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FORMULATION AND EVALUATION OF FEXOFENADINE HYDROCHLORIDE LOADED CHITOSAN NANOPARTICLES FOR TREATMENT OF SKIN ALLERGY
An attempt was made to formulate and evaluate Fexofenadine HCl loaded chitosan nanoparticles using biodegradable polymers such as chitosan and sodium tripolyphosphate as a crosslinker in different ratio and proportions. In this formulation, Fexofenadine HCl was selected because of wide range of its use in treatment of skin allergy in the form of coated tablet and pediatric suspension. Different fo...
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ANTIMICROBIAL INVESTIGATION OF SOME ARID ZONE PLANTS OF RAJASTHAN
In the present study, the inhibitory effect of crude ethanolic extracts from four plants viz. Bauhinia racemosa Lamk (stem bark and roots), Holoptelea integrifolia (Roxb.) Planch. (roots), Kirganelia reticulata (Poir) Baill. (Stem bark) and Phyllanthus maderaspatensis Linn. (whole plant) were undertaken against some test bacteria and test fungi using Disc Diffusion Method. The screening data indic...
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BEHAVIORAL STUDIES OF DASATINIB AND RESVERATROL IN ROTENONE INDUCED PARKINSON’S RAT MODEL
Neurodegeneration accounts for diseases like Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, etc. that come under neurodegenerative diseases. Parkinson’s disease is the second most common neurodegenerative disease. The main hallmarks of Parkinson’s disease are progressive loss of motor control and cognitive dysfunction. Current treatments are of reducing the symptoms, do ...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-{4-[(6-CHLORO-4-OXO-4H-CHROMEN-3-YLMETHYLENE) IMINO] PHENYL}-2-(SUBSTITUTED PHENOXY ACETAMIDE) DERIVATIVES
Some N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-(substituted phenoxy) acetamide derivatives (3) were synthesized by reacting N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-chloroacetamide (2) with some substituted phenol in dry acetone in the presence of K2CO3 and catalytic amount of KI. The chemical structures of the compounds were elucidated by IR, 1H-NMR ...
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MOLECULAR MODELLING AND MOLECULAR DOCKING STUDIES OF CYP450 INHIBITORS
The present study explains computational methods to design 3D structure of “Cytochrome P450 4A11” of Homo sapiens enzyme using the sequence available from Uniprot (Uniprot KB - Q02928). Homology modelling study was performed to generate a 3D model of Cytochrome P450 protein. The model was developed by using Modeler 9.17 software tool. The developed model was further docked with already existin...
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PHARMACOGNOSTICAL OVERVIEW ON TERMINALIA ARJUNA: A JUSTIFICATION OF FOLKLORIC BELIEF
The application of medicinal plants such as Terminalia arjuna to maintain health and treat disease started since time immemorial and still is a part of medical practice. The phytochemical analysis of bark of T. arjuna in methanolic, hydromethanolic (1:1), aqueous and petroleum ether extracts revealed the presence of carbohydrates, amino acid, alkaloids, saponins, tannins, flavonoids, terpenoids, g...
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DESIGN AND IN-VITRO EVALUATION OF TENOXICAM NANOGEL CONTAINING NOVEON POLYMER
The aim of present work is to design a Tenoxicam loaded nanogel for the anti-inflammatory and analgesic effect of prepared nanogel. Tenoxicam is one of the NSAIDs of oxicam class; it is very potent and useful for chronic use in rheumatoid arthritis and osteriostatis. The formulations of nanogel based materials have high drug loading capacity, biocompatibility, and biodegradability which are the ke...
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STUDIES ON ANTIMICROBIAL ACTIVITY OF ZIZIPHUS RUGOSA LAM. PERICARP
The desire of the present study was to investigate in-vitro antimicrobial activity on different crude extracts of Ziziphus rugosa pericarp. The antibacterial assay was carried out against Bacillus subtilis MTCC 1133, Staphylococcus aureus MTCC 7443, Escherichia coli MTCC 1692 and Salmonella typhi ATCC 19430. Meanwhile, Candida albicans ATCC 18804, Aspergillus niger ATCC 16404, Trichoderma harzianu...
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MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...
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DESIGN OF EXPERIMENTS: A MANIFEST APPROACH IN DESIGNING OPTIMIZED DRUG PRODUCTS
The recent scenario of accomplishment with faultlessness indulges a bent towards the techniques that develop the final formulations with the precise use of experimental designs. Also, the application of computer-aided optimization techniques has proved to be favorable in the development of drug delivery systems with reliable results. The optimization techniques have a comprehensive range of design...
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