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ISOLATION, PURIFICATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM STACHYTARPHETA URTICIFOLIA (SALISB.) SIMS
Natural products from various medicinal plants, in the form of pure compounds or standardized extracts, which provide unlimited opportunities for discovery of new drug leads, is due to the unmatched availability of chemical diversity. There is an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, interest, particularly in edible plants,...
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pH RESPONSIVE CASEIN MICROPARTICLES AS A CARRIER FOR METHOTREXATE
Casein microparticles cross linked with glutaraldehyde were prepared by steric stabilization process and the controlled release of drug from the particles were evaluated in-vitro. Casein is a natural biopolymer present abundantly in milk is utilized because of its biocompatibility through oral route. Methotrexate loaded Casein microparticles of size 0.5 to 5 µm were prepared. The release of metho...
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A STUDY OF NEUROBEHAVIORAL AND BIOCHEMICAL ACTIVITIES OF ACORUS CALAMUS LINN. ON RESTRAINT STRESSED WISTAR RATS
Life span of human, a gradually increase can occur with change in diet and life style which play an important role in delay or even block the progression of age related degenerative problems like dementia, alzheimer’s disease. Exposure to various stress is the emerging greatest challenge to the society recent years. The ill-effect of stress is release of oxidants which is found to be always asso...
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IDENTIFICATION OF E.COLI NISSLE 1917 PROTEINS BY USING 2-D GEL ELECTROPHORESIS UNDER THE INFLUENCE OF COCOS NUCIFERA SAP AND WINE
Proteomics is the large scale study of proteins. Before going to analyse the differentially expressed proteins, through 2-D gel electrophoresis the proteins were extracted in a sample under stress. In the present study, we were isolated the protein samples of E. coli Nissle 1917 treated with cocoti sap and wine stress. The isolated proteins washed with 2-D clean up kit because it was very sensit...
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ROLE OF VITAMINS ON LEAD INDUCED ALTERATIONS IN DEVELOPING TESTIS OF SWISS MICE
Aim: The aim of the present study was to evaluate lead toxicity on the male reproductive system during developing period of neonates. Methods: Histopathological alterations were observed in testis of neonates on PND 1 and PND 21. Lead acetate was administered via oral gavaging at 320 mg/kg BW to pregnant Swiss mice from 10th day of gestation upto 21st day of lactation. OralExposure of 160 mg/kg...
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TISSUE CHLOROQUINE LEVELS IN DIABETIC RATS
Diabetes mellitus is a disorder of metabolism resulting from insulin abnormality. Tissue levels of chloroquine in diabetes were investigated. Few diseases have such plural effects in the body as diabetes mellitus. Chloroquine distribution in the tissue and blood was investigated in diabetic rats to a certain how diabetes mellitus affects the levels of chloroquine in tissues and blood. This may pro...
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SYNTHESIS AND STUDY OF ANALGESIC, ANTI-INFLAMMATORY ACTIVITIES OF BIS (INDOLYL) METHANES (BIMs)
Gastro-intestinal (GI) toxicity is the common adverse effect which has been associated with most of NSAIDs available in the market. So the search for new therapeutic agents with high margin of safety and freedom from normally associated GI toxic effects has been a priority of pharmacologists and pharmaceutical industries. There are virtually limitless series of structurally novel heterocyclic comp...
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VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS
The voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetr...
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INVESTIGATION FOR POTENTIAL EFFECT OF NYCTANTHES ARBORTRISTIS IN EXPERIMENTALLY INDUCED ASTHMA
Aim of study: In this study, we investigate the potential effect of Nyctanthes arbortristis leaf extract in experimentally induced asthma in rats. The leaf has shown the prominent effect against the inflammation. Materials and methods: Asthma was induced experimentally in rats using Sephadex and in another model croton oil was applied on ear of rats; this model also mimics the biological event ...
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COMPARATIVE ANTIANXIETY POTENTIAL OF EUPHORBIA NERIIFOLIA LINN. LEAVES AND EUPHORBIA HIRTA LINN. AERIAL PARTS
Euphorbia neriifolia and Euphorbia hirta have been traditionally used for relieving anxiety and other nervous disorders. The present study was designed to evaluate and compare the antianxiety activity of E. nerrifolia leaves and E. hirta aerial parts using elevated plus maze model. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of both the plants were prepared and evaluated f...
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