Most Popular
ANALYSIS OF THE CHANGES IN PRICING REGULATION ON LEADING ANALGESICS MEDICINES PRICES AND UTILIZATION IN BULGARIA
In 2004, the new pricing regulation was enforced in Bulgaria. It liberates the OTC medicines pricing procedure from reference pricing to registration according to marketing authorization holder proposal. The goal is to analyse the changes in the pricing regulations concerning OTC and its impact on prices and utilization of analgesic medicines. Two main hypotheses are tested in the study. H1: The ...
3672
1544
MODELING OF BAKER TRIAZINE DERIVATIVES AS DHFR INHIBITORS USING QUANTUM CHEMICAL DESCRIPTORS
DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Tri...
3672
1597
MECHANISMS OF UROLOGIC COMPLICATIONS IN STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS
Patients with DM are often afflicted by debilitating urologic complications. The main aim of this study is to investigate the effect of streptozotocin (STZ)-induced type I diabetes on contractile responses to numerous stimuli, intracellular cation concentrations and morphology in the rat. Adult rats (n=12) were humanely killed and detrusor muscles of urinary bladder located and excised rapidly a...
3672
1473
CONCEPTION OF A POTENT DRUG THROUGH TOXICITY AND PHARMACOPHORE STUDY FOR INHIBITING CD 1 INVOLVED IN CANCER BY MOLECULAR DOCKING STUDIES
Cancer is a class of disease, where the cells uncontrollably divide without any control over cell cycle and cell division. Various factors contribute to cause of cancer in many ways. Ultimately the cancer cell proliferates without control over cell cycle. Many factors involve in cell cycle amongst that one of the ideal target is Cyclin D1 which couples with cyclin dependent kinase 4, phosphorylate...
3671
2201
ASSESMENT OF CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF AZADIRACTA INDICA
The aim of the research is to observe the cytotoxic activity of methanolic crude extracts of Azadirachta indica, a plant belonging to the family Meliaceae. The root of Azadirachta indica was extracted with organic solvent and the extracts were fractionated by using three fractions (n-hexane, ethyl acetate and chloroform). The crude extracts were screened for antitumor properties using brine shrimp...
3670
1486
PYRAZOLIDINE-3, 5-DIONE AND 2-METHYL-4-OXO-4H-THIOCHROMENE-8-CARBONYL CONJUGATES: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING
In this study, a novel series of heterocyclic compounds containing pyrazolidine-3, 5-dione nucleus has been synthesized. The compounds were synthesized in four steps; esterification of 2-mercaptobenzoic acid in an acidic medium to yield 2-mercapto-benzoic acid ethyl ester which was cyclized using ethyl acetoacetate to form 2-methyl-4-oxo-4H-thiochromene-8-carboxylic acid ethyl ester. These were re...
3670
1838
IN VIVO EVALUATION OF THE ANTICANCER ACTIVITY OF A WATER-IN-GARLIC OIL NANOEMULSION LOADED WITH DOCETAXEL
Docetaxel (Doc) is an antitumor drug used to treat various types of cancers. However, it has certain limitations in clinical use due to its side effects. The major objective of this study was to assess the antitumor activity and cardiotoxicity of the Doc loaded in a nanoemulsion formulated with the garlic oil (Doc-NEGO) in Ehrlich ascites carcinoma (EAC)-bearing mice. One hundred mice were split i...
3670
1721
DETERMINATION OF As, Hg, Pb, Cd AND Al IN THE LIPSTICKS IN THE KINGDOM OF SAUDI ARABIA
Using inductively coupled plasma optical emission spectroscopy (ICP–OES) I determined the concentrations of heavy metals, arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd) and aluminum (Al) element after digestion using microwave pressure for 32 different types from the most popular and widely sold lipsticks in Riyadh markets. Analysis was conducted for the samples of expensive and cheap brand...
3670
1457
SYNTHESIS AND BIOLOGICAL ASSESMENT OF QUINAZOLONE BASED AMIDE LINKAGE CONTAINING THIAZOLIDINONE AND THEIR DERIVATIVES
A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4- (4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesi...
3669
1535
ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT OF THE AQUEOUS METHANOLIC AND PET-ETHER EXTRACT OF THE LEAVES OF MESUA FERREA
The purpose of the study is to evaluate the antimicrobial and cytotoxic activity of methanolic and pet-ether extract of leaves of Mesua ferrea. The antimicrobial activity was investigated against eight pathogenic Gram-positive and Gram-negative bacterial species at three concentrations (100, 300, 500 µg/disc) by using disc diffusion method. Both extracts showed moderate antibacterial activity aga...
3667
1390