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DNA BINDING AND CYTOTOXICITY STUDIES OF TERNARY COPPER(II) COMPLEXES CONTAINING HETEROCYCLIC BASES AND THIOUREA
This article describes the Cu(II) complexes including [Cu(phen)(L-val)TU)] 1 & [Cu(bpy)(L-val)TU)] 2 (phen = 1, 10-phenanthroline; bpy = 2,2’-bipyridyl, L-val = L-valine and TU = Thiourea). The complexes were synthesized by ligand substitution method and characterized by various physicochemical techniques. The intense UV band around 270 nm was due to n-π* transition. The binding behaviors o...
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DIURETIC ACTIVITY OF ROOT AND BARK OF ERYTHRINA INDICA LAM.
Purpose: The present study was undertaken to investigate diuretic effect of aqueous and methanol extracts of the dried seeds of erythrina indica in normal rats. Method: Aqueous and methanol extracts of erythrina indica seeds were administered to experimental rats orally at doses of 25 and 30 ml/kg p.o. Furosemide (10 mg/kg) was used as positive control in the study. The diuretic effect of the extr...
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ASSESSMENT OF PRIMARY HEALTH CARE WORKERS’ KNOWLEDGE, ATTITUDES AND PRACTICES ON UNCOMPLICATED MALARIA MANAGEMENT IN PLATEAU STATE, NIGERIA
Overcoming the scourge of malaria infection is possible when healthcare workers have good levels of understanding and attitudes towards the disease, which will influence their treatment practices. This study assessed healthcare workers’ levels of knowledge, attitudes, and practices (KAP) in uncomplicated malaria treatment at primary healthcare (PHC) facilities in Plateau state, Nigeria. The stud...
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TEFF MILLET: NUTRITIONAL, PHYTOCHEMICAL AND ANTIOXIDANT POTENTIAL
Teff millet is progressively gaining importance worldwide due to its recognition as gluten-free food. Interestingly, its attractive nutritional profile and additional functions related to maintaining health play an important role in its identification as a nutraceutical food. The present study was conducted to analyze the nutritional, phytochemical, and antioxidant properties of teff millet. Moist...
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EFFECTS OF PORPHYRA VIETNAMENSIS EXTRACT ON TNBS-INDUCED COLITIS IN RATS
Objective: This study aimed to investigate the intestinal anti-inflammatory activity of a methanolic extract of Porphyra vietnamensis in the TNBS model of intestinal inflammation in rats. Methods: The study included (i) Identification and quantification of Porphyra-334 in P. vietnamensis, (ii) investigation of the effect of methanolic extract on DNA cleavage induced by H2O2 UV-photolysis, (iii) 50...
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STUDIES ON STRUCTURAL PROPERTIES OF THE BINARY MIXTURES OF PHARMACEUTICAL INTERMEDIATES THROUGH DIELECTRIC INVESTIGATIONS
The homo and hetero interaction in the binary mixtures of Ethyl acetate + n-Butylamine, Ethyl acetate + Cyclohexylamine and Ethyl acetate + Diethylamine has been investigated through the orientation of dipoles using dielectric polarization method. The dielectric and thermodynamic parameters such as Kirkwood correlation factor, Excess permittivity, Bruggemann factor and Dipolar excess free energy f...
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SEROLOGICAL TESTING IN ASTHMA PATIENTS VISITING MAHAVIR HOSPITAL AND RESEARCH CENTRE
Background: The hypothalamic pituitary adrenal (HPA) axis in asthmatic patients is influenced by many factors. Stress, cytokines and exogenous corticosteroids play an important role in regulating the HPA axis and thus affecting the adreno corticotrophic hormone (ACTH) and cortisol levels among these patients. It is well accepted that the HPA axis represents a major immune-regulatory system that pl...
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SPECTROPHOTOMETRIC DETERMINATION OF Co(II) AS A COMPLEX WITH 1, 2 – PROPANEDIONE, 1- PHENYL – 1 – ( 2 – HYDROXYL – 5 – BROMO – BENZILIDINEAZINE)-2-OXIME [PDPHBBAO]
The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as Mass spectrometry. This reagent was then applied for the development of the analytical method for the extractive spectrophotometric determination of Cobalt (II). Cobalt metal forms yellow coloured complex, which can be extracted in chloroform at pH 9.0 having absorption maxima at 430 nm. Be...
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SYNTHESIS, CHARACTERIZATION, INDUSTRIAL APPLICATION AND ANTICANCER ACTIVITY OF NEW N-MUSTARD SUBSTITUTED COUMARIN DERIVATIVES
A series of N-mustard substituted coumarin have been synthesized characterized and evaluated for their in-vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-2-oxo-2H-chromene-3-carbo...
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ANTIBODY ENGINEERING AND IMMUNOCONJUGATES FOR CANCER THERAPY
In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of b...
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