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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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20.

MECHANISMS OF UROLOGIC COMPLICATIONS IN STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS

Patients with DM are often afflicted by debilitating urologic complications. The main aim of this study is to investigate the effect of streptozotocin (STZ)-induced type I diabetes on contractile responses to numerous stimuli, intracellular cation concentrations and morphology in the rat.  Adult rats (n=12) were humanely killed and detrusor muscles of urinary bladder located and excised rapidly a...

V. C. Sangar *, P. Shakil and J. Singh

Department of Virology, Haffkine Institute for Training Research and testing, Parel, Mumbai, India

DOI: 10.13040/IJPSR.0975-8232.7(6).2435-43

2435-43

3670

1471

24.

ANALYSIS OF THE CHANGES IN PRICING REGULATION ON LEADING ANALGESICS MEDICINES PRICES AND UTILIZATION IN BULGARIA

In 2004, the new pricing regulation was enforced in Bulgaria. It liberates the OTC medicines pricing procedure from reference pricing to registration according to marketing authorization holder proposal. The goal is to analyse the changes in the pricing regulations concerning OTC and its impact on prices and utilization of analgesic medicines. Two main hypotheses are tested in the study. H1: The ...

N.D. Mateev, M.M. Manova* and G. I. Petrova

Faculty of Pharmacy, Departement of Social Pharmacy, Medical University Sofia, 2 Dunav Str., Sofia 1000, Bulgaria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).231-36

231-236

3669

1542

40.

PYRAZOLIDINE-3, 5-DIONE AND 2-METHYL-4-OXO-4H-THIOCHROMENE-8-CARBONYL CONJUGATES: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING

In this study, a novel series of heterocyclic compounds containing pyrazolidine-3, 5-dione nucleus has been synthesized. The compounds were synthesized in four steps; esterification of 2-mercaptobenzoic acid in an acidic medium to yield 2-mercapto-benzoic acid ethyl ester which was cyclized using ethyl acetoacetate to form 2-methyl-4-oxo-4H-thiochromene-8-carboxylic acid ethyl ester. These were re...

R. Chaubey *, N. D. Jasuja and G. Garg

School of Pharmacy, Suresh Gyan Vihar University, Jagatpur, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(5).2249-57

2249-2257

3669

1837

51.

ASSESMENT OF CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF AZADIRACTA INDICA

The aim of the research is to observe the cytotoxic activity of methanolic crude extracts of Azadirachta indica, a plant belonging to the family Meliaceae. The root of Azadirachta indica was extracted with organic solvent and the extracts were fractionated by using three fractions (n-hexane, ethyl acetate and chloroform). The crude extracts were screened for antitumor properties using brine shrimp...

Md. Mahabubul Alam Rakib and Mohammad Musarraf Hussain*

Assistant Professor, Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1585-90

1585-1590

3668

1485

16.

CONCEPTION OF A POTENT DRUG THROUGH TOXICITY AND PHARMACOPHORE STUDY FOR INHIBITING CD 1 INVOLVED IN CANCER BY MOLECULAR DOCKING STUDIES

Cancer is a class of disease, where the cells uncontrollably divide without any control over cell cycle and cell division. Various factors contribute to cause of cancer in many ways. Ultimately the cancer cell proliferates without control over cell cycle. Many factors involve in cell cycle amongst that one of the ideal target is Cyclin D1 which couples with cyclin dependent kinase 4, phosphorylate...

Katarikonda Sudhakar

Department of Pharmacology, Vagdevi College of Phramacy and Research Centre, Brahmadevam, Nellore - 524346, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(2).645-51

645-651

3668

2200

33.

MODELING OF BAKER TRIAZINE DERIVATIVES AS DHFR INHIBITORS USING QUANTUM CHEMICAL DESCRIPTORS

DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Tri...

R. Chouksey*, S. Malik , A. Thakur and N. Upadhyay

Assistant Professor Chameli Devi Group of Institutions Near Toll Naka, Khandwa Road Indore (M.P.) 452020, India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2090-96

2090-96

3668

1595

28.

DETERMINATION OF As, Hg, Pb, Cd AND Al IN THE LIPSTICKS IN THE KINGDOM OF SAUDI ARABIA

Using inductively coupled plasma optical emission spectroscopy (ICP–OES) I determined the concentrations of heavy metals, arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd) and aluminum (Al) element after digestion using microwave pressure for 32 different types from the most popular and widely sold lipsticks in Riyadh markets. Analysis was conducted for the samples of expensive and cheap brand...

M. A. Alnuwaiser

Department of Chemistry, Faculty of Science, Princess Nourahbint Abdulrahman University, P.O. Box 28445, Riyadh, 11437, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.9(11).4750-58

4750-4758

3668

1456

12.

SYNTHESIS OF FUSED [1, 4] DIAZEPINES BY BASE CATALYSED CONDENSATION OF 1, 2-DIAMINES WITH CARBONYL COMPOUNDS

Based on the principle of base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1, 4-diazepines was developed. High yields were obtained for both electron-releasing as well as electron-withdrawing substituted 1, 4-diazepine derivatives by the mentioned method...

B. A. Bapat*, V. V. Shah, R. V. Ghadage and P. J. Shirote

Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(9).2328-31

2328-2331

3667

2068

56.

IN VIVO EVALUATION OF THE ANTICANCER ACTIVITY OF A WATER-IN-GARLIC OIL NANOEMULSION LOADED WITH DOCETAXEL

Docetaxel (Doc) is an antitumor drug used to treat various types of cancers. However, it has certain limitations in clinical use due to its side effects. The major objective of this study was to assess the antitumor activity and cardiotoxicity of the Doc loaded in a nanoemulsion formulated with the garlic oil (Doc-NEGO) in Ehrlich ascites carcinoma (EAC)-bearing mice. One hundred mice were split i...

M. H. Alkhatib*, B. M. Binsiddiq and W. S. Backer

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(12).5373-79

5373-5379

3667

1720

15.

SYNTHESIS AND BIOLOGICAL ASSESMENT OF QUINAZOLONE BASED AMIDE LINKAGE CONTAINING THIAZOLIDINONE AND THEIR DERIVATIVES

A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A  Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4- (4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesi...

Bhavna Kandpal* and Jyotsna Meshram

Bhavna Kandpal*1 and Jyotsna Meshram 2

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3408-15

3408-3415

3666

1531