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A STUDY OF ANTIMICROBIAL PRESCRIPTION PATTERN IN THE EAR, NOSE AND THROAT INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL, RAJKOT
Introduction: The ear, nose and throat (ENT) infections can be caused by a variety of microorganisms such as bacteria, fungi and viruses. Their treatment involves the use of appropriate antimicrobial agents and inappropriate use is closely linked to antibiotic resistance. Hence, present study was planned to evaluate the prescribing pattern of antimicrobials in the ENT outpatient department of a te...
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BULK AND SURFACE PROPERTIES OF TIN BASED HERBAL DRUG DURING ITS PREPARATION: FINGERPRINTING OF THE ACTIVE PHARMACEUTICAL CONSTITUENT
The Tin based herbal drug (Vangaparpam - a Siddha system of Medicine) has been widely used for the treatment of urinogenital infection and Arthritis. It was prepared by ten sequential stages of calcinations of the medicinally purified tin along with Aloe vera extract. In this study we analysed samples from various stages of preparation using analytical techniques viz., Fourier Transformed Infrared...
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NATURAL ANTIOXIDANT (FLAVONE GLYCOSIDE) FROM SESBANIA ACULEATA PERS. AND ITS POTENTIAL ACTIVITY
This paper deals with the significance and importance of medicinal plants.New flavone glycoside A, m.p. 222-224oC, m.f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Sesbania aculeata Pers. along with three known compounds Kaempferol 3-O-a-L-rhamnopyranosyl-(1®2)-b-D-glucopyranoside, (B) and Mearnsetin-3-O-a-L-rhamnopyranoside (C) Gehuain(isoflavone) (D). The compound A was ch...
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DESIGN, FORMATION AND EVALUATION OF A CO-DRIED DIRECTLY COMPRESSIBLE EXCIPIENT “TSAG-15” AND ITS UTILIZATION IN THE FORMULATION OF A RAPID RELEASE-MOUTH DISINTEGRATING ASCORBIC ACID TABLETS
A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using...
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SYNTHESIS AND ANTIMICROBIAL STUDIES OF SOME NEW HALOGENATED ISOXAZOLINE DERIVATIVES
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this rea...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 3, 6- DISUBSTITUTED IMIDAZO [2, 1-B] [1, 3] THIAZOLES
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method aga...
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PHYTOCHEMICAL, ANTIOXIDANT, ANTIBACTERIAL ACTIVITIES OF NERVILIA CROCIFORMIS (ZOLL. & MORITZI) SEIDENF. AND NERVILIA INFUNDIBULIFOLIA BLATT. & MC CANN (ORCHIDACEAE) COLLECTED FROM KASARGOD DISTRICT, KERALA, INDIA
The whole plant extracts of N. crociformis and N. infundibulifolia was analyzed by priliminary phytochemical, total phenolics, flavonoid, carbohydrate and alkaloid content by standard methods. In-vitro antioxidant DPPH assay and Phosphomolybdenum assay developed by Braca et al., Prieto et al., respectively. In-vitro antibacterial (agar well diffusion) activity by gram negative Pseudomonas aerogino...
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PHYTOCHEMICAL SCREENING AND HPTLC FINGERPRINTING PROFILE OF STEM BARK EXTRACTS OF MAYTENUS EMARGINATA
Objective: To establish the preliminary phytochemical screening and fingerprint profile of stem bark Extracts of Maytenus emarginata by using high-performance thin layer chromatography (HPTLC) technique. Methods: Preliminary phytochemical screening was done, physical constants were evaluated, and HPTLC studies were carried out. CAMAG make HPTLC system equipped with Linomat 5 applicator, TLC scanne...
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VALIDATION THROUGH RE-DOCKING, CROSS-DOCKING AND LIGAND ENRICHMENT IN VARIOUS WELL-RESOLUTED MAO-B RECEPTORS
Molecular docking is one of the most utilized in silico techniques, which drastically reduces the cost and the time needed for the design of novel drugs. Recently, the tremendous growth of resolved crystallographic MAO-B structures, together with the rapidly rising computing power, has resulted in accelerated and moderately correct docking studies. However, initial validations of the docking proto...
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PHARMACOLOGICAL ACTIVITY OF SILVER NANOPARTICLES SYNTHESIZED USING STEMODIA VISCOSA AQUEOUS EXTRACT
The Pharmacological effects of silver nanoparaticle of Stemodia viscosa aqueous plant extract on albino wistar rats was explored. The plant extract 40 ml was added to 10 ml of 10mM silver nitrate aqueous solution and kept at room temperature for synthesizing silver nanoparaticle. Diabetes was induced in overnight fasted mice by single intra-peritoneal injection of 55 mg/kg of Streptozotozin (STZ),...
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