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MANAGEMENT AGAINST COVID-19 THROUGH NUTRITIONAL SUPPLEMENTATION TO BUILD ADAPTIVE IMMUNITY – A SYSTEMATIC REVIEW
As humanity is progressing, many new borne infections are borne, and the stability and efficiency of the human body are being tested. Today the World is fighting with a deadly Novel infection named Corona Virus Disease. The aim of this systematic review is to find out the efficacy of Nutritional Interventions against the infections caused in the body due to pathogens. Further, the recommendations ...
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MICROARRAY BASED IDENTIFICATION REVEALS ARTERIAL ANGIOTENSIN SYSTEM EXPRESSION IN HUMAN
Purpose: We studied by microarray analysis the tissue angiotensin system organization. We elucidated the expression of chymase, cathepsins D, G and angiotensin-converting enzyme (ACE), potentially involved in intraparietal angiotensin II formation and atheroma. Methods: mRNA gene expression was measured by an Affymetrix Gene Chip Human Gene 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RN...
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PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF THEVETIA PERUVIANA: A REVIEW
In any nation's public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins...
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MANAGEMENT OF ADVANCED STAGE OF CARCINOMA LARYNX
AIM: The aim of this study was to analyze the efficacy and safety of concurrent chemotherapy with Cisplatin, Paclitaxel and radiotherapy on survival, functional and quality of life outcomes in locally advanced carcinoma of larynx. MATERIALS & METHODS: From June 2004 to Sep 2006, seventy four inoperable, previously untreated, histopathologically proven, locally advanced patients of carcinoma...
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APOPTOSIS SIGNALING; A DRUG DESIGN IN CANCER THERAPY: A REVIEW
Apoptosis plays an important role in development, growth, differentiation, altered gravity conditions, tissue homeostasis, immune defense, and cancer to control cell number in tissues and to eliminate individual cells that threaten the animal’s survival. The purposes of this review are to describe the signaling pathways and the cellular changes that occur with apoptosis. Currently, two pathways ...
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EFFECT OF VIMLIV ON LIPID PEROXIDES AND ANTIOXIDANTS IN ETHANOL INDUCED HEPATOTOXICITY IN ALBINO WISTER RATS
This study was carried out to investigate the hepatoprotective and antioxidant properties of vimliv in ethanol-induced hepatotoxicity in rats. The liver toxicity was induced by the administration of ethanol to the animals at dose of 3 g/kg orally for 35 days. During the period of vimliv was co-administered to the rats at doses of 25 and 50 mg/kg for 35 days. The levels of lipidperoxidative product...
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ANTI-ATHEROSCLEROTIC POTENTIAL OF PIOGLITAZONE AND N-ACETYLCYSTEINE
Atherosclerosis involves disturbances in endothelium and the resultant cascade of inflammatory reactions involving generation of ROS (Reactive Oxygen Species). Peroxisome proliferator-activated receptor-g (PPAR-g) receptors are more expressed during atherosclerosis process and its stimulation results in inhibition of formation of atherosclerotic plaque. N-acetylcysteine (NAC) stimulates GSH (gluta...
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DEVELOPMENT OF SIMULTANEOUS SPECTROPHOTOMETRIC METHOD FOR QUANTIFICATION OF RESVERATROL AND FOLIC ACID IN AN OROGEL
A simple and precise UV-Visible spectrophotometric method for the simultaneous estimation of Resveratrol and folic acid in fixed-dose combination (FDC) has been successfully developed and validated. A suitable FDC of Resveratrol and folic acid was formulated for the treatment of oral squamous cell carcinoma. The present method involves the application of simultaneous equations (Vierodt’s method)...
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INJECTION SITE REACTION TO REPEATED INTRAVENOUS BOLUS INJECTION OF DICLOFENAC SODIUM IN TAIL VEIN OF WISTAR RAT
Diclofenac is the most popular and widely prescribed non-steroidal anti-inflammatory drug (NSAID). However, no preclinical data are available on repeated diclofenac IV bolus injection. In the present study, forty male Wistar rats were randomly divided in in total of four groups with 10 rats in each group. The control group received 0.9% sodium chloride injection. Marketed injectable Diclofenac Sod...
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SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACEUTICAL IMPORTANCE OF NOVEL 4H-1, 4-BENZOTHIAZINES, AND THEIR SULFONE ANALOGUES
In recent years, synthesis and biological evaluation of novel 4H-1, 4-benzothiazines and their sulfone analogues have gained momentum due to their medicinal and industrial importance. The present article describes the synthesis of new 4H-1, 4-benzothiazines via condensation and oxidative cyclization of substituted 2-aminobenzenethiols with compounds containing active methylene groups. It is believ...
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