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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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12.

IMMUNOLOGICAL AND MOLECULAR DETECTION OF CHLAMYDIA TRACHOMATIS AMONG WOMEN AT REPRODUCTIVE AGE ATTENDING OMDURMAN MATERNITY HOSPITAL

Chlamydia trachomatis is the most common bacterial sexually transmitted disease. Over 100 million men and women worldwide are infected with Chlamydia at any point in time. The aim of this study to detect the presence of C. trachomatis antibodies and antigen among women on the reproductive age and to study the relationship between the presence of C. trachomatis and age, abortion and ectopic pregnan...

L. A. Kaddam *, M. O. Mohager, A. A. Adam and M. A. Tahan

Department of Microbiology, Soba Teaching Hospital, University of Khartoum, Khartoum, Sudan.

DOI: 10.13040/IJPSR.0975-8232.5(9).3664-68

3664-3668

3507

1660

51.

IDENTIFICATION OF INTER SPECIES GENETIC VARIABILITY BETWEEN TWO MORPHOLOGICALLY SIMILAR SPECIES OF WITHANIA THROUGH PROTEIN AND RAPD MARKERS

The two species of Withania i.e. Withania obtusifolia and Withania somnifera were usually misinterpreted because of their co-existence in mixed populations. The present investigation involves analyzed of interspecific relationship between these two species. A careful morphological, anatomic and phytochemical, identification of the two species has led to the findings that there was a slight variati...

A. Ramachandran, M. Senthil Kumar , K. Paneerselvam , D. Vinothkumar and A. Shajahan

Climate Change and Adaptation Research, Anna University 1, Guindy Campus- 620 025, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.4(7).2817-20

2817-2820

3506

1733

5.

A STUDY ON PRESCRIBING PATTERN OF ANTIHYPERTENSIVES AT A TERTIARY CARE HOSPITAL

The retrospective study on prescribing patterns of antihypertensives showed that the prevalence of hypertension was predominantly more with male patients than in female patients. It was also found that the average age of the overall study population was 56 years. The average age of the population clearly indicates the elderly patients were affected more. The results indicates that around 57.6% of ...

S Palanisamy *, R Tharabai and A Sumathy

Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8).43-50

43-50

3506

1409

28.

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF SYNTHESIZED AGENTS USING UGI MULTICOMPONENT REACTION

In the present study, analgesic and anti-inflammatory activities of the synthesized agents derived from Ugi four component reactions (Ugi-4CR) has been described. The synthesized novel Ugi derivatives 7 (a-h) were characterized on the basis of I.R, 1H NMR and mass spectral analysis. Healthy Wistar Albino rats were used to carry out these activities. Analgesic activity was evaluated by Eddy hot pla...

Ipsita Mohanram* and Jyotsna Meshram

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2286-91

2286-2291

3506

1700

42.

ENCAPSULATION OF REPAGLINIDE INTO EUDRAGIT RS MICROSPHERES AND MODULATION OF THEIR RELEASE CHARACTERISTICS BY USE OF SURFACTANTS

Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and cl...

V. K. Yadav*, A. K. Rai and A. K. Ghosh

Department of Pharmacy, Prasad Institute of Technology, Jaunpur - 222002, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3936-47

3936-3947

3506

1527

15.

HEMAGGLUTININ PROTEIN 35.7 kDA ACTS AS AN ADHESION MOLECULE IN THE OUTER MEMBRANE PROTEIN (OMP) OF SHIGELLA DYSENTERIAE

Shigellosis becomes a major health problem of developing countries. It is caused by Shigella spp. Shigella dysenteriae causes the most severe; prolonged and fatal Shigellosis by its ability in producing Shigatoxin (Stx). Unfortunately, there has not been any effective vaccine available in worldwide and using antibiotic is no longer effective. Adhesion molecule of bacteria can be used as component ...

F. E. Lestari, H. Suyuti and S. R. Prawiro*

Head of Magister Biomedical Program, Faculty of Medicine, University Brawijaya, Jalan Veteran, East Java, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.8(10).4180-85

4180-4185

3506

1471

9.

DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC (HPTLC) METHOD FOR ESTIMATION OF TAPENTADOL HYDROCHLORIDE IN BULK AND ITS TABLET DOSAGE FORM

A simple, accurate, rapid and sensitive high performance thin layer chromatographic method has been developed for the estimation of Tapentadol Hydrochloride in bulk and its tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of methanol: toluene (4:1v/v). Densitometri...

Pragati Amin*, Manisha Tayde and Prakruti Amin

Department of Pharmaceutical Chemistry, M.G.V'S Pharmacy College, Panchavati, Nasik, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(7).2651-56

2651-2656

3505

1857

5.

ENHANCEMENT OF POOR ORAL ABSORPTION DRUG VIA LIPID FORMULATION: SELF EMULSIFYING DRUG DELIVERY SYSTEM

The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Sel...

S. B. Gavhane, S. Mantry *, S. A. Joshi, G. Y. Dama and S. Mohanto

Department of Pharmaceutics, SGMSPM’s Sharadchandra Pawar College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).1042-56

1042-1056

3505

1842

25.

INFUSION OF ADRENOMEDULLIN-2 ANTAGONIST INDUCES APOPTOSIS AND CHANGES m-RNA EXPRESSION LEVELS OF ADM2 RECEPTORS IN PLACENTA OF PREGNANT RATS DURING LATE GESTATION AND CAUSES FETOPLACENTAL GROWTH RESTRICTION

Adrenomedullin-2 or Intermedin (ADM2/IMD) is newly identified novel hormone belongs to peptide family like AM, calcitonin, CGRP, amylin and it is widely distributed in various tissues including ovaries, uterus & placenta. The aim of present study was to investigate the role endogenous ADM2 in fetoplacental development in pregnant rats during late gestation period through infusion of ADM2 antag...

G. Lakshmi Deepika and Penchalaneni Josthna*

Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati 517502, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(3).1137-49

1137-1149

3503

1868

20.

PARTIAL PURIFICATION AND CHARACTERIZATION OF 3-CYANOPRIDINASE RESPONSIBLE FOR PRODUCTION OF NICOTINIC ACID

A thermostable bacterial 3-cyanopyridinase enzyme has been identified that catalyze 3-cyanopyridine to nicotinic acid and ammonia. Nicotinic acid is mainly used in food, pharmaceutical and biochemical industries. This study was undertaken to optimize the purification of 3-cyanopyridinase enzyme and characterization of its various kinetic properties. The partial purification of enzyme has been carr...

T. Arfi, L. Singh, D. Prabhakar and V. K. Nigam*

Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.8(11).4666-74

4666-4674

3503

1449