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A REVIEW ON ANTIMICROBIAL POTENTIAL OF SULFONAMIDE SCAFFOLD
Sulfonamides, sometimes called sulfa drugs, are the first drug that is largely employed and systematically essential for preventive and chemotherapeutic agents against various bacteria. Sulfonamides possess a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti-epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, antiretroviral, non-peptidic ...
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AN EFFICIENT, GREENER MICROWAVE ASSISTED MULTI-COMPONENT ONE POT SYNTHESIS OF [1, 3, 4] THIADIAZIN-2-YL-THIAZOLIDIN-4-ONES
This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), s...
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A REVIEW ON METABOLIC SYNDROME: A NEW ENEMY OF PUBLIC HEALTH
Metabolic Syndrome is a cluster of several cardiovascular risk factors that include glucose intolerance, central obesity, dyslipidemia, and hypertension. The public health impact of this syndrome is weighty; given it is a primary risk factor for cardiovascular diseases, obstructive sleep apnea, and type II diabetes. This current plight is further underscored by recently emerging evidence that Meta...
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TEMPERATURE STRESS MEDIATED CONSEQUENCES ON PHYSIOLOGY AND SECONDARY METABOLITES OF DATURA STRAMONIUM (L.)
Datura stramonium (L.), a multipurpose plant of Himalayan regions which possess antiseptic, sedative, antidiarrhoeal properties used for treating various diseases which include treatment of ulcer, skin disorder, jaundice, fever, heart diseases, etc. To evaluate the temperature stress-mediated morphological, physiochemical, and antioxidative defense in Datura stramonium, plants were subjected to di...
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NEW SPECTROPHOTOMETRIC TECHNIQUES FOR THE ESTIMATION OF BREXPIPRAZOLE IN TABLET DOSAGE FORM
Brexpiprazole is an atypical antipsychotic drug indicated for the treatment of schizophrenia. Four novels, simple, precise and accurate spectrophotometric methods were developed for the determination of Brexpiprazole (Rexulti) in pharmaceutical dosage forms. The absorption maxima was found to be at 214 nm in method A (0.1N HCl) and shows linearity over the concentration range of 0.002-0.02 µg/mL ...
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UV SPECTROPHOTOMETRIC ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CLOMIPHENE CITRATE IN METHANOL
The present study describes simple, accurate, precise and cost effective UV-spectroscopic method for the estimation of clomiphene citrate in methanol as per ICH guidelines. The absorption maxima for clomiphene citrate in methanol was found to be 235nm and 294 nm. The drug follows linearity (linearity 1, linearity 2 & linearity 3) in the concentration range 3-40 μg/ml at 294 nm and 3-24 μg/ml...
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INVESTIGATION OF PHYTOCONSTITUENTS IN STEM BARK OF FICUS BENGHALENSIS LINN. USING GC-MS TECHNIQUE
Objective of the present study is to investigate the chemical composition of methanol extract of stem bark of Ficus benghalensis Linn. (Indian Banyan Tree). Shade and air dried stem bark were powdered and extract was prepared according to selective sequential extraction using different solvents of increasing polarity. Methanol extract of stem bark of this plant was further subjected to gas chromat...
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PHYSICO-CHEMICAL EVALUATION OF WHOLE PLANT OF COCCULUS PENDULUS (J.R. & G. FORST.) DIELS
The whole plant of Cocculus pendulus (J.R. & G. Forst.) Diels is reported to have quality medicinal values in traditional system of medicines. The various physico-chemical parameters included determination of extractive value, loss on drying, ash values, fluorescence analysis, HPTLC analysis and preliminary phytochemical analysis were performed. The preliminary identification of Cocculus pendu...
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IN-VITRO ANTIOXIDANT AND IN-VIVO HEPATOPROTECTIVE ACTIVITY OF GANODERMA LUCIDIUM STRAINS DARL-4 & MS-1 AGAINST PARACETAMOL INDUCED HEPATOTOXICITY
The purpose of current research work is to evaluate the in-vitro antioxidant and in-vivo hepatoprotective activity of Ganoderma lucidum strains DARL-4 and MS-1. Antioxidant activity of different extracts was evaluated by using DPPH and ABTS method. Hepatoprotective activity of hydroalcoholic extract of G. lucidum strain DARL-4 and MS-1 were evaluated by paracetamol-induced liver damage in rats. Th...
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PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITY OF DIFFERENT CITRUS FRUIT PEELS
Citrus fruit is a very rich source of Vitamin C, A, E, and flavonoids, alkaloids, and minerals. Citrus fruits are medicinal plants that present rutaceae family and include some fruits such as orange (Citrus sinensis), kinnow (Citrus reticulata), mosambi (Citrua ltmetta), grapefruit (Citrus maxima) lime, pomelo lemon. Antibacterial antiviral, antifungal activity of different solvent extracts (Ace...
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