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A DIETRY GUIDE TO PREVENTION AND MANAGEMENT OF OSTEOPOROSIS
Osteoporosis is a debilitating disease that affects many older people. Characterized by low bone mass and microarchitectural deterioration (MAD) of bone tissue, Fragility fractures are the hallmark of osteoporosis. There are potentially numerous nutrients and a dietry component that can influence bone health. Bone mineral consists of calcium phosphate, and phosphorus is as important as calcium i...
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ANTIBODY ENGINEERING AND IMMUNOCONJUGATES FOR CANCER THERAPY
In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of b...
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ANTIBACTERIAL ACTIVITY OF RUBIA TINCTORUM LINN. ROOT EXTRACTS
This research aimed to determine the antibacterial activity of methanolic, aqueous, chloroformic and petroleum ether extracts of Rubia tinctorum roots against two gram positive and two gram negative bacteria using agar well-diffusion method. The minimum inhibitory concentration (MIC) was determined using microdilution method. Extracts were dissolved in DMSO to obtain a concentration of 10% (w/v), ...
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EFFECT OF EDAPHIC FACTORS ON MAJOR SECONDARY METABOLITES OF TINOSPORA CORDIFOLIA AND NEEM GUDUCHI WITH RESPECT TO THEIR IMMUNOMODULATORY EFFECT
Tinospora cordifolia is a requisite medicinal plant, has been used for the treatment of various diseases and has been recommended for improving the immune system mentioned in Ayurveda and other systems of medicine as a monoherbal or polyherbal preparation. Nonetheless, Ayurvedic and other ancient literature reported that Tinospora cordifolia growing on neem plant gives better immunomodulatory acti...
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AN INVESTIGATION OF IN-VITRO RELEASE OF RABEPRAZOLE SODIUM FROM PULSATILE RELEASE TABLETS CONTAINING HPMC-EC BLEND AS TIME LAGGED PRESS COATING
To develop new pulsatile release tablets of Rabeprazole sodium (RS), that can suppress drug release in stomach and release the drug rapidly after a predetermined lag time for about 4 h in intestine, a multiple unit dosage forms was designed that contain, drug-containing core, a coating to achieve time lag in drug release and an outermost acid resistant enteric coating. Time lagged press coating wa...
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POSTNATAL DEVELOPMENT OF STOMACH IN SWISS MICE INDUCED BY LEAD ACETATE
Histopathological changes in developing stomach caused by lead acetate exposure at different days of the postnatal development were investigated in Swiss mice. In this study, pregnant Swiss mice were exposed to 533 mg/kg BW of lead acetate from 10th day of gestation to 21st day of lactation. The pups of exposed groups were sacrificed at 1, 7, 14 and 21 day of lactation period, and the effects of l...
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ANTIBACTERIAL, ANTIOXIDANT, CYTOTOXICITY AND QUALITATIVE PHYTO-CHEMICAL EVALUATION OF SEED EXTRACTS OF NIGELLA SATIVA AND ITS SILVER NANOPARTICLES
Nigella sativa is considered a miracle herb plant belongs to the Ranunculaceae family, inhabitant to South Asia and South-west Asia. The most important part of the Nigella sativa plant used by human beings are seeds, mostly as a spice because it contains a specific aroma. The seeds derived from Nigella sativa being exploited by people and used for thousands of years for culinary purposes, to cure ...
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IN-VITRO STUDIES ON OIL DEGRADING BACTERIA ISOLATED FROM OIL CONTAMINATED SOIL OF VANIYAMBADI AND AMBUR AREAS OF VELLORE DISTRICT
The oil polluted soil has many hydrocarbons which can be degraded by microbes. These oil degrading microbes were isolated from the oil contaminated soil through plate and dilution technique. The oil contaminated soils were collected from the oil spilled places of Vaniyambadi and Ambur areas of Vellore District, Tamil nadu, India. Through the biochemical tests, the isolated bacterial strains were i...
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INJECTION SITE REACTION TO REPEATED INTRAVENOUS BOLUS INJECTION OF DICLOFENAC SODIUM IN TAIL VEIN OF WISTAR RAT
Diclofenac is the most popular and widely prescribed non-steroidal anti-inflammatory drug (NSAID). However, no preclinical data are available on repeated diclofenac IV bolus injection. In the present study, forty male Wistar rats were randomly divided in in total of four groups with 10 rats in each group. The control group received 0.9% sodium chloride injection. Marketed injectable Diclofenac Sod...
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ACUTE TOXICITY OF HYDROXYUREA IN MALE ALBINO MICE
This study was carried out to investigate the acute oral toxicity LD50 of an anti-neoplastic and a chemotherapeutic agent hydroxyurea in male albino mice by using up α Down method. The result revealed that LD50 of hydroxyurea was (7868.5 mg/kg. b.w). Orally after 24 h of exposure. That’s mean it is slightly toxic agent. To study the effect of lethal doses of hydroxyurea on the some of blood par...
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