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ESTIMATION OF SOME HEAVY METALS BIOACCUMULATION IN TISSUES OF THE INTESTINAL CESTODA POSTGANGESIA ARMATA AND ITS DEFINITIVE HOST; THE EUROPEAN CATFISH SILURUS GLANIS (L.) FROM TIGRIS RIVER PASSING THROUGH NORTHERN N. GOVERNORATE, IRAQ
Objective: The purpose of the study is to pursue some heavy metals in the aqueous environment of Tigris river that passes through Mosul city prior to the bioaccumulation of such metals in catfish Silurus glanis and its intestinal tapeworm Postgangesia armata. Methods: Silurus glanis, a freshwater fish were hunted from Tigris river passing through Al-Rashidiya region/Nineveh Governorate, North Iraq...
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ANTIBACTERIAL, ANTIOXIDANT, CYTOTOXICITY AND QUALITATIVE PHYTO-CHEMICAL EVALUATION OF SEED EXTRACTS OF NIGELLA SATIVA AND ITS SILVER NANOPARTICLES
Nigella sativa is considered a miracle herb plant belongs to the Ranunculaceae family, inhabitant to South Asia and South-west Asia. The most important part of the Nigella sativa plant used by human beings are seeds, mostly as a spice because it contains a specific aroma. The seeds derived from Nigella sativa being exploited by people and used for thousands of years for culinary purposes, to cure ...
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ANTIFUNGAL ACTIVITY OF AMPHOTERICIN-B ETHOSOMAL GEL AGAINST CANDIDA ALBICANS: A COMPARATIVE STUDY
Amphotericin B is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. Work aimed to formulate the amphotericin B (AmB) ethosomal gel (EF), evaluate its antifungal activity against fungal isolates of human origin and compare its antifungal activity with marketed liposomal gel (MLG). AmB ethosomal gel (EF) was formulated and characterized for thei...
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DRUG UTILIZATION STUDY OF ANTIHYPERTENSIVE TREATMENT BEING PRESCRIBED IN PATIENTS COMING TO MEDICINE OPD OF A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 ...
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SYNTHESIS AND EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY OF NOVEL THIAZOLIDINONE DERIVATIVES
A series of, 2-thioxo-4-thiazolidinone (rhodanine) and 2,4-thiazolidine-dinone derivatives were synthesized by reacting 4-thiazolidine-dione/rhodanine moieties with 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide, in equimolar proportions. The authentication of synthesized compounds was done by FTIR, 1HNMR, and mass spectrophotometry. The derivatives, N-(phenyl) -2- {4-[ (4-oxo-2-thioxo-1, 3-th...
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FORMULATION DEVELOPMENT AND EVALUATION OF METOPROLOL SUCCINATE SUSTAINED RELEASE AND HYDROCHLOROTHIAZIDE IMMEDIATE RELEASE BILAYER TABLET
Bilayer tablet concept has been investigated to develop a combination of sustained and immediate release formulations. The present study aims to develop and evaluate to provide a combined therapy through a single tablet in which combinations of Metoprolol succinate and Hydrochlorothiazide were used. The pharmacokinetics advantage of this formulation was, drug release from the fast releasing layer ...
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EFFECT OF ASPARAGUS CURILLUS ON LEVELS OF MATRIX METALLO PROTEINASES IN GCF AND SALIVA OF PERIODONTAL PATIENTS
This study was planned to evaluate the anti-inflammatory effect of roots of Asparagus curillus in periodontal inflammation via assessing gingival crevicular fluid (GCF) and salivary inflammatory markers namely MMP-8, -9, 13, TIMP-1 and IL-6. Samples of GCF and saliva were obtained from patients with chronic periodontitis (n = 98) and healthy controls (n = 27). Study population (n = 98) was divided...
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DEVELOPMENT CHARACTERIZATION OPTIMIZATION OF ETHOSOME CONTAINING DULOXETINE FOR TRANSDERMAL DELIVERY
The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 32 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1)....
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GREEN SYNTHESIS OF SILVER NANOPARTICLE BY USING TINOSPORA CORDIFOLIA LEAF EXTRACT AND ITS ANTIMICROBIAL PROPERTY
Tinospora cordifolia is one of the best medicinal plants holds most prominent place in Ayurveda Rasayana herbs and it also known as “rejuvenate herbs” because of its medicinal properties. It has been found to exhibit anti-microbial properties, its anti-microbial feature found in root, stem, and leaf extracts on pathogenic micro-organisms. Green synthesis of AgNPs can potentially eliminate chem...
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NANOCOCHLEATE: A NOVEL APPROACH FOR DELIVERY OF BIOLOGICAL MOLECULES
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs...
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