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TREATMENT EFFECT OF ALCUREMON PREPARATION ON ETHANOL-INDUCED NEUROTRANSMITTERS IMBALANCE AND ALCOHOLIC LIVER DISEASE IN RATS
Alcohol use disorders (AUDs) recognized as substantial public health problem. It is grown-up many risk factors influence on alcoholism including social, behavior, an environment, and heredity conditions on the global. Alcuremon preparation was based on medicinal herbs and used for the treatment of alcohol-related disease and alcoholic liver disease in traditional Mongolian medicine. Male Wistar ra...
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A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ANTI-VIRAL CLASS OF ELBASVIR AND GRAZOPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM
Objective: To develop accurate, precise stability indicating a method for simultaneous estimation of Elbasvir and Grazoprevir in bulk and pharmaceutical dosage form. Materials and Methods: Simple, rapid, precise, sensitive and reproducible validated stability-indicating Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the quantitative analysis of Elbasvir and Grazoprevir i...
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PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEAF EXTRACT PREPARED BY SOXHLET EXTRACTION OF SELECTED MEMBERS OF APOCYNACEAE
The present study aimed to understand, phytochemistry and antioxidant property of five members belonging to Apocynaceae, Catharanthus roseus (L) G. Don; Plumeria alba L.; Pentalinon luteum (L) B. F. Hanson & Wunderlin; Rauvolfia tetraphylla L and Nerium oleander L. The preliminary phytochemical analysis was carried out using the methanolic extract for protein, carbohydrate, alkaloids, phenol, ...
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NATURAL ANTIOXIDANT (FLAVONE GLYCOSIDE) FROM SESBANIA ACULEATA PERS. AND ITS POTENTIAL ACTIVITY
This paper deals with the significance and importance of medicinal plants.New flavone glycoside A, m.p. 222-224oC, m.f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Sesbania aculeata Pers. along with three known compounds Kaempferol 3-O-a-L-rhamnopyranosyl-(1®2)-b-D-glucopyranoside, (B) and Mearnsetin-3-O-a-L-rhamnopyranoside (C) Gehuain(isoflavone) (D). The compound A was ch...
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SYNTHESIS AND ANTIMICROBIAL STUDIES OF SOME NEW HALOGENATED ISOXAZOLINE DERIVATIVES
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this rea...
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ANTIHYPERLIPIDEMIC EFFECT OF REOSTO, A HERBOMINERAL FORMULATION IN TRITON INDUCED HYPERLIPIDAEMIC RATS
In the present study, an aqueous extract from a marketed mineralo-herbal preparation Reosto was evaluated for its hypocholesterolaemic and hypertriglyceridemic activities using Triton WR-1339 induced hyper- lipidemic rats as experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton (200 mg/kg body weight). The animals were divided into control (CG), hyperlipidemic (HG...
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ASSESSMENT OF INJECTION USE PRACTICES AND COMPLETENESS OF PRESCRIPTIONS: THE CASE OF AYDER REFERRAL HOSPITAL, MEKELLE, NORTHERN ETHIOPIA
Back Ground: Overuse of injections is considered as an important indicator of irrational prescribing pattern in a given health care setting owing to the invasive nature of such drug delivery system. Moreover, blood-borne diseases such as hepatitis B, hepatitis C and HIV/AIDS can be transmitted through unsafe injections due to poor injection practices and injection overuse. If the use of injectio...
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PHYTOCHEMICAL, ANTIOXIDANT, ANTIBACTERIAL ACTIVITIES OF NERVILIA CROCIFORMIS (ZOLL. & MORITZI) SEIDENF. AND NERVILIA INFUNDIBULIFOLIA BLATT. & MC CANN (ORCHIDACEAE) COLLECTED FROM KASARGOD DISTRICT, KERALA, INDIA
The whole plant extracts of N. crociformis and N. infundibulifolia was analyzed by priliminary phytochemical, total phenolics, flavonoid, carbohydrate and alkaloid content by standard methods. In-vitro antioxidant DPPH assay and Phosphomolybdenum assay developed by Braca et al., Prieto et al., respectively. In-vitro antibacterial (agar well diffusion) activity by gram negative Pseudomonas aerogino...
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SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE THROUGH CHARGE TRANSFER INTERACTIONS
This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5-dinitrosalicylic acid (DNSA), and picric acid (PA), (all of w...
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ANTI-WRINKLE ACTIVITY AND UPLC-MS/MS METABOLIC PROFILING OF POMEGRANATE AND GRAPE SEEDS EXTRACTS
UV irradiation is one of the main causes of what is known as photoaging characterized by loss of skin elasticity and the appearance of wrinkles. In this study, the anti-wrinkle activity of grape seed extract (GSE) and Pomegranate seed extract (PSE) was studied through evaluation of their in-vitro antioxidant, anti-tyrosinase and in-vivo anti-wrinkle activity in UVB-irradiated mice through topical ...
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