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EFFECT OF VIMLIV ON LIPID PEROXIDES AND ANTIOXIDANTS IN ETHANOL INDUCED HEPATOTOXICITY IN ALBINO WISTER RATS
This study was carried out to investigate the hepatoprotective and antioxidant properties of vimliv in ethanol-induced hepatotoxicity in rats. The liver toxicity was induced by the administration of ethanol to the animals at dose of 3 g/kg orally for 35 days. During the period of vimliv was co-administered to the rats at doses of 25 and 50 mg/kg for 35 days. The levels of lipidperoxidative product...
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COMPARISON OF 7 – DAY CONCOMITANT THERAPY REGIMEN VERSUS CLASSIC TRIPLE THERAPY REGIMEN IN HELICOBACTER PYLORI ERADICATION: A RANDOMIZED CLINICAL TRIAL
There are various treatment regimens including different antibiotics and antacid medications for eradicating Helicobacter pylori to compare the effectiveness of 7-day concomitant regime with classic triple regimen in eradicating H. pylori. In this randomized clinical trial, 206 dyspeptic patients proven H. pylori infection, attended to a gastrointestinal clinic in Khorramabad (west of Iran) were s...
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FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF ATENOLOL BY USING NATURAL GUM
The recent work is based on the extraction and purification of natural gum from the bark of plant Terminalia elliptica (local name - Saaj) and the use of this gum to prepare pulsatile Drug Delivery System of Atenolol for the chronotherapy of cardiovascular diseases. Three formulations CF1, CF2, CF3 of core tablets were prepared by direct compression technique by varying concentrations of crospovid...
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CONVENTIONAL AND MICROWAVE ASSISTED SYNTHESIS OF SOME NEW DERIVATIVES OF COUMARIN CONTAINING PYRAZOLINE AND INVESTIGATION OF THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES
Pyrazoline derivatives, being used as potential medicinal agents, 3-Acetyl-2H-chromen-2one (I) was prepared by Knoevenagel condensation of salicyladehyde with ethylacetoacetate in presence of piperidine. A series of 3-[(2E)-3-substituted-prop-2-enoyl]-2H-chro men-2-one derivatives (II a-h) were prepared by Claisen-Schmidt condensation of 3-acetyl coumarin with aromatic aldehydes. Treatment of 3-su...
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STRUCTURE ELUCIDATION AND THERAPEUTIC APPLICATIONS OF ENDOPHYTIC FUNGI DERIVED BIOACTIVE COMPOUNDS OBTAINED FROM XIMENIA AMERICANA WESTERN GHATS OF KARNATAKA INDIA
The objective of the present investigation was the bioprospection of pharmaceutically vital bioactive compounds from endophytic Thielaviopsis basicola with antagonistic and antioxidant activity isolated from Ximenia americana, Western Ghats of Karnataka, India. The fresh and healthy leaves and roots of Ximenia americana were collected from the forests of Western Ghats of Karnataka, India and subme...
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MICROARRAY BASED IDENTIFICATION REVEALS ARTERIAL ANGIOTENSIN SYSTEM EXPRESSION IN HUMAN
Purpose: We studied by microarray analysis the tissue angiotensin system organization. We elucidated the expression of chymase, cathepsins D, G and angiotensin-converting enzyme (ACE), potentially involved in intraparietal angiotensin II formation and atheroma. Methods: mRNA gene expression was measured by an Affymetrix Gene Chip Human Gene 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RN...
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FORMULATION AND EVALUATION OF CLARITHROMYCIN – LOADED SELF – MICRO EMULSIFIED DRUG DELIVERY SYSTEM
Clarithromycin is a lipophilic and poorly water-soluble macrolide antibiotic which belongs to class II of the biopharmaceutics classification system. Its oral absorption and related bioavailability are dissolution rate-limited and relatively low. Subsequently, the formulation of oral clarithromycin delivery systems poses a huge challenge to the formulation scientist. Utilization of self - micro em...
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PHYSICOCHEMICAL AND PHYTOCHEMICAL ANALYSIS OF METHANOLIC EXTRACT OF LEAVES AND FRUITS OF FLACOURTIA JANGOMAS (LOUR.) RAEUSCH
Plants have been used extensively as medicine for the treatment of various ailments for centuries. The present study was conducted to analyze physicochemical and phytochemical parameters of leaves and fruit of Flacourtia jangomas (Lour.) Raeusch Physicochemical profile showed the high total ash, water-soluble ash, and acid-soluble ash content in F. jangomas leaf when compared to the fruit. The w...
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SYNTHESIS, SPECTRAL CHARACTERIZATION AND PHARMACEUTICAL IMPORTANCE OF NOVEL 4H-1, 4-BENZOTHIAZINES, AND THEIR SULFONE ANALOGUES
In recent years, synthesis and biological evaluation of novel 4H-1, 4-benzothiazines and their sulfone analogues have gained momentum due to their medicinal and industrial importance. The present article describes the synthesis of new 4H-1, 4-benzothiazines via condensation and oxidative cyclization of substituted 2-aminobenzenethiols with compounds containing active methylene groups. It is believ...
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STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND LOSARTAN POTASSIUM AND CHARACTERISATION OF ACID DEGRADANT PRODUCT OF LOSARTAN
An accurate, precise, sensitive and selective stability indicating High-Performance Thin Layer Chromatographic method has been developed and validated for simultaneous estimation of Amlodipine besylate (AML) and Losartan potassium (LOS) in bulk and pharmaceutical dosage formulation. Chromatographic separation of both the drugs was achieved by using TLC aluminum plates pre-coated with silica gel 60...
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