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SYNTHESIS OF FUSED [1, 4] DIAZEPINES BY BASE CATALYSED CONDENSATION OF 1, 2-DIAMINES WITH CARBONYL COMPOUNDS
Based on the principle of base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1, 4-diazepines was developed. High yields were obtained for both electron-releasing as well as electron-withdrawing substituted 1, 4-diazepine derivatives by the mentioned method...
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DETERMINATION OF As, Hg, Pb, Cd AND Al IN THE LIPSTICKS IN THE KINGDOM OF SAUDI ARABIA
Using inductively coupled plasma optical emission spectroscopy (ICP–OES) I determined the concentrations of heavy metals, arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd) and aluminum (Al) element after digestion using microwave pressure for 32 different types from the most popular and widely sold lipsticks in Riyadh markets. Analysis was conducted for the samples of expensive and cheap brand...
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IN-VITRO EVALUATION OF THE ANTIOXIDANT POTENTIAL, TOTAL PHENOLIC AND FLAVONOID CONTENTS AND ANTIBACTERIAL ACTIVITY OF LAMIUM ALBUM EXTRACTS
Lamium album is used as a blood purifier, in the treatment of the respiratory tract diseases, diarrhea and bleeding. In this study antioxidants and anti-bacterial activities of its aerial parts and roots were investigated. Extracts were prepared by Soxhlet apparatus. Methanol used as extracting solvent. Phenol and flavonoids contents and antioxidant properties were evaluated by different methods. ...
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SERUM LEVELS OF SELENIUM IN UNCOMPLICATED TYPE-2 DIABETIC PATIENTS AND HEALTHY INDIVIDUALS
Selenium (Se) plays a vital role in maintaining the body’s homeostasis. Selenoproteins have been found to play an integral role in the body’s defense against oxidative stress. Type-2 diabetes mellitus is considered as an inflammatory state with high oxidative load and is one of the major chronic diseases prevalent in Pakistan. Serum levels of selenium in type 2 diabetic patients and healthy in...
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FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN ALCOHOL INDUCED STERILITY OF MALE WISTAR RATS – AN HISTOMORPHOMETRIC STUDY
Alcohol abuse is well known to impair reproductive performances due to impaired testosterone production and testicular atrophy. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of alcohol induced sterile male albino rats. A total of 30 healthy young m...
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ANTITUMOR POTENTIAL OF STANDARDIZED EXTRACT FROM AEGLE MARMELOS ROOT ON DALTON’S LYMPHOMA INDUCED MICE MODEL
The antitumor property of the successive, standardized methanolic (MeOH) extract of Aegle marmelos roots (MAM) was investigated in Dalton’s ascites lymphoma mice model. Materials and methods: Flavonoid present in MAM was quantitatively estimated using high performance thin layer chromatography. MAM (100, 300 mg/kg) was administered orally for 15 days to assess antitumor activity. The tumor was i...
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INTRODUCTION OF INTEGRATED TEACHING AND ITS COMPARISON WITH OTHER TEACHING METHODS IN PHARMACOLOGY FOR UNDER GRADUATES
Background and Purpose: Integrated teaching is new in pharmacology. In the present study, evaluation and comparison of integrated teaching, conventional theory teaching and tutorial has been done. Material and methods: Ten pre and post tests were conducted each for integrated teaching, theory class and tutorial for 126 students. Student’s attitude towards these teaching methods and bedside cl...
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A VALIDATED RP- HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND NAPROXEN IN TABLET FORMULATION
The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 μm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent fl...
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PREPARATION OF CARBAPOL COATED NANOPARTICLES BY EMULSION POLYMERIZATION TECHNIQUE
Nowadays there has been considerable interest in developing new routes alternative to injection for delivering macromolecules such as proteins and peptides. However, peptides and protein drugs are degraded before they reach the blood stream and can not cross the mucosal barrier. The mucoadhesive polymer coated nanoparticles can solve these problems. They were prepared by emulsion polymerization. M...
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ORAL LIPID BASED DRUG DELIVERY SYSTEM: A REVIEW
In the recent progressive era of pharmaceutical technology, newly investigated most of the drugs come under BCS class II and IV having low solubility as well bioavailability. The drugs are not suitable candidate for the conventional oral delivery of drug. The reason is that the drugs are not able to dissolve in aqueous environment of GI (gastrointestinal) tract. Poor water solubility of drug is ch...
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