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ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECT OF HYDRO-METHANOLIC EXTRACT OF LEAF OF ABROMA AUGUSTA IN STREPTOZOTOCIN INDUCED DIABETIC MALE ALBINO RAT
The present study was conducted to investigate protective effect of hydro-methanolic (2:3) extract of leaf of Abroma augusta in streptozotocin induced diabetic male albino rat. For this purpose animals were divided into three treatment groups (n = 6): control group, STZ induced diabetic group (STZ 4 mg / 0.1 ml citrate buffer/ 100 g body weight), hydro-methanolic extract of leaf of Abroma augusta ...
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BIOACTIVE COMPOUND IN CURCUMA CAESIA (ROXB.) FROM BASTAR AND ITS SPECTRAL ANALYSIS BY HPLC, UV-VISIBLE, FT-IR, NMR, AND ESI-MS
The increasing failures of chemotherapeutics and antibiotic resistance exhibited by pathogenic microbes have led to the screening of several medicinal plants for their potential antimicrobial activity. Thus, the present endeavour deals with the exploration of antibacterial efficacy of Curcuma caesia (Roxb.) (Family Zingiberaceae) against bacterial cultures procured from IMTECH, Chandigarh as a scr...
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DEVELOPMENT OF pH-INDEPENDENT ACRYLIC-WAX MATRIX TYPE SUSTAINED RELEASE DRUG DELIVERY SYSTEM OF ACEBROPHYLLINE
The aim of the present study was to improve commercial twice-a-day Acebrophylline formulation to once-a-day new formulation to improve patient compliances. The double-layered tablet was composed of the fast release layer (Acebrophylline 50 mg) and sustained release layer (Acebrophylline 150 mg). To develop the double-layered tablet, the fast release and sustained release layers were prepared using...
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ANTI-INFLAMMATORY ACTIVITY OF WHOLE PLANT OF POLYGALA ROSMARINIFOLIA WIGHT & ARN (POLYGALACEAE)
In the present study, Polygala rosmarinifolia whole plant was extracted with ethanol and evaluated for anti-inflammatory activity in rats using a carrageenan induced paw edema method. Ethanol extract exhibits potent anti-inflammatory activity at 200mg/kg at 3rd hr after administration is compared with reference standard drug, Indomethacin. Observed pharmacological activity in the present study pro...
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HPTLC DENSITOMETRIC QUANTIFICATION OF SECONDARY METABOLITES FROM POLYCARPAEA CORYMBOSA LAMS
Polycarpaea corymbosa has been used traditionally as medicine for the treatment of various ailments. In the present investigation an attempt has been made to quantify phenol, flavonoid and steroid in methanol extract of aerial and root parts of P.corymbosa Lam. by HPTLC method. Different compositions of the mobile phase for HPTLC analysis were tested in order to obtain high resolution and re...
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A NOVEL USE OF OXIDATIVE COUPLING REACTIONS FOR DETERMINATION OF ANTIBIOTIC AND ANTI-INFLAMMATORY DRUGS IN PHARMACEUTICAL FORMULATIONS
The present work describes new spectrophotometeric methods for the assay of four drugs namely Meropenem (MPN), Cefditoren Pivoxil (CTP), Mesalamine (MSL) and Cefdinir (CDN) in both pure form and Pharmaceutical formulations. All methods involve the oxidative coupling reaction of MPN, CTP, MSL and CDN with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in presence of Fe(III) in an acidi...
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EFFECT OF NOVEL BENZISOXAZOLE DERIVATIVES AGAINST EHRLICH ASCITES CARCINOMA CELLS IN SWISS ALBINO MICE: CYTOTOXIC AND HAEMATALOGICAL STUDIES
The present study is to investigate the cytotoxicity properties and haematological indices of synthesized molecules (S1-S4) in comparison to the standard drug 5 fluorouracil which reflects the anticancer potentials of the above molecules. Cytotoxicity studies were performed by in vitro MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyl teterazolium bromide) assay. Haematological studies were done b...
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STUDIES ON SOME BIOCHEMICAL CHANGES DURING CITRIC ACID PRODUCTION IN A SYNTHETIC MEDIUM BY A MUTANT ASPERGILLUS NIGER AB1801
An experimental study was carried out to examine the biochemical changes in the fermentation broth during citric acid production by a mutant Aspergillus niger AB1801. The production of citric acid was increased upto 8th day of fermentation, and then declined. pH decreased continuously, dry cell weight followed continuous increment pattern. Amino nitrogen and urea nitrogen decreased gradually, but ...
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QSAR STUDIES ON POLYCHLORINATED AROMATIC COMPOUNDS USING TOPOLOGICAL DESCRIPTORS
Polychlorinated dibenzo-p-dioxins(PCDDs) and Polychlorinated dibenzofurans(PCDFs) represent a large group of industrial and byproduct compound is resistance to chemical and biological degradation and highly toxic.A series of 18 PCDD and PCDF compounds is subjected to QSTR studies by using differnt molecular descripters. The dependent variable used in this study represents log(EC50) values (EC50-...
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EFFECT OF MARINE BROWN ALGA LOBOPHORA VARIEGATA (J.V. LAMOUROUX) WOMERSLEY EX E. C. OLIVEIR VARIOUS SOLVENTS EXTRACTS ON DERMATOPHYTES
We here in the report the investigation of the antifungal activity of various solvent extracts obtained from a marine brown alga, Lobophora variegata against three fungal dermatophytes, namely Candida albicans, Candida tropicalis, Trichophyton mentagrophytes and a nondermatophyte Aspergillus flavus using disc diffusion method. Among the solvent extracts tested in the investigation, only the methan...
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