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EFFECT OF CHITOSAN COATING ON THE PHYSIOCHEMICAL CHARACTERISTICS OF GEFITINIB LOADED NANOLIPOSOMES
In the present work the nanoliposomes prepared by using REV and MEU methods were coated with different concentration of chitosan solutions. The main objective behind this work was to assess the physical properties, stability and in vitro release of uncoated and chitosan coated nanoliposomes of gefitinib. The existence of a covering on the exterior of nanoliposomes was confirmed by the modification...
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MICROWAVE-ASSISTED SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR ANTI-INFLAMMATORY ACTIVITY
A series of novel Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by 1H-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds ...
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A REVIEW ON THE PHARMACOGNOSTICAL, ECOLOGY AND PHARMACOLOGICAL STUDIES ON MARINE RED ALGAE – HYPNEA VALENTIAE
Seaweeds are the potential marine living resources in the world. More than 20,000 seaweeds are distributed throughout the world, of which only 221 (1.1%) are commercially utilized, which includes 145 species for food and 110 species for phycocolloid production. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active...
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THERAPEUTIC AND PREVENTIVE ROLE OF FUNCTIONAL FOODS IN PROCESS OF NEURODEGENERATION
Diet and dietary habits of an individual are considered to be an essential factor based on biologically active compounds extracted or modified from either known or unknown natural sources, contributing to completing the dietary and nutritional needs beyond the traditional supplements. Moreover, the latest research information about their supportive and therapeutic utility suggests that they play a...
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ANTIOXIDANT POTENTIAL OF THE WHOLE PLANT EXTRACT OF MOLLUGO PENTAPHYLLA LINN. ON ETHANOL INDUCED LIVER DAMAGE
The potential antioxidant effect ethanol induced liver damage was investigated using crude methanolic extract of the whole plant of Mollugo pentaphylla Linn. The standard drug used was ascorbic acid mg / kg/day. Serum cholesterol, triglycerides aspartate amino transferase (AST) and alanine amino transferase (ALT) levels were measured as antioxidant indicators. There was a significant reduction...
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FIXED HEXA-HELIX: AN AMENDED QUAD HELIX FOR A COMPLIANCE DRIVEN PEDIATRIC PATIENT- A INNOVATIVE CASE APPROACH
Introduction: Early treatment in growing patient is of value as the guidance of occlusion to normalcy can shorten the treatment time in mature patients. The removable appliance is commonly used by pediatric dentist to intercept malocclusion in such patients, but it brings a major drawback with it of being compliance dependent. Fixed appliance therapy is better accepted and has better wear complian...
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DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC (HPTLC) METHOD FOR ESTIMATION OF TAPENTADOL HYDROCHLORIDE IN BULK AND ITS TABLET DOSAGE FORM
A simple, accurate, rapid and sensitive high performance thin layer chromatographic method has been developed for the estimation of Tapentadol Hydrochloride in bulk and its tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of methanol: toluene (4:1v/v). Densitometri...
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EFFECT OF SOME MEDICINAL HERBAL EXTRACTS ON CLINICALLY IMPORTANT BACTERIAL PATHOGENS
Medicinal plant products when compared with synthetic antibiotics minimize the infections at a major part. Phytochemical screening of medicinal plants showed positive results for most of the phytochemical constituents namely tannins, saponins, flavonoids, carbohydrates, alkaloids, anthraquinones, protein and aminoacids, mixed oils and fats etc., This study provided a good medicinal plant based t...
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ENCAPSULATION OF REPAGLINIDE INTO EUDRAGIT RS MICROSPHERES AND MODULATION OF THEIR RELEASE CHARACTERISTICS BY USE OF SURFACTANTS
Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and cl...
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A PRELIMINARY EVALUATION OF ANTIBACTERIAL AND TOXIC POTENTIALS OF P. GUINEENSE SWARTZ. FRUIT PULP FROM DIFFERENT STAGES OF RIPENESS
Psidium guineense Swartz is a shrub native to Brazil. It is consumed in natura or in the form of pulp, which presents a high content of C vitamin and proteins. The chemical prospection of the aqueous extracts from unripe and mature pulp revealed the presence of tannins and flavonoids. The extracts demonstrated moderate antibacterial activity against the most of strains tested, and the best result ...
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