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SPECTROPHOTOMETRIC DETERMINATION OF Co(II) AS A COMPLEX WITH 1, 2 – PROPANEDIONE, 1- PHENYL – 1 – ( 2 – HYDROXYL – 5 – BROMO – BENZILIDINEAZINE)-2-OXIME [PDPHBBAO]
The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as Mass spectrometry. This reagent was then applied for the development of the analytical method for the extractive spectrophotometric determination of Cobalt (II). Cobalt metal forms yellow coloured complex, which can be extracted in chloroform at pH 9.0 having absorption maxima at 430 nm. Be...
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FORMULATION AND CHARACTERIZATION OF ECONAZOLE NITRATE LOADED TRANSFERSOMAL GEL FOR ANTIFUNGAL ACTIVITY
The aim of the present work is to formulate and characterize Econazole nitrate (EN) loaded transfersomal gel for antifungal activity. EN is a broad-spectrum imidazole antifungal agent that belongs to BCS Class II. Due to poor solubility, EN is incompletely absorbed after oral administration and bioavailability vary among individuals. Topical treatment of fungal infections is usually preferred, but...
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2001
FORMULATION AND EVALUATION OF CETUXIMAB LOADED POLYMERIC NANOPARTICLES
Nanoparticles speak to one of the appealing choices in the compelling treatment of tumor chemo-treatment. In the present work, definition, and improvement of a novel Cetuximab (MTX)- stacked biodegradable nanoparticles utilizing poly(D, L-lactide-co-glycolide) (PLGA) was done. Nanoparticles stacked with anticancer operators can effectively build sedate focus in malignancy tissues and furthermore a...
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AQUEOUS EXTRACTS OF VERNONIA AMYGDALINA AND OCIMUM GRATISSIMUM PROTECT AGAINST ELECTROLYTE DERANGEMENT IN SALT-LOADED RATS
The study aimed at checking the effects of aqueous extracts of Vernonia amygdalina and Ocimum gratissimum on the electrolyte level of salt-loaded rats. 25 male rats weighing 160-220g were shared into 5 groups of 5 rats. Group 1 animals that were fed standard feed and water served as the control. Animals in group 2-5 which were salt-loaded orally with 2 ml of 4% sodium chloride solution for 2 weeks...
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PREVENTIVE EFFECTS OF CARISSA CARANDAS FRUIT EXTRACT AGAINST DMBA INDUCED SKIN CARCINOGENESIS STUDIES IN SKIN OF SWISS ALBINO MICE: MORPHOLOGICAL AND HISTOPATHOLOGICAL STUDY
Antitumor and antioxidative efficacy of Carissa carandas extract (CCE) was investigated in this study against skin carcinogenesis which was initiated by a single topical application of 7, 12-dimethyl-benz(a)anthracene (100 mg / 100 ml acetone in 1% acetone) and two weeks, later promoted by repeated treatment of TPA (Croton oil) for 16 weeks (in 1% acetone) in Swiss albino mice. Oral administration...
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BEHAVIORAL STUDIES OF DASATINIB AND RESVERATROL IN ROTENONE INDUCED PARKINSON’S RAT MODEL
Neurodegeneration accounts for diseases like Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, etc. that come under neurodegenerative diseases. Parkinson’s disease is the second most common neurodegenerative disease. The main hallmarks of Parkinson’s disease are progressive loss of motor control and cognitive dysfunction. Current treatments are of reducing the symptoms, do ...
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ASSESSMENT OF FOOD, ETHNOBOTANICAL AND ANTIBACTERIAL ACTIVITY OF TRICHOSANTHES CUCUMIRINA L.
Trichosanthes cucumirina L., locally known as “Chachindra” among the tribal and rural mass of Similipal Biosphere Reserve (SBR) forest. Plant parts are used as ethnomedicine among inhabitants of SBR. They use the fruits, leaves and roots against various diseases and traditional practices are continuing since long. Leaves are used against microbial infections, roots against diabetic and fruits ...
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RAS GTPase AS THE DRUG TARGET FOR ANTI-CANCER DESIGNING OF DRUG FROM TEMPLATE
Ras proteins in association with GTP and GDP act as a bio-molecular switch for signaling cell growth, cell survival and signal transduction. The presence of mutated Ras proteins is found to vary in different cancer types and the highest occurrence of about 90% is observed in pancreatic cancer. The Ras GTPase binding site is mainly involved in signal cell proliferation. Hence, this binding site h...
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GAINING INSIGHT INTO PATIENTS MEDICATIONS AND THEIR SELF-REPORTED EXPERIENCE OF ADVERSE DRUG REACTIONS: A CROSS SECTIONAL STUDY IN THE EMERGENCY DEPARTMENT
Aim: To gain an insight into patients medications and their experience of self-reported adverse drug reactions. Methods: A cross sectional study was conducted in the Emergency Department of a teaching hospital in the Midlands, United Kingdom from February to March, 2012.The study included patients aged 16 or over and currently on treatment with one or more medications. All patients were questioned...
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DYSLIPIDEMIC AND PROTECTIVE EFFECTS OF ASPIRIN AND CLOPIDOGREL IN OBESE RATS
Introduction: Antiplatelets play a crucial role in improving many metabolic disorders and complications, including dyslipidemia, atherosclerosis, diabetes mellitus and cardiovascular diseases. The most common and effective antiplatelets used widely are aspirin and clopidogrel. The aim of this study is to evaluate the dyslipidemic and protective effects of aspirin and clopidogrel in obese rats. Mat...
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