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ASSESSMENT OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF DIFFERENT FRACTIONS OF CRUDE EXTRACT OF STEPHANIA JAPONICA STEM
The different fractions of crude methanol extract of stem of Stephania japonica (Thunb.) Miers (Menispermaceae) was screened for its analgesic and antidiarrhoeal activities. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at the dose of 250 and 500 mg/kg body weight comparable to the standard drug diclofenac sodium at the do...
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VIRTUAL TOXICITY STUDIES OF NOVEL SPIROAZETIDIN-2-ONES TETHERED WITH FURANS
Background and aim: Spiroazetidin-2-ones and furans are commonly used as anti-bacterial, anti-fungal, anti-inflammatory, cardiovascular activities, anticancer, antiparkinson agents etc. The purpose of this study was to perform virtual toxicity studies of the synthesized compounds 1-(substitutedphenyl)-3-chloro-5,9-bis(furan-2-ylmethylidene)-1-azaspiro[3.5]nonan-2-ones (3a-3h). Materials and method...
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COENZYME Q10: A POTENTIAL BREAKTHROUGH IN PHYSIOLOGICAL DYSFUNCTIONS
Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent stud...
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FORMULATION AND EVALUATION OF DERMA HEAL CREAM AGAINST WOUND AND BURN HEALING ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR ALBINO RAT
Delayed wound healing is producing a high economic burden on the society and is generally associated with Diabetes mellitus or a related complication thus needs safe treatment like herbal formulation. Dermas heal cream (an anti-diabetic ayurvedic formulation) was evaluated for wound and burn healing potential in normal and diabetic rats. The effect of Derma heal cream on wound healing has been stu...
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FIXED HEXA-HELIX: AN AMENDED QUAD HELIX FOR A COMPLIANCE DRIVEN PEDIATRIC PATIENT- A INNOVATIVE CASE APPROACH
Introduction: Early treatment in growing patient is of value as the guidance of occlusion to normalcy can shorten the treatment time in mature patients. The removable appliance is commonly used by pediatric dentist to intercept malocclusion in such patients, but it brings a major drawback with it of being compliance dependent. Fixed appliance therapy is better accepted and has better wear complian...
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SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SUBSTITUTED N-(3-FORMYL-4-OXO-4H-CHROMEN-2-YL)-N- PHENYLBENZENESULFONAMIDE AND ITS DERIVATIVES
Modification of a drug molecule of a series having optimal activity is widely used and continues to be an important factor necessary for new drug discovery. Infectious diseases which increase dramatically by resistant and multi resistant microbes are now a days the second major cause of death worldwide and the third leading cause of death in the developed countries. Although, the search for new le...
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ANTIPSORIATIC EFFECTS OF CLOBETASOL LOADED SOLID LIPID NANOPARTICLES ON IMIQUIMOD INDUCED PSORIASIS IN BALB/C MICE
The aim of the current investigation was to prepare and investigate the potential of Clobetasol (CP) loaded solid lipid nanoparticles based gel (SLN-gel) for the dermal delivery and to evaluate its anti-psoriatic efficacy by comparing with conventional ointment formulation. This study will provide an insight into the use of nanocarriers, esp. SLNs loaded with CP for the effective treatment of psor...
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FORMULATION AND EVALUATION OF CLARITHROMYCIN – LOADED SELF – MICRO EMULSIFIED DRUG DELIVERY SYSTEM
Clarithromycin is a lipophilic and poorly water-soluble macrolide antibiotic which belongs to class II of the biopharmaceutics classification system. Its oral absorption and related bioavailability are dissolution rate-limited and relatively low. Subsequently, the formulation of oral clarithromycin delivery systems poses a huge challenge to the formulation scientist. Utilization of self - micro em...
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STUDIES ON VIBURNUM NERVOSUM HOOK CHEMISTRY AND SPECTROSCOPY OF BERGENIN AND ITS DERIVATIVES
Bergenin is reported to occur in Viburnum nervosum (Capprifoliaceae). This is the first report of its occurrence in genus Viburnum. Derivative of Bergenin viz Bergenin diethyl ether, its penta acetate and diethyl ether triacetate have been prepared. Their method of preparation and characterization by spectroscopy is reported for the first time....
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STATISTICAL OPTIMIZATION FOR DEVELOPMENT OF COLON TARGETED pH DEPENDANT METRONIDAZOLE GRANULES USING FULL FACTORIAL DESIGN
The objective of this study was to evaluate and optimize Eudragit concentration and coating level on metronidazole release from granules for colon delivery using 32 full factorial design. Independent variables selected were Eudragit conc. (10, 15 and 20%) and coating level (10, 15 and 20%), the evaluated responses were percent drug release at 5 h, 24 h and time to release 50% of the drug. The diss...
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