicity study and subchronic toxicity study with methanol extracts of Bougainvillea glabra and Mucuna pruriens on Wistar albino rats. The acute dose was administered at 2000 mg/kg body weight on 1st day and observed for 14 days, while chronic dose was given at 250, 500, and 1000 mg/kg b.w. for 90 days. In subchronic toxicity study, hematological (...
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RP-HPLC METHOD QUANTITATIVE ESTIMATION OF TAPENTADOL HYDROCHLORIDE AND ITS TABLETS
The objective was to develop and validate an easy, economical, fast, reliable, reproducible, precise and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of tapentadol hydrochloride (TAP, a mu opioid-receptor agonist, and noradrenaline reuptake inhibitor) in the bulk and pharmaceutical dosage form. The chromatographic separation was achieved by u...
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