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A STUDY ON PRESCRIBING PATTERN OF ANTIHYPERTENSIVES AT A TERTIARY CARE HOSPITAL
The retrospective study on prescribing patterns of antihypertensives showed that the prevalence of hypertension was predominantly more with male patients than in female patients. It was also found that the average age of the overall study population was 56 years. The average age of the population clearly indicates the elderly patients were affected more. The results indicates that around 57.6% of ...
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ENCAPSULATION OF REPAGLINIDE INTO EUDRAGIT RS MICROSPHERES AND MODULATION OF THEIR RELEASE CHARACTERISTICS BY USE OF SURFACTANTS
Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and cl...
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IDENTIFICATION OF INTER SPECIES GENETIC VARIABILITY BETWEEN TWO MORPHOLOGICALLY SIMILAR SPECIES OF WITHANIA THROUGH PROTEIN AND RAPD MARKERS
The two species of Withania i.e. Withania obtusifolia and Withania somnifera were usually misinterpreted because of their co-existence in mixed populations. The present investigation involves analyzed of interspecific relationship between these two species. A careful morphological, anatomic and phytochemical, identification of the two species has led to the findings that there was a slight variati...
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DEVELOPMENT OF SIMULTANEOUS SPECTROPHOTOMETRIC METHOD FOR QUANTIFICATION OF RESVERATROL AND FOLIC ACID IN AN OROGEL
A simple and precise UV-Visible spectrophotometric method for the simultaneous estimation of Resveratrol and folic acid in fixed-dose combination (FDC) has been successfully developed and validated. A suitable FDC of Resveratrol and folic acid was formulated for the treatment of oral squamous cell carcinoma. The present method involves the application of simultaneous equations (Vierodt’s method)...
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DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC (HPTLC) METHOD FOR ESTIMATION OF TAPENTADOL HYDROCHLORIDE IN BULK AND ITS TABLET DOSAGE FORM
A simple, accurate, rapid and sensitive high performance thin layer chromatographic method has been developed for the estimation of Tapentadol Hydrochloride in bulk and its tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of methanol: toluene (4:1v/v). Densitometri...
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EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF SYNTHESIZED AGENTS USING UGI MULTICOMPONENT REACTION
In the present study, analgesic and anti-inflammatory activities of the synthesized agents derived from Ugi four component reactions (Ugi-4CR) has been described. The synthesized novel Ugi derivatives 7 (a-h) were characterized on the basis of I.R, 1H NMR and mass spectral analysis. Healthy Wistar Albino rats were used to carry out these activities. Analgesic activity was evaluated by Eddy hot pla...
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A NOVEL, SENSITIVE, BIOANALYTICAL METHOD FOR ESTIMATION OF AMLODIPINE BESYLATE IN RAT PLASMA USING FLOURESCENCE DETECTION BY RP-HPLC
The aim of the present work was to develop and validate a novel, rapid, sensitive, accurate and specific RP-HPLC assay with fluorescence detection for the quantification of amlodipine besylate in rat plasma to be applied to preclinical studies. Flourescein was used as internal standard (IS) and the detection was carried out by an online wavelength switching which enabled detection of amlodipine &a...
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HEMAGGLUTININ PROTEIN 35.7 kDA ACTS AS AN ADHESION MOLECULE IN THE OUTER MEMBRANE PROTEIN (OMP) OF SHIGELLA DYSENTERIAE
Shigellosis becomes a major health problem of developing countries. It is caused by Shigella spp. Shigella dysenteriae causes the most severe; prolonged and fatal Shigellosis by its ability in producing Shigatoxin (Stx). Unfortunately, there has not been any effective vaccine available in worldwide and using antibiotic is no longer effective. Adhesion molecule of bacteria can be used as component ...
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PARTIAL PURIFICATION AND CHARACTERIZATION OF 3-CYANOPRIDINASE RESPONSIBLE FOR PRODUCTION OF NICOTINIC ACID
A thermostable bacterial 3-cyanopyridinase enzyme has been identified that catalyze 3-cyanopyridine to nicotinic acid and ammonia. Nicotinic acid is mainly used in food, pharmaceutical and biochemical industries. This study was undertaken to optimize the purification of 3-cyanopyridinase enzyme and characterization of its various kinetic properties. The partial purification of enzyme has been carr...
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ENHANCEMENT OF POOR ORAL ABSORPTION DRUG VIA LIPID FORMULATION: SELF EMULSIFYING DRUG DELIVERY SYSTEM
The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Sel...
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