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SOLVENT-FREE SOLID SUPPORTED AND PHASE TRANSFERRED CATALYZED SYNTHESIS OF BENZANILINE DERIVATIVES USING MICROWAVE IRRADIATION
In this study, solvent-free and phase transfer catalysis conditions coupled with microwave irradiation and their advantages in synthesis of N-alkylation of primary anilines were reported. In this way two different microwave processing techniques were compared in terms of reaction yields. Consequently, microwave irradiation significantly reduced reaction times compared to traditional heating method...
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PELLETIZATION OF LAMOTRIGINE SOLID DISPERSION FOR IMPROVED SOLUBILIZATION
Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was ch...
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PYRAZOLINE HETEROCYCLIC: A REVIEW
Pharmaceutical chemistry is devoted to the discovery and development of new agents for treating diseases. Inorganic compound continues to be important in therapy, for example, as antacids, mineral supplements, and radiopharmaceuticals, but organic molecules with increasingly specific pharma-cological activities are clearly dominant. The five and six-membered heterocyclic nitrogen-containing system...
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ASSESSMENT OF OFF-LABEL DRUG USE IN A TERTIARY CARE HOSPITAL
Off-label use is defined as the use of pharmaceutical drugs for an unapproved indication or unapproved age group, dose, dosage or route of administration. An off-label use provides the best intervention for the patient when medical evidence justifies its use, but this can also be harmful due to the increased risk of adverse drug reactions when lacking a solid evidentiary basis. Hence, the aim was ...
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ACECLOFENAC ENCAPSULATED ETHANOLIC NANO-VESICLES FOR EFFECTIVE TREATMENT OF OSTEOARTHRITIS
In the present study, ethanolic nanovesicles of Aceclofenac developed for the site specific delivery to joints for effective treatment of osteoarthritis. Ethanolic nano-vesicles were prepared by solvent dispersion method. Vesicles were characterized for vesicular size, surface morphology, size and size distribution, zeta potential, entrapment efficiency. Formulations were also evaluated for drug-v...
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TRANSDERMAL PENETRATION EFFICACY OF ETHOSOMAL SYSTEMS WITH AND WITHOUT PENETRATION ENHANCER: A COMPARATIVE STUDY
Ethosomal systems are now a days attracting attention of many researchers. This study is designed to observe the effect of penetration enhancers in ethosomal formulations. Ascorbic acid is taken as a model drug; phosphatidylcholine and ethanol are taken for ethosome preparation. Propylene glycol is taken as a penetration enhancer. Ethosomes are prepared by solvent dispersion method with and withou...
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THE HYPOXIC VENTILLATORY RESPONSE AND HEPATIC CYP3A4 UPREGULATION IN HUMAN AT HIGH ALTITUDE
The Hypoxic Ventillatory Response (HVR) at high altitude was hypothesized to cause pharmacokinetics changes, especially metabolism of drugs due to the up regulation of CYP3A4 isoenzyme. These pharmacokinetic alteration could affect pharmacotherapy, probably lead to either sub therapeutic or supra therapeutic effects. This hypothesis was studied with a pop-PK study conducted in healthy male volunte...
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DNA- BINDING AND CLEAVAGE STUDIES OF Mn(II) AND Co(II) COMPLEXES OF 1-(2,5-DIOXOPYRROLIDIN-1-YL)(4-HYDROXY PHENYL)METHYL) THIOUREA)
A novel Mannich base ligand 1-(2,5-dioxopyrrolidin-1-yl) (4-hydroxy phenyl)methyl)thiourea (PSTU) and its Manganese (II) and Cobalt (II) complexes have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, FT-IR, 1H NMR and 13C NMR spectroscopic studies. The antimicrobial activities and antioxidant activities of the free lig...
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NEAR INFRA-RED SPECTROSCOPY FOR QUALITY ASSESSMENT OF INDIAN TRADITIONAL HERBAL MEDICINES: A REVIEW
Herbal Medicines (HM) and their preparations have been widely used for hundreds of years all over the world. However, they have not been officially recognized due to lack of adequate or accepted research methodology for their evaluation. Traditional systems of Indian Herbal medicine include Ayurveda, Yoga, Naturopathy, Unani and Siddha. Among them Ayurveda, Siddha and Unani systems (ASU) use plant...
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EFFECT OF VIMLIV ON LIPID PEROXIDES AND ANTIOXIDANTS IN ETHANOL INDUCED HEPATOTOXICITY IN ALBINO WISTER RATS
This study was carried out to investigate the hepatoprotective and antioxidant properties of vimliv in ethanol-induced hepatotoxicity in rats. The liver toxicity was induced by the administration of ethanol to the animals at dose of 3 g/kg orally for 35 days. During the period of vimliv was co-administered to the rats at doses of 25 and 50 mg/kg for 35 days. The levels of lipidperoxidative product...
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