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ANATOMICAL AND HISTOCHEMICAL CHARACTERISTICS OF MORINDA CITRIFOLIA L. (RUBIACEAE)
Morinda citrifolia (L.) is an important medicinal plant belonging to the family Rubiaceae and commonly known as “Noni” in Tamil was highly distributed in South India. The aim of this research is to understand the concept and techniques of anatomical and histochemical localization of secondary metabolites in Morinda citrifolia (L.) as well as take part in the standardization of herbal medicine....
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A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DICYCLOMINE AND ETHYL MORPHINE IN BULK AND PHARMACEUTICAL FORMULATION
The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitri...
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STUDIES ON FORMULATION AND EVALUATION OF BILAYERED TABLETS OF CURCUMIN
Bilayer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of the successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The bi-layered tablet is a very different asp...
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PHARMACOLOGICAL ACTIVITIES OF MUNTINGIA CALABURA: AN OVERVIEW OF THE LAST LUSTRUM
Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of ...
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ROLE OF BISOPROLOL ADDING TO ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR AND FUROSEMIDE COMBINATION ON THE LEFT VENTRICULAR FUNCTION IN SYSTOLIC HEART FAILURE PATIENTS
Background: β-blocker is an established therapeutic strategy for stage C systolic heart failure based on the American Heart Association guideline, nonetheless limited studies analyzed the role of β-blocker primarily Bisoprolol adding to ACE inhibitor and furosemide combination on the left ventricular function in systolic heart failure patients. Objectives: This study was designed to analyze t...
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AN INVESTIGATION OF ACOUSTIC, THERMODYNAMIC AND ANTIMICROBIAL ACTIVITY STUDY OF A DRUG IN A PEPTIDE
Peptides are recognized for being highly selective efficacious and at the same time, relatively safe and well tolerated. Consequently, there is an increased interest in peptides, in pharmaceutical research and development (R&D) and approximately 140 peptide therapeutics are currently being evaluated in clinical trials. Ultrasonic is an area of intense scientific and technological research, sci...
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EVALUATION OF DATE PALM POLYSACCHARIDE (DPP) AS A BIOMUCOADHESENT AND ITS COMPARISON WITH VARIOUS MUCOADHESIVE POLYMERS
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physi...
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MOLECULAR DOCKING STUDIES OF INDENOISOQUINOLINE DERIVATIVES WITH DNA-TOPOISOMERASE I COMPLEX
The aim of the present study is to find the effectiveness of two series of indenoisoquinolines compounds against cancer. Topoisomerase I (Top 1) an essential enzyme that participates in the processes associated with separation of DNA strands and manages the super helical tensions through the transient breakage of one strand of duplex DNA, monitored by the unwinding of supercoiled DNA. The Top 1-DN...
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AN INVESTIGATION OF IN-VITRO RELEASE OF RABEPRAZOLE SODIUM FROM PULSATILE RELEASE TABLETS CONTAINING HPMC-EC BLEND AS TIME LAGGED PRESS COATING
To develop new pulsatile release tablets of Rabeprazole sodium (RS), that can suppress drug release in stomach and release the drug rapidly after a predetermined lag time for about 4 h in intestine, a multiple unit dosage forms was designed that contain, drug-containing core, a coating to achieve time lag in drug release and an outermost acid resistant enteric coating. Time lagged press coating wa...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-(4-FLUORO BENZYLTHIO)-N-(SUBSTITUTED PHENYL)PYRIMIDINE-4-AMINES
Reaction of 4-fluorobenzylchloride with 2-thiouracil (1) gave 2-(4-fluorobenzylthio)pyrimidin-4(3H)-one (2), which on chlorination with POCl3 furnished 4-chloro-2-(4-fluorobenzylthio)-4-chloropyrimidine (3). This intermediate when treated with various substituted anilines gave desired targeted compounds 4(a-k) in 50-90% yield. Structural assignments of the synthesized compounds were based on their...
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