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IN-VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF BARK OF FICUS RACEMOSA LINN. (MORACEAE)
The plant Ficus racemosa L., is a woody large deciduous tree distributed all over India, and grows in the evergreen forest, moist localities, along with the sides of ravines and banks of streams belonging to the family Moraceae, locally know as Attimara and Hindi known as Gular. Ethnobotanically the bark used for anti-diabetic, wounds, useful in asthma and piles recommended in uropathy and treatme...
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THE IMPORTANCE OF DOMINANT HAND AT PLACEBO EFFECT OF INERT SPRAY TO MUSCULAR FATIGUE INDUCED EXPERIMENTALLY
Purpose: Placebo effect is a phenomenon where the patient's symptoms can be relieved by a false treatment in pharmacological aspects, most likely because of the patient expectations or believes that the treatment will have success. So, it is a psychological response to the treatment, without being accompanied by the improvement of physical condition. Placebo is often defined as: “Substance or pr...
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NATURAL OCCURRENCE OF MYCOFLORA AND DETERIORATION OF TOTAL ALKALOIDS AND GLYCOSIDES AMOUNTS IN STEREOSPERMUM CHELONOIDES DC. ROOTS UNDER STORAGE
In the present study, total 15 fungal species isolated from roots of drug Stereospermum chelonoides DC. such as: Fusarium solani, F. lateritum, F. semitectum, F. oxysporum, Aspergillus ochraceus, A. niger, A. terreus, Theilavia terricola, Papulaspora immerse, Scytallidium thermophilum, Didymostilbe sp., Cunningamella elegans, Aphanomyces sp., Sordaria fimicola and Mucor praini. Species of Fu...
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PHENOTYPICALLY AND GENETICALLY VARIATION OF Rif r MUTANTS STRAINS OF PSEUDOMONAS FLUORESCENCE pf2T2 AND pf2m1
The present study was Rifampicin-resistant (Rif r) mutants of Pseudomonas fluorescens pf2T2 and pf2m1 were isolated from different localities of onion plant rhizosphere soil in an around the Tamil Nadu. However, the mutants of P. fluorescens were of two general categories. Group 1 showed fast growing in terms of growth rate, competitive fitness, and membrane protein composition. Group 2 showed a s...
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IN-VITRO ANTIBACTERIAL EFFECT OF MUPIROCIN IN COMBINATION WITH THREE ESSENTIAL OILS AGAINST STAPHYLOCOCCUS AUREUS
Mupirocin is a topical antibiotic which is very effective against staphylococci, streptococci and Methicillin-Resistant Staphylococcus aureus (MRSA) infection. Because of its high effectiveness against MRSA infection, it is frequently used in clinical practice for decolonization of MRSA. Due to the increased use of mupirocin, increased resistance rates have been reported. Essential oil is a natura...
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IN-SILICO DESIGN, SYNTHESIS AND IN-VITRO ANTI-TUBERCULAR AND ANTI-MICROBIAL SCREENING OF NOVEL BENZIMIDAZOLE DERIVATIVES
The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligan...
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ASSESSMENT OF PRESCRIBING PATTERN OF ANTIEPILEPTICS IN PAEDIATRIC IN-PATIENTS OF A TERTIARY CARE HOSPITAL
Purpose: To study the prescribing pattern of AEDs for a different type of seizures in the pediatric population and disease conditions other than epilepsy and to identify the drug interactions with the use of AEDs among the study population. Methods: This six months long prospective observational study was conducted at in-patient wards of JSS Hospital. The case sheets of all in-patients were review...
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EFFECT OF METFORMIN AND ROSUVASTATIN ON ERYTHROCYTES OF PATIENTS WITH SICKLE CELL DISEASE: AN IN-VITRO STUDY
Objectives: Sickle cell disease (SCD) is a common hereditary blood disease with a progressive clinical course and multiple end organs damage. Due to its intercalated pathophysiology, several trials have been conducted targeting its pathophysiology in an attempt to modify the clinical course and minimize complications. Metformin and rosuvastatin are known to have pleiotropic effects such as antioxi...
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DEVELOPMENT OF SIMULTANEOUS SPECTROPHOTOMETRIC METHOD FOR QUANTIFICATION OF RESVERATROL AND FOLIC ACID IN AN OROGEL
A simple and precise UV-Visible spectrophotometric method for the simultaneous estimation of Resveratrol and folic acid in fixed-dose combination (FDC) has been successfully developed and validated. A suitable FDC of Resveratrol and folic acid was formulated for the treatment of oral squamous cell carcinoma. The present method involves the application of simultaneous equations (Vierodt’s method)...
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COMPUTATIONAL INSIGHTS ON ANTIVIRAL RESISTANCE MECHANISM OF HIV-1 PROTEASE WITH GS-8374
Human immunodeficiency virus type 1 (HIV-1), is an etiologic agent of the most life-threatening disease AIDS. HIV-1 protease (HIVP) is a key enzyme that performs an essential step in the life cycle of the virus. HIV-1 protease assembled as a dimer in the functional form and involved in cutting “polyprotein" into the proper protein-sized pieces. The two chains assemble to form a long tunnel cover...
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