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STUDYING THE EFFECT OF DISPERSED DRUG CRYSTAL IN THE ORGANIC PHASE ON THE ENCAPSULATION BY SOLVENT EVAPORATION TECHNIQUE; (2) X-RAY DIFFRACTION AND DSC AS TOOLS TO STUDY THE MICROCAPSULE STRUCTURE IN RELATION TO THE SUGGESTED DIVISION MECHANISM
The method of entrapment of the drug in the microcapsules structure prepared with different theoretical drug content (TDC) and having different particle size ranges were studied using x-ray diffraction and DSC analysis methods. Also, in the light of the analysis methods, a trial to correlate the actual microcapsule structure with the actual drug content (ADC) and the division mechanism suggested b...
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FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF DICLOFENAC SODIUM LOADED SUSTAINED RELEASE MATRIX TABLET CONTAINING BOTH NATURAL AND SEMI-SYNTHETIC POLYMERS
Objective: The persistence of this effort was to frame, evaluate and examine the impact of natural and semi-synthetic polymer in changing the release rates of matrix tablet loaded with diclofenac sodium. Materials and method: Matrix tablets of diclofenac sodium were made-up by varying the concentrations of both natural polymer i.e Guar gum and semi-synthetic polymer i.e HPMC K4M via straight compr...
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PRIMARY FALLOPIAN TUBE ADENOCARCINOMA: A CASE REPORT
Purpose: Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles to epithelial ovarian cancer (EOC). The purpose of this study is to present a case history, treatment & review the current available literature on PFTC. Material, methods and results: Early clinical presentation and prompt investigation often lead to diagnosis at an early stage. The...
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DEVELOPMENT OF HPLC METHOD FOR DETERMINING THE FOREIGN IMPURITIES IN THE SUBSTANCE OF CARBOREN
A High-Performance Liquid Chromatography (HPLC) technique has been developed for the determining of foreign impurities in the parent substance of carboren. We have proposed the most sensitive, selective and also the universal HPLC method to be used, which would allow to conduct the qualitative and quantitative analysis under the same conditions so that to determine foreign impurities in the substa...
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SYNTHESIS AND CHARACTERIZATION OF TRANSITION METAL COMPLEXES OF N’-[(2Z, 3E)-3-(HYDROXYIMINO) BUTAN-2-YLIDENE] BENZOHYDRAZIDE
Synthesis and characterization of Co(II), Ni(II), Cu(II) and Pd(II) complexes of ligand N'-[(2Z,3E)-3-(hydroxyimino) butan-2-ylidene] benzohydrazide are reported. The ligand is monobasic and bidentate in nature. The molar conductivities reveal that all the metal complexes are non-electrolyte. The metal complexes have been characterized on the basis of spectral and magnetic studies. Co(II) ion form...
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ANALYSIS OF PROTEOMIC DIVERSITY AND CALCIUM BINDING PROTEIN(s) IN SEEDS OF HORSE GRAM (MACROTYLOMA UNIFLORUM) CULTIVARS FROM UTTARAKHAND
Proteomic study of Macrotyloma uniflorum is quite useful for exploration of its Calcium binding proteins (CBPs) and their antilithiasis character. CBPs play an important role in prevention of kidney stone formation. Considering this fact the study was design to identify CBPs in M. uniflorum. Total six samples were collected from different elevations of Uttarakhand. Total buffer soluble proteins of...
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STUDY OF POTENTIAL TO INHIBIT HEMOZOIN FORMATION OF SOME NOVEL AMINOPROPANOLS
One of the factors responsible for malaria pathogenesis is the suppression of host immune responses. This suppression enhances parasitemia and diminishes the host immune response to malaria-expressed proteins and other pathogens. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the d...
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FORMULATION AND EVALUATION OF GASTRO RETENTIVE NOVEL FLOATING IN-SITU GELLING SYSTEM OF CURCUMIN
The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 º...
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ADDING NIACIN WITH ATORVASTATIN IN PATIENTS WITH RENAL ISCHEMIA: A COMPARATIVE STUDY
The study was aimed to compare the effect of lipid lowering only through Atorvastatin and lipid lowering combined with HDL-C raise by adding Niacin on the lipid profile and renal outcomes in renovascular disease. It was prospective, analytical hospital based study. In diagnosed patients Atorvastatin (20mg) and/or in combination with Niacin Extended Release 500mg/day was prescribed randomly distrib...
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ANTIDIABETIC ACTIVITY OF PARKINSONIA ACCULEATA LINN IN RABBITS, EMPHASIS ON C REACTIVE PROTIENS
Parkinsonia acculeata is used in traditional medicine for the treatment of jaundice and diabetes. Accordingly, the present study was designed to investigate the effects of Pet ether and aqueous extracts of the leaves of Parkinsonia acculeata on glucose homeostasis in alloxan induced diabetis in rabbits. After 7 days of study it showed that Parkinsonia acculeata reduced glucose levels significantly...
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