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IN-VITRO EVALUATION OF ANTIASTHMATIC ACTIVITY OF FICUS RACEMOSA L. (MORACEAE)
Asthma is a disease of the human respiratory system. The different extract of bark was obtained by successive extraction with petroleum ether, butanol, ethyl acetate and alcohol by Soxhlet. These extracts were evaluated for antiasthmatic activity by using in-vitro model, i.e., spasmolytic activity in isolated guinea pig lung strip using histamine for induction of bronchoconstriction in guinea pigs...
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MECHANISM OF DRUG INDUCED RENAL FAILURE: A REVIEW
Acute renal failure (ARF) is characterized by a rapid, potentially reversible decline in renal function, including a rapid fall in glomerular filtration rate (GFR) and retention of nitrogenous waste products over a period of hours or days. The mortality rate of patients with ARF has remained 25–70% despite the use of various pharmacologic agents. Due to the multiple causes of renal failure, many...
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ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF STEPHANIA JAPONICA (THUNB.) MIERS. TENRIL IN ALLOXAN INDUCED DIABETIC MICE
The present study was carried out to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and antihyperlipidemic (Total cholesterol and triglycerides) effects of the methanolic extract of Stephania japonica (Thunb.) Miers. tenril (MSJT). The MSJT was administered orally as a dose of 250 and 500 mg/kg body weight to alloxan induced hyperglycemic rats and found to reduce blood gluco...
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HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC DETERMINATION OF COLCHICINE IN PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL FLUIDS
A simple and rapid high performance thin layer chromatographic (HPTLC) method was developed for the assay of colchicine in bulk drug, pharmaceutical preparations and biological fluids. The method has a linear range of 4 - 35 μg/ml. The limits of detection and quantification were 1 and 4 μg/ml respectively. The results obtained by the proposed method were compared statistically by means...
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EFFECT OF STANDARDIZED EURYCOMA LONGIFOLIA EXTRACT ON ROSIGLITAZONE METABOLISM IN THE OLD NORMAL MALE RAT HEPATOCYTES: A MECHANISM STUDY
Eurycoma longifolia has been widely used by society as an aphrodisiac especially in Indonesia, Vietnam and Malaysia. However, only few studies have been published related to the herb-drug interaction. Previous study showed that the standardized extract of E. longifolia affected phase I rosiglitazone metabolism especially in the old male rat hepatocytes for both diabetic and normal rats. The presen...
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SOME CONNECTIVITY INDICES AND ZAGREB INDEX OF HONEYCOMB GRAPHS
In this paper, we investigate several topological indices in honeycomb graphs: Randić connectivity index, sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, First and Second Zagreb indices and Zagreb polynomials. Formulas for computing the above topological descriptors in honeycomb graphs are given....
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IN VIVO ANTI-INFLAMMATORY ACTIVITY OF ETHYL ACETATE EXTRACT DERIVED FROM MARINE STREPTOMYCES CARPATICUS
Anti-inflammatory activity of the SC-EA extract of the marine Streptomyces carpaticus was studied in Wistar rats using acute and chronic inflammatory models like carrageenan induced paw edema and cotton pellet induced granuloma models respectively. The acute toxicity of SC-EA extract was tested on adult Wistar rats. The maximum dose of SC-EA extract at 2000mg/kg does not show any sign of visual ch...
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IMPACT OF CELL SENESCENCE ON AGE – RELATED NEURODEGENERATIVE DISORDERS: THE MECHANISM TO THERAPY- A REVIEW
Aging is a natural phenomenon; it is a well-known fact that everyone is aging as time passes. A major contributor to this process is cell senescence. Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can be due to telomere shortening is also known as end replication problem. It was first observed by Hayflick. Senescent cells ...
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ANTIDEPRESSANT ACTIVITY OF DURENTA REPENS LINN.
The pet ether and chloroform extracts of Durenta repens leaves was screened for antidepressant action in tail suspension model. Both the extracts showed antidepressant action at the dose of 200mg/kg. Chloroform extract produced significant (p<0.001) mobilisation of the animals when compared with that of the standard drug Imipramine (10mg/kg) and acts as a potent centrally acting antidepressant ...
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ANTIDIABETIC AND GLYCOGENESIS EFFECTS OF DIFFERENT FRACTIONS OF METHANOLIC EXTRACT OF MOMORDICA CHARANTIA (LINN.) IN ALLOXAN INDUCED DIABETIC RATS
The study was undertaken to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of methanolic extract of Momordica charantia. The different fractions of the extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced as well as glucose i...
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