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PREVALENCE OF MEASLES VIRUS INFECTION AMONG VACCINATED AND NON-VACCINATED CHILDREN IN NORTHERN INDIA
Introduction: Measles virus (MeV) is still a common acute illness caused by viruses belonging to the family Paramyxoviridae and genus Morbillivirus. The objective of this study was to determine the prevalence of MeV in both vaccinated and unvaccinated children and consecutively, testing the efficacy of MeV vaccination among children in north India. Materials and Methods: A total of 323 blood sampl...
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COENZYME Q10: A POTENTIAL BREAKTHROUGH IN PHYSIOLOGICAL DYSFUNCTIONS
Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent stud...
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PAEDIATRICIANS COGNIZANCE ABOUT THE DELETERIOUS EFFECT OF ANTIBIOTICS AND DENTAL CARIES – A PRELIMINARY STUDY
Aim: To evaluate pediatricians’ cognizance about the use of antibiotics and dental caries. Materials and Method: 200 Pediatricians’ who were willing to participate were selected randomly from public and private medical hospitals in South India. A pretested questionnaire was distributed to the Paediatricians’ and was personally contacted to receive the responses within a week’s time. Descri...
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COMPARISON OF 7 – DAY CONCOMITANT THERAPY REGIMEN VERSUS CLASSIC TRIPLE THERAPY REGIMEN IN HELICOBACTER PYLORI ERADICATION: A RANDOMIZED CLINICAL TRIAL
There are various treatment regimens including different antibiotics and antacid medications for eradicating Helicobacter pylori to compare the effectiveness of 7-day concomitant regime with classic triple regimen in eradicating H. pylori. In this randomized clinical trial, 206 dyspeptic patients proven H. pylori infection, attended to a gastrointestinal clinic in Khorramabad (west of Iran) were s...
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DEVELOPMENT OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF METFORMIN HYDROCHLORIDE
The aim of the present study was to formulate an osmotically controlled drug delivery system (O-CDDS) of Metformin hydrochloride to reduce the frequency of multiple dosing in non-insulin dependent diabetes mellitus-II which is a lifelong disease. Metformin hydrochloride a BCS Class-III drug having a poor biological half-life of 6 h. O-CDDS of Metformin hydrochloride is a recent approach for the ze...
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COMPUTATIONAL APPROACH FOR DESIGNING AND DEVELOPMENT OF POTENT DRUG INHIBITOR FOR APP GENE IN ALZHEIMER’S DISEASE
Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, reasoning, planning, language, and perception, and eventually even the ability to carry out the simplest tasks. Many scientists believe that Alzheimer's disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain ...
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DESIGN OF QUINOLONE DERIVATIVES AS POTENTIAL ANTIBACTERIAL USING MOLECULAR DESCRIPTORS
In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some quinolone derivatives as a potential antibacterial agent using statistical work. The regression analysis of the data has shown that the activities of the compound can be modeled excellently in bi-parametric model.A heurisimatedtic algorithm selects the best multiple line...
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LETHAL EFFECTS OF PISTACIA ATLANTICA LEAVES EXTRACT AGAINST PROTO-SCOLECES OF HYDATID CYSTS
Surgery is one of the best options to treat cystic echinococcosis (CE, hydatid cyst). To date, surgeon used different protoscolicidal drugs to eliminate of protoscoleces during CE surgery, but most of these agents have some serious side effects. The current study aims to explore the in-vitro protoscolicidal effects of Pistacia atlantica leave extract against hydatid cyst proto-scolices. Proto-sc...
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EFFECT OF SOLANUM CHRYSOTRICHUM SCHLDL. ON CELL PROLIFERATION IN VITRO
The effect of four extracts of Solanum chrysotrichum on the proliferation of bacteria, yeasts, mouse spleen cells and human transformed cells was determined. Dry leaves grounded were consecutively macerated 24 h with hexane, chloroform, methanol and water. Dilutions of 1, 10 and 100 µg/mL / DMSO were used for the assays with normal mouse spleen cells, DU-145 and MCF-7 cells. The cellular prolifer...
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A STUDY OF ETHNOMEDICINAL PLANT DIVERSITY OF SACRED NATURAL SITES OF PANCHKOSHI PILGRIMAGE OF VARANASI, UTTAR PRADESH INDIA
Introduction: Medicinal plants have always played a major role in primary health care system since time immemorial. Sacred natural sites is the prime place to encompass large medicinal plant with wide range of natural resources. It potentially conserves plant biodiversity with inclusion of sacred places and sacred water bodies. Apart from social and religious importance it, regulate air and water ...
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