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OUTCOMES OF COMMUNITY PHARMACIST’ CARDIOVASCULAR RISK INTERVENTION AMONG HIGH RISK RURAL DWELLERS
Community pharmacists are well placed to contribute to reduction of premature deaths from cardiovascular disease by implementing risk assessment and reduction strategies. The objective of this study was to assess outcomes of pharmacist's cardiovascular risk reduction intervention among high risk persons dwelling in a rural community. Cardiovascular risk reduction intervention was carried out among...
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IN-VITRO ANTIOXIDANT POTENTIAL OF SELECTED NUTRACEUTICALS
The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...
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DESIGN, SYNTHESIS, AND EVALUATION OF 1,4-NAPHTHOQUINONE DERIVATIVES AS POTENTIAL EPITHELIAL GROWTH FACTOR RECEPTOR INHIBITORS
In this manuscript, we designed and synthesized 1,4-naphthoquinone derivatives. These derivatives were characterized using the different analytical techniques such as 1H NMR, 13C NMR, FTIR, Mass spectroscopy, melting point, and elemental analysis. The synthesized compounds (MB (1-10)) further subjected to assess the anticancer activity using different cancer cell lines such as MCF-7, HeLa, and Hep...
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FORMULATION AND EVALUATION OF PROPRANOLOL HYDROCHLORIDE ORAL DISINTEGRATING TABLETS
Background and purpose of the study: Propranolol hydro-chloride beta-adrenergic receptor antagonist utilized in the treatment of high blood pressure, atrial fibrillation, myocardial infarction, angina and migraine headaches. The pharmacokinetic parameters make Propranolol hydrochloride an appropriate candidate for oral disintegrating tablets. This work aims to develop orally disintegrating tablets...
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MACORVIS – A NEW OPPORTUNITY FOR ADDITION TO THE TREATMENT OF CARDIOVASCULAR DISEASES
Standartizated plants extracts are new opportunity in addition with standard therapy. Hawthorn extract, Tribulus terrestris extract and magnesium gluconate are forming well balanced nutritional supplement that could benefits people with cardiovascular diseases and diabetes. All three substances are well known in the common herbal medicine in our country and abroad. Their mechanisms’ of actions i...
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TRITERPENE ACIDS FROM n-HEHANE EXTRACT 0F ALBIZZIA LEBBECK BENTH.
Two triterpine acids like 2α, 19α- dihydroxy – 3-oxo-12- ursen- 28-oic acid (1), 2α, 16α, 19α- trihydroxy – 3-oxo-12- ursen- 28-oic acid (2) were isolated from the n-hexane soluble fractions of a methanol extract of the root of Albizzia lebbeck Benth. The structures of the isolated compounds were elucidated as by extensive spectroscopic studies, including high field NMR analyses. This i...
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COMPARISON OF 3%, 5% AND 8% CONCENTRATIONS OF SEVOFLURANE FOR INDUCTION AND INTUBATION IN ADULTS WITHOUT USING NEUROMUSCULAR BLOCKING AGENTS
Introduction: Tracheal intubation is commonly facilitated by the use of muscle relaxants. Sevoflurane fulfills the criteria for successful rapid & smooth inhalational induction when muscle relaxants are contra-indicated. Aim: To compare the success rate of intubation characteristics, hemodynamic changes, the effectiveness of the trapezius squeezing test for an adequate condition for intubation...
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TOXICITY STUDIES OF BOUGAINVILLEA GLABRA AND MUCUNA PRURIENS
The present study was aimed to evaluate the acute toxicity study and subchronic toxicity study with methanol extracts of Bougainvillea glabra and Mucuna pruriens on Wistar albino rats. The acute dose was administered at 2000 mg/kg body weight on 1st day and observed for 14 days, while chronic dose was given at 250, 500, and 1000 mg/kg b.w. for 90 days. In subchronic toxicity study, hematological (...
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GOLD NANOPARTICLES: PROMISING AND POTENTIAL NANOMATERIAL
Gold nanoparticles (AuNPs) have appeared as an attractive candidate for delivery of various drug molecules or considered as extraordinary molecular carriers for the targeting, intracellular trafficking and delivery of a huge array of biomolecules including DNA, RNA, proteins, peptides, drugs, genes and other molecules of therapeutic significance. Particularly gold nanoparticles have attracted inte...
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PAEDIATRICIANS COGNIZANCE ABOUT THE DELETERIOUS EFFECT OF ANTIBIOTICS AND DENTAL CARIES – A PRELIMINARY STUDY
Aim: To evaluate pediatricians’ cognizance about the use of antibiotics and dental caries. Materials and Method: 200 Pediatricians’ who were willing to participate were selected randomly from public and private medical hospitals in South India. A pretested questionnaire was distributed to the Paediatricians’ and was personally contacted to receive the responses within a week’s time. Descri...
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