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ASSESSMENT OF FREE RADICAL SCAVENGING ACTIVITY AND ANTIOXIDANT MEDIATED HEPATOPROTECTIVE EFFECTS OF MALLOTUS ROXBURGHIANUS MUELL. IN DOXORUBICIN INDUCED OXIDATIVE STRESS IN SWISS ALBINO MICE
The aim of this study was to investigate the phytochemical constituents and therapeutic potential of various solvent extracts of Mallotus roxburghianus both in-vitro and in-vivo. Free radicals scavenging activities of various extracts were determined in a cell free system and the hepatoprotective effects was investigated in doxorubicin induced oxidative stress in Swiss Albino mice by estimating va...
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ANTIBODY ENGINEERING AND IMMUNOCONJUGATES FOR CANCER THERAPY
In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of b...
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DETERMINATION OF ANTI MICROBIAL ACTIVITY OF ESSENTIAL OILS IN DIFFERENT CONCENTRATIONS
Preservatives are added to pharmaceuticals to ensure safety and shelf life. A number of Essential oil components are identified as effective antimicrobials. The antimicrobial activity is assessed of pure oils. Oils were evaluated based on Refractive index, Specific gravity and Antimicrobial activity. In present study Syrups were prepared using Peppermint, Rose and Orange oils in different concentr...
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THE IN-VIVO EFFECTS OF PARTIALLY PURIFIED SUB-FRACTION (TAF2) OF THE CRUDE METHANOLIC EXTRACT OF EURYCOMA LONGIFOLIA ROOTS ON THE HAEMATOLOGICAL, BIOCHEMICAL AND HISTOLOGY PARAMETERS
Eurycoma longifolia (E. longifolia) Jack has been widely used in traditional medicine for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic and anticancer activities. As yet, no study has been done on biosafety of partially purified sub-fraction (TAF2) of the crude methanolic extract of E. longifolia roots. This study aims to evaluate, in vivo, the effects of TAF2 on the ha...
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PLANT REGENERATION FROM THE NODAL PART OF CITRULLUS COLOCYNTHIS (L.) SCHARD.
Citrullus colocynthis, belonging to the family of cucurbitaceae. It is a xerophytic desert plant, widely used for its medicinal purpose. In tribal areas it is used for the treatment of constipation, oedema, bacterial infection, cancer, diabetes and abortifacient. Present study is based on developing a protocol for plantlet regeneration from the nodal segment. The sterilized explants were inoculate...
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IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS -1
The development of a highly effective AIDS vaccine will depend on the success of designing immunogens that will elicit immune response against broadly neutralizing antibodies to naturally circulating strains of HIV- can be done by reverse vaccinology. Reverse vaccinology is a good approach for provoking the broadly neutralizing antibody response by identifying the specific epitopes i.e. surface pr...
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ANTI-GLYCATION EFFECT OF WHITTON ROOT (EULOPHIA NUDA) IN-VITRO CONDITION
Non enzymatic glycation takes place when elevated levels of reduced sugars react with amino groups of proteins and is called as advanced glycation end products (AGEs) are responsible for Diabetes Mellitus. Hydroalcoholic extract of Whitton root (Eulophia nuda) was tested for in-vitro inhibition of non-enzymatic glycation of Immunoglobin G. Plant extracts have their own importance and now being s...
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PHARMACEUTICAL SCIENCE BRINGS GENETICS AND IMMUNOLOGY TOGETHER TO EVOLVE A NEW DIMENSION IN TREATING CHILDHOOD CANCER: A REVIEW
Surgery, chemotherapy and radiation therapy has been the cornerstone of cancer management for decades. Since a decade or so, targeted therapies by way of Imatinib and Trastuzumab arrived that specifically target cancer cells and reply on specific molecular changes to identify them. These are in fact the standard treatment at present in several forms of cancer. But now in recent times, the fifth pi...
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AQUEOUS ETHANOLIC EXTRACT OF ACALYPHA INFERNO LEAVES IS SAFE IN ANIMALS
Acalypha inferno (AI) is a well-known ornamental plant, presently with no known documentation concerning its therapeutic use and safety profile. However, other plants of the same genus, Acalypha, have been reported to have various uses ranging from food to medicine with their related adverse effects. This study therefore focused on the acute and subchronic toxicity effects of aqueous ethanolic le...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN CLUBBED OXAZINES
Coumarin segment have been reported broad spectrum of different biological activities with the oxazine derivatives. In view that we have synthesized newer coumarin clubbed 4-(4-fluorophenyl)-6-substituted phenyl-2H-1,3-oxazin-2-amine and screened for their biological studies. 4-(4-fluorophenyl)-6-substituted phenyl-2H-1,3-oxazin-2-amine IIa-j condensed with 4-Methyl-6-nitro-2-oxo-2H-chromen-7-yl c...
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