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PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ETHANOLIC EXTRACT OF THE ARTOCARPUS HIRSUTUS LAM. LEAVES
Artocarpus hirsutus Lam. is a common plant with a variety of folk medicinal value. The present study was conducted to evaluate the phytochemical and pharmacological properties of the ethanolic extract of Artocarpus hirsutus. The screening for various phytochemicals was conducted by using various standard procedures. Acute toxicity of the extract was determined by using OECD guidelines 423. The ant...
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SPAN 40/TWEEN 80-BASED SOYBEAN OLEOGELS: MODELING OF GELATION KINETICS AND DRUG RELEASE
Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80-based soybean oleogels for topical appli...
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DASHAMULARISHTA: PHYTOCHEMICAL AND ANTIMICROBIAL SCREENING AGAINST EFFECT OF ENVIRONMENTAL POLLUTION
Pollution have a serious impact on human health and environment. The incidences of various diseases are becoming prominent with the increase in rate of population. The diseases mainly include respiratory disorders, cardiovascular disorders, throat inflammation, skin infections etc. In the present study, widely claimed crude drug Dashamularishta, have been screened for their antibacterial activit...
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A REVIEW ARTICLE ON ANTIOXIDANT PROFILE OF BLUE TEA POLYPHENOLS IN THE TREATMENT OF VARIOUS DISEASES
Clitoria ternatea (Blue tea) is a traditional medicinal plant belonging to family Fabaceae having generous amount of anthocyanins which possess majorly antioxidant properties. It contains wide range of phytoconstituents such as triterpenoids, flavanol glycosides, tannins, alkaloids, amino acids, proteins, ternatins (poly acylated anthocyanins) and carbohydrates etc. According to the data obtained ...
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NIGELLA SATIVA AMELIORATES OXIDATIVE STRESS INDUCED BY DIETHYL PHTHALATE – AN IN VITRO STUDY
The present experiment was designed to assess oxidative stress, if any, caused by diethyl phthalate and its amelioration by Nigella sativa seed extract. For this, the liver and kidney homogenates were treated with different concentrations (10-40 µg/mL) of DEP with or without Nigella sativa seed extract. Lipid peroxidation, a marker for oxidative stress along with total protein content was analyze...
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ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF STEPHANIA JAPONICA (THUNB.) MIERS. TENRIL IN ALLOXAN INDUCED DIABETIC MICE
The present study was carried out to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and antihyperlipidemic (Total cholesterol and triglycerides) effects of the methanolic extract of Stephania japonica (Thunb.) Miers. tenril (MSJT). The MSJT was administered orally as a dose of 250 and 500 mg/kg body weight to alloxan induced hyperglycemic rats and found to reduce blood gluco...
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SYNTHESIS OF QUINAZOLINONE DERIVATIVES AND THEIR ANTIMICROBIAL EVALUATION
Some new series of 3-(4-substituted-phenyl)- 2-thioxo-2,3-dihydroquinazolin-4(1H)-one, 3-(4-substituted-phenyl)-2-(methylthio)quinazolin-4(3H)-one and 3-(4-substituted-phenyl)-2-hydrazinylquinazolin-4(3H)-one were synthesized by cyclization of 4-substituted-phenylcarbamodithioate with methyl anthranilate followed by reaction with dimethylsulphate and then prepared compound was refluxed with hydr...
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CONCEPTS OF ANTI-HIV THERAPY & ITS APPLICATIONS IN RESOURCE POOR SETTINGS
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...
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STUDY OF ELECTRODE KINETICS AND THERMODYNAMIC PARAMETERS OF TINIDAZOLE POLAROGRAPHYCALLY
The electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at di...
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MECHANISM OF DRUG INDUCED RENAL FAILURE: A REVIEW
Acute renal failure (ARF) is characterized by a rapid, potentially reversible decline in renal function, including a rapid fall in glomerular filtration rate (GFR) and retention of nitrogenous waste products over a period of hours or days. The mortality rate of patients with ARF has remained 25–70% despite the use of various pharmacologic agents. Due to the multiple causes of renal failure, many...
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