Most Popular
TARGET BASED PHARMACOLOGICAL APPROACHES FOR DRUG DEVELOPMENT AGAINST NOVEL CORONA VIRUS (COVID-19)
The novel coronavirus (COVID-19) outbreak has covered almost 185 countries worldwide, causing infection to 32, 50,000 people and the death of approximately 2, 30,000 people to date. World Health Organisation (WHO) has declared it a pandemic that seems to be unstoppable as no vaccine or drug is available as of now to kill the virus. Several research labs are trying to develop a vaccine against the ...
3583
1523
VIRUSES AS HIJACKERS
Viruses are like hijackers. They invade living, normal cells, and replicate and create other viruses like themselves using those cells. This can destroy, harm, or change the cells and cause sickness. Various viruses in the human body invade other cells, such as the liver, respiratory system, or blood. Viruses are too small germs. Inside a protein matrix, they are made of genetic material inside of...
3583
1347
PRIMITIVE NEUROECTODERMAL TUMOR PRESENTING AS QUADRI-PARESIS: A RARE OCCURRENCE
Primary spinal cord presentation of Primitive neuroectodermal tumors (PNET) is a rare occurrence and carries poor prognosis. A 13-year-old boy presented with pain in neck region, bilateral upper and lower limb weakness and bladder and bowel dysfunction. Neurological examination revealed the marked paresis with hyporeflexia of both the upper and lower extremities. Preoperative MRI of spine revealed...
3582
1600
PHYTOCHEMICAL ASSESSMENT AND METABOLIC FINGERPRINTING OF BOERHAVIA DIFFUSA AND CEPHALANDRA INDICA FROM INDIAN SUB-CONTINENT
The medicinal plants, Boerhavia diffusa and Cephalandra indica are both perennial climbing herbs commonly used in traditional system of medicine for the treatment of several ailments because of their healing properties. The present study aimed to identify the phytochemical constituents of methanolic extracts of these plants, followed by their metabolic fingerprinting, which was carried out by HPTL...
3582
1700
PHYSICOCHEMICAL AND PHYTOCHEMICAL ANALYSIS OF METHANOLIC EXTRACT OF LEAVES AND FRUITS OF FLACOURTIA JANGOMAS (LOUR.) RAEUSCH
Plants have been used extensively as medicine for the treatment of various ailments for centuries. The present study was conducted to analyze physicochemical and phytochemical parameters of leaves and fruit of Flacourtia jangomas (Lour.) Raeusch Physicochemical profile showed the high total ash, water-soluble ash, and acid-soluble ash content in F. jangomas leaf when compared to the fruit. The w...
3581
1904
COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM105A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES
In this study, homology modeling and molecular docking studies were performed to explore structural features and binding mechanism of synthesized benzimidazole derivatives as ubiquitin inhibitors. A homology modeling procedure was employed to construct a 3D model of ubiquitin protein by using MODELLER9.15. For this procedure, the X-ray crystal structure of Gumby / fam105b in Complex with linear Di...
3580
1706
MITIGATING POTENTIAL OF ALLLIUM SATIVUM ON ARTESUNATE INDUCED RENAL TOXICITY IN MALE MICE
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antim...
3580
1470
PHYTOCHEMICAL AND PHARMACOGNOSTIC STUDIES OF TELOSMA AFRICANUM (N.E.Br) COLVILLE LEAF AND STEM
Telosma africanum (N.E.Br) Colville (Ascelpiadaceae) is a slender riverine and deciduous climber used traditionally in the treatment of venereal diseases. Using standard procedures, the pharmacognostic studies, fluorescence analysis and phytochemical screening were carried out. This study revealed the presence of combined Anthraquinone, Saponin, Cardiac glycoside, alkaloids in the leaf and ste...
3578
1789
ANTICONVULSANT STUDIES ON LEAF EXTRACT OF ERYTHRINA INDICA LAM.
To determine the anticonvulsant activity of the leaf extract of Erythrina Indica in mice and rats, and in order to verify the traditional use of the plant in the treatment of epilepsy. The pentyleneterazole (PTZ) and the maximal electroshock seizure (MES) models were used for assessing the anticonvulsant effects of the chloroform leaf extract in mice and rats. The chloroform extract (500 mg/kg p.o...
3578
1347
MOLECULAR DOCKING AND ADMET STUDIES OF BIOACTIVE COMPOUNDS OF RHIZOPORA MUCORNATA AGAINST BACTERIAL ENZYME PROTEIN TYROSINE PHOSPHATASE
Objective: The bioactive compounds of Rhizopora mucornata were docked against the bacterial enzyme protein tyrosine phosphatase to determine the potential inhibition. In this research the molecular docking analysis of drug compounds with virulent protein was studied. Material and Methods: Protein Tyrosine phosphatase is an enzyme that is being present in staphylococcus infection that plays an impo...
3577
1412