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PHARMACOVIGILANCE STUDY OF PATIENTS RECEIVING TREATMENT AT MEDICAL ICU OF C. U. SHAH MEDICAL COLLEGE & HOSPITAL, SURENDRANAGAR
Background: Medical Intensive Care Unit (ICU) can be a potential place for Pharmacovigilance due to high frequency of Adverse Drug Reactions (ADRs). Regular evaluation can help in understanding the pattern of ADR and reduce the incidence of it. Aims and Objectives: To evaluate incidence of ADRs in patients receiving various modes of treatment at medical ICU of our tertiary care hospital and classi...
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ROLE OF A NOVEL TERPENOID AS EFFLUX INHIBITOR IN TARGETING THE EFFLUX PROTEIN (MexA) OF MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA
Pseudomonas aeruginosa, is one among the few drug resistant organisms causing Urinary Tract Infection. Most strains of Pseudomonas aeruginosa are significantly more resistant, even in the absence of R plasmids, to many antimicrobial agents, including β-lactams, tetracycline, chloramphenicol, and fluoroquinolones, than most other gram-negative rods. This broad-range resistance has so far been ass...
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ANTI-MICROBIAL AND ANTI-TUBERCULAR ACTIVITY EVALUATION OF NEWLY SYNTHESIZED ZINC COMPLEXES OF AMINOTHIOPHENE SCHIFF BASES
Tridentate Schiff bases were obtained in succession from the condensation of ethyl 2-amino-5,6-dihydro-4H-cyclopenta [b] thiophene-3-carboxylate and different aryl aldehydes in 1:1 molar ratio. Zinc chloride complexes of these new aminothiophene Schiff bases were prepared in 1:1 metal: ligand stichometry. These complexes were characterized using IR, UV-Visible, elemental analysis and molar conduct...
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POSSIBLE MECHANISM OF HYPERGLYCEMIA INDUCED DECREASE IN ANTINOCICEPTIVE EFFECT OF ANALGESICS IN RATS
Diabetes induced neuropathic pain is recognized as one of the most difficult pain to treat and conventional analgesic are well known to be partially effective or ineffective. Non-steroidal anti-inflammatory drugs and opioids are effective antinociceptive drugs, however, their antinociceptive activity decreased in diabetic neuropathy. The study was designed to investigate the mechanism of diabetes ...
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SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL EVALUATIONS OF SOME NOVEL 1, 3, 4-THIADIAZOLE DERIVATIVES
A series of 1, 3, 4-thiadiazole derivatives were synthesized. The structures of these compounds were established by means of IR, 1H-NMR and mass spectrum analysis. All the compounds were evaluated for antibacterial and antifungal activities. Most of the compounds have shown significant antibacterial and antifungal activity when compared with the standard drugs...
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EXOGENOUS HYDROGEN SULFIDE (H2S) IMPROVES THE ENDOTHELIAL AND RENAL EXCRETORY FUNCTIONS IN STREPTOZOTOCIN INDUCED WKY DIABETIC RATS
Nephropathy is one of the most common microvascular complications of diabetes. Hydrogen sulfide(H2S)has been implicated in controlling the renal glomerular (vascular) and tubular functions. This study investigates the metabolism of H2S and its effect on the progression of diabetic nephropathy. Diabetes was induced in WKY rats by streptozotocin in two groups. One diabetic group received NaHS, a H2S...
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THE EFFECT OF PSYCHIATRIC EDUCATION ON THE ATTITUDE OF MEDICAL STUDENTS OF GUILAN UNIVERSITY OF MEDICAL SCIENCES TOWARD PSYCHIATRY
Introduction: While many medical students have a special talent in psychiatry, attracting them to this specialty is a problem. The purpose of this study was to examine the impact of psychiatric education on the attitude of medical students on psychiatric patients. Method: In this observational study, 200 medical externs and interns were recruited. Before and after attending the 4-week psychiatry e...
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TETRACYCLINE COORDINATION COMPOUND AS ANTIMICROBIAL AGENT
The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8) MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram ...
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A CURRENT REVIEW FROM RECENT LITERATURE ON NOVEL SARS-COV-2 OUTBREAK
The outbreak of a novel coronavirus 2019 was traced back in China in late 2019, followed by their worldwide transmission as a pandemic. From January to August 2020, a total of 1,724 papers were published, where 125 were only published in August 2020, demonstrating the importance and need for current awareness and research to overcome this deleterious virus. This paper briefly highlighted the major...
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ANTIMICROBIAL ACTIVITY OF EXACUM LAWII EXTRACTS AND VOLATILE OIL AGAINST OCULAR INFECTION
Exacum lawii is folklore medicinal herb, boiled with oil and used traditionally for ocular infection. The aim of the present study is to evaluate the in-vitro antibacterial and antifungal activity against ocular infection. Ethanolic extract, petroleum ether extract and volatile oil were extracted from Exacum lawii whole plant. Antibacterial activity and antifungal activity against strains causing ...
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