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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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58.

SYNTHESIS, CHARACTERISATION OF IMPURITY PRESENT IN THE MANUFACTURE OF LOPRAZOLAM AND STUDY OF IMPURITY PROFILE BY HPLC

The reaction of 5- (2- chlorophenyl)- 7- nitro- 3H- 1, 4-benzodiazepin-2-thione (I) with glycine (A) by means of Na2CO3 in refluxing ethanol in water gives 2-carboxymethylamino-7-nitro-5-(2-chlorophenyl)-3H-1, 4-benzodiazepine(II), which is cyclized by means of dicyclohexylcarbodiimide in methylene chloride to afford 8-nitro-(2-chlorophenyl)-1,2-dihydro-1H,4H-imidazo[1, 2-a] [1, 4]benzodiazepin-1-...

M. Joseph *, S. Alexander and A. K. Das

Department of Pharmaceutical Chemistry, Nehru College of Pharmacy, Pambadi, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).3009-20

3009-3020

3610

2274

44.

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME ARYL PIPERAZINE COMPOUNDS

In this planed research work, aryl piperazine derivatives will be synthesized because aryl piperazine currently the most important constructive block in drug discovery with positive pharmacological evaluation. A series N- (4- (benzo[d]thiazol-2-yl) phenyl)-2-[4-(aryl-substituted) piperazines-1-yl]acetamide, N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4-(arylsubstituted)piperazines-1-yl]acetamide and Synt...

D. G. Bari *, K. Saravanan and R. Ahmad

Bhagwant University, Ajmer, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4479-86

4479-4486

3610

1714

53.

FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF VERAPAMIL HYDROCHLORIDE

Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump.  As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the proced...

M. A. Shivnikar * and P. N. Bhong

Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2976-83

2976-2983

3609

1731

23.

FORMULATION AND EVALUATION OF EFFERVESCENT GRANULES PREPARED BY USING MORINGA OLEIFERA (LAM) LEAF EXTRACT

Moringa oleifera leaves, have a high antioxidant content, which is beneficial for overcoming free radicals in the body. The leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate w...

S. Amudha *, V. Vijaya Kumar, G. Sharmila and K. Pradeep

Department of Pharmaceutics, School of Pharmacy, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(4).1203-08

1203-1208

3609

2130

22.

AN IN VITRO INVESTIGATION OF SUITABILITY OF PRESS-COATED TABLETS WITH HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE (HPMCAS) AND SODIUM ALGINATE IN OUTER SHELL FOR COLON TARGETING

The aim of present study was to develop a new colon targeting formulation, which can minimize the escape of Mesalazine completely in upper gastro-intestinal tract and ensure availability of maximum amount of drug to achieve the desired site i.e. distal colon. The use of press coated tablets with Hydroxypropylmethylcellulose acetate succinate (HPMCAS) and sodium alginate in outer shell was investig...

Krishnakumar Devrao Lone* and Jyoti Arjunrao Dhole

Lecturer in Pharmaceutics , JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2244-51

2244-2251

3608

1383

47.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZO THIAZOLE CHALCONES AS ANTIOXIDANT AGENT

A series of condensed Imidazo [2, 1-b] [1,3] thiazole Chalcones have been synthesized by Claisen–Schmidt condensation reaction. Imidazo thiazole Chalcones are associated with immense biological activities. Novel Imidazo thiazole-based chalcones were synthesized using Imidazo thiazole-3-carboxaldehydes and various acetyl ketones in PEG-400. The structures of the compounds were characterized by I...

V. Sonawane *, D. Hiwarale, B. Sonawane, S. Kamble, K. Sonawane and R. Bhosale

Smt. Kusumtai Rajarambapu Patil Kanya Mahavidyalaya Islampur, Walva, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2439-46

2439-2446

3608

1982

52.

ROLE OF VITAMINS ON LEAD INDUCED ALTERATIONS IN DEVELOPING TESTIS OF SWISS MICE

Aim: The aim of the present study was to evaluate lead toxicity on the male reproductive system during developing period of neonates. Methods: Histopathological alterations were observed in testis of neonates on PND 1 and PND 21. Lead acetate was administered via oral gavaging at 320 mg/kg BW to pregnant Swiss mice from 10th day of gestation upto 21st day of lactation. OralExposure of 160 mg/kg...

Ragini Sharma and Umesh Garu

Environmental and Developmental Toxicology Research Laboratory, Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4488-93

4488-4493

3607

1513

39.

INVESTIGATION FOR POTENTIAL EFFECT OF NYCTANTHES ARBORTRISTIS IN EXPERIMENTALLY INDUCED ASTHMA

Aim of study: In this study, we investigate the potential effect of Nyctanthes arbortristis leaf extract in experimentally induced asthma in rats. The leaf has shown the prominent effect against the inflammation. Materials and methods: Asthma was induced experimentally in rats using Sephadex and in another model croton oil was applied on ear of rats; this model also mimics the biological event ...

M.M. Meshram , R.S. Sahane* S.B. Rangari , S.P. Ingale

Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(11).4322-31

4322-4331

3607

1376

43.

ESTIMATION OF MACRO AND MICRO NUTRIENTS CONTENT IN THE LEAVES OF MURRAYA KOENIGII (L.) SPRENGE

The macro and micro nutrients content estimation was carried out for leaves of indigenous medicinal plant Murraya koenigii (L.) Sprenge collected from different places of North Karnataka region viz. Bidar, Kalaburagi, Shahapur, Sandur and Kappathgudda. About few kg of leaves of Murraya koenigii (L.) Sprenge plant material was collected and then they were washed in deionized water to eliminate cont...

M. Pattar, S. S. Teerthe and B. R. Kerur *

Department of Physics, Gulbarga University, Kalaburagi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3926-32

3926-3932

3607

1371

58.

EVALUATION OF IN-VITRO ANTI-OXIDANT ACTIVITY OF SOME SYNTHESIZED NOVEL L-ARGININE ANALOGUES

A series of novel L-arginine analogues were synthesized and screened for in-vitro anti-oxidant activity by Nitric oxide (NO) scavenging and 1-1-diphenyl-2-picrylhydrazyl (DPPH) scavenging methods. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for in-vitro anti-oxidant activity by NO...

S. K. Arifa Begum , M.Madhuri , A.Rajani and K. Hemamalini *

Associate Professor & HOD, Department of pharmacology, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2051-54

2051-2054

3606

1774