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ANTIHYPERCHOLESTROLEMIC POTENTIAL OF OMEGA-3-FATTY ACID CONCENTRATE IN ALLOXAN INDUCED DIABETIC RODENT
Exhaustive study of scientific literature provides the initial evidence that omega-3-fatty acids the principal component of fish oil is responsible for exerting important biological effects when administered to population at risk of coronary heart diseases and diabetes mellitus. The main reason behind the study was to evaluate the anti-atherogenic properties of marine lipids in alloxan induced dia...
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THE HYPOXIC VENTILLATORY RESPONSE AND HEPATIC CYP3A4 UPREGULATION IN HUMAN AT HIGH ALTITUDE
The Hypoxic Ventillatory Response (HVR) at high altitude was hypothesized to cause pharmacokinetics changes, especially metabolism of drugs due to the up regulation of CYP3A4 isoenzyme. These pharmacokinetic alteration could affect pharmacotherapy, probably lead to either sub therapeutic or supra therapeutic effects. This hypothesis was studied with a pop-PK study conducted in healthy male volunte...
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PRELIMINARY PHYTOCHEMICAL AND ANTIBACTERIAL SCREENING ON EXTRACTS OF THE AERIAL PARTS OF GALIUM SPURIUM (SUBSPECIES- AFRICANUM)
The common usage of Galium spp. in the Ethiopian traditional medicine, as described in few documentations, are generally related to diseases associated with the nervous system, the immune system, infections and inflammation. Preliminary phytochemical and antimicrobial screening on extracts of the aerial parts of Galium spurium (subspecies africanum) was done in order to partly rationalize some of ...
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1637
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF DIOSPYROS EBENUM J. KOENIG EX RETZ., LEAVES EXTRACT
Phytochemical screening and antioxidant activities with different solvents extracts of Diospyros ebenum were investigated. The phytochemical screening of this study indicated the presence of alkaloids, carbohydrates, coumarins, flavonoids, glycosides, phenols, proteins, saponins, steroids, tannins, and terpenoids. The methanolic extract of D. ebenum was significantly higher phenolic content when c...
3473
2007
PROTECTIVE EFFICACY OF THE EXTRACT OF VOLVARIELLA VOLVACEA (BULLIARD EX FRIES) SINGER. AGAINST CARBONTETRACHLORIDE INDUCED HEPATIC INJURY
Carbon tetrachloride is a xenobiotic that produces hepatotoxicity. Aqueous extract Volvariella volvacea (500, 1000 mg/kg, p.o) showed significant hepatoprotective activity against carbontetrachloride induced hepatotoxicity in rats by normalizing the levels of serum AST, ALT, ALP, LDH and total bilirubin. The extract improved the activity of Catalase (CAT), Superoxide dismutase (SOD), and hepatic g...
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HPTLC QUANTIFICATION OF N-OCTACOSANOL IN TINOSPORA CORDIFOLIA MIERS. STEM OBTAINED FROM DIFFERENT GEOGRAPHICAL SOURCES
n-octacosanol is a normolipidemic aliphatic primary alcohol obtained from the plant Tinospora cordifolia Miers. In the present study, the plant stems were collected from five accessions namely Anniyalam, Chennai, Hassan, Vishakhapatnam and Bangalore between June and August. Later a simple HPTLC method has been established for determination of n-octacosanol in methanolic extracts of all these geogr...
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AMELIORATIVE EFFECT OF CURCUMIN ON PROFENOFOS INDUCED OXIDATIVE DAMAGE OF RENAL TISSUE IN MICE
The aim of the present study is to evaluate the ameliorative effect of curcumin against profenofos induced oxidative damage of renal tissue in mice. Animals were divided into four different groups namely Group-I (control mice; NC), Group-II (NC gavaged 100µl ethanol for 30 days; EC), Group-III (NC gavaged 25mg/kg b.w profenofos for alternate 30 days; PC) and Group-IV (PC treated with 120mg/kg b.w...
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IMMUNOLOCALIZATION OF METALLOTHIONEIN IN DIFFERENT TISSUES OF FRESH WATER CATFISH, CLARIAS GARIEPINUS ON EXPOSURE TO CADMIUM
Metallothionein (MT) is a cysteine-rich protein that binds to heavy metals, and it is induced by them. The objective of this study to identify the MT protein induction/expression and localization in liver and kidney tissues (treated with 20 mg/L of CdCl2 for 72 hours) by immunohistochemical techniques and Western Blotting methods in the fresh water catfish, Clarias gariepinus. MT expression (MT-I ...
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1609
HPLC METHOD DEVELOPMENT OF AMLODIPINE BY RP-HPLC IN ITS BULK DOSAGE FORMS
A new, simple, precise, sensitive, accurate and reproducible Reverse phase HPLC method was developed and validated for the analysis of amlodipine in bulk dosage forms. The separation was conducted by using c-18 RP-HPLC coloumn, which was maintained at ambient temperature. The mobile phase consisting of Phosphate buffer and Acetonitrile (90:10v/v) was delivered at a rate of 1.5 ml/min. The anal...
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STUDY OF THERAPEUTIC OUTCOME AND MONITORING OF ADVERSE DRUG REACTIONS (ADRS) IN PATIENTS COMING TO OUTDOOR PATIENT DEPARTMENT (OPD) OF DERMATOLOGY, VENEREOLOGY AND LEPROSY IN TERTIARY CARE HOSPITAL OF NORTHERN INDIA
Introduction: Cutaneous adverse drug reactions (CADRs) associated with significant morbidity and mortality are probably the most frequent of all manifestations of drug sensitivity. Material and Methods: It was a prospective observational study where newly diagnosed patients with ADRs reporting to OPD of Dermatology, K.G.M.U, Lucknow and satisfying inclusion criteria were enrolled. The various stud...
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