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TOXICOLOGICAL ASSESSMENT OF CONSUMPTION OF BENZENE-POLLUTED WATER ON THE HEART AND BLOOD OF ALBINO RATS
The long-term effects of daily consumption of benzene-contaminated water over a period of Sixty-five days on rats’ cellular system were inspected. Haematological parameters such as haemoglobin, packed cell volume etc were determined. Standard enzyme assays were conducted on some enzymes (alkaline phosphatase, acid phosphatase and lactate dehydrogenase) activities of the heart and serum. Signific...
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INFUSION OF ADRENOMEDULLIN-2 ANTAGONIST INDUCES APOPTOSIS AND CHANGES m-RNA EXPRESSION LEVELS OF ADM2 RECEPTORS IN PLACENTA OF PREGNANT RATS DURING LATE GESTATION AND CAUSES FETOPLACENTAL GROWTH RESTRICTION
Adrenomedullin-2 or Intermedin (ADM2/IMD) is newly identified novel hormone belongs to peptide family like AM, calcitonin, CGRP, amylin and it is widely distributed in various tissues including ovaries, uterus & placenta. The aim of present study was to investigate the role endogenous ADM2 in fetoplacental development in pregnant rats during late gestation period through infusion of ADM2 antag...
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A REVIEW ON THE PHARMACOGNOSTICAL, ECOLOGY AND PHARMACOLOGICAL STUDIES ON MARINE RED ALGAE – HYPNEA VALENTIAE
Seaweeds are the potential marine living resources in the world. More than 20,000 seaweeds are distributed throughout the world, of which only 221 (1.1%) are commercially utilized, which includes 145 species for food and 110 species for phycocolloid production. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active...
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1916
DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC (HPTLC) METHOD FOR ESTIMATION OF TAPENTADOL HYDROCHLORIDE IN BULK AND ITS TABLET DOSAGE FORM
A simple, accurate, rapid and sensitive high performance thin layer chromatographic method has been developed for the estimation of Tapentadol Hydrochloride in bulk and its tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of methanol: toluene (4:1v/v). Densitometri...
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1879
A STUDY ON PRESCRIBING PATTERN OF ANTIHYPERTENSIVES AT A TERTIARY CARE HOSPITAL
The retrospective study on prescribing patterns of antihypertensives showed that the prevalence of hypertension was predominantly more with male patients than in female patients. It was also found that the average age of the overall study population was 56 years. The average age of the population clearly indicates the elderly patients were affected more. The results indicates that around 57.6% of ...
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PARTIAL PURIFICATION AND CHARACTERIZATION OF 3-CYANOPRIDINASE RESPONSIBLE FOR PRODUCTION OF NICOTINIC ACID
A thermostable bacterial 3-cyanopyridinase enzyme has been identified that catalyze 3-cyanopyridine to nicotinic acid and ammonia. Nicotinic acid is mainly used in food, pharmaceutical and biochemical industries. This study was undertaken to optimize the purification of 3-cyanopyridinase enzyme and characterization of its various kinetic properties. The partial purification of enzyme has been carr...
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HETEROGENEITY OF IRON STATUS AND ANTIRETROVIRAL THERAPY DURING PREGNANCY IN CÔTE D’IVOIRE
Antiretroviral therapy for decades is the appropriate treatment for infected populations with human immunodeficiency virus (HIV). However, it is associated with complications that affect the organism infected. The combination of antiretroviral therapy and pregnancy degrades iron metabolism. This work aims to evaluate and characterize the impact of the interaction between antiretroviral therapy and...
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AN EVALUATION OF ACUTE AND SUBCHRONIC TOXICITIES OF A NIGERIAN POLYHERBAL ANTIDIABETIC REMEDY
The acute and subchronic toxicities of Nigerian polyherbal antidiabetic remedy, prepared from Gongrenema latifolium and Allium cepa (1:1) leaves was investigated in Swiss albino mice and rats of both sexes. For acute toxicity study, 1000-5000mg/kg of the combined extract were administered orally to rats and observed for 24 hours for obvious toxic symptoms and mortality. The median lethal dose of t...
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FORMULATION AND EVALUATION OF ENTERIC COATED ELEMENTARY OSMOTIC PUMP (ECEOP) TABLETS OF DICLOFENAC SODIUM
The objective of this study was to formulate a Novel drug delivery device that is capable of releasing the drug in controlled kinetics through the oral route, bypassing the acidic environment of the stomach. Therefore, it was planned to develop an osmotic device with an enteric coating. It was projected to enhance the strength of the semi-permeable membrane for the osmotic device to control drug r...
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PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDIZATION OF TUBEROUS ROOT OF SMILAX CHINA L.
In this study, the pharmacognostic and phytochemical standardization of tuberous roots of Smilax china L. belongs to the Family Liliaceae was performed in detail. Pharmacognostical standardizations like macroscopical and microscopical studies, powder microscopy, quantitative microscopy, physicochemical analysis, fluorescence study, determination of heavy metal contamination, qualitative and quanti...
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