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DESIGN OF EXPERIMENT UTILIZATION TO DEVELOP AND VALIDATE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUE FOR ESTIMATION OF SERTACONAZOLE NITRATE
A novel method of estimation and validation of Sertaconazole nitrate (SER) by Reverse Phase-High Performance Liquid Chromatography coupled with Ultra-violet detection was developed which had high potential in determining drug concentration with more precision and high accuracy. The process of elution was conducted using Phenomenex C18 (250 mm × 4.6 mm i.d., 5.0 μm) using 0.01M monobasic sodium p...
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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SAXAGLIPTIN AND DAPAGLIFLOZIN IN BULK AND DOSAGE FORM
Objective: In the present work, A Simple, rapid, sensitive, precise, and reproducible, specific UV spectrophotometric method for the determination of Saxagliptin (SAXA) and Dapagliflozin (DAPI) in bulk drug and pharmaceutical dosage form were developed and validated. Methods: A simple double beam UV spectrophotometric method has been developed and validated with different parameters such as linear...
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TISSUE CHLOROQUINE LEVELS IN DIABETIC RATS
Diabetes mellitus is a disorder of metabolism resulting from insulin abnormality. Tissue levels of chloroquine in diabetes were investigated. Few diseases have such plural effects in the body as diabetes mellitus. Chloroquine distribution in the tissue and blood was investigated in diabetic rats to a certain how diabetes mellitus affects the levels of chloroquine in tissues and blood. This may pro...
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THE EFFECT OF HYRDRAZIDE GROUP ON THE OXYDATION OF FERROCENE AT TWO DIFFERENT ELECTRODES USING ROTATING DISK ELECTRODE (RDE) IN ORGANIC MEDIUM
Through this work we adopted Rotating Disk Electrode (RDE) Voltammetry to study the kinetics of oxidation and the effect of hydrazide group on ferrocene in organic medium. Thus, two different electrodes (Pt and Gc) were used in ordre to determine this latter. According to the ferrocene taken as a witness the hydrazide group related to the ferrocene made oxydation more difficult. This ferrocenic de...
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PHARMACOLOGICAL ACTIVITY OF SILVER NANOPARTICLES SYNTHESIZED USING STEMODIA VISCOSA AQUEOUS EXTRACT
The Pharmacological effects of silver nanoparaticle of Stemodia viscosa aqueous plant extract on albino wistar rats was explored. The plant extract 40 ml was added to 10 ml of 10mM silver nitrate aqueous solution and kept at room temperature for synthesizing silver nanoparaticle. Diabetes was induced in overnight fasted mice by single intra-peritoneal injection of 55 mg/kg of Streptozotozin (STZ),...
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SYNTHESIS AND STUDY OF ANALGESIC, ANTI-INFLAMMATORY ACTIVITIES OF BIS (INDOLYL) METHANES (BIMs)
Gastro-intestinal (GI) toxicity is the common adverse effect which has been associated with most of NSAIDs available in the market. So the search for new therapeutic agents with high margin of safety and freedom from normally associated GI toxic effects has been a priority of pharmacologists and pharmaceutical industries. There are virtually limitless series of structurally novel heterocyclic comp...
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SELF-ASSEMBLED LIPID NANOTUBES, NANOSHEETS AND NANOPIPES
Three N,N’-diacyl-2,6-diaminopyridines were synthesized with a saturated undecanoic acid or an unsaturated undecenoic acid in order to study the effect of the alkyl-chain on the nano architectures. The imaging studies showed that the compound possessing two unsaturated alkyl chains exhibited a tubular structure. On the other hand compound possessing two saturated alkyl chain showed poorly formed...
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PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF AQUEOUS EXTRACT OF THE AERIAL PARTS OF VIBURNUM PUNCTATUM BUCH. – HAM. Ex. D. DON
The genus Viburnum punctatum Linn. Under the family Caprifoliaceae (formerly) and Adoxaceae (currently) consists of about 200 species throughout the world. Many of these species have been recognized for their medicinal properties from very early times of this century. The aerial parts of Viburnum punctatum was collected from Nilgiri hills, Tamilnadu, India and was authenticated by Dr. A. B. Rema...
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FORMULATION AND EVALUATION OF DILTIAZEM HCl FAST DISSOLVING TABLETS USING DIFFERENT CO-PROCESSED EXCIPIENTS BY DIRECT COMPRESSION METHOD
The aim of present work was to prepare Diltiazem HCl Fast Dissolving tablets by Direct compression method because of their convenience in administration and suitability for patients having dysphagia using Co-processed excipients - Disintequik MCC25, Disintequik MCC, Lubritose MCC, Lubritose SD, Lubritose AN, NF Fast flo Lactose Monohydrate modified spray dried. The Prepared powdered blend and tabl...
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SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NOVEL SEMICARBAZONE DERIVATIVES CONTAINING QUINOXALINE MOIETY
Various 1-(substituted benzylidene)-5-(3-hydroxyquinoxaline-2-yl) carbonohydrazide were synthesized starting from orthophenylenediamine. Structures of all the compounds were confirmed on the basis of spectral analyses. All the newly synthesized compounds were screened for anticonvulsant activity. Some of the compounds showed significant anticonvulsant activity with no neurotoxicity....
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