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IN-VITRO AND EX-VIVO STUDIES ON SYNERGISTIC EFFECTS OF LIMONIA ACIDISSIMA AND APPLE CIDER VINEGAR ON ANTI-UROLITHIATIC ACTIVITY
Kidney stones are aggregations of minerals such as calcium, oxalate, phosphates, uric acid, cysteine, etc. which can obstruct any part of the urinary system. This can turn fatal if left untreated as the major route of excretion is blocked causing the toxicity level to rise in the body which might lead to organ failure, coma and death. Limonia acidissima (wood apple) and Apple cider vinegar were fo...
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TETRACYCLINE COORDINATION COMPOUND AS ANTIMICROBIAL AGENT
The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8) MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram ...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE
Ondansetron hydrochloride (ONH) is an exceptionally harsh, powerful antiemetic drug utilized for the treatment and prophylaxis of chemotherapy or radiotherapy or postoperative prompted emesis. This investigation aims to detail and assesses taste-covered quick-dissolving tablets (FDTs) of ONH to expand patient consistence. ONH taste veiled granules were set up by a strong scattering procedure. Diss...
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A BROAD SURVEY AND COMPREHENSIVE STUDY ON UTILIZATION PATTERN OF ANTIBIOTICS IN TERTIARY CARE TEACHING HOSPITAL IN NORTH KARNATAKA
An ongoing, systematic process designed to maintain the appropriate and effective use of drugs is Drug Use Evaluation (DUE). It involves a comprehensive review of patient’s prescription and medication data before, during, and after dispensing in order to assure appropriate therapeutic decision making and positive patient outcomes. The aim of the present study is to conduct a prospective study o...
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PREVENTION OF RADIATION INDUCED HEMATOLOGICAL ALTERATIONS IN MICE BY ALSTONIA SCHOLARIS EXTRACT
Backround: The present study has been carried out to evaluate the radio-protective effects of Alstonia scholaris extract (ASE) on peripheral blood of mice. Materials & Methods: Male Swiss albino mice were selected from an inbred colony and assorted into 4 groups. Animals in Group I were administered with double distilled water (DDW), volume equal to ASE, by oral gavage to serve as vehicle t...
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AMELIORATING EFFECT OF TURMERIC ON KIDNEY FUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Background: Diabetes mellitus is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins, and relative or absolute insulin depletion. Various long-term complications of diabetes develop due to chronic hyperglycemia and insulin resistance. Chronic kidney disease (CKD) and diabetes mellitus (DM) are major public health problems worldwide. Turmeric is one of the ...
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SCOPE FOR HARMONISATION OF HERBAL MEDICINE REGULATIONS
Herbal Medicinal Products are gaining acceptance among people across the world due to rising awareness of lifestyle diseases and improper food habits. During the latter part of the twentieth century, increasing interest in self-care resulted in enormous growth in the popularity of traditional healing modalities, including the use of Herbal remedies. Side effects caused by the use of modern medicin...
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ANTICANCER DRUG INDUCED INFUSION REACTIONS: A SINGLE INSTITUTE EXPERIENCE
Objective: To know the occurrence, onset and severity of infusion reactions associated with anticancer drug in an oncology hospital. Methods: For the patients who developed infusion reactions, causative drug, cycle of therapy, onset and duration of reaction, associated symptoms were recorded. The adverse drug reaction reporting form (yellow form) was used to report the infusion reaction. On the ba...
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A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DICYCLOMINE AND ETHYL MORPHINE IN BULK AND PHARMACEUTICAL FORMULATION
The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitri...
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DRUG DISCOVERY AND DEVELOPMENT: A BASIC APPROACH TO IMPROVE THE SUCCESS OF DRUG DISCOVERY
Drug discovery is a process that aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening, and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the drug development process earlier ...
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