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TISSUE CHLOROQUINE LEVELS IN DIABETIC RATS
Diabetes mellitus is a disorder of metabolism resulting from insulin abnormality. Tissue levels of chloroquine in diabetes were investigated. Few diseases have such plural effects in the body as diabetes mellitus. Chloroquine distribution in the tissue and blood was investigated in diabetic rats to a certain how diabetes mellitus affects the levels of chloroquine in tissues and blood. This may pro...
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1007
BIOCHEMICAL STUDIES ON THE EFFECT OF ETHANOLIC EXTRACTS OF TRICHOSANTHES DIOICA AND CLITORIA TERNATEA IN STREPTOZOTOCIN INDUCED DIABETIC MALE WISTAR RATS
To investigate the effect of ethanolic extracts of leaf and fruit of Trichosanthe dioica (T. dioica) and leaf of Clitoria ternatea (C. ternatea) on the biochemical parameters in streptozotocin (STZ) induced diabetic Wistar albino rats. Healthy male adult Albino rats of Wistar strain were randomly divided into eleven groups of six rats each were assigned into normal and diabetic groups (Group I to ...
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944
ROLE OF SERUM BILIRUBIN IN CLINICALLY ADMITTED PATIENTS TO PREVENT THE RISK OF CARDIAC DISEASES
ABSTRACT: Background: Coronary artery disease /coronary vascular disease (CAD/CVD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development with lipid oxidation. Lipid oxidation, which accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the patho physiology of CVD. Bilirubin...
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1214
OXONE AND IODOBENZENE ARE USEFUL REACTION SYSTEM FOR SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES FROM EASILY AVAILABLE THIOUREA AND ALKYL / ARYL KETONES
A quick one step, innovative approach for the Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl / aryl ketones with the help of Oxone and Iodobenzene reaction system has been developed in aqueous acetonitrile solution. The developed procedure is applicable to several types of substituted 2-aminothiazole derivatives to get the corresponding products. The developed me...
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989
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 3, 6- DISUBSTITUTED IMIDAZO [2, 1-B] [1, 3] THIAZOLES
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method aga...
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938
PREVALENCE OF ANEMIA AND ITS ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CENTER IN SHARJAH, UAE
Anemia during pregnancy is a common complication which can involve a mother’s health, baby’s health, or both. Socioeconomic status is affecting the prevalence of maternal anemia, which is varied substantially across regions and countries. Although, the prevalence of maternal anemia in UAE has not yet been well documented nationwide. Therefore, knowledge of the prevalence and determinants of lo...
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1088
SYNTHESIS AND ANTIMICROBIAL STUDIES OF SOME NEW HALOGENATED ISOXAZOLINE DERIVATIVES
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this rea...
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1143
A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ANTI-VIRAL CLASS OF ELBASVIR AND GRAZOPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM
Objective: To develop accurate, precise stability indicating a method for simultaneous estimation of Elbasvir and Grazoprevir in bulk and pharmaceutical dosage form. Materials and Methods: Simple, rapid, precise, sensitive and reproducible validated stability-indicating Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the quantitative analysis of Elbasvir and Grazoprevir i...
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846
PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITY ON THE FRUITS OF HUGONIA MYSTAX L. (LINACEAE)
An ethnomedicinal plant, Hugonia mystax L., was examined for preliminary phytochemical screening and antimicrobial activity. Preliminary phytochemical screening showed the presence of various classes of secondary metabolites such as flavonoids, phenols, saponins, steroids, tannins and terpenoids. Antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous fruits extracts showed ...
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1135
RP-HPLC METHOD FOR QUANTIFICATION OF OROTIC ACID IN CAPSULE FORMULATION
A simple, sensitive and specific RP-HPLC method was developed and validated for the determination of Orotic acid in bulk and capsule dosage form. Chromatography was carried out on an Enable C18G (250 × 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and methanol in the ratio of 60:40% v/v as mobile phase at a flow rate of 1 ml/min and effluent was monitored at 280 nm. ...
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