Most Popular
PRELIMINARY PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS FOR IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM ABUTILON FRUTICOSUM GUILL AND PERR. A RARE AND ENDEMIC PLANT OF INDIAN THAR DESERT
Present work was aimed to determine, identify, and characterize the bioactive chemical compounds from methanolic leaves extract of Abutilon fruticosum by GC-MS analysis. Fresh disease-free leaves were collected shade dried and powdered for extraction with HPLC grade methanol. Preliminary phytochemical screening of methanolic leaves extract was performed using standard methods to determine the pres...
2060
1595
A STUDY ON CLINICAL PROFILE OF METABOLIC SYNDROME AND ITS IMPACT ON MYOCARDIAL INFARCTION AT A TERTIARY CARE HOSPITAL IN KERALA
Background: Metabolic syndrome has a significant impact on the severity and prognosis of various risk factors that may contribute to cardiovascular events. We examined the clinical profile and prevalence of MetS among MI patients along with the estimation of associated risk factors and determined the components of the MetS which conferred the paramount cardiovascular risk. Methods: A prospective o...
2059
799
FORMULATION AND EVALUATION OF SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR DRUG MIRTAZAPINE
Objective: In the present dissertation work, the aim was to prepare self-emulsifying drug delivery systems (SEDDS) of mirtazapine to improve its solubility with a view to enhance its oral bioavailability. Methods: The prepared SEDDS was the concentrate of the drug, oil-Capmule MCM EP, surfactant tween 80 and PEG 400 as a co-surfactant. The optimized microemulsion was converted into solid form by a...
2058
979
GC-MS ANALYSIS AND IDENTIFICATION OF PHYTOCONSTITUENTS FROM HEXANE EXTRACTS OF ADHATODA VASICA NEES AND ADHATODA BEDDOMEI CB CLARKE LEAVES
The medicinal plants, Adhatoda vasica, and Adhatoda beddomei are commonly used in the treatment of several illnesses and respiratory disorders viz., cold, severe cough, chronic bronchitis, asthma and tuberculosis. The present study aimed to identify the phytochemical constituents and quantification of bioactive contents of hexane extracts of these plants, followed by metabolic fingerprinting, whic...
2056
995
A PROSPECTIVE STUDY TO COMPARE HYPO-FRACTIONATED RADIOTHERAPY VERSUS CONVENTIONAL RADIOTHERAPY IN CARCINOMA BREAST
Background: The standard management of operable LABC is by initial modified radical mastectomy. Because of the high risk of metastasis, systemic therapy is involved as an additional integral part of treatment. The postmastectomy radiation is given to reduce the high risk (20-40%) of loco-regional relapse following adjuvant systemic therapy. The loco-regional control ranges from 85% to 90% for 10 y...
2055
773
FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESION AND FLOATING MICROSPHERES OF ETODOLAC USING IONIC GELATION METHOD
The purpose of this study is to formulation and evaluation of floating and mucoadhesion microspheres of etodolac using ionic gelation method. The floating and mucoadhesion microspheres were studied for micromeritic properties were found to be within limits. The percentage yield of floating microsphere formulation F1 to F6 and mucoadhesive microspheres M1 to M3 were in the range of 77.14 ± 0.64 to...
2055
951
SYNTHESIS AND IN-VITRO EVALUATION OF PEPTIDE LINKED PRODRUGS OF SELECTED CEPHALOSPORIN
Cephalosporins are drug of choice for many infectious microorganisms even against many antibiotic resistant cases. Ceftriaxone, a third generation cephalosporin is effective in many infections including fluoro-quinolone resistant strains of Salmonella typhi, the causative pathogen for enteric fever (typhoid). The antibiotic is supposed to act in the intestinal cells but gastric instability limits ...
2053
1080
HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF RIFABUTIN IN BULK AND CAPSULE DOSAGE FORM
A selective, accurate, HPLC method was developed by this study for the determination of rifabutin in bulk and capsule dosage form. This method was developed by SHIMADZU LC-2010 HT using C18 column in solvents methanol: acetonitrile: ammonium acetate buffer (50: 45: 05) as mobile phase. At 1.0 ml/min flow rate the mobile phase was pumped, and the sample was detected at 278 nm. For standard rifabuti...
2053
749
ANTIMICROBIAL SUSCEPTIBILITY TEST ANALYSIS OF AEGLE MARMELOS BARK EXTRACTS
India is a land of medicinal flora, there are large numbers of plants with miraculous medicinal values has been used traditionally to cure several diseases from decades in Ayurveda. So the present study was designated to evaluate the antimicrobial activities of Aegle marmelos (bale) bark extracts. In this study different bark extracts were prepared using various solvents, further these extracts we...
2052
781
BIOTHERAPEUTICS AS DRUGS, ITS DELIVERY ROUTES AND IMPORTANCE OF NOVEL CARRIERS IN BIOTHERAPEUTICS
Biopharmaceuticals or biologics are the therapeutic agents which are biomolecules (DNA, Protein, Peptide, RNA, antibodies) in nature. These are high molecular weight (300-1000000Da) molecules, which deify Lipinski rules. At present, a large portion of the market share is occupied by protein biotherapeutics. However, peptide-based therapeutics is replacing protein biotherapeutics, as the former has...
2051
1245