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THE ACTIVITY OF EURYCOMANONE DERIVATIVES ON CANCER CELL LINES
Eurycomanone from the roots of Eurycoma longifolia Jack (ELJ) has been reported to exhibit anticancer activity. Four of ester eurycomanone derivatives: eurycomanone dibutyrate, eurycomanone monovalerate, eurycomanone dimethoxybenzene, and eurycomanone disuccinate were synthesized for knowing their activities on cancer cell lines T47D, MCF-7, Hela, WIDR and Vero cells. The cancer activity was evalu...
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PERFORMANCE IMPLICATIONS OF CLINICAL PHARMACIST INFORMATION ON GESTATIONAL DIABETES MELLITUS AT A TEACHING HOSPITAL IN SOUTHERN INDIA
Context: Gestational diabetes mellitus (GDM) early diagnosis of disease can reduce the morbidity and mortality by prevention of maternal and fetal complications. Aims: To assess the impact of clinical pharmacist knowledge on GDM mothers. Setting Tertiary care teaching hospital of North Karnataka, India. Methods and Materials: A randomized controlled cross-sectional study was carried out for a peri...
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QUANTITATIVE EVALUATION OF SOLUBILITY AND SURFACE MICRO-HARDNESS OF ENAMEL ON EXPOSURE TO VARIOUS SOFT DRINKS – AN EX-VIVO STUDY
Objective: To evaluate and compare pH and titrable acidity (TA) of various commonly consumed commercially available soft drinks. To evaluate and compare the weight of enamel dissolution and surface micro-hardness of the tooth after exposure to commonly consumed commercially available soft drinks. Methods: 60 human enamel specimens were randomly divided into 5 groups: Group 1: Kinley water (control...
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COMPARE THE EFFICACY AND SAFETY OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS WITH OTHER ORAL HYPOGLYCEMIC AGENTS IN TYPE 2 DIABETES MELLITUS PATIENTS
Background: The incidence of Diabetes Mellitus has increased dramatically in recent decades. Di Peptidyl Peptidase 4 inhibitors (DPP-4) have their role in glycemic control. An impaired ‘incretin effect’, occurs in patients with type 2 Diabetes Mellitus in response to glucose intake. Objectives: The main objective of the study is to compare therapeutic outcomes and adverse drug reactions among ...
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FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE FILMS OF ZOLMITRIPTAN
Formulation development for new drugs, an extension of formulations, finding an alternative to conventional dosage forms for better therapeutic response are some of the research impetus in Pharmaceutical F and D. The new -untried routes of administration are also an avenue that can be explored. Under this research zolmitriptan, an antimigraine, BCS class II drug is formulated into mucoadhesive fil...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM, LEVOCETIRIZINE DIHYDROCHLORIDE AND ACEBROPHYLLINE IN FIXED-DOSE COMBINATION TABLETS
A fixed-dose combination of montelukast sodium, levocetirizine dihydrochloride, and acebrophyl line is used in the treatment of asthma, COPD, allergic rhinitis and other conditions where patients feel difficulty in breathing. The present study was designed to develop and validate a simple, sensitive, precise and accurate isocratic reverse-phase high-performance liquid chromatography (HPLC) method ...
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ANTIBACTERIAL, ANTIOXIDANT, CYTOTOXICITY AND QUALITATIVE PHYTO-CHEMICAL EVALUATION OF SEED EXTRACTS OF NIGELLA SATIVA AND ITS SILVER NANOPARTICLES
Nigella sativa is considered a miracle herb plant belongs to the Ranunculaceae family, inhabitant to South Asia and South-west Asia. The most important part of the Nigella sativa plant used by human beings are seeds, mostly as a spice because it contains a specific aroma. The seeds derived from Nigella sativa being exploited by people and used for thousands of years for culinary purposes, to cure ...
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THE NOVEL CORONA VIRUS (nCoV2) SEEMS TO DEFY ALL LAWS OF VIROLOGY
Amongst the known coronaviruses, many were responsible for causing disease in humans knowingly from the common cold to acute severe respiratory syndrome. The novel coronavirus, nCoV-2 has been implied to cause increasingly severe damage to public health besides demolishing the global economy with a staggering figure of continuous rise in mortality within the afflicted cases in almost every country...
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SYNTHESIS AND EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY OF NOVEL THIAZOLIDINONE DERIVATIVES
A series of, 2-thioxo-4-thiazolidinone (rhodanine) and 2,4-thiazolidine-dinone derivatives were synthesized by reacting 4-thiazolidine-dione/rhodanine moieties with 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide, in equimolar proportions. The authentication of synthesized compounds was done by FTIR, 1HNMR, and mass spectrophotometry. The derivatives, N-(phenyl) -2- {4-[ (4-oxo-2-thioxo-1, 3-th...
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DRUG UTILIZATION STUDY OF ANTIHYPERTENSIVE TREATMENT BEING PRESCRIBED IN PATIENTS COMING TO MEDICINE OPD OF A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 ...
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