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IN-VITRO EVALUATION OF ANTIASTHMATIC ACTIVITY OF FICUS RACEMOSA L. (MORACEAE)
Asthma is a disease of the human respiratory system. The different extract of bark was obtained by successive extraction with petroleum ether, butanol, ethyl acetate and alcohol by Soxhlet. These extracts were evaluated for antiasthmatic activity by using in-vitro model, i.e., spasmolytic activity in isolated guinea pig lung strip using histamine for induction of bronchoconstriction in guinea pigs...
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PHYTOCHEMICAL AND PHARMACOGNOSTIC STUDIES OF TELOSMA AFRICANUM (N.E.Br) COLVILLE LEAF AND STEM
Telosma africanum (N.E.Br) Colville (Ascelpiadaceae) is a slender riverine and deciduous climber used traditionally in the treatment of venereal diseases. Using standard procedures, the pharmacognostic studies, fluorescence analysis and phytochemical screening were carried out. This study revealed the presence of combined Anthraquinone, Saponin, Cardiac glycoside, alkaloids in the leaf and ste...
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ANALYSIS OF PROTEOMIC DIVERSITY AND CALCIUM BINDING PROTEIN(s) IN SEEDS OF HORSE GRAM (MACROTYLOMA UNIFLORUM) CULTIVARS FROM UTTARAKHAND
Proteomic study of Macrotyloma uniflorum is quite useful for exploration of its Calcium binding proteins (CBPs) and their antilithiasis character. CBPs play an important role in prevention of kidney stone formation. Considering this fact the study was design to identify CBPs in M. uniflorum. Total six samples were collected from different elevations of Uttarakhand. Total buffer soluble proteins of...
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Akt: A NEW APPROACH FOR CANCER TREATMENT
Direct genetic alterations leading to deregulated PI3K/Akt signaling are common in a significant fraction of human malignancies. Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. Nuclear Akt1 expression and Akt activation are common in cancer invasion. However, the mechanisms for this association and its causal role in invasion are uncertain....
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DESIGN AND EVLUATION OF COLLOIDAL CARRIER SYSTEM FOR ORAL DELIVERY OF ENZYME
The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...
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ASSESSING THE PREVALENCE OF DISABILITY AND ITS RELATIONSHIP WITH DEMOGRAPHIC CHARACTERISTICS OF THE ELDERLY IN ZAHEDAN CITY IN IRAN
Aging is among the phenomena more commonly discussed in world health in recent years. Disability is a good indicator to measure health status in the aging population. Accordingly, the primary objective of this study was to determine the prevalence of disability and its relationship with demographic characteristics of the elderly in Zahedan city in Iran in 2016. This is a cross-sectional descriptiv...
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ASSESSMENT OF FOOD, ETHNOBOTANICAL AND ANTIBACTERIAL ACTIVITY OF TRICHOSANTHES CUCUMIRINA L.
Trichosanthes cucumirina L., locally known as “Chachindra” among the tribal and rural mass of Similipal Biosphere Reserve (SBR) forest. Plant parts are used as ethnomedicine among inhabitants of SBR. They use the fruits, leaves, and roots against various diseases and traditional practices are continuing since long. Leaves are used against microbial infections, roots against diabetic and fruits...
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TETRACYCLINE COORDINATION COMPOUND AS ANTIMICROBIAL AGENT
The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8) MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram ...
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AN EVALUATION OF ACUTE AND SUBCHRONIC TOXICITIES OF A NIGERIAN POLYHERBAL ANTIDIABETIC REMEDY
The acute and subchronic toxicities of Nigerian polyherbal antidiabetic remedy, prepared from Gongrenema latifolium and Allium cepa (1:1) leaves was investigated in Swiss albino mice and rats of both sexes. For acute toxicity study, 1000-5000mg/kg of the combined extract were administered orally to rats and observed for 24 hours for obvious toxic symptoms and mortality. The median lethal dose of t...
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DEVELOPMENT OF Se DOPED ZnO NANOPARTICLES: ANTIMICROBIAL ACTIVITY AND IN VIVO ACUTE NANOTOXICOLOGICAL IMPACT ON SWISS ALBINO MICE
Selenium nanoparticles are attracting more and more attention due to their excellent photoelectrical characteristics and high biological activity. Selenium is also found to be effective against cancer. ZnO nanoparticles are reported to inhibit the growth of a wide range of pathogenic bacteria under normal visible lighting conditions. In this research work, we report the preparation of a set of Sel...
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