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A KINETIC AND MECHANISTIC APPROACH TO PROTECTION AND REPAIR OF TERT-BUTOXYL RADICALS INDUCED URACIL RADICALS BY CHLOROGENIC ACID
The rates of oxidation of uracil and chlorogenic acid (CGA) by tert-butoxyl radicals have been studied by measuring the absorbance of uracil at 258 nm and CGA at 328 nm spectrophotometrically. tert-butoxyl radicals are generated by the photolysis of tert-butyl hydroperoxide in presence of tert-butyl alcohol to scavenge ·OH radicals. The rates and the quantum yields (f) of oxidation of CGA by t-Bu...
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INTRODUCTION OF INTEGRATED TEACHING AND ITS COMPARISON WITH OTHER TEACHING METHODS IN PHARMACOLOGY FOR UNDER GRADUATES
Background and Purpose: Integrated teaching is new in pharmacology. In the present study, evaluation and comparison of integrated teaching, conventional theory teaching and tutorial has been done. Material and methods: Ten pre and post tests were conducted each for integrated teaching, theory class and tutorial for 126 students. Student’s attitude towards these teaching methods and bedside cl...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF PHENOBARBITONE AS BULK DRUG AND IN PHARMACEUTICAL FORMULATION
A sensitive, selective, precise and stability indicating high performance thin layer chromatographic method of analysis of Phenobarbitone both as a bulk drug and in formulations was developed and validated in pharmaceutical dosage form. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of dichloromethane: ethyl acetate:...
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KNOWLEDGE ON MEDICATION TAKING BEHAVIOUR, BALANCED DIET AND PHYSICAL ACTIVITY – A SURVEY AMONG THE ADOLESCENTS
ABSTRACT: The main objective of the study is to promote awareness and assess the knowledge of adolescents on medication use, importance of balanced diet and physical activity. The study was conducted among the adolescents’ aged from16-18 years in regions of Guntur. The volunteers are allowed to fill their informed consent to be a part of the study. The questionnaire was distributed to all the vo...
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF 3-(1H-BENZO[d]IMIDAZOL-2-YLSULFANYL) METHYL-4-[PHENOXY(PHENYL) ACETAMIDO)-5-MERCAPTO-1,2,4-TRIAZOLE AND RELATED ARYLOXY COMPOUNDS
A series of new 1H-benzo[d]imidazole derivatives of 3, 4-substituted triazole. 3-(1H-Benzo[d]imidazol-2-ylsulfanyl) methyl-4-[phenyloxy(phenylacetamido)]-5-mercapto-1,2,4-triazole and related aryloxy compounds were synthesised, analysed and characterised by FTIR, 1HNMR and elemental analysis. These compounds were screened for antibacterial and antifungal activity. The antibacterial activities were...
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NON-PROLIFERATIVE ACTIVITY OF SAPONINS ISOLATED FROM THE LEAVES OF GYMNEMA SYLVESTRE AND ECLIPTA PROSTRATA ON HEPG2 CELLS- IN VITRO STUDY
The non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5-Fluorouracil (5FU) a posit...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHROMONES BEARING 1, 5-BENZO THIAZEPINYL MOIETY
1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The chalcones on oxidative cyclisation in DMSO - I2 yielded the titled compounds3a-d. The microbial evaluati...
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POLY (METH) ACRYLATES NANOSPHERES OF CENTRALLY ACTING ANALGESIC DRUG FOR POSTOPERATIVE PAIN: IN-VITRO AND IN-VIVO CHARACTERIZATION STUDY
Postoperative pain management is prerequisite element for care of surgical patient. Objective of this study was to develop and evaluate nefopam hydrochloride loaded poly (meth) acrylates nanospheres (NFH-NS) for post-incisional pain treatment. Nefopam hydrochloride (NFH) is a centrally acting, non-opioid analgesic exclusive for treatment of post-incisional pain. NFH-NS were fabricated using eudrag...
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PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF SCOPARIA DULCIS AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS
The objective of the present study is to carry out the photochemical investigation and hepatoprotective activity study of different extracts of Scoparia dulcis. Scoparia dulcis Linn. belongs to the family Scrophulariaceae and have ruminate medicinal properties. The different extracts of this plant were prepared by successive extraction with petroleum ether, chloroform and ethanol. These extracts (...
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DEVELOPMENT AND VALIDATION OF RATIO DERIVATIVE SPECTROPHOTOMETRIC FOR SIMULTANEOUS ESTIMATION OF METOLAZONE AND SPIRONOLACTONE IN PHARMACEUTICAL DOSAGE FORM
In the present work for the simultaneous estimation of Metolazone (METO) and Spironolactone (SPI) Ratio Derivative Spectrophotometric method have been developed. In this method the overlapping spectra of Metolazone and Spironolactone were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. Methanol:water (1:4) was used as solvent for the method. Am...
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