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SYNTHESIS OF FUSED [1, 4] DIAZEPINES BY BASE CATALYSED CONDENSATION OF 1, 2-DIAMINES WITH CARBONYL COMPOUNDS
Based on the principle of base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1, 4-diazepines was developed. High yields were obtained for both electron-releasing as well as electron-withdrawing substituted 1, 4-diazepine derivatives by the mentioned method...
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POLY (METH) ACRYLATES NANOSPHERES OF CENTRALLY ACTING ANALGESIC DRUG FOR POSTOPERATIVE PAIN: IN-VITRO AND IN-VIVO CHARACTERIZATION STUDY
Postoperative pain management is prerequisite element for care of surgical patient. Objective of this study was to develop and evaluate nefopam hydrochloride loaded poly (meth) acrylates nanospheres (NFH-NS) for post-incisional pain treatment. Nefopam hydrochloride (NFH) is a centrally acting, non-opioid analgesic exclusive for treatment of post-incisional pain. NFH-NS were fabricated using eudrag...
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INTRODUCTION OF INTEGRATED TEACHING AND ITS COMPARISON WITH OTHER TEACHING METHODS IN PHARMACOLOGY FOR UNDER GRADUATES
Background and Purpose: Integrated teaching is new in pharmacology. In the present study, evaluation and comparison of integrated teaching, conventional theory teaching and tutorial has been done. Material and methods: Ten pre and post tests were conducted each for integrated teaching, theory class and tutorial for 126 students. Student’s attitude towards these teaching methods and bedside cl...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF PHENOBARBITONE AS BULK DRUG AND IN PHARMACEUTICAL FORMULATION
A sensitive, selective, precise and stability indicating high performance thin layer chromatographic method of analysis of Phenobarbitone both as a bulk drug and in formulations was developed and validated in pharmaceutical dosage form. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of dichloromethane: ethyl acetate:...
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KNOWLEDGE ON MEDICATION TAKING BEHAVIOUR, BALANCED DIET AND PHYSICAL ACTIVITY – A SURVEY AMONG THE ADOLESCENTS
ABSTRACT: The main objective of the study is to promote awareness and assess the knowledge of adolescents on medication use, importance of balanced diet and physical activity. The study was conducted among the adolescents’ aged from16-18 years in regions of Guntur. The volunteers are allowed to fill their informed consent to be a part of the study. The questionnaire was distributed to all the vo...
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ROLE OF SPERM NUCLEAR DNA INTEGRITY STATUS AND THE SEMEN QUALITY OF FERTILE AND INFERTILE MEN
The aim of the study is to evaluate the diagnostic DNA profiles of the assessment of semen analysis data with respect to male fertility potential. Seman analysis taken form 50 patients of known fertility and 50 suspended infertility were studied by conventional semen analysis by suitable methods. The acridine orange test was used to assess the integrity of sperm DNA. The data throw doubt upon the ...
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CHEMICAL COMPOSITION AND ANTIMICROBIAL PROPERTIES OF DIFFERENT BASIL OILS
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; taneth...
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LYOPHILIZATION- A PROCESS OF OPTIMIZATION OF DOSAGE FORMS
Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain the best quality products compared to products dried with traditional methods. In the pharmaceutical field, lyophilization has become an important subject to ongoing development and its expansion. In this 21st century, Lyophilization emerges...
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EFFECT OF TRIGONELLA FOENUM GRAECUM ON LACTATE DEHYDROGENASE (LDH) ACTIVITY OF BLOOD, LIVER AND PANCREAS IN NORMAL AND ALLOXAN- INDUCED DIABETIC MICE
The effect of aqueous seeds extract of Trigonella foenum graecumLinn was studied on Lactate dehydrogenase (LDH) activity of blood, liver and pancreas in normal and alloxan- induced diabetic mice. Our study showed that aqueous seeds extract, Oral administration of 50 mg/animal (0.5 ml of extract) in alternative days up to 7 days (1st, 3rd, 5th & 7th day). In alloxan induced diabetic mice, there...
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DRUG UTILIZATION PATTERN IN GERIATRIC PATIENTS OF GENERAL MEDICINE IN A SECONDARY CARE HOSPITAL
The purpose of the research was to assess the prescribing pattern in geriatrics and to analyze the prescription using World Health Organization (WHO) core prescribing indicators and American Geriatric Society (AGS) Beers criteria 2012 for potentially inappropriate medication use in older adults. This prospective drug utilization study was conducted for a period of 6-months. Patients of either gend...
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