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SCHWANNOMA PRESENTING AS A GYNAECOLOGICAL MASS WITH PREGNANCY- A CASE REPORT
Schwannomas are usually benign tumors that result from the proliferation of the perineural cells. Since these tumors are very rare, misdiagnosis is common. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous patt...
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STUDY OF ANTIDEPRESSANT ACTIVITY OF CHRONIC ADMINISTRATION OF TRAMADOL AND WHEN IT IS CO-ADMINISTERED WITH FLUOXETINE IN LOW DOSES IN SWISS ALBINO MICE USING DESPAIR SWIM TEST
Objective: To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods: The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as...
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SYNTHESIS NEW MOLECULARLY IMPRINTED POLYMERS FOR THE SELECTIVE ELECTRODES OF ISOPROPAMIDE FROM PHARMACEUTICAL SAMPLES
Liquid electrodes of polymers imprinted with Isopropamide (ISP) were synthesized based on precipitation polymerization mechanism. The molecularly imprinted polymer (MIP) and non-imprinted polymers (NIP) were synthesized using (ISP) as a template. In the polymerization process, 2-Hydroxyethyl meth acrylate (2-HEMA) and 2-Vinyl pyridine (2-VP) were used as monomers. Di-vinylbanzene (DVB) was used as...
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THE ROLE OF AQUEOUS EXTRACT OF CITRUS SINENSIS PEEL IN CADMIUM MEDIATED HEPATOTOXICITY
Predisposing exposures to cadmium have been implicated in hepatotoxicity, hence the search for therapeutic interventions. Thirty Wistar rats were randomly grouped into six (1-6) with 5 rats each. Group 1 received only 5mg/kg body weight (b.wt) of Cadmium Chloride (CdCl2) intra-peritoneally. Group 2 received feed and water ad libitum. Groups 3 and 4 received CdCl2 followed by low and high dose (10m...
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ASSESSMENT OF COMPLIANCE TO TREATMENT AMONG AMBULATORY ASTHMATIC PATIENTS IN A SECONDARY HEALTH CARE FACILITY IN NIGERIA
This study assessed the level of compliance using three different methods: pill count, self report and peak expiratory flow rate, in asthmatic patients attending a secondary health care facility. Self report (using a pre-tested structured questionnaire), peak expiratory flow rate and pill count were used to assess patient’s compliance and identify the factors which may be responsible for non com...
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QSAR STUDIES ON POLYCHLORINATED AROMATIC COMPOUNDS USING TOPOLOGICAL DESCRIPTORS
Polychlorinated dibenzo-p-dioxins(PCDDs) and Polychlorinated dibenzofurans(PCDFs) represent a large group of industrial and byproduct compound is resistance to chemical and biological degradation and highly toxic.A series of 18 PCDD and PCDF compounds is subjected to QSTR studies by using differnt molecular descripters. The dependent variable used in this study represents log(EC50) values (EC50-...
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STUDY OF BEHAVIOURAL RESPONSE OF AIR- BREATHING CATFISH MYSTUS CAVASIUS (HAMILTON) EXPOSED TO ELECTROPLATING INDUSTRIAL EFFLUENT CHROMIUM
In the present experiment effect of electroplating industrial effluent chromium on the behavioral responses of freshwater air-breathing cat fish Mystus cavasius was studied. The toxicity of chromium to aquatic life is strongly influenced by the form of chromium and quality of water. The two most prevalent chromium forms found in plating industry waste water are hexavalent chromium (Cr+6) and triva...
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AN IN SILICO APPROACH TO IDENTIFY NEW ANTI-HIV INTEGRASE INHIBITOR LIKE LEADS BY DOCKING STUDIES
The Human immunodeficiency virus(HIV)type-1 integrase is one of the most important target of highly active anti retrovirus therapy (HAART), due toits role to incorporate genetic information into the host DNA, so its prevention to its proper function results in very fine therapeutic effect for the treatment of all acquired immune deficiency syndrome(AIDS), extensive research work on integrase inhib...
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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AREA UNDER CURVE METHOD QUANTITATIVE ESTIMATION OF PIPERACILLIN
The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Piperacillin (Pip) with potassium hydrogen peroxo-monosulfate in alkaline medium is studied by the increase of forming product light absorbance. A scheme of peroxoacid oxidation and perhydrolysis conjugated reactions of Piperacillin by means of hydrogen peroxomonosulfate is proposed. The procedure of the quantitative analysis ...
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EVALUATION OF ANTI- INFLAMMATORY ACTIVITY OF CAPPARIS GRANDIFLORA WALL. EX HOOK. F. & THOMSON IN RODENTS
Capparis grandiflora was used to treat diarrhoea and other infective disorders in folklore. The present study aims at evaluating the action of chloroform soluble fraction, ethanol soluble fraction and ether soluble fraction of the leaves of Capparis grandiflora against inflammatory diseases. The anti-inflammatory effects were investigated by employing acute inflammatory model i.e.; carrageenan-ind...
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