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COMPATIBILITY STUDIES BETWEEN PACLITAXEL AND EXCIPIENTS IN THE PREFORMULATION PHASE OF NANOCRYSTAL FORMULATION
Paclitaxel is one of the best anti-cancer drugs and recently known as the best anti-cancer products of natural origin. The purpose of the present work was to study the physicochemical properties and compatibility of paclitaxel with the selected surfactants employed in nanocrystal formulations. The melting point and loss on drying of paclitaxel were found 216 °C and 0.11% respectively. A log P val...
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EFFECT OF VITAMIN B12 SUPPLEMENT ON SERUM LEVELS OF VITAMIN B12 AND MEMORIZING ABILITY ON PRESCHOOL CHILDREN
This research aimed to analyze the effect of vitamin B12 supplementation on vitamin B12 serum level and memorizing ability of preschool children. A community - randomized controlled trial of 29 preschool children (4-6 year) was conducted for six months. Subjects were divided into two groups, treatment group (received 10 mcg of vitamin B12 daily syrup) and control group (placebo). Serum vitamin B12...
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NANOSTRUCTURED LIPID CARRIERS: A NOVEL TARGETED DRUG DELIVERY SYSTEM
Over the previous decade, several drug delivery systems have come into view, and an alluring part of this is the advancement of nanoparticle systems. Lipid drug delivery systems has considered as one of the emerging technologies and obtained attention due to features like biocompatibility, lipophilic characteristics. Among nanoparticle Nanostructured lipid carriers (NLC) have numerous advantages t...
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SYNTHESIS, CHARACTERIZATION, BIOLOGICAL EVALUATION AND ADME STUDIES USING IN SILICO TECHNIQUES OF NOVEL DERIVATIVES OF BENZOTHIAZOLYL-AMIDES AS NON-ACIDIC ANTI-INFLAMMATORY AGENTS
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat various ailments for over 100 years. As a class, these drugs possess anti-inflammatory, anti-allergy, analgesic and antipyretic activity. A series of benzothiazolyl-amides has been synthesized and tested for anti-inflammatory activity. Basic NSAIDs are gaining interest because of their improved biological properties with the ai...
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POSSIBLE LINKS BETWEEN OBESITY AND TYPE 2 DIABETES MELLITUS
In this article, an attempt has been made to explore a positive correlation between obesity and type 2 diabetes mellitus. The possible role of several important agents in causing both has been discussed in detail. From the discussion, it seems that obesity is definitely and intimately linked to type 2 diabetes....
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DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF ILOPERIDONE IN RAT PLASMA
A simple and fast isocratic reverse phase- high performance liquid chromatography (RP-HPLC) method was developed for estimation of iloperidone from rat plasma employing a photo diode array (PDA) detector. The plasma samples were prepared by protein precipitation using acetonitrile as extracting solvent. The chromatographic separation was performed on a BDS Hypersil Phenyl column (250 mm × 4.6 ...
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INCREASED INSULIN RESISTANCE, DYSLIPIDEMIA, PRO-INFLAMMATORY MARKERS AND ENDOTHELIAL DYSFUNCTION IN CASTRATED MALE RATS: ROLE OF TESTOSTERONE REPLACEMENT
Molecular effects of androgens on cardiovascular system are variable in nature and are concentration dependent. In spite of the evidences favoring possible involvement of reduced endogenous androgens in the pathogenesis of atherosclerotic vascular disease, there is no certain role of exogenous testosterone supplementation in normal or hypogonadal males to slow down the progression of atheroscleros...
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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA-1
Hypothyroidism is a common disorder of endocrine system in which the thyroid gland does not produce enough thyroid hormone. The most common cause of hypothyroidism is inflammation of the thyroid gland, which damages the gland’s cells. It can affect growth, cellular processes and many other body functions. As more damage accumulates, the risk of Hypothyroidism increases. In order to make an impac...
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EXTRACELLULAR LIPASE FROM BACILLUS SUBTILIS KUBT4: ISOLATION, IDENTIFICATION AND CHARACTERIZATION
Lipases occupy a prominent place amongst biocatalysts as they can hydrolyze fats into fatty acids and glycerol at the water-lipid interface. Lipase production is a prime area of interest for microbiologists, process engineers, and biochemists. Recent advances in green energy have led to renewed interest in the ability of microbial lipases to catalyze trans-esterification reaction for biodiesel pro...
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TREATMENT EFFECT OF ALCUREMON PREPARATION ON ETHANOL-INDUCED NEUROTRANSMITTERS IMBALANCE AND ALCOHOLIC LIVER DISEASE IN RATS
Alcohol use disorders (AUDs) recognized as substantial public health problem. It is grown-up many risk factors influence on alcoholism including social, behavior, an environment, and heredity conditions on the global. Alcuremon preparation was based on medicinal herbs and used for the treatment of alcohol-related disease and alcoholic liver disease in traditional Mongolian medicine. Male Wistar ra...
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