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COMPARISON OF EFFICACY OF FIVE VARIOUS COMMERCIAL PRODUCTS OF CIPROFLOXACIN AGAINST STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA
A study was undertaken to evaluate the efficacy of five various commercial products of ciprofloxacin (a broad spectrum antibiotic), manufactured by different pharmaceutical companies. The drug was evaluated for their performance based on equivalent MIC breakpoint, which is a measure of efficacy of drugs against Staphylococcus aureus ATCC6538 and Pseuomanas aeruginosa ATCC25668 when tested in vitro...
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MAPPING OF NATURAL KAPOSI SARCOMA INHIBITOR USING NETWORK BIOLOGY APPROACH
Identification of protein-ligand interactionnetworks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics. In this study we have developed a novel computational strategy to identify ligand binding profiles of proteins across gene families and applied it to predi...
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HPLC METHOD DEVELOPMENT OF AMLODIPINE BY RP-HPLC IN ITS BULK DOSAGE FORMS
A new, simple, precise, sensitive, accurate and reproducible Reverse phase HPLC method was developed and validated for the analysis of amlodipine in bulk dosage forms. The separation was conducted by using c-18 RP-HPLC coloumn, which was maintained at ambient temperature. The mobile phase consisting of Phosphate buffer and Acetonitrile (90:10v/v) was delivered at a rate of 1.5 ml/min. The anal...
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EXTRACELLULAR LIPASE FROM BACILLUS SUBTILIS KUBT4: ISOLATION, IDENTIFICATION AND CHARACTERIZATION
Lipases occupy a prominent place amongst biocatalysts as they can hydrolyze fats into fatty acids and glycerol at the water-lipid interface. Lipase production is a prime area of interest for microbiologists, process engineers, and biochemists. Recent advances in green energy have led to renewed interest in the ability of microbial lipases to catalyze trans-esterification reaction for biodiesel pro...
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PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITIES OF SOME WILD MEDICINAL PLANTS OF THE WESTERN MEDITERRANEAN COASTAL REGION, EGYPT
Four wild plant species (Chrysthanthemum cornarium, Capparis spinosa, Carthamus lanatus, Haplophyllum tuberculatum) were investigated for their antioxidant activity, phenolic and flavonoid contents of their methanolic extracts. The antioxidant activity of the extracts was assessed their free radical scavenging properties using DPPH. Total phenolics and total flavonoids were detected by spectrophot...
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BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND ZN(II) COMPLEXES WITH SCHIFF BASE 4, 4-(1, 4-PHENYLENE BIS(AZAN-1-YL-1- YLIDENE)) BIS(METHAN-1-YL-1-1-YLIDENE)-1, 2-DIOL. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
Condensation reaction of 1, 4-phenylene diamine and Protochatechu aldehyde in 1:2 molar ratio resulted in the formation of new Schiff base ligand 4, 4-(1,4-phenylene bis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-1-ylidene)-1, 2-diol; (H4L) .From the direct reaction of the ligand (1) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II)nitrates in 2M:1L molar ratio, the five new neutral comp...
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DEVELOPMENT OF MALTODEXTRIN BASED PRONIOSOMES DERIVED NIOSOMES OF OFLOXACIN
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes,...
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IDENTIFICATION OF HEAVY METAL TOXICITY INDUCED BIOMARKERS AND THE PROTECTIVE ROLE OF ASCORBIC ACID SUPPLEMENTATION IN CHANNA PUNCTATUS
Arsenic and mercury are presently the most common pollutants of freshwater bodies. There is a continuous increase in the toxic level of these pollutants with some seasonal changes, affecting the aquatic biota. The present study aimed to identify cellular biomarkers of arsenic and mercury toxicity in freshwater fish Channa punctatus. Antioxidant defense like catalase (CAT), superoxide dismutase (SO...
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FABRICATION AND COMPARATIVE EVALUATION OF CURCUMIN AND PACLITAXEL- LOADED SOLID LIPID NANOPARTICLE; THE PATHWAY OF EFFECTIVE CANCER THERAPY
The objective of the present study is to develop, evaluate and compare potent phytoconstituents of curcumin loaded solid lipid nanoparticles (CUR-SLN) and Paclitaxel loaded solid lipid nanoparticles (PTX-SLN) for the treatment of malignancy. Curcumin is an active phenolic compound of Curcuma longa as a promising phytoconstituent has been extensively studied over the past several years. The result ...
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SYNTHESIS, CHARACTERIZATION AND NUCLEASE ACTIVITY OF AU (III) – COMPLEXES OF BIACETYL MONOXIME THIOSEMICARBAZONE (BAMOT) AND SUBSTITUTED THIOSEMICARBAZONES
Metal complexes of Au(III) with Thiosemicarbazone and Substituted Thiosemicarbazones different thiosemicarbazones have been synthesized. The present communication reports the structural study of the Au(III) complexes with Biacetyl Monoxime Thiosemicarbazones and these complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physicochemical and spe...
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