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HEMAGGLUTININ PROTEIN 35.7 kDA ACTS AS AN ADHESION MOLECULE IN THE OUTER MEMBRANE PROTEIN (OMP) OF SHIGELLA DYSENTERIAE
Shigellosis becomes a major health problem of developing countries. It is caused by Shigella spp. Shigella dysenteriae causes the most severe; prolonged and fatal Shigellosis by its ability in producing Shigatoxin (Stx). Unfortunately, there has not been any effective vaccine available in worldwide and using antibiotic is no longer effective. Adhesion molecule of bacteria can be used as component ...
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INFUSION OF ADRENOMEDULLIN-2 ANTAGONIST INDUCES APOPTOSIS AND CHANGES m-RNA EXPRESSION LEVELS OF ADM2 RECEPTORS IN PLACENTA OF PREGNANT RATS DURING LATE GESTATION AND CAUSES FETOPLACENTAL GROWTH RESTRICTION
Adrenomedullin-2 or Intermedin (ADM2/IMD) is newly identified novel hormone belongs to peptide family like AM, calcitonin, CGRP, amylin and it is widely distributed in various tissues including ovaries, uterus & placenta. The aim of present study was to investigate the role endogenous ADM2 in fetoplacental development in pregnant rats during late gestation period through infusion of ADM2 antag...
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PARTIAL PURIFICATION AND CHARACTERIZATION OF 3-CYANOPRIDINASE RESPONSIBLE FOR PRODUCTION OF NICOTINIC ACID
A thermostable bacterial 3-cyanopyridinase enzyme has been identified that catalyze 3-cyanopyridine to nicotinic acid and ammonia. Nicotinic acid is mainly used in food, pharmaceutical and biochemical industries. This study was undertaken to optimize the purification of 3-cyanopyridinase enzyme and characterization of its various kinetic properties. The partial purification of enzyme has been carr...
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ANALYTICAL QUALITY BY DESIGN APPROACH IN RP-HPLC METHOD DEVELOPMENT FOR THE ASSAY OF PITAVASTATIN IN TABLET DOSAGE FORM
Chromatographic method was developed according to Quality by Design (QbD) approach as per ICH Q8 (R2) guidelines for estimation of pitavastatin in pharmaceutical dosage form. By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of Pitavastatin has been optimized using analytical ...
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HETEROGENEITY OF IRON STATUS AND ANTIRETROVIRAL THERAPY DURING PREGNANCY IN CÔTE D’IVOIRE
Antiretroviral therapy for decades is the appropriate treatment for infected populations with human immunodeficiency virus (HIV). However, it is associated with complications that affect the organism infected. The combination of antiretroviral therapy and pregnancy degrades iron metabolism. This work aims to evaluate and characterize the impact of the interaction between antiretroviral therapy and...
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PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDIZATION OF TUBEROUS ROOT OF SMILAX CHINA L.
In this study, the pharmacognostic and phytochemical standardization of tuberous roots of Smilax china L. belongs to the Family Liliaceae was performed in detail. Pharmacognostical standardizations like macroscopical and microscopical studies, powder microscopy, quantitative microscopy, physicochemical analysis, fluorescence study, determination of heavy metal contamination, qualitative and quanti...
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APPLICATION OF STABILITY INDICATING UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CAFFEINE IN GEL FORMULATION, PLASMA AND URINE
A simple, sensitive and stability indicating UV spectrophotometric method was developed and validated for the estimation of caffeine in a gel formulation, plasma and urine samples using acidified alcohol as solvent. At absorbance maxima of 265 nm, the linearity was found to be in range of 4-20 µg/ml with correlation coefficient 0.9988. The method was applied for estimation of caffeine in a gel fo...
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PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY STUDIES OF LEAF OF BRASSICA JUNCEA VAR RUGOSA THROUGH SEQUENTIAL SOLVENT EXTRACTION
Objectives: To find out different qualitative and quantitative phytochemical properties, it’s in-vitro antioxidant properties and peroxidase activity of Brassica juncea var. Rugosa (record tro- 50197928) with fresh and sequential solvent extracts. Methods: The leaf sample of Brassica juncea var. rugosa was collected from Manipur and the sample was dried. The dried powder was extracted using Soxh...
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FORMULATION AND EVALUATION OF SPHERICAL CRYSTALS OF INDOMETHACIN FOR THE IMPROVEMENT OF SOLUBILITY AND MICROMERITIC PROPERTIES
Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Spherical agglomerates were prepared by crystallo-co agglomeration technique. Crystallization medium used for spherical agglomerates of Indomethacin consisted of acetone (good solvent); water (poor solvent); dichloromethane (bridging liquid). HPMC, PVP and PEG6000 this polymer were used in the agglomeratio...
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PHYTOCHEMICAL INVESTIGATION AND BIOLOGICAL ASSESSMENT OF 12-HYDROXY-OCTADEC-CIS-9-ENOIC ACID ISOLATED FROM SWIETENIA HUMILIS ZUCC. SEED OIL
The genus Swietenia belongs to Meliaceae family which consists of 37 genera and about 300 species which is found in most of the parts of India. In present investigation we made an efficient effort to extract ricinoleic acid from the seed oil of Swietenia humilis, Zucc. They are used in medicine folklore to cure various diseases in Mexico, Africa and India. Physicochemical properties of Swietenia h...
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